GENTAUR Molecular Products.

 ATF3_RAT                Reviewed;         181 AA.
 P29596;
 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
 01-APR-1993, sequence version 1.
 28-MAR-2018, entry version 135.
 RecName: Full=Cyclic AMP-dependent transcription factor ATF-3;
          Short=cAMP-dependent transcription factor ATF-3;
 AltName: Full=Activating transcription factor 3;
 AltName: Full=Liver regeneration factor 1;
          Short=LRF-1;
 Name=Atf3; Synonyms=Lrf1;
 Rattus norvegicus (Rat).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Rattus.
 NCBI_TaxID=10116;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA].
 STRAIN=Fischer; TISSUE=Liver;
 PubMed=1902565; DOI=10.1073/pnas.88.9.3511;
 Hsu J.-C., Laz T., Mohn K.L., Taub R.;
 "Identification of LRF-1, a leucine-zipper protein that is rapidly and
 highly induced in regenerating liver.";
 Proc. Natl. Acad. Sci. U.S.A. 88:3511-3515(1991).
 [2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 TISSUE=Lung;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 -!- FUNCTION: In solution, it binds the cAMP response element (CRE)
     (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many
     viral and cellular promoters but also has affinity for related
     sites. May have a unique and critical role in growth regulation of
     regenerating liver and mitogen-stimulated cells.
 -!- SUBUNIT: ATF3 alone can bind DNA, but it preferentially forms
     heteromeric complexes with JUN and JUNB and does not interact with
     FOS.
 -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
     ProRule:PRU00978}.
 -!- TISSUE SPECIFICITY: In tissues containing skeletal muscle or
     smooth muscle, and at low levels in some tumor cells.
 -!- INDUCTION: Rapidly and highly induced in regenerating liver and
     mitogen-stimulated cells.
 -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
     {ECO:0000305}.
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 EMBL; M63282; AAA41542.1; -; mRNA.
 EMBL; BC078903; AAH78903.1; -; mRNA.
 PIR; A39382; A39382.
 RefSeq; NP_037044.1; NM_012912.2.
 UniGene; Rn.9664; -.
 ProteinModelPortal; P29596; -.
 SMR; P29596; -.
 CORUM; P29596; -.
 STRING; 10116.ENSRNOP00000005085; -.
 PaxDb; P29596; -.
 Ensembl; ENSRNOT00000005085; ENSRNOP00000005085; ENSRNOG00000003745.
 Ensembl; ENSRNOT00000089841; ENSRNOP00000071188; ENSRNOG00000003745.
 GeneID; 25389; -.
 KEGG; rno:25389; -.
 CTD; 467; -.
 RGD; 2165; Atf3.
 eggNOG; KOG1414; Eukaryota.
 eggNOG; ENOG4111CH5; LUCA.
 GeneTree; ENSGT00730000110847; -.
 HOGENOM; HOG000034126; -.
 HOVERGEN; HBG003381; -.
 InParanoid; P29596; -.
 KO; K09032; -.
 OMA; LVYMLNL; -.
 OrthoDB; EOG091G0M4N; -.
 PhylomeDB; P29596; -.
 TreeFam; TF326301; -.
 PRO; PR:P29596; -.
 Proteomes; UP000002494; Chromosome 13.
 Bgee; ENSRNOG00000003745; -.
 Genevisible; P29596; RN.
 GO; GO:1990622; C:CHOP-ATF3 complex; ISO:RGD.
 GO; GO:0005730; C:nucleolus; IEA:Ensembl.
 GO; GO:0005634; C:nucleus; ISO:RGD.
 GO; GO:0003677; F:DNA binding; ISO:RGD.
 GO; GO:0003700; F:DNA binding transcription factor activity; ISO:RGD.
 GO; GO:0042802; F:identical protein binding; ISO:RGD.
 GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
 GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
 GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
 GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:RGD.
 GO; GO:0044212; F:transcription regulatory region DNA binding; ISO:RGD.
 GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISO:RGD.
 GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
 GO; GO:0001709; P:cell fate determination; TAS:RGD.
 GO; GO:0034198; P:cellular response to amino acid starvation; ISO:RGD.
 GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISO:RGD.
 GO; GO:0006094; P:gluconeogenesis; ISO:RGD.
 GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
 GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
 GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
 GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
 GO; GO:1903984; P:positive regulation of TRAIL-activated apoptotic signaling pathway; ISO:RGD.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
 GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; ISO:RGD.
 GO; GO:0035914; P:skeletal muscle cell differentiation; ISO:RGD.
 GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
 InterPro; IPR000837; AP-1.
 InterPro; IPR029812; ATF3.
 InterPro; IPR004827; bZIP.
 PANTHER; PTHR23351; PTHR23351; 1.
 PANTHER; PTHR23351:SF23; PTHR23351:SF23; 1.
 Pfam; PF00170; bZIP_1; 1.
 PRINTS; PR00042; LEUZIPPRFOS.
 SMART; SM00338; BRLZ; 1.
 PROSITE; PS50217; BZIP; 1.
 PROSITE; PS00036; BZIP_BASIC; 1.
 2: Evidence at transcript level;
 Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
 Phosphoprotein; Reference proteome; Repressor; Transcription;
 Transcription regulation; Ubl conjugation.
 CHAIN         1    181       Cyclic AMP-dependent transcription factor
                              ATF-3.
                              /FTId=PRO_0000076583.
 DOMAIN       86    149       bZIP. {ECO:0000255|PROSITE-
                              ProRule:PRU00978}.
 REGION       88    110       Basic motif. {ECO:0000255|PROSITE-
                              ProRule:PRU00978}.
 REGION      114    142       Leucine-zipper. {ECO:0000255|PROSITE-
                              ProRule:PRU00978}.
 MOD_RES     162    162       Phosphothreonine.
                              {ECO:0000250|UniProtKB:P18847}.
 CROSSLNK     78     78       Glycyl lysine isopeptide (Lys-Gly)
                              (interchain with G-Cter in SUMO2).
                              {ECO:0000250|UniProtKB:P18847}.
 CROSSLNK    175    175       Glycyl lysine isopeptide (Lys-Gly)
                              (interchain with G-Cter in SUMO2).
                              {ECO:0000250|UniProtKB:P18847}.
 SEQUENCE   181 AA;  20764 MW;  E36971E1A96F262B CRC64;
 MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS
 ALESVTINNR PLEMSVTKSE VAPEEDERKR RRRERNKIAA AKCRNKKKEK TECLQKESEK
 LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ
 S

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