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Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid-rich protein) (GARP)

 CNGB1_HUMAN             Reviewed;        1251 AA.
Q14028; H3BN09; O43636; Q13059; Q14029; Q9UMG2;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-SEP-2009, sequence version 2.
25-OCT-2017, entry version 158.
RecName: Full=Cyclic nucleotide-gated cation channel beta-1;
AltName: Full=Cyclic nucleotide-gated cation channel 4;
Short=CNG channel 4;
Short=CNG-4;
Short=CNG4;
AltName: Full=Cyclic nucleotide-gated cation channel gamma;
AltName: Full=Cyclic nucleotide-gated cation channel modulatory subunit;
AltName: Full=Cyclic nucleotide-gated channel beta-1;
Short=CNG channel beta-1;
AltName: Full=Glutamic acid-rich protein;
Short=GARP;
Name=CNGB1; Synonyms=CNCG2, CNCG3L, CNCG4, RCNC2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS RCNC2A AND RCNC2B).
TISSUE=Retina;
PubMed=7682292; DOI=10.1038/362764a0;
Chen T.-Y., Peng Y.-W., Dhallan R.S., Ahamed B., Reed R.R., Yau K.-W.;
"A new subunit of the cyclic nucleotide-gated cation channel in
retinal rods.";
Nature 362:764-767(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GARP2), AND VARIANT HIS-100.
TISSUE=Retina;
PubMed=7590744; DOI=10.1006/geno.1995.1102;
Ardell M.D., Makhija A.K., Oliveira L., Miniou P.,
Viegas-Pequignot E., Pittler S.J.;
"cDNA, gene structure, and chromosomal localization of human GAR1
(CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-
gated channel.";
Genomics 28:32-38(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RCNC2B), AND VARIANT HIS-100.
TISSUE=Retina;
PubMed=8766832; DOI=10.1016/0014-5793(96)00588-1;
Ardell M.D., Aragon I., Oliveira L., Porche G.E., Burke E.,
Pittler S.J.;
"The beta subunit of human rod photoreceptor cGMP-gated cation channel
is generated from a complex transcription unit.";
FEBS Lett. 389:213-218(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RCNC2B), FUNCTION, AND VARIANT
HIS-100.
TISSUE=Retina;
PubMed=9535905; DOI=10.1074/jbc.273.15.9148;
Grunwald M.E., Yu W.P., Yu H.H., Yau K.W.;
"Identification of a domain on the beta-subunit of the rod cGMP-gated
cation channel that mediates inhibition by calcium-calmodulin.";
J. Biol. Chem. 273:9148-9157(1998).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15616553; DOI=10.1038/nature03187;
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
Rubin E.M., Pennacchio L.A.;
"The sequence and analysis of duplication-rich human chromosome 16.";
Nature 432:988-994(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
ALTERNATIVE SPLICING.
PubMed=10717482; DOI=10.1016/S0378-1119(00)00023-8;
Ardell M.D., Bedsole D.L., Schoborg R.V., Pittler S.J.;
"Genomic organization of the human rod photoreceptor cGMP-gated cation
channel beta-subunit gene.";
Gene 245:311-318(2000).
[8]
MUTAGENESIS OF LEU-568.
PubMed=15195096; DOI=10.1038/nn1266;
Bradley J., Boenigk W., Yau K.-W., Frings S.;
"Calmodulin permanently associates with rat olfactory CNG channels
under native conditions.";
Nat. Neurosci. 7:705-710(2004).
[9]
ALTERNATIVE SPLICING (ISOFORM GARP2), AND FUNCTION.
PubMed=16407240; DOI=10.1074/jbc.M507488200;
Pentia D.C., Hosier S., Cote R.H.;
"The glutamic acid-rich protein-2 (GARP2) is a high affinity rod
photoreceptor phosphodiesterase (PDE6)-binding protein that modulates
its catalytic properties.";
J. Biol. Chem. 281:5500-5505(2006).
[10]
CHARACTERIZATION OF THE GARPS PROTEINS.
PubMed=16280326; DOI=10.1074/jbc.M505012200;
Batra-Safferling R., Abarca-Heidemann K., Korschen H.G., Tziatzios C.,
Stoldt M., Budyak I., Willbold D., Schwalbe H., Klein-Seetharaman J.,
Kaupp U.B.;
"Glutamic acid-rich proteins of rod photoreceptors are natively
unfolded.";
J. Biol. Chem. 281:1449-1460(2006).
[11]
ALTERNATIVE SPLICING (ISOFORM GARP2).
Cote R.H.;
Unpublished observations (MAY-2009).
[12]
VARIANT RP45 VAL-993.
PubMed=11379879; DOI=10.1007/s004390100496;
Bareil C., Hamel C.P., Delague V., Arnaud B., Demaille J.,
Claustres M.;
"Segregation of a mutation in CNGB1 encoding the beta-subunit of the
rod cGMP-gated channel in a family with autosomal recessive retinitis
pigmentosa.";
Hum. Genet. 108:328-334(2001).
