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Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)

 KCRU_BOVIN              Reviewed;         416 AA.
Q9TTK8; Q3ZCF8;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
25-OCT-2017, entry version 111.
RecName: Full=Creatine kinase U-type, mitochondrial;
EC=2.7.3.2;
AltName: Full=Acidic-type mitochondrial creatine kinase;
Short=Mia-CK;
AltName: Full=Ubiquitous mitochondrial creatine kinase;
Short=U-MtCK;
Flags: Precursor;
Name=CKMT1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Retina;
PubMed=10433856; DOI=10.1006/exer.1999.0693;
Komori N., Usukura J., Jackson K.W., Tobin S.L., Matsumoto H.,
Nishizawa Y.;
"Initiating ocular proteomics for cataloging bovine retinal proteins:
microanalytical techniques permit the identification of proteins
derived from a novel photoreceptor preparation.";
Exp. Eye Res. 69:195-212(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
ATP and various phosphogens (e.g. creatine phosphate). Creatine
kinase isoenzymes play a central role in energy transduction in
tissues with large, fluctuating energy demands, such as skeletal
muscle, heart, brain and spermatozoa (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
{ECO:0000255|PROSITE-ProRule:PRU10029}.
-!- SUBUNIT: Exists as an octamer composed of four MTCK homodimers.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250}; Intermembrane side
{ECO:0000250}.
-!- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
{ECO:0000255|PROSITE-ProRule:PRU00842, ECO:0000255|PROSITE-
ProRule:PRU00843}.
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EMBL; AB003307; BAA88431.1; -; mRNA.
EMBL; BC102422; AAI02423.1; -; mRNA.
RefSeq; NP_776700.1; NM_174275.2.
RefSeq; XP_005222173.1; XM_005222116.3.
RefSeq; XP_005222174.1; XM_005222117.3.
UniGene; Bt.49713; -.
ProteinModelPortal; Q9TTK8; -.
SMR; Q9TTK8; -.
STRING; 9913.ENSBTAP00000009871; -.
PaxDb; Q9TTK8; -.
PeptideAtlas; Q9TTK8; -.
PRIDE; Q9TTK8; -.
Ensembl; ENSBTAT00000009871; ENSBTAP00000009871; ENSBTAG00000007502.
GeneID; 281692; -.
KEGG; bta:281692; -.
CTD; 1159; -.
eggNOG; KOG3581; Eukaryota.
eggNOG; COG3869; LUCA.
GeneTree; ENSGT00550000074561; -.
HOGENOM; HOG000232165; -.
HOVERGEN; HBG001339; -.
InParanoid; Q9TTK8; -.
KO; K00933; -.
OMA; LCDKATP; -.
OrthoDB; EOG091G0HZ0; -.
TreeFam; TF314214; -.
Reactome; R-BTA-71288; Creatine metabolism.
Proteomes; UP000009136; Chromosome 21.
Bgee; ENSBTAG00000007502; -.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004111; F:creatine kinase activity; IEA:UniProtKB-EC.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
Gene3D; 1.10.135.10; -; 1.
Gene3D; 3.30.590.10; -; 1.
InterPro; IPR000749; ATP-guanido_PTrfase.
InterPro; IPR022415; ATP-guanido_PTrfase_AS.
InterPro; IPR022414; ATP-guanido_PTrfase_cat.
InterPro; IPR022413; ATP-guanido_PTrfase_N.
InterPro; IPR036802; ATP-guanido_PTrfase_N_sf.
InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
PANTHER; PTHR11547; PTHR11547; 1.
Pfam; PF00217; ATP-gua_Ptrans; 1.
Pfam; PF02807; ATP-gua_PtransN; 1.
SUPFAM; SSF48034; SSF48034; 1.
SUPFAM; SSF55931; SSF55931; 1.
PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
2: Evidence at transcript level;
ATP-binding; Complete proteome; Kinase; Membrane; Mitochondrion;
Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein;
Reference proteome; Transferase; Transit peptide.
TRANSIT 1 39 Mitochondrion. {ECO:0000250}.
CHAIN 40 416 Creatine kinase U-type, mitochondrial.
/FTId=PRO_0000016589.
DOMAIN 45 131 Phosphagen kinase N-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00842}.
DOMAIN 158 400 Phosphagen kinase C-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00843}.
NP_BIND 161 165 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
NP_BIND 353 358 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
REGION 40 64 Cardiolipin-binding. {ECO:0000250}.
BINDING 224 224 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 269 269 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 325 325 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
BINDING 368 368 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00843}.
MOD_RES 151 151 Phosphoserine.
{ECO:0000250|UniProtKB:P25809}.
MOD_RES 196 196 Phosphoserine.
{ECO:0000250|UniProtKB:P25809}.
MOD_RES 232 232 Phosphoserine.
{ECO:0000250|UniProtKB:P30275}.
MOD_RES 365 365 Phosphoserine.
{ECO:0000250|UniProtKB:P30275}.
SEQUENCE 416 AA; 46897 MW; 283F2C9F49C9C176 CRC64;
MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRSEPVRAA SERRRLYPPS AEYPDLRKHN
NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP FIKTVGMVAG DEETYEVFAE
LFDPVIQERH NGYDPRTMKH TTDLDASKIR SGYFDERYVL SSRVRTGRSI RGLSLPPACT
RAERREVERV VVDALSGLKG DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM
ARDWPDARGI WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK KVFERFCRGL KEVERLIQER
GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL QKRGTGGVDT
AATGSVFDIS NLDRLGKSEV ELVQLVIDGV NFLIDCERRL ERGQDIRIPP PLPNKH


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