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Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4) (Cyclic nucleotide-gated olfactory channel subunit OCNC2)

 CNGA4_RAT               Reviewed;         575 AA.
Q64359; Q6Q2I4;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
10-MAY-2017, entry version 121.
RecName: Full=Cyclic nucleotide-gated cation channel alpha-4;
AltName: Full=Cyclic nucleotide-gated channel alpha-4;
Short=CNG channel alpha-4;
Short=CNG-4;
Short=CNG4;
AltName: Full=Cyclic nucleotide-gated olfactory channel subunit OCNC2;
Name=Cnga4; Synonyms=Cgn2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=7522325; DOI=10.1073/pnas.91.19.8890;
Bradley J., Li J., Davidson N., Lester H.A., Zinn K.;
"Heteromeric olfactory cyclic nucleotide-gated channels: a subunit
that confers increased sensitivity to cAMP.";
Proc. Natl. Acad. Sci. U.S.A. 91:8890-8894(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Olfactory neuroepithelium;
PubMed=7522482; DOI=10.1016/0896-6273(94)90029-9;
Liman E.R., Buck L.B.;
"A second subunit of the olfactory cyclic nucleotide-gated channel
confers high sensitivity to cAMP.";
Neuron 13:611-621(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-191.
STRAIN=Sprague-Dawley;
Lozach A., Castel H.L.N., Garrel G., Vaudry H., Counis R.;
"Characterization and functional expression of cyclic nucleotide-gated
channels in rat pituitary gonadotrophs.";
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-35.
STRAIN=Sprague-Dawley;
Bradley J., Zhang Y., Bakin R., Lester H.A., Ronnett G., Zinn K.;
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
[5]
ENZYME REGULATION.
PubMed=15195096; DOI=10.1038/nn1266;
Bradley J., Boenigk W., Yau K.-W., Frings S.;
"Calmodulin permanently associates with rat olfactory CNG channels
under native conditions.";
Nat. Neurosci. 7:705-710(2004).
[6]
SUBUNITS.
PubMed=15134638; DOI=10.1016/S0896-6273(04)00253-3;
Zheng J., Zagotta W.N.;
"Stoichiometry and assembly of olfactory cyclic nucleotide-gated
channels.";
Neuron 42:411-421(2004).
-!- FUNCTION: Second messenger, cAMP, causes the opening of cation-
selective cyclic nucleotide-gated (CNG) channels and
depolarization of the neuron (olfactory sensory neurons, OSNs).
CNGA4 is the modulatory subunit of this channel which is known to
play a central role in the transduction of odorant signals and
subsequent adaptation. By accelerating the calcium-mediated
negative feedback in olfactory signaling it allows rapid
adaptation to odor stimulation and extends its range of odor
detection (By similarity). {ECO:0000250}.
-!- ENZYME REGULATION: Calcium-calmodulin exerts its inhibitory effect
in cAMP sensitivity by binding to IQ-like motif of CNGA4 and
preferably binds to the channel in the closed state. Inhibition by
PIP3 of the CNG channel probably occurs via CGNA2 binding.
{ECO:0000269|PubMed:15195096}.
-!- SUBUNIT: Heterotetramer composed of two subunits of CNGA2, one of
CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-
gated (CNG) channel of olfactory sensory neurons.
{ECO:0000269|PubMed:15134638}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Olfactory neurons.
-!- DOMAIN: The C-terminal coiled-coil domain mediates trimerization
of CNGA subunits. {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. CNGA4 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U12623; AAA21464.1; -; mRNA.
EMBL; U12425; AAA64748.1; -; mRNA.
EMBL; AY564233; AAS87325.1; -; Genomic_DNA.
EMBL; U76219; AAC17596.1; -; Genomic_DNA.
PIR; I59327; I59327.
RefSeq; NP_445948.2; NM_053496.2.
UniGene; Rn.91104; -.
ProteinModelPortal; Q64359; -.
SMR; Q64359; -.
DIP; DIP-61290N; -.
STRING; 10116.ENSRNOP00000023751; -.
PaxDb; Q64359; -.
PRIDE; Q64359; -.
GeneID; 85258; -.
KEGG; rno:85258; -.
UCSC; RGD:619844; rat.
CTD; 1262; -.
RGD; 619844; Cnga4.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
HOGENOM; HOG000007898; -.
HOVERGEN; HBG000281; -.
InParanoid; Q64359; -.
KO; K04951; -.
PhylomeDB; Q64359; -.
PRO; PR:Q64359; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0030553; F:cGMP binding; IDA:RGD.
GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IDA:RGD.
GO; GO:0005223; F:intracellular cGMP activated cation channel activity; IDA:RGD.
GO; GO:0005221; F:intracellular cyclic nucleotide activated cation channel activity; IDA:RGD.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0051290; P:protein heterotetramerization; IDA:RGD.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
2: Evidence at transcript level;
cAMP; cAMP-binding; Coiled coil; Complete proteome; Ion channel;
Ion transport; Ligand-gated ion channel; Membrane; Nucleotide-binding;
Olfaction; Reference proteome; Sensory transduction; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 575 Cyclic nucleotide-gated cation channel
alpha-4.
/FTId=PRO_0000219322.
TOPO_DOM 1 33 Cytoplasmic. {ECO:0000255}.
TRANSMEM 34 54 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 55 65 Extracellular. {ECO:0000255}.
TRANSMEM 66 86 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 87 112 Cytoplasmic. {ECO:0000255}.
TRANSMEM 113 133 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 134 168 Extracellular. {ECO:0000255}.
TRANSMEM 169 189 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 190 218 Cytoplasmic. {ECO:0000255}.
TRANSMEM 219 239 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 240 244 Extracellular. {ECO:0000255}.
TRANSMEM 245 265 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 266 575 Cytoplasmic. {ECO:0000255}.
NP_BIND 348 471 cNMP.
COILED 493 536 {ECO:0000250}.
MOTIF 292 302 IQ-type. {ECO:0000250}.
SEQUENCE 575 AA; 65675 MW; FCF01C563214F575 CRC64;
MSQDGKVKTT ESTPPAPTKA RKWLPVLDPS GDYYYWWLNT MVFPIMYNLI IVVCRACFPD
LQHSYLVAWF VLDYTSDLLY LLDIGVRFHT GFLEQGILVV DKGMIASRYV RTWSFLLDLA
SLVPTDAAYV QLGPHIPTLR LNRFLRVPRL FEAFDRTETR TAYPNAFRIA KLMLYIFVVI
HWNSCLYFAL SRYLGFGRDA WVYPDPAQPG FERLRRQYLY SFYFSTLILT TVGDTPLPDR
EEEYLFMVGD FLLAVMGFAT IMGSMSSVIY NMNTADAAFY PDHALVKKYM KLQHVNKRLE
RRVIDWYQHL QINKKMTNEV AILQHLPERL RAEVAVSVHL STLSRVQIFQ NCEASLLEEL
VLKLQPQTYS PGEYVCRKGD IGREMYIIRE GQLAVVADDG VTQYAVLGAG LYFGEISIIN
IKGNMSGNRR TANIKSLGYS DLFCLSKEDL REVLSEYPQA QAVMEEKGRE ILLKMNKLDV
NAEAAEIALQ EATESRLKGL DQQLDDLQTK FARLLAELES SALKIAYRIE RLEWQTREWP
MPEDMGEADD EAEPGEGTSK DGEGKAGQAG PSGIE


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