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Cyclic AMP receptor 1 (cAMP receptor 1)

 CAR1_DICDI              Reviewed;         392 AA.
P13773; Q557I7;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
25-OCT-2017, entry version 126.
RecName: Full=Cyclic AMP receptor 1;
Short=cAMP receptor 1;
Name=carA-1; Synonyms=car1; ORFNames=DDB_G0273397;
and
Name=carA-2; Synonyms=car1; ORFNames=DDB_G0273533;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=3047871; DOI=10.1126/science.3047871;
Klein P.S., Sun T.J., Saxe C.L. III, Kimmel A.R., Johnson R.L.,
Devreotes P.N.;
"A chemoattractant receptor controls development in Dictyostelium
discoideum.";
Science 241:1467-1472(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=12097910; DOI=10.1038/nature00847;
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A.,
Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G.,
Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A.,
Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[4]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=1692327; DOI=10.1083/jcb.110.5.1549;
Sun T.J., Van Haastert P.J.M., Devreotes P.N.;
"Surface cAMP receptors mediate multiple responses during development
in Dictyostelium: evidenced by antisense mutagenesis.";
J. Cell Biol. 110:1549-1554(1990).
[5]
DEVELOPMENTAL STAGE.
PubMed=1989903; DOI=10.1101/gad.5.1.1;
Saxe C.L. III, Johnson R.L., Devreotes P.N., Kimmel A.R.;
"Expression of a cAMP receptor gene of Dictyostelium and evidence for
a multigene family.";
Genes Dev. 5:1-8(1991).
[6]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=1849108; DOI=10.1101/gad.5.4.572;
Sun T.J., Devreotes P.N.;
"Gene targeting of the aggregation stage cAMP receptor cAR1 in
Dictyostelium.";
Genes Dev. 5:572-582(1991).
[7]
INDUCTION.
PubMed=8392183; DOI=10.1073/pnas.90.13.5969;
Louis J.M., Saxe C.L. III, Kimmel A.R.;
"Two transmembrane signaling mechanisms control expression of the cAMP
receptor gene CAR1 during Dictyostelium development.";
Proc. Natl. Acad. Sci. U.S.A. 90:5969-5973(1993).
[8]
FUNCTION.
PubMed=7925004;
Soede R.D.M., Insall R.H., Devreotes P.N., Schaap P.;
"Extracellular cAMP can restore development in Dictyostelium cells
lacking one, but not two subtypes of early cAMP receptors (cARs).
Evidence for involvement of cAR1 in aggregative gene expression.";
Development 120:1997-2002(1994).
[9]
DEVELOPMENTAL STAGE.
PubMed=8150078; DOI=10.1016/0014-5793(94)80509-1;
Abe F., Maeda Y.;
"Precise expression of the cAMP receptor gene, CAR1, during transition
from growth to differentiation in Dictyostelium discoideum.";
FEBS Lett. 342:239-241(1994).
[10]
PHOSPHORYLATION, AND MUTAGENESIS OF SER-299; SER-302; SER-303;
SER-304; SER-308; SER-324; SER-325; SER-331; 360-SER--SER-368; SER-383
AND SER-385.
PubMed=8120068;
Hereld D., Vaughan R., Kim J.-Y., Borleis J.A., Devreotes P.N.;
"Localization of ligand-induced phosphorylation sites to serine
clusters in the C-terminal domain of the Dictyostelium cAMP receptor,
cAR1.";
J. Biol. Chem. 269:7036-7044(1994).
[11]
SUBCELLULAR LOCATION.
PubMed=7876207; DOI=10.1074/jbc.270.9.4418;
Caterina M.J., Hereld D., Devreotes P.N.;
"Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a
reduction in affinity which depends upon COOH-terminal serine
residues.";
J. Biol. Chem. 270:4418-4423(1995).
[12]
SUBCELLULAR LOCATION.
PubMed=9334341; DOI=10.1083/jcb.139.2.365;
Xiao Z., Zhang N., Murphy D.B., Devreotes P.N.;
"Dynamic distribution of chemoattractant receptors in living cells
during chemotaxis and persistent stimulation.";
J. Cell Biol. 139:365-374(1997).
[13]
PHOSPHORYLATION AT SER-302; SER-303 AND SER-304, AND MUTAGENESIS OF
SER-299; SER-302; SER-303 AND SER-304.
