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Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) (Liver regeneration factor 1) (LRF-1)
ATF3_RAT Reviewed; 181 AA.
P29596;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
28-MAR-2018, entry version 135.
RecName: Full=Cyclic AMP-dependent transcription factor ATF-3;
Short=cAMP-dependent transcription factor ATF-3;
AltName: Full=Activating transcription factor 3;
AltName: Full=Liver regeneration factor 1;
Short=LRF-1;
Name=Atf3; Synonyms=Lrf1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer; TISSUE=Liver;
PubMed=1902565; DOI=10.1073/pnas.88.9.3511;
Hsu J.-C., Laz T., Mohn K.L., Taub R.;
"Identification of LRF-1, a leucine-zipper protein that is rapidly and
highly induced in regenerating liver.";
Proc. Natl. Acad. Sci. U.S.A. 88:3511-3515(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: In solution, it binds the cAMP response element (CRE)
(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many
viral and cellular promoters but also has affinity for related
sites. May have a unique and critical role in growth regulation of
regenerating liver and mitogen-stimulated cells.
-!- SUBUNIT: ATF3 alone can bind DNA, but it preferentially forms
heteromeric complexes with JUN and JUNB and does not interact with
FOS.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00978}.
-!- TISSUE SPECIFICITY: In tissues containing skeletal muscle or
smooth muscle, and at low levels in some tumor cells.
-!- INDUCTION: Rapidly and highly induced in regenerating liver and
mitogen-stimulated cells.
-!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
{ECO:0000305}.
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EMBL; M63282; AAA41542.1; -; mRNA.
EMBL; BC078903; AAH78903.1; -; mRNA.
PIR; A39382; A39382.
RefSeq; NP_037044.1; NM_012912.2.
UniGene; Rn.9664; -.
ProteinModelPortal; P29596; -.
SMR; P29596; -.
CORUM; P29596; -.
STRING; 10116.ENSRNOP00000005085; -.
PaxDb; P29596; -.
Ensembl; ENSRNOT00000005085; ENSRNOP00000005085; ENSRNOG00000003745.
Ensembl; ENSRNOT00000089841; ENSRNOP00000071188; ENSRNOG00000003745.
GeneID; 25389; -.
KEGG; rno:25389; -.
CTD; 467; -.
RGD; 2165; Atf3.
eggNOG; KOG1414; Eukaryota.
eggNOG; ENOG4111CH5; LUCA.
GeneTree; ENSGT00730000110847; -.
HOGENOM; HOG000034126; -.
HOVERGEN; HBG003381; -.
InParanoid; P29596; -.
KO; K09032; -.
OMA; LVYMLNL; -.
OrthoDB; EOG091G0M4N; -.
PhylomeDB; P29596; -.
TreeFam; TF326301; -.
PRO; PR:P29596; -.
Proteomes; UP000002494; Chromosome 13.
Bgee; ENSRNOG00000003745; -.
Genevisible; P29596; RN.
GO; GO:1990622; C:CHOP-ATF3 complex; ISO:RGD.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISO:RGD.
GO; GO:0003677; F:DNA binding; ISO:RGD.
GO; GO:0003700; F:DNA binding transcription factor activity; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISO:RGD.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
GO; GO:0001709; P:cell fate determination; TAS:RGD.
GO; GO:0034198; P:cellular response to amino acid starvation; ISO:RGD.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISO:RGD.
GO; GO:0006094; P:gluconeogenesis; ISO:RGD.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:1903984; P:positive regulation of TRAIL-activated apoptotic signaling pathway; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; ISO:RGD.
GO; GO:0035914; P:skeletal muscle cell differentiation; ISO:RGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR000837; AP-1.
InterPro; IPR029812; ATF3.
InterPro; IPR004827; bZIP.
PANTHER; PTHR23351; PTHR23351; 1.
PANTHER; PTHR23351:SF23; PTHR23351:SF23; 1.
Pfam; PF00170; bZIP_1; 1.
PRINTS; PR00042; LEUZIPPRFOS.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 181 Cyclic AMP-dependent transcription factor
ATF-3.
/FTId=PRO_0000076583.
DOMAIN 86 149 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 88 110 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 114 142 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
MOD_RES 162 162 Phosphothreonine.
{ECO:0000250|UniProtKB:P18847}.
CROSSLNK 78 78 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P18847}.
CROSSLNK 175 175 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P18847}.
SEQUENCE 181 AA; 20764 MW; E36971E1A96F262B CRC64;
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS
ALESVTINNR PLEMSVTKSE VAPEEDERKR RRRERNKIAA AKCRNKKKEK TECLQKESEK
LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ
S
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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1182: Eukaryotic Transcription Initiation
WP1238: Eukaryotic Transcription Initiation
WP1541: Energy Metabolism
WP177: Eukaryotic Transcription Initiation
WP1822: Generic Transcription Pathway
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP1930: Transcription
WP344: Eukaryotic Transcription Initiation
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