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Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta]

 ATF6B_MOUSE             Reviewed;         699 AA.
O35451;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
25-OCT-2017, entry version 148.
RecName: Full=Cyclic AMP-dependent transcription factor ATF-6 beta;
Short=cAMP-dependent transcription factor ATF-6 beta;
AltName: Full=Activating transcription factor 6 beta;
Short=ATF6-beta;
AltName: Full=cAMP response element-binding protein-related protein;
Short=Creb-rp;
AltName: Full=cAMP-responsive element-binding protein-like 1;
Contains:
RecName: Full=Processed cyclic AMP-dependent transcription factor ATF-6 beta;
Name=Atf6b; Synonyms=Crebl1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=129;
PubMed=14656967; DOI=10.1101/gr.1736803;
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
Campbell R.D., Hood L.;
"Analysis of the gene-dense major histocompatibility complex class III
region and its comparison to mouse.";
Genome Res. 13:2621-2636(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon, and Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 654-699.
STRAIN=C57BL/6 X CBA;
PubMed=9795100; DOI=10.1016/S0378-1119(98)00355-2;
Ikuta T., Sogawa N., Ariga H., Ikemura T., Matsumoto K.;
"Structural analysis of mouse tenascin-X: evolutionary aspects of
reduplication of FNIII repeats in the tenascin gene family.";
Gene 217:1-13(1998).
-!- FUNCTION: Transcriptional factor that acts in the unfolded protein
response (UPR) pathway by activating UPR target genes induced
during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER
stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y
is bound to ERSE (By similarity). {ECO:0007001}.
-!- SUBUNIT: Homodimer and heterodimer with ATF6-alpha. The dimer
interacts with the nuclear transcription factor Y (NF-Y) trimer
through direct binding to NF-Y subunit C (NF-YC) (By similarity).
{ECO:0007001}.
-!- INTERACTION:
P20029:Hspa5; NbExp=2; IntAct=EBI-8361741, EBI-772325;
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0007001}; Single-pass type II membrane protein {ECO:0007001}.
-!- SUBCELLULAR LOCATION: Processed cyclic AMP-dependent transcription
factor ATF-6 beta: Nucleus {ECO:0000270|PROSITE-ProRule:PRU00978}.
Note=Under ER stress the cleaved N-terminal cytoplasmic domain
translocates into the nucleus. {ECO:0007001}.
-!- PTM: During unfolded protein response, a fragment of approximately
60 kDa containing the cytoplasmic transcription factor domain is
released by proteolysis. The cleavage is probably performed
sequentially by site-1 and site-2 protease (By similarity).
{ECO:0007001}.
-!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
{ECO:0000320}.
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EMBL; AF030001; AAB82014.1; -; Genomic_DNA.
EMBL; BC013534; AAH13534.1; -; mRNA.
EMBL; BC052635; AAH52635.1; -; mRNA.
EMBL; AB010266; BAA24435.1; -; Genomic_DNA.
PIR; T09069; T09069.
UniGene; Mm.4068; -.
ProteinModelPortal; O35451; -.
SMR; O35451; -.
DIP; DIP-61156N; -.
IntAct; O35451; 2.
MINT; MINT-4088730; -.
STRING; 10090.ENSMUSP00000015605; -.
iPTMnet; O35451; -.
PhosphoSitePlus; O35451; -.
MaxQB; O35451; -.
PaxDb; O35451; -.
PeptideAtlas; O35451; -.
PRIDE; O35451; -.
MGI; MGI:105121; Atf6b.
eggNOG; KOG4343; Eukaryota.
eggNOG; ENOG410ZAAP; LUCA.
HOGENOM; HOG000253938; -.
HOVERGEN; HBG050608; -.
InParanoid; O35451; -.
PhylomeDB; O35451; -.
TreeFam; TF316079; -.
ChiTaRS; Atf6b; mouse.
PRO; PR:O35451; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0000794; C:condensed nuclear chromosome; HMP:UniProtKB.
GO; GO:0005769; C:early endosome; HMP:UniProtKB.
GO; GO:0012505; C:endomembrane system; HMP:UniProtKB.
GO; GO:0005789; C:endoplasmic reticulum membrane; IGI:MGI.
GO; GO:0005615; C:extracellular space; HTP:BHF-UCL.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBD:ParkinsonsUK-UCL.
GO; GO:0005622; C:intracellular; IGI:MGI.
GO; GO:0005815; C:microtubule organizing center; HMP:UniProtKB.