PubMed=7721769; DOI=10.1074/jbc.270.15.8667;
Caterina M.J., Devreotes P.N., Borleis J.A., Hereld D.;
"Agonist-induced loss of ligand binding is correlated with
phosphorylation of cAR1, a G protein-coupled chemoattractant receptor
from Dictyostelium.";
J. Biol. Chem. 270:8667-8672(1995).
[14]
FUNCTION, AND MUTAGENESIS OF 288-LYS--ASN-392.
PubMed=9341180; DOI=10.1074/jbc.272.43.27313;
Kim J.-Y., Soede R.D.M., Schaap P., Valkema R., Borleis J.A.,
Van Haastert P.J.M., Devreotes P.N., Hereld D.;
"Phosphorylation of chemoattractant receptors is not essential for
chemotaxis or termination of G-protein-mediated responses.";
J. Biol. Chem. 272:27313-27318(1997).
[15]
FUNCTION, AND MUTAGENESIS OF ASN-148; VAL-154; SER-155; PHE-156 AND
THR-157.
PubMed=9578623; DOI=10.1006/dbio.1998.8882;
Kim J.-Y., Borleis J.A., Devreotes P.N.;
"Switching of chemoattractant receptors programs development and
morphogenesis in Dictyostelium: receptor subtypes activate common
responses at different agonist concentrations.";
Dev. Biol. 197:117-128(1998).
[16]
PHOSPHORYLATION.
PubMed=9880518; DOI=10.1074/jbc.274.3.1440;
Xiao Z., Yao Y., Long Y., Devreotes P.N.;
"Desensitization of G-protein-coupled receptors. agonist-induced
phosphorylation of the chemoattractant receptor cAR1 lowers its
intrinsic affinity for cAMP.";
J. Biol. Chem. 274:1440-1448(1999).
[17]
FUNCTION.
PubMed=11319871; DOI=10.1006/dbio.2001.0217;
Briscoe C., Moniakis J., Kim J.-Y., Brown J.M., Hereld D.,
Devreotes P.N., Firtel R.A.;
"The phosphorylated C-terminus of cAR1 plays a role in cell-type-
specific gene expression and STATa tyrosine phosphorylation.";
Dev. Biol. 233:225-236(2001).
[18]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=11422293; DOI=10.1046/j.1440-169x.2001.00572.x;
Tsujioka M., Yokoyama M., Nishio K., Kuwayama H., Morio T., Katoh M.,
Urushihara H., Saito T., Ochiai H., Tanaka Y., Takeuchi I., Maeda M.;
"Spatial expression patterns of genes involved in cyclic AMP responses
in Dictyostelium discoideum development.";
Dev. Growth Differ. 43:275-283(2001).
[19]
FUNCTION.
PubMed=11559759;
Dormann D., Kim J.-Y., Devreotes P.N., Weijer C.J.;
"cAMP receptor affinity controls wave dynamics, geometry and
morphogenesis in Dictyostelium.";
J. Cell Sci. 114:2513-2523(2001).
[20]
DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
PubMed=11923193;
Van Driessche N., Shaw C., Katoh M., Morio T., Sucgang R., Ibarra M.,
Kuwayama H., Saito T., Urushihara H., Maeda M., Takeuchi I.,
Ochiai H., Eaton W., Tollett J., Halter J., Kuspa A., Tanaka Y.,
Shaulsky G.;
"A transcriptional profile of multicellular development in
Dictyostelium discoideum.";
Development 129:1543-1552(2002).
[21]
DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
PubMed=12796308; DOI=10.1128/EC.2.3.627-637.2003;
Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S.,
Morio T., Urushihara H., Tanaka Y., Loomis W.F.;
"Changing patterns of gene expression in Dictyostelium prestalk cell
subtypes recognized by in situ hybridization with genes from
microarray analyses.";
Eukaryot. Cell 2:627-637(2003).
[22]
DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
PubMed=12912885; DOI=10.1128/EC.2.4.664-670.2003;
Iranfar N., Fuller D., Loomis W.F.;
"Genome-wide expression analyses of gene regulation during early
development of Dictyostelium discoideum.";
Eukaryot. Cell 2:664-670(2003).
