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Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) (Transcription factor LRG-21)

 ATF3_MOUSE              Reviewed;         181 AA.
Q60765;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 140.
RecName: Full=Cyclic AMP-dependent transcription factor ATF-3;
Short=cAMP-dependent transcription factor ATF-3;
AltName: Full=Activating transcription factor 3;
AltName: Full=Transcription factor LRG-21;
Name=Atf3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ; TISSUE=Macrophage;
PubMed=8960123; DOI=10.1016/S0161-5890(96)00043-0;
Drysdale B.E., Howard D.L., Johnson R.J.;
"Identification of a lipopolysaccharide inducible transcription factor
in murine macrophages.";
Mol. Immunol. 33:989-998(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II; TISSUE=Mammary gland, and Osteoblast;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
INDUCTION.
PubMed=22242125; DOI=10.1371/journal.pone.0029498;
Alter J., Bengal E.;
"Stress-induced C/EBP homology protein (CHOP) represses MyoD
transcription to delay myoblast differentiation.";
PLoS ONE 6:E29498-E29498(2011).
-!- FUNCTION: This protein binds the cAMP response element (CRE)
(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many
viral and cellular promoters. Represses transcription from
promoters with ATF sites. It may repress transcription by
stabilizing the binding of inhibitory cofactors at the promoter
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Binds DNA as a homodimer or a heterodimer.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- INDUCTION: By stress. {ECO:0000269|PubMed:22242125}.
-!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
{ECO:0000305}.
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EMBL; U19118; AAB48941.1; -; mRNA.
EMBL; BC019946; AAH19946.1; -; mRNA.
EMBL; BC064799; AAH64799.1; -; mRNA.
CCDS; CCDS15616.1; -.
RefSeq; NP_031524.2; NM_007498.3.
UniGene; Mm.2706; -.
ProteinModelPortal; Q60765; -.
SMR; Q60765; -.
BioGrid; 198234; 5.
STRING; 10090.ENSMUSP00000027941; -.
iPTMnet; Q60765; -.
PhosphoSitePlus; Q60765; -.
MaxQB; Q60765; -.
PaxDb; Q60765; -.
PRIDE; Q60765; -.
Ensembl; ENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
Ensembl; ENSMUST00000195117; ENSMUSP00000141492; ENSMUSG00000026628.
GeneID; 11910; -.
KEGG; mmu:11910; -.
UCSC; uc007ece.1; mouse.
CTD; 467; -.
MGI; MGI:109384; Atf3.
eggNOG; KOG1414; Eukaryota.
eggNOG; ENOG4111CH5; LUCA.
GeneTree; ENSGT00730000110847; -.
HOGENOM; HOG000034126; -.
HOVERGEN; HBG003381; -.
InParanoid; Q60765; -.
KO; K09032; -.
OMA; LVYMLNL; -.
OrthoDB; EOG091G0M4N; -.
PhylomeDB; Q60765; -.
TreeFam; TF326301; -.
PRO; PR:Q60765; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026628; -.
CleanEx; MM_ATF3; -.
ExpressionAtlas; Q60765; baseline and differential.
Genevisible; Q60765; MM.
GO; GO:1990622; C:CHOP-ATF3 complex; ISO:MGI.
GO; GO:0005730; C:nucleolus; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISO:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISO:MGI.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0034198; P:cellular response to amino acid starvation; IMP:ParkinsonsUK-UCL.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:ParkinsonsUK-UCL.
GO; GO:0006094; P:gluconeogenesis; IDA:MGI.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:CACAO.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO; GO:1903984; P:positive regulation of TRAIL-activated apoptotic signaling pathway; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; ISO:MGI.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.880.10; -; 1.
InterPro; IPR000837; AP-1.
InterPro; IPR029812; ATF3.
InterPro; IPR004827; bZIP.
InterPro; IPR008917; TF_DNA-bd_sf.
PANTHER; PTHR23351; PTHR23351; 1.
PANTHER; PTHR23351:SF23; PTHR23351:SF23; 1.
Pfam; PF00170; bZIP_1; 1.
PRINTS; PR00042; LEUZIPPRFOS.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 181 Cyclic AMP-dependent transcription factor
ATF-3.
/FTId=PRO_0000076582.
DOMAIN 86 149 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 88 110 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 114 142 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
MOD_RES 162 162 Phosphothreonine.
{ECO:0000250|UniProtKB:P18847}.
CROSSLNK 78 78 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P18847}.
CROSSLNK 175 175 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P18847}.
SEQUENCE 181 AA; 20722 MW; D641C8C6D14A457D CRC64;
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS
ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA AKCRNKKKEK TECLQKESEK
LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ
S


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