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Cyclic nucleotide-gated cation channel alpha-3 (Cone photoreceptor cGMP-gated channel subunit alpha) (Cyclic nucleotide-gated channel alpha-3) (CNG channel alpha-3) (CNG-3) (CNG3)

 CNGA3_MOUSE             Reviewed;         631 AA.
Q9JJZ8; Q8CFV6; Q9WV01;
04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
25-OCT-2017, entry version 144.
RecName: Full=Cyclic nucleotide-gated cation channel alpha-3;
AltName: Full=Cone photoreceptor cGMP-gated channel subunit alpha;
AltName: Full=Cyclic nucleotide-gated channel alpha-3;
Short=CNG channel alpha-3;
Short=CNG-3;
Short=CNG3;
Name=Cnga3; Synonyms=Cng3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Retina;
PubMed=10813773;
DOI=10.1002/(SICI)1096-9861(20000522)421:1<80::AID-CNE5>3.0.CO;2-O;
Hirano A.A., Hack I., Waessle H., Duvoisin R.M.;
"Cloning and immunocytochemical localization of a cyclic nucleotide-
gated channel alpha-subunit to all cone photoreceptors in the mouse
retina.";
J. Comp. Neurol. 421:80-94(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-631.
STRAIN=129/Sv;
PubMed=10377453; DOI=10.1073/pnas.96.13.7553;
Biel M., Seeliger M., Pfeifer A., Kohler K., Gerstner A., Ludwig A.,
Jaissle G., Fauser S., Zrenner E., Hofmann F.;
"Selective loss of cone function in mice lacking the cyclic
nucleotide-gated channel CNG3.";
Proc. Natl. Acad. Sci. U.S.A. 96:7553-7557(1999).
[4]
FUNCTION, AND SUBUNIT.
PubMed=10662822;
Gerstner A., Zong X., Hofmann F., Biel M.;
"Molecular cloning and functional characterization of a new modulatory
cyclic nucleotide-gated channel subunit from mouse retina.";
J. Neurosci. 20:1324-1332(2000).
-!- FUNCTION: Visual signal transduction is mediated by a G-protein
coupled cascade using cGMP as second messenger. This protein can
be activated by cyclic GMP which leads to an opening of the cation
channel and thereby causing a depolarization of cone
photoreceptors. Essential for the generation of light-evoked
electrical responses in the red-, green- and blue sensitive cones
(By similarity). Induced a flickering channel gating, weakened the
outward rectification in the presence of extracellular calcium,
increased sensitivity for L-cis diltiazem and enhanced the cAMP
efficacy of the channel when coexpressed with CNGB3. {ECO:0000250,
ECO:0000269|PubMed:10662822}.
-!- SUBUNIT: Tetramer formed of three CNGA3 and one CNGB3 modulatory
subunits. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Prominently expressed in retina.
-!- DOMAIN: The C-terminal coiled-coil domain mediates
homotrimerization of CNGA subunits. {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. CNGA3 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AJ243933; CAB89685.1; -; mRNA.
EMBL; BC035272; AAH35272.1; -; mRNA.
EMBL; BC049145; AAH49145.1; -; mRNA.
EMBL; AJ238239; CAB42891.1; -; Genomic_DNA.
EMBL; AJ238240; CAB42891.1; JOINED; Genomic_DNA.
EMBL; AJ238241; CAB42891.1; JOINED; Genomic_DNA.
CCDS; CCDS14890.1; -.
RefSeq; NP_001268939.1; NM_001282010.1.
RefSeq; NP_034048.1; NM_009918.2.
RefSeq; XP_017169234.1; XM_017313745.1.
UniGene; Mm.214224; -.
ProteinModelPortal; Q9JJZ8; -.
SMR; Q9JJZ8; -.
STRING; 10090.ENSMUSP00000027288; -.
iPTMnet; Q9JJZ8; -.
PhosphoSitePlus; Q9JJZ8; -.
PaxDb; Q9JJZ8; -.
PRIDE; Q9JJZ8; -.