[23]
DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
PubMed=15470253; DOI=10.1128/EC.3.5.1241-1248.2004;
Maruo T., Sakamoto H., Iranfar N., Fuller D., Morio T., Urushihara H.,
Tanaka Y., Maeda M., Loomis W.F.;
"Control of cell type proportioning in Dictyostelium discoideum by
differentiation-inducing factor as determined by in situ
hybridization.";
Eukaryot. Cell 3:1241-1248(2004).
[24]
MUTAGENESIS OF LEU-100; ILE-102; ILE-104; VAL-136 AND ASN-225.
PubMed=15574880; DOI=10.1091/mbc.E04-06-0456;
Zhang M., Goswami M., Hereld D.;
"Constitutively active G protein-coupled receptor mutants block
dictyostelium development.";
Mol. Biol. Cell 16:562-572(2005).
[25]
MUTAGENESIS OF ILE-104.
PubMed=17630977; DOI=10.1111/j.1365-2958.2007.05803.x;
Zhang M., Goswami M., Sawai S., Cox E.C., Hereld D.;
"Regulation of G protein-coupled cAMP receptor activation by a
hydrophobic residue in transmembrane helix 3.";
Mol. Microbiol. 65:508-520(2007).
-!- FUNCTION: Receptor for cAMP. Coordinates the aggregation of
individual cells into a multicellular organism and regulates the
expression of a large number of developmentally regulated genes.
The activity of this receptor is mediated by G proteins.
{ECO:0000269|PubMed:11319871, ECO:0000269|PubMed:11559759,
ECO:0000269|PubMed:1692327, ECO:0000269|PubMed:1849108,
ECO:0000269|PubMed:3047871, ECO:0000269|PubMed:7925004,
ECO:0000269|PubMed:9341180, ECO:0000269|PubMed:9578623}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7876207,
ECO:0000269|PubMed:9334341}; Multi-pass membrane protein
{ECO:0000269|PubMed:7876207, ECO:0000269|PubMed:9334341}.
-!- DEVELOPMENTAL STAGE: Expressed predominantly during early
aggregation and at low levels during later stage.
{ECO:0000269|PubMed:11422293, ECO:0000269|PubMed:11923193,
ECO:0000269|PubMed:12796308, ECO:0000269|PubMed:12912885,
ECO:0000269|PubMed:15470253, ECO:0000269|PubMed:1692327,
ECO:0000269|PubMed:1849108, ECO:0000269|PubMed:1989903,
ECO:0000269|PubMed:8150078}.
-!- PTM: C-terminal Ser or Thr residues may be phosphorylated.
{ECO:0000269|PubMed:7721769, ECO:0000269|PubMed:8120068,
ECO:0000269|PubMed:9880518}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 5 family.
{ECO:0000305}.
-!- CAUTION: The gene for this protein is duplicated in strains AX3
and AX4. These strains contain a duplication of a segment of 750
kb of chromosome 2 compared to the corresponding sequence in
strain AX2. {ECO:0000305}.
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EMBL; M21824; AAA33177.1; -; mRNA.
EMBL; AAFI02000010; EAL70653.1; -; Genomic_DNA.
EMBL; AAFI02000010; EAL70721.1; -; Genomic_DNA.
PIR; A41238; A41238.
RefSeq; XP_644603.1; XM_639511.1.
RefSeq; XP_644648.1; XM_639556.1.
ProteinModelPortal; P13773; -.
STRING; 44689.DDB0238333; -.
TCDB; 9.A.14.5.1; the g-protein-coupled receptor (gpcr) family.
iPTMnet; P13773; -.
PaxDb; P13773; -.
EnsemblProtists; EAL70653; EAL70653; DDB_G0273397.
EnsemblProtists; EAL70721; EAL70721; DDB_G0273533.
GeneID; 8618967; -.
GeneID; 8619010; -.
KEGG; ddi:DDB_G0273397; -.
KEGG; ddi:DDB_G0273533; -.
dictyBase; DDB_G0273397; carA-1.
dictyBase; DDB_G0273533; carA-2.
InParanoid; P13773; -.
KO; K04629; -.
OMA; IACFCAT; -.