GO; GO:0016363; C:nuclear matrix; HMP:UniProtKB.
GO; GO:0005730; C:nucleolus; IGI:MGI.
GO; GO:0005634; C:nucleus; IGI:MGI.
GO; GO:0032993; C:protein-DNA complex; IGI:MGI.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IGI:MGI.
GO; GO:0035497; F:cAMP response element binding; RCA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IGI:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; IGI:MGI.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; RCA:InterPro.
GO; GO:0016458; P:gene silencing; HMP:UniProtKB.
GO; GO:0007076; P:mitotic chromosome condensation; HMP:UniProtKB.
GO; GO:0045014; P:negative regulation of transcription by glucose; HMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; HMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; RCA:UniProtKB-KW.
InterPro; IPR029809; ATF6B.
InterPro; IPR004827; bZIP.
PANTHER; PTHR22952:SF168; PTHR22952:SF168; 1.
Pfam; PF00170; bZIP_1; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
1: Evidence at protein level;
Acetylation; Activator; Complete proteome; DNA-binding;
Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus;
Reference proteome; Signal-anchor; Transcription;
Transcription regulation; Transmembrane; Transmembrane helix;
Unfolded protein response.
INIT_MET 1 1 Removed. {ECO:0007001|UniProtKB:Q99941}.
CHAIN 2 699 Cyclic AMP-dependent transcription factor
ATF-6 beta.
/FTId=PRO_0000076591.
CHAIN 2 ? Processed cyclic AMP-dependent
transcription factor ATF-6 beta.
/FTId=PRO_0000296202.
TOPO_DOM 2 393 Cytoplasmic. {ECO:0000270}.
TRANSMEM 394 414 Helical; Signal-anchor for type II
membrane protein. {ECO:0000270}.
TOPO_DOM 415 699 Lumenal. {ECO:0000270}.
DOMAIN 322 385 bZIP. {ECO:0000270|PROSITE-
ProRule:PRU00978}.
REGION 324 344 Basic motif. {ECO:0000270|PROSITE-
ProRule:PRU00978}.
REGION 347 354 Leucine-zipper. {ECO:0000270|PROSITE-
ProRule:PRU00978}.
COMPBIAS 93 102 Poly-Ser.
SITE 407 407 Important for cleavage by PS2.
{ECO:0007001}.
SITE 410 410 Important for cleavage by PS2.
{ECO:0007001}.
SITE 437 438 Cleavage; by PS1. {ECO:0007001}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0007001|UniProtKB:Q99941}.
CARBOHYD 473 473 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
CARBOHYD 502 502 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
CARBOHYD 607 607 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
CARBOHYD 624 624 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
CARBOHYD 673 673 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
SEQUENCE 699 AA; 76007 MW; 6EBE22386D63868B CRC64;
MAELMLLSEI ADPTRFFTDN LLSPEDWDST LYSGLDEVAE EQAQLFRCVE QDVPFDSSSL
DVGMDVSPPE PPWDPLPIFP DLQVKSEPSS PCSSSSLSSE SSHLSTEPPS QVPGVGEVLH
VKMESLAPPL CLLGDDPASP FETVQITVGS ASDDLSDIQT KLEPASPSSS VHSEASLLSA
DSPSQPFIGE EVLEVKTESP SPPGCLLWDV PASSLGAVQI SMGPSPDSSS GKAPATRKPP
LQPKPVVLTT VPVPPRAGPT SAAVLLQPLV QQPAVSPVVL IQGAIRVQPE GPAPAAPRPE
RKSIVPAPMP GNSCPPEVDA KLLKRQQRMI KNRESACQSR RKKKEYLQGL EARLQAVLAD
NQQLRRENAA LRRRLEALLA ENSGLKLGSG NRKVVCIMVF LLFIAFNFGP VSISEPPPAP
MSPRMSREEP RPQRHLLGFS EPGPAHGMEP LREAAQSPGE QQPSSAGRPS FRNLTAFPGG
AKELLLRDLD QLFLSSDCRH FNRTESLRLA DELSGWVQRH QRGRRKIPHR AQERQKSQLR
KKSPPVKPVP TQPPGPPERD PVGQLQLYRH PGRSQPEFLD AIDRREDTFY VVSFRRDHLL
LPAISHNKTS RPKMSLVMPA MAPNETVSGR GPPGDYEEMM QIECEVMDTR VIHIKTSTVP
PSLRKQPSPS PGNTTGGPLP GSAASPAHQA SQPLYLNHP


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