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Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Luman) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3]

 CREB3_BOVIN             Reviewed;         368 AA.
Q8SQ19; Q0V894; Q3T167; Q5EA05; Q5EA30;
09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 2.
12-SEP-2018, entry version 120.
RecName: Full=Cyclic AMP-responsive element-binding protein 3;
Short=CREB-3;
Short=cAMP-responsive element-binding protein 3;
AltName: Full=Luman;
Contains:
RecName: Full=Processed cyclic AMP-responsive element-binding protein 3;
Name=CREB3;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-368.
Budihal P.C., Misra V.;
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
[4]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=10623756; DOI=10.1128/JVI.74.2.934-943.2000;
Lu R., Misra V.;
"Potential role for luman, the cellular homologue of herpes simplex
virus VP16 (alpha gene trans-inducing factor), in herpesvirus
latency.";
J. Virol. 74:934-943(2000).
-!- FUNCTION: Endoplasmic reticulum (ER)-bound sequence-specific
transcription factor that directly binds DNA and activates
transcription. Plays a role in the unfolded protein response
(UPR), promoting cell survival versus ER stress-induced apoptotic
cell death. Also involved in cell proliferation, migration and
differentiation, tumor suppression and inflammatory gene
expression. Acts as a positive regulator of LKN-1/CCL15-induced
chemotaxis signaling of leukocyte cell migration. Associates with
chromatin to the HERPUD1 promoter. Also induces transcriptional
activation of chemokine receptors. Functions as a negative
transcriptional regulator in ligand-induced transcriptional
activation of the glucocorticoid receptor NR3C1 by recruiting and
activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also
decreases the acetylation level of histone H4. Does not promote
the chemotactic activity of leukocyte cells.
{ECO:0000250|UniProtKB:O43889}.
-!- FUNCTION: Processed cyclic AMP-responsive element-binding protein
3: This is the transcriptionally active form that translocates to
the nucleus and activates unfolded protein response (UPR) target
genes during endoplasmic reticulum (ER) stress response. Binds the
cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and
C/EBP sequences present in many promoters to activate
transcription of the genes. Binds to the unfolded protein response
element (UPRE) consensus sequences sites. Binds DNA to the 5'-
CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3').
{ECO:0000250|UniProtKB:O43889}.
-!- SUBUNIT: Homodimer. Interacts with HCFC1; the interaction is
required to stimulate CREB3 transcriptional activity. Interacts
with CREBZF; the interaction occurs only in combination with
HCFC1. Interacts (via central part and transmembrane region) with
DCSTAMP (via C-terminus cytoplasmic domain). Interacts with OS9.
Interacts (via leucine-zipper domain) with CREBRF (via leucine-
zipper domain); the interaction occurs only after CREB3 activation
and promotes CREB3 degradation. Interacts (via C-terminal domain)
with CCR1. {ECO:0000250|UniProtKB:O43889}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:O43889}; Single-pass type II membrane
protein {ECO:0000250|UniProtKB:O43889, ECO:0000255}. Golgi
apparatus {ECO:0000250|UniProtKB:O43889}. Nucleus
{ECO:0000250|UniProtKB:O43889}. Cytoplasm
{ECO:0000250|UniProtKB:O43889}. Note=Colocalizes with HCFC1 in
neuronal cell bodies of the trigeminal ganglia. Colocalizes with
DCSTAMP in the ER membrane of immature dendritic cell (DC).
Colocalizes with CANX, CCR1, HCFC1 in the ER membrane.
{ECO:0000250|UniProtKB:O43889}.
-!- SUBCELLULAR LOCATION: Processed cyclic AMP-responsive element-
binding protein 3: Nucleus {ECO:0000250|UniProtKB:O43889}.
Note=Upon RIP activation the transcriptional active processed
cyclic AMP-responsive element-binding protein 3 form translocates
into the nucleus. Detected in the nucleus upon dendritic cell
maturation and RIP activation. Colocalizes with CREBRF in nuclear
foci. Colocalizes with CREBZF in promyelocytic leukemia protein
nuclear bodies (PML-NB). {ECO:0000250|UniProtKB:O43889}.
-!- TISSUE SPECIFICITY: Expressed in trigeminal ganglia (at protein
level). {ECO:0000269|PubMed:10623756}.
-!- PTM: First proteolytically cleaved by site-1 protease (S1P) that
generates membrane-associated N-terminus and a luminal C-terminus
forms. The membrane-associated N-terminus form is further
proteolytically processed probably by the site-2 protease (S2P)
through a regulated intramembrane proteolysis (RIP), releasing the
transcriptional active processed cyclic AMP-responsive element-
binding protein 3 form, which is transported to the nucleus. The
proteolytic cleavage is strongly induced during dendritic cell
(DC) maturation and inhibited by DCSTAMP. That form is rapidly
degraded. {ECO:0000250|UniProtKB:O43889}.
-!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:O43889}.
-!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; BT020739; AAX08756.1; -; mRNA.