PhylomeDB; P13773; -.
PRO; PR:P13773; -.
Proteomes; UP000002195; Chromosome 2.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0009986; C:cell surface; IDA:dictyBase.
GO; GO:0005829; C:cytosol; IDA:dictyBase.
GO; GO:0005887; C:integral component of plasma membrane; TAS:dictyBase.
GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
GO; GO:0030552; F:cAMP binding; IDA:dictyBase.
GO; GO:0001646; F:cAMP receptor activity; IDA:dictyBase.
GO; GO:0001637; F:G-protein coupled chemoattractant receptor activity; IDA:dictyBase.
GO; GO:0004871; F:signal transducer activity; IDA:dictyBase.
GO; GO:0007190; P:activation of adenylate cyclase activity; IGI:dictyBase.
GO; GO:0090630; P:activation of GTPase activity; IMP:dictyBase.
GO; GO:0000187; P:activation of MAPK activity; IMP:dictyBase.
GO; GO:0032148; P:activation of protein kinase B activity; IMP:dictyBase.
GO; GO:0023058; P:adaptation of signaling pathway; IMP:dictyBase.
GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:UniProtKB.
GO; GO:0019933; P:cAMP-mediated signaling; IMP:dictyBase.
GO; GO:0019934; P:cGMP-mediated signaling; IMP:dictyBase.
GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
GO; GO:0002029; P:desensitization of G-protein coupled receptor protein signaling pathway; IMP:UniProtKB.
GO; GO:1900275; P:negative regulation of phospholipase C activity; IMP:dictyBase.
GO; GO:0045762; P:positive regulation of adenylate cyclase activity; IDA:dictyBase.
GO; GO:0045860; P:positive regulation of protein kinase activity; IMP:dictyBase.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
GO; GO:0050764; P:regulation of phagocytosis; IMP:dictyBase.
GO; GO:0046578; P:regulation of Ras protein signal transduction; IMP:dictyBase.
GO; GO:1902168; P:response to catechin; IDA:dictyBase.
GO; GO:1904643; P:response to curcumin; IDA:dictyBase.
GO; GO:0097696; P:STAT cascade; IMP:dictyBase.
InterPro; IPR022343; GCR1-cAMP_receptor.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR000848; GPCR_cAMP.
PRINTS; PR02001; GCR1CAMPR.
PRINTS; PR00247; GPCRCAMP.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
1: Evidence at protein level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Phosphoprotein; Receptor; Reference proteome; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 392 Cyclic AMP receptor 1.
/FTId=PRO_0000195080.
TOPO_DOM 1 13 Extracellular. {ECO:0000255}.
TRANSMEM 14 33 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 34 47 Cytoplasmic. {ECO:0000255}.
TRANSMEM 48 68 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 69 83 Extracellular. {ECO:0000255}.
TRANSMEM 84 109 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 110 120 Cytoplasmic. {ECO:0000255}.
TRANSMEM 121 139 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 140 162 Extracellular. {ECO:0000255}.
TRANSMEM 163 181 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 182 205 Cytoplasmic. {ECO:0000255}.
TRANSMEM 206 224 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 225 235 Extracellular. {ECO:0000255}.
TRANSMEM 236 260 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 261 392 Cytoplasmic. {ECO:0000255}.
COMPBIAS 337 356 Asn-rich.
COMPBIAS 360 368 Ser-rich.
MOD_RES 299 299 Phosphoserine. {ECO:0000255}.
MOD_RES 302 302 Phosphoserine.
{ECO:0000269|PubMed:7721769}.
MOD_RES 303 303 Phosphoserine.
{ECO:0000269|PubMed:7721769}.
MOD_RES 304 304 Phosphoserine.
{ECO:0000269|PubMed:7721769}.
MOD_RES 308 308 Phosphoserine. {ECO:0000255}.
MOD_RES 360 360 Phosphoserine. {ECO:0000255}.
MOD_RES 361 361 Phosphoserine. {ECO:0000255}.
MOD_RES 362 362 Phosphoserine. {ECO:0000255}.
MOD_RES 363 363 Phosphoserine. {ECO:0000255}.
MOD_RES 364 364 Phosphoserine. {ECO:0000255}.
