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Creatine kinase B-type (EC 2.7.3.2) (B-CK) (Creatine kinase B chain)

 KCRB_RABIT              Reviewed;         381 AA.
P00567;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
25-OCT-2017, entry version 105.
RecName: Full=Creatine kinase B-type;
EC=2.7.3.2;
AltName: Full=B-CK;
AltName: Full=Creatine kinase B chain;
Name=CKB;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3857581; DOI=10.1073/pnas.82.8.2310;
Pickering L., Pang H., Biemann K., Munro H., Schimmel P.;
"Two tissue-specific isozymes of creatine kinase have closely matched
amino acid sequences.";
Proc. Natl. Acad. Sci. U.S.A. 82:2310-2314(1985).
-!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
ATP and various phosphogens (e.g. creatine phosphate). Creatine
kinase isoenzymes play a central role in energy transduction in
tissues with large, fluctuating energy demands, such as skeletal
muscle, heart, brain and spermatozoa.
-!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
{ECO:0000255|PROSITE-ProRule:PRU10029}.
-!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
the major form in skeletal muscle and myocardium, MB existing in
myocardium, and BB existing in many tissues, especially brain.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
{ECO:0000255|PROSITE-ProRule:PRU00842, ECO:0000255|PROSITE-
ProRule:PRU00843}.
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EMBL; M11306; AAA31201.1; -; mRNA.
PIR; A00678; KIRBCB.
RefSeq; NP_001075730.1; NM_001082261.1.
UniGene; Ocu.3366; -.
ProteinModelPortal; P00567; -.
SMR; P00567; -.
STRING; 9986.ENSOCUP00000007616; -.
PRIDE; P00567; -.
GeneID; 100009085; -.
KEGG; ocu:100009085; -.
CTD; 1152; -.
eggNOG; KOG3581; Eukaryota.
eggNOG; COG3869; LUCA.
HOGENOM; HOG000232165; -.
HOVERGEN; HBG001339; -.
InParanoid; P00567; -.
KO; K00933; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005739; C:mitochondrion; ISS:AgBase.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004111; F:creatine kinase activity; IEA:UniProtKB-EC.
GO; GO:0007420; P:brain development; ISS:AgBase.
GO; GO:0030644; P:cellular chloride ion homeostasis; ISS:AgBase.
Gene3D; 1.10.135.10; -; 1.
Gene3D; 3.30.590.10; -; 1.
InterPro; IPR000749; ATP-guanido_PTrfase.
InterPro; IPR022415; ATP-guanido_PTrfase_AS.
InterPro; IPR022414; ATP-guanido_PTrfase_cat.
InterPro; IPR022413; ATP-guanido_PTrfase_N.
InterPro; IPR036802; ATP-guanido_PTrfase_N_sf.
InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
PANTHER; PTHR11547; PTHR11547; 1.
Pfam; PF00217; ATP-gua_Ptrans; 1.
Pfam; PF02807; ATP-gua_PtransN; 1.
SUPFAM; SSF48034; SSF48034; 1.
SUPFAM; SSF55931; SSF55931; 1.
PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
2: Evidence at transcript level;
ATP-binding; Complete proteome; Cytoplasm; Kinase; Nitration;
Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase.
CHAIN 1 381 Creatine kinase B-type.
/FTId=PRO_0000211969.
DOMAIN 11 98 Phosphagen kinase N-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00842}.
DOMAIN 125 367 Phosphagen kinase C-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00843}.
NP_BIND 128 132 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
NP_BIND 320 325 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 130 130 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 132 132 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 191 191 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 232 232 Substrate. {ECO:0000250}.
BINDING 236 236 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 285 285 Substrate. {ECO:0000250}.
BINDING 292 292 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 320 320 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 335 335 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
MOD_RES 4 4 Phosphoserine.
{ECO:0000250|UniProtKB:P12277}.
MOD_RES 35 35 Phosphothreonine.
{ECO:0000250|UniProtKB:P12277}.
MOD_RES 125 125 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q04447}.
MOD_RES 199 199 Phosphoserine.
{ECO:0000250|UniProtKB:P12277}.
MOD_RES 269 269 Nitrated tyrosine.
{ECO:0000250|UniProtKB:Q04447}.
MOD_RES 309 309 Phosphoserine.
{ECO:0000250|UniProtKB:P07335}.
MOD_RES 322 322 Phosphothreonine.
{ECO:0000250|UniProtKB:Q04447}.
SEQUENCE 381 AA; 42663 MW; 0001F0FF3A1F3F40 CRC64;
MPFSNTHNTL KLRFPAEDEF PDLSAHNNHM AKVLTPEMDA ELRAKSTPSG FTLDDVIQTG
VDNPGHPFIM TVGCVAGDEE SYEAFKELFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD
LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAVEKLAVE ALSSLDGDLA GRYYALKSMT
EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM
QKGGNMKEVF TRFCNGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP
HLGQHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL
IEMEQRLEQG QAIDDLMPAQ K


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