EMBL; BT020752; AAX08769.1; -; mRNA.
EMBL; BT020764; AAX08781.1; -; mRNA.
EMBL; BT020801; AAX08818.1; -; mRNA.
EMBL; BT021155; AAX31337.1; -; mRNA.
EMBL; BT026325; ABG81481.1; -; mRNA.
EMBL; BC102092; AAI02093.1; -; mRNA.
EMBL; AF387035; AAL84006.1; -; mRNA.
RefSeq; NP_776711.1; NM_174286.2.
UniGene; Bt.7492; -.
ProteinModelPortal; Q8SQ19; -.
SMR; Q8SQ19; -.
STRING; 9913.ENSBTAP00000015193; -.
PaxDb; Q8SQ19; -.
Ensembl; ENSBTAT00000015193; ENSBTAP00000015193; ENSBTAG00000011429.
GeneID; 281715; -.
KEGG; bta:281715; -.
CTD; 10488; -.
VGNC; VGNC:27693; CREB3.
eggNOG; KOG0709; Eukaryota.
eggNOG; ENOG410ZZQM; LUCA.
GeneTree; ENSGT00520000055538; -.
HOGENOM; HOG000133026; -.
HOVERGEN; HBG051114; -.
InParanoid; Q8SQ19; -.
KO; K09048; -.
OMA; HVSIDLD; -.
OrthoDB; EOG091G0GTJ; -.
TreeFam; TF316079; -.
Reactome; R-BTA-8874211; CREB3 factors activate genes.
Proteomes; UP000009136; Chromosome 8.
Bgee; ENSBTAG00000011429; Expressed in 10 organ(s), highest expression level in colon.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO; GO:0016604; C:nuclear body; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0035497; F:cAMP response element binding; IEA:InterPro.
GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO; GO:0042994; P:cytoplasmic sequestering of transcription factor; ISS:UniProtKB.
GO; GO:0019043; P:establishment of viral latency; ISS:UniProtKB.
GO; GO:0050930; P:induction of positive chemotaxis; ISS:UniProtKB.
GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:2000326; P:negative regulation of nuclear receptor transcription coactivator activity; ISS:UniProtKB.
GO; GO:0090045; P:positive regulation of deacetylase activity; ISS:UniProtKB.
GO; GO:0002230; P:positive regulation of defense response to virus by host; ISS:UniProtKB.
GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0006990; P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0001558; P:regulation of cell growth; ISS:UniProtKB.
GO; GO:0019046; P:release from viral latency; ISS:UniProtKB.
GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
InterPro; IPR004827; bZIP.
InterPro; IPR029808; Luman.
PANTHER; PTHR22952:SF100; PTHR22952:SF100; 1.
Pfam; PF00170; bZIP_1; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
1: Evidence at protein level;
Activator; Chemotaxis; Complete proteome; Cytoplasm; DNA-binding;
Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane;
Nucleus; Reference proteome; Repressor; Signal-anchor; Transcription;
Transcription regulation; Transmembrane; Transmembrane helix;
Unfolded protein response.
CHAIN 1 368 Cyclic AMP-responsive element-binding
protein 3.
/FTId=PRO_0000076601.
CHAIN 1 ? Processed cyclic AMP-responsive element-
binding protein 3.
/FTId=PRO_0000296203.
TOPO_DOM 1 229 Cytoplasmic. {ECO:0000255}.
TRANSMEM 230 250 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 251 368 Lumenal. {ECO:0000255}.
DOMAIN 153 216 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 1 95 Transcription activation (acidic).
REGION 155 184 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 186 193 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
MOTIF 16 20 LXXLL motif 1.
MOTIF 57 61 LXXLL motif 2.
MOTIF 81 84 HCFC1-binding-motif (HBM).
SITE 266 267 Cleavage; by PS1. {ECO:0000250}.
SITE 269 270 Cleavage; by PS1. {ECO:0000250}.
CARBOHYD 344 344 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 46 46 E -> EPVNLNPVQ (in Ref. 1; AAX08756).
{ECO:0000305}.
SEQUENCE 368 AA; 40912 MW; 8DE9D4EAAF636638 CRC64;
MSHMELALDP GDHDLLGFLL EESGGLGAAP DEALTSPPDW ELPLSESLSD WDVEDFLSCL
PSPPAVLNVF SNSDPCLVQH DHTYSLSQEH VSIDLDNESY EKERAQMTPL RVEEPADQEI
ARLILTEEEK RLLEKEGLTL PGMLPLTKME EQVLKRVRRK IRNKKSAQES RRKKKVYVGG
LESRVLKYTA QNLELQNKVQ LLEEQNLSLL DQLRRLQAMV IQTANKASSS STCVLVLLFS
FCLLLVPAMY SSDTRGSLPA EHRVLSRQLR ALPSEDPPQL EPPALQSEVP KDSLNPELQA
ASNSCCLFHL MPQAPRAEPP LQLPLPDGFS GCSCPDSISP LHANLTREEG WLPTPSPTSV
ILQGRYSG


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