MOD_RES 366 366 Phosphoserine. {ECO:0000255}.
MOD_RES 367 367 Phosphoserine. {ECO:0000255}.
MOD_RES 368 368 Phosphoserine. {ECO:0000255}.
CARBOHYD 10 10 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
MUTAGEN 100 100 L->H: In DN3; constitutive
phosphorylation and greatly increased
affinity for cAMP.
{ECO:0000269|PubMed:15574880}.
MUTAGEN 102 102 I->T: In DN2; constitutive
phosphorylation and greatly increased
affinity for cAMP; when associated with
D-225. {ECO:0000269|PubMed:15574880}.
MUTAGEN 104 104 I->N: In DN4; constitutive
phosphorylation and greatly increased
affinity for cAMP. In DN1; Constitutive
phosphorylation and greatly increased
affinity for cAMP; when associated with
A-136. {ECO:0000269|PubMed:15574880,
ECO:0000269|PubMed:17630977}.
MUTAGEN 104 104 I->X: Most substitutions increase
affinity for cAMP and the most polar
substitutions block development.
{ECO:0000269|PubMed:15574880,
ECO:0000269|PubMed:17630977}.
MUTAGEN 136 136 V->A: In DN1; constitutive
phosphorylation and greatly increased
affinity for cAMP; when associated with
N-104. {ECO:0000269|PubMed:15574880}.
MUTAGEN 148 148 N->G: Reduces the affinity for cAMP by
100 to 1000-fold when associated with D-
154; N-155; Y-156 and D-157.
{ECO:0000269|PubMed:9578623}.
MUTAGEN 154 154 V->D: Reduces the affinity for cAMP by
100 to 1000-fold when associated with G-
148; N-155; Y-156 and D-157.
{ECO:0000269|PubMed:9578623}.
MUTAGEN 155 155 S->N: Reduces the affinity for cAMP by
100 to 1000-fold when associated with G-
148; D-154; Y-156 and D-157.
{ECO:0000269|PubMed:9578623}.
MUTAGEN 156 156 F->Y: Reduces the affinity for cAMP by
100 to 1000-fold when associated with G-
148; D-154; N-155 and D-157.
{ECO:0000269|PubMed:9578623}.
MUTAGEN 157 157 T->D: Reduces the affinity for cAMP by
100 to 1000-fold when associated with G-
148; D-154; N-155 and Y-156.
{ECO:0000269|PubMed:9578623}.
MUTAGEN 225 225 N->D: In DN2; constitutive
phosphorylation and greatly increased
affinity for cAMP; when associated with
T-102. {ECO:0000269|PubMed:15574880}.
MUTAGEN 288 392 Missing: No effect on cAMP-dependent gene
expression, chemotaxis, aggregation and
differentiation.
{ECO:0000269|PubMed:9341180}.
MUTAGEN 299 299 S->A: Greatly reduces ligand induced
phosphorylation; when associated with G-
302; A-303; G-304 and A-308.
{ECO:0000269|PubMed:7721769,
ECO:0000269|PubMed:8120068}.
MUTAGEN 302 302 S->G: Greatly reduces ligand induced
phosphorylation; when associated with A-
299; A-303; G-304 and A-308.
{ECO:0000269|PubMed:7721769,
ECO:0000269|PubMed:8120068}.
MUTAGEN 303 303 S->A: Greatly reduces ligand induced
phosphorylation; when associated with A-
299; G-302; G-304 and A-308.
{ECO:0000269|PubMed:7721769,
ECO:0000269|PubMed:8120068}.
MUTAGEN 304 304 S->G: Greatly reduces ligand induced
phosphorylation; when associated with A-
299; G-302; A-303 and A-308.
{ECO:0000269|PubMed:7721769,
ECO:0000269|PubMed:8120068}.
MUTAGEN 308 308 S->A: Greatly reduces ligand induced
phosphorylation; when associated with A-
299; G-302; A-303 and G-304.
{ECO:0000269|PubMed:8120068}.
MUTAGEN 324 324 S->G: Slightly reduces ligand induced and
basal phosphorylation; when associated
with A-325 and A-331.
{ECO:0000269|PubMed:8120068}.
MUTAGEN 325 325 S->A: Slightly reduces ligand induced and
basal phosphorylation; when associated
with G-324 and A-331.