Ensembl; ENSMUST00000027288; ENSMUSP00000027288; ENSMUSG00000026114.
Ensembl; ENSMUST00000194195; ENSMUSP00000142075; ENSMUSG00000026114.
GeneID; 12790; -.
KEGG; mmu:12790; -.
UCSC; uc007ari.2; mouse.
CTD; 1261; -.
MGI; MGI:1341818; Cnga3.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
GeneTree; ENSGT00900000140801; -.
HOGENOM; HOG000007898; -.
HOVERGEN; HBG000281; -.
InParanoid; Q9JJZ8; -.
KO; K04950; -.
TreeFam; TF319048; -.
PRO; PR:Q9JJZ8; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026114; -.
CleanEx; MM_CNGA3; -.
ExpressionAtlas; Q9JJZ8; baseline and differential.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:1902495; C:transmembrane transporter complex; ISO:MGI.
GO; GO:0030553; F:cGMP binding; ISO:MGI.
GO; GO:0005223; F:intracellular cGMP activated cation channel activity; ISO:MGI.
GO; GO:0005221; F:intracellular cyclic nucleotide activated cation channel activity; IPI:MGI.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0006812; P:cation transport; ISO:MGI.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
GO; GO:0046549; P:retinal cone cell development; IMP:MGI.
GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
1: Evidence at protein level;
cGMP; cGMP-binding; Coiled coil; Complete proteome; Ion channel;
Ion transport; Ligand-gated ion channel; Membrane; Nucleotide-binding;
Reference proteome; Sensory transduction; Transmembrane;
Transmembrane helix; Transport; Vision.
CHAIN 1 631 Cyclic nucleotide-gated cation channel
alpha-3.
/FTId=PRO_0000219318.
TRANSMEM 112 133 Helical. {ECO:0000255}.
TRANSMEM 244 264 Helical. {ECO:0000255}.
TRANSMEM 320 340 Helical. {ECO:0000255}.
NP_BIND 423 546 cGMP.
COILED 567 610 {ECO:0000250}.
BINDING 490 490 cGMP. {ECO:0000255}.
BINDING 505 505 cGMP. {ECO:0000255}.
CONFLICT 110 110 Y -> C (in Ref. 1; CAB89685).
{ECO:0000305}.
CONFLICT 157 157 L -> V (in Ref. 3; CAB42891).
{ECO:0000305}.
SEQUENCE 631 AA; 72702 MW; 4FAD66E3A8A3FE6C CRC64;
MAKVNTQCSQ PSPTQLSIKN ADRDLDHVEN GLGRVSRLII SIRAWASRHL HDEDQTPDSF
LDRFHGSELK EVSTRESNAQ PNPGEQKPPD GGEGRKEEPI VVDPSSNIYY RWLTAIALPV
FYNWCLLVCR ACFDELQSEH LTLWLVLDYS ADVLYVLDML VRARTGFLEQ GLMVRDTKRL
WKHYTKTLHF KLDILSLIPT DLAYLKLGVN YPELRFNRLL KFSRLFEFFD RTETRTNYPN
VFRIGNLVLY TLIIIHWNAC IYFAISKFIG FGTDSWVYPN TSKPEYARLS RKYIYSLYWS
TLTLTTIGET PPPVKDEEYL FVVIDFLVGI LIFATIVGNV GSMISNMNAP RVEFQAKIDS
VKQYMQFRKV TKDLETRVIR WFDYLWANRK TVDEKEVLKN LPDKLKAEIA INVHLDTLKK
VRIFQDCEAG LLVELVLKLR PTVFSPGDYI CKKGDIGREM YIIKEGKLAV VADDGVTQFV
VLSDGSYFGE ISILNIKGSK SGNRRTANIR SIGYSDLFCL SKDDLMEALT EYPDAKRALE
EKGRQILMKD NLIDEDLVAA RVDTRDVEEK VEYLESSLDI LQTRFARLLA EYSASQMKLK
QRLTRLESQM NRRCCGFSPD RENSEDASKT D


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