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Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (TCR-ATF1)

 ATF1_MOUSE              Reviewed;         269 AA.
P81269;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 1.
30-AUG-2017, entry version 143.
RecName: Full=Cyclic AMP-dependent transcription factor ATF-1;
Short=cAMP-dependent transcription factor ATF-1;
AltName: Full=Activating transcription factor 1;
AltName: Full=TCR-ATF1;
Name=Atf1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1531847;
Lee M.-R., Chung C.-S., Liou M.-L., Wu M., Li W.-F., Hsueh Y.-P.,
Lai M.-Z.;
"Isolation and characterization of nuclear proteins that bind to T
cell receptor V beta decamer motif.";
J. Immunol. 148:1906-1912(1992).
[2]
PHOSPHORYLATION AT SER-63.
PubMed=18690222; DOI=10.1038/ni.1644;
Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J.,
Park J.M., Wingate A., Monk C.E., Toth R., Santos S.G., Iversen L.,
Arthur J.S.;
"The kinases MSK1 and MSK2 act as negative regulators of Toll-like
receptor signaling.";
Nat. Immunol. 9:1028-1036(2008).
-!- FUNCTION: Binds the cAMP response element (CRE) (consensus: 5'-
GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular
promoters. Binds to the Tax-responsive element (TRE) of HTLV-I.
Mediates PKA-induced stimulation of CRE-reporter genes. Represses
the expression of FTH1 and other antioxidant detoxification genes.
Triggers cell proliferation and transformation (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Binds DNA as a dimer. Interacts with HIPK2 and CDK3 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- PTM: Phosphorylated at Ser-196 by HIPK2 in response to genotoxic
stress. This phosphorylation promotes transcription repression of
FTH1 and other antioxidant detoxification genes. The CDK3-mediated
phosphorylation at Ser-63 promotes its transactivation and
transcriptional activities (By similarity). Phosphorylated at Ser-
63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress
stimuli. {ECO:0000250, ECO:0000269|PubMed:18690222}.
-!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
{ECO:0000305}.
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EMBL; M63725; AAA40395.1; -; mRNA.
CCDS; CCDS27832.1; -.
PIR; A46490; A46490.
RefSeq; NP_031523.3; NM_007497.3.
RefSeq; XP_006520414.1; XM_006520351.3.
RefSeq; XP_006520415.1; XM_006520352.3.
UniGene; Mm.676; -.
ProteinModelPortal; P81269; -.
SMR; P81269; -.
IntAct; P81269; 2.
STRING; 10090.ENSMUSP00000023769; -.
iPTMnet; P81269; -.
PhosphoSitePlus; P81269; -.
MaxQB; P81269; -.
PaxDb; P81269; -.
PeptideAtlas; P81269; -.
PRIDE; P81269; -.
Ensembl; ENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027.
GeneID; 11908; -.
KEGG; mmu:11908; -.
UCSC; uc007xqs.1; mouse.
CTD; 466; -.
MGI; MGI:1298366; Atf1.
eggNOG; KOG3584; Eukaryota.
eggNOG; ENOG410ZZJZ; LUCA.
GeneTree; ENSGT00390000008655; -.
HOGENOM; HOG000007365; -.
HOVERGEN; HBG011077; -.
InParanoid; P81269; -.
KO; K09053; -.
OMA; HIAQQMS; -.
OrthoDB; EOG091G0FTJ; -.
PhylomeDB; P81269; -.
TreeFam; TF106464; -.
Reactome; R-MMU-199920; CREB phosphorylation.
PRO; PR:P81269; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000023027; -.
CleanEx; MM_ATF1; -.
ExpressionAtlas; P81269; baseline and differential.
Genevisible; P81269; MM.
GO; GO:1990590; C:ATF1-ATF4 transcription factor complex; IDA:ParkinsonsUK-UCL.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0032403; F:protein complex binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; ISO:MGI.
GO; GO:0043623; P:cellular protein complex assembly; IEA:Ensembl.
GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0032025; P:response to cobalt ion; IEA:Ensembl.
GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
InterPro; IPR004827; bZIP.
InterPro; IPR003102; Coactivator_CBP_pKID.
InterPro; IPR001630; Leuzip_CREB.
Pfam; PF00170; bZIP_1; 1.
Pfam; PF02173; pKID; 1.
PRINTS; PR00041; LEUZIPPRCREB.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
PROSITE; PS50953; KID; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 269 Cyclic AMP-dependent transcription factor
ATF-1.
/FTId=PRO_0000076576.
DOMAIN 31 90 KID. {ECO:0000255|PROSITE-
ProRule:PRU00312}.
DOMAIN 211 269 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 213 237 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 239 260 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
MOD_RES 63 63 Phosphoserine; by CaMK1, CDK3, RPS6KA4
and RPS6KA5.
{ECO:0000305|PubMed:18690222}.
MOD_RES 196 196 Phosphoserine; by HIPK2.
{ECO:0000250|UniProtKB:P18846,
ECO:0000255|PROSITE-ProRule:PRU00312}.
CROSSLNK 206 206 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P18846}.
SEQUENCE 269 AA; 29238 MW; 9885265159D64A0C CRC64;
MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS SQKAHGILAR
RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI YQTSSGQYIA IAPNGALQLA
SPSTDGVQAL QTLTMTNSSS TQQGTILQYA QTSDGQQILV PSNQVVVQTA SGDMQTYQIR
TTPSATSLPQ TVVMTSPVTL ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE
NRVAVLENQN KTLIEELKTL KDLYSHKSV


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