{ECO:0000269|PubMed:8120068}.
MUTAGEN 331 331 S->A: Slightly reduces ligand induced and
basal phosphorylation; when associated
with G-324 and A-325.
{ECO:0000269|PubMed:8120068}.
MUTAGEN 360 368 Missing: Greatly reduces basal
phosphorylation.
{ECO:0000269|PubMed:8120068}.
MUTAGEN 383 383 S->A: No effect on phosphorylation.
{ECO:0000269|PubMed:8120068}.
MUTAGEN 385 385 S->A: No effect on phosphorylation.
{ECO:0000269|PubMed:8120068}.
SEQUENCE 392 AA; 44312 MW; 38C4561EE1CC9A69 CRC64;
MGLLDGNPAN ETSLVLLLFA DFSSMLGCMA VLIGFWRLKL LRNHVTKVIA CFCATSFCKD
FPSTILTLTN TAVNGGFPCY LYAIVITYGS FACWLWTLCL AISIYMLIVK REPEPERFEK
YYYLLCWGLP LISTIVMLAK NTVQFVGNWC WIGVSFTGYR FGLFYGPFLF IWAISAVLVG
LTSRYTYVVI HNGVSDNKEK HLTYQFKLIN YIIVFLVCWV FAVVNRIVNG LNMFPPALNI
LHTYLSVSHG FWASVTFIYN NPLMWRYFGA KILTVFTFFG YFTDVQKKLE KNKNNNNPSP
YSSSRGTSGK TMGGHPTGDD VQCSSDMEQC SLERHPNMVN NQQNLNNNYG LQQNYNDEGS
SSSSLSSSDE EKQTVEMQNI QISTSTNGQG NN


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Catalog number Product name Quantity
K3019-C Cyclic AMP Direct EIA Kit (One Plate) Measure cAMP in lysed cells, tissue , plasma, saliva, urine or TCM Measure to less than 4 fmol cAMP per sample High optical density in 2.5 hours This Cyclic 96 rxns
EH1324 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Elisa Kit 96T
CSB-EL017681HU Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) ELISA kit 96T
EIAAB30284 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,Mouse,Mus musculus,Pde10a
EIAAB30283 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,Pde10a,Rat,Rattus norvegicus
EIAAB30285 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,Homo sapiens,Human,PDE10A
DL-cAMP-Ge General Cyclic Adenosine Monophosphate (cAMP) ELISA Kit 96T
E0003Ge ELISA kit cAMP,Cyclic adenosine monophosphate,cyclic AMP,cyclicAMP 96T
U0003Ge CLIA cAMP,Cyclic adenosine monophosphate,cyclic AMP,cyclicAMP 96T
E0003Ge ELISA cAMP,Cyclic adenosine monophosphate,cyclic AMP,cyclicAMP 96T
E1158h ELISA Kit FOR cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; organism: Human; gene name: PDE10A 96T
E1158m ELISA Kit FOR cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; organism: Mouse; gene name: Pde10a 96T
PKE-CAMP-500 Cell signaling activators: cAMP, sodium salt, nucleotide, CAS number: 37839-81-9, Chemical name: Adenosine- 3', 5'- cyclic monophosphate 500
K3019-1 Cyclic AMP Direct Chemiluminescent EIA kit (One Plate) Measure cAMP in lysed cells, plasma, saliva, urine or tissue Measure to less than 1 fmol cAMP per sample _ most sensitive kit available H 96 rxns
AP00244PU-N cAMP (cyclic AMP) 0.1 ml
NB120-832 cAMP (cyclic AMP) 0.1 ml
AP00244PU-N cAMP (cyclic AMP) 0.1 ml
GTX20832 cAMP (cyclic AMP) 100 µl
GTX12414 cAMP (cyclic AMP) 100 Tests
BP2213 cAMP (cyclic AMP) 0.2 ml
28101 cAMP (cyclic AMP) 0.2 ml
BP2213 cAMP (cyclic AMP) 0.2 ml
GTX12414 cAMP (cyclic AMP) 100 Tests
BP2213 cAMP (cyclic AMP) 0.2 ml
GTX20832 cAMP (cyclic AMP) 100 µl


 

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