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Cyclic AMP receptor 4 (cAMP receptor 4)

 CAR4_DICDI              Reviewed;         443 AA.
Q9TX43; Q54YI6;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
04-DEC-2007, sequence version 2.
23-MAY-2018, entry version 99.
RecName: Full=Cyclic AMP receptor 4;
Short=cAMP receptor 4;
Name=carD; Synonyms=car4; ORFNames=DDB_G0277831;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
Dictyosteliaceae; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE, FUNCTION, AND DEVELOPMENTAL STAGE.
STRAIN=NC-4;
PubMed=7958880; DOI=10.1101/gad.8.17.2086;
Louis J.M., Ginsburg G.T., Kimmel A.R.;
"The cAMP receptor CAR4 regulates axial patterning and cellular
differentiation during late development of Dictyostelium.";
Genes Dev. 8:2086-2096(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
-!- FUNCTION: Receptor for cAMP. Regulates axial patterning and
cellular differentiation during late development. The activity of
this receptor is mediated by G proteins.
{ECO:0000269|PubMed:7958880}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- DEVELOPMENTAL STAGE: Initially expressed during tip elongation and
continues to accumulate into culmination.
{ECO:0000269|PubMed:7958880}.
-!- PTM: C-terminal Ser or Thr residues may be phosphorylated.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 5 family.
{ECO:0000305}.
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EMBL; AAFI02000023; EAL68088.1; -; Genomic_DNA.
PIR; A54813; A54813.
RefSeq; XP_642216.1; XM_637124.1.
ProteinModelPortal; Q9TX43; -.
STRING; 44689.DDB0216256; -.
PaxDb; Q9TX43; -.
EnsemblProtists; EAL68088; EAL68088; DDB_G0277831.
GeneID; 8621423; -.
KEGG; ddi:DDB_G0277831; -.
dictyBase; DDB_G0277831; carD.
InParanoid; Q9TX43; -.
KO; K04629; -.
OMA; DEMSNAN; -.
PhylomeDB; Q9TX43; -.
PRO; PR:Q9TX43; -.
Proteomes; UP000002195; Chromosome 3.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0005887; C:integral component of plasma membrane; TAS:dictyBase.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0030552; F:cAMP binding; IDA:dictyBase.
GO; GO:0001646; F:cAMP receptor activity; ISS:dictyBase.
GO; GO:0019933; P:cAMP-mediated signaling; ISS:dictyBase.
GO; GO:0030154; P:cell differentiation; IMP:dictyBase.
GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
GO; GO:0010629; P:negative regulation of gene expression; IMP:dictyBase.
GO; GO:0071901; P:negative regulation of protein serine/threonine kinase activity; IMP:dictyBase.
GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
GO; GO:1903615; P:positive regulation of protein tyrosine phosphatase activity; IMP:dictyBase.
InterPro; IPR022343; GCR1-cAMP_receptor.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR000848; GPCR_cAMP.
PRINTS; PR02001; GCR1CAMPR.
PRINTS; PR00247; GPCRCAMP.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
2: Evidence at transcript level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Phosphoprotein; Receptor; Reference proteome; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 443 Cyclic AMP receptor 4.
/FTId=PRO_0000195083.
TOPO_DOM 1 11 Extracellular. {ECO:0000255}.
TRANSMEM 12 32 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 33 44 Cytoplasmic. {ECO:0000255}.
TRANSMEM 45 65 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 66 89 Extracellular. {ECO:0000255}.
TRANSMEM 90 110 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 111 119 Cytoplasmic. {ECO:0000255}.
TRANSMEM 120 140 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 141 161 Extracellular. {ECO:0000255}.
TRANSMEM 162 182 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 183 208 Cytoplasmic. {ECO:0000255}.
TRANSMEM 209 229 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 230 263 Extracellular. {ECO:0000255}.
TRANSMEM 264 284 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 285 443 Cytoplasmic. {ECO:0000255}.
COMPBIAS 293 443 Asn-rich.
COMPBIAS 293 298 Poly-Asn.
COMPBIAS 332 339 Poly-Gln.
COMPBIAS 342 352 Poly-Gln.
COMPBIAS 411 425 Poly-Asn.
CARBOHYD 8 8 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 122 122 F -> I (in Ref. 1). {ECO:0000305}.
CONFLICT 164 165 LF -> YI (in Ref. 1). {ECO:0000305}.
CONFLICT 323 323 H -> HH (in Ref. 1). {ECO:0000305}.
CONFLICT 388 388 N -> I (in Ref. 1). {ECO:0000305}.
CONFLICT 431 431 Missing (in Ref. 1). {ECO:0000305}.
SEQUENCE 443 AA; 51467 MW; F6EDF7F32E180CB4 CRC64;
MKVLQEINLT YSILVIADFS SIFGCLLVLI AFKKLKLLRN HITRVIACFC VSSLLKDIIS
TGLTLSLGPQ NEAGSTSFQC YLYAITITYG SLACWLWTLC LAFSIYNLIV KREPEPEKYE
KFYHGVCWTI PLICVIVMLA KKTIEPVGNW CWISEKYVGY RFGLFYGPFF AIWIISAVLV
GLTSRYTYSV IRNSVSDNKD KHMTYQFKLI NYIIVFLLCW VFAIVNRILN GLGYYPTLPN
ILHTYFSVSH GFFASVTFIY NNPLMWRYWG SKIFLIFAKF GYFVELQRRL DRNKNNNNPS
PILNSYAATV YHSSTIESLS LQHNNDISND NQQQQQQQQT PQQPQQQFQQ QQSPTVIEMQ
NLKQDQNIEN NEQNENCYNT IDTNIEINTN KLNDNSFEIT QPSNDLNTIE NNNNYNNNNN
NNNNNSLVIE KEKDEREKKD NKF


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