-!- FUNCTION: Subunit of cyclic nucleotide-gated (CNG) channels,
nonselective cation channels, which play important roles in both
visual and olfactory signal transduction. When associated with
CNGA1, it is involved in the regulation of ion flow into the rod
photoreceptor outer segment (ROS), in response to light-induced
alteration of the levels of intracellular cGMP.
-!- FUNCTION: Isoform GARP2 is a high affinity rod photoreceptor
phosphodiesterase (PDE6)-binding protein that modulates its
catalytic properties: it is a regulator of spontaneous activation
of rod PDE6, thereby serving to lower rod photoreceptor 'dark
noise' and allowing these sensory cells to operate at the single
photon detection limit.
-!- SUBUNIT: Tetramer formed of three CNGA1 and one CNGB1 modulatory
subunits. {ECO:0000250}.
-!- INTERACTION:
Q5ICW4:GRB14 (xeno); NbExp=2; IntAct=EBI-7959609, EBI-7639273;
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Comment=There is no evidence for an ortholog to bovine GARP1 in
the human genome.;
Name=RCNC2B;
IsoId=Q14028-1; Sequence=Displayed;
Name=RCNC2A;
IsoId=Q14028-2; Sequence=VSP_001110;
Name=GARP2; Synonyms=GARP;
IsoId=Q14028-3; Sequence=VSP_037921, VSP_037922;
Note=In the rod cells, the CNGB1 locus encodes the cyclic
nucleotide-gated cation channel beta-1 subunit and several
glutamic-acid-rich proteins (GARPs).;
Name=4;
IsoId=Q14028-4; Sequence=VSP_053421;
-!- DISEASE: Retinitis pigmentosa 45 (RP45) [MIM:613767]: A retinal
dystrophy belonging to the group of pigmentary retinopathies.
Retinitis pigmentosa is characterized by retinal pigment deposits
visible on fundus examination and primary loss of rod
photoreceptor cells followed by secondary loss of cone
photoreceptors. Patients typically have night vision blindness and
loss of midperipheral visual field. As their condition progresses,
they lose their far peripheral visual field and eventually central
vision as well. {ECO:0000269|PubMed:11379879}. Note=The disease is
caused by mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. CNGB1 subfamily. {ECO:0000305}.
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EMBL; L15296; AAA65620.1; -; Genomic_DNA.
EMBL; L15297; AAA65619.1; -; Genomic_DNA.
EMBL; U18945; AAA91633.1; -; mRNA.
EMBL; U58837; AAB63387.1; -; mRNA.
EMBL; AF042498; AAC04830.1; -; mRNA.
EMBL; AC010543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471092; EAW82957.1; -; Genomic_DNA.
CCDS; CCDS42169.1; -. [Q14028-1]
CCDS; CCDS45495.1; -. [Q14028-3]
CCDS; CCDS67042.1; -. [Q14028-4]
PIR; A57652; A57652.
PIR; S32538; S32538.
PIR; S69275; S69275.
RefSeq; NP_001129111.1; NM_001135639.1. [Q14028-3]
RefSeq; NP_001273059.1; NM_001286130.1. [Q14028-4]
RefSeq; NP_001288.3; NM_001297.4. [Q14028-1]
UniGene; Hs.147062; -.
ProteinModelPortal; Q14028; -.
SMR; Q14028; -.
BioGrid; 107658; 2.
IntAct; Q14028; 2.
MINT; MINT-4853474; -.
STRING; 9606.ENSP00000251102; -.
TCDB; 1.A.1.5.3; the voltage-gated ion channel (vic) superfamily.
iPTMnet; Q14028; -.
PhosphoSitePlus; Q14028; -.
BioMuta; CNGB1; -.
DMDM; 257051004; -.
EPD; Q14028; -.
PaxDb; Q14028; -.
PeptideAtlas; Q14028; -.
PRIDE; Q14028; -.
DNASU; 1258; -.
Ensembl; ENST00000251102; ENSP00000251102; ENSG00000070729. [Q14028-1]
Ensembl; ENST00000311183; ENSP00000311670; ENSG00000070729. [Q14028-3]
Ensembl; ENST00000564448; ENSP00000454633; ENSG00000070729. [Q14028-4]
GeneID; 1258; -.
KEGG; hsa:1258; -.
UCSC; uc002emt.3; human. [Q14028-1]
CTD; 1258; -.
DisGeNET; 1258; -.
EuPathDB; HostDB:ENSG00000070729.13; -.
GeneCards; CNGB1; -.
GeneReviews; CNGB1; -.
H-InvDB; HIX0038536; -.
HGNC; HGNC:2151; CNGB1.
HPA; HPA039159; -.
HPA; HPA060355; -.
MalaCards; CNGB1; -.
MIM; 600724; gene.
MIM; 613767; phenotype.
neXtProt; NX_Q14028; -.
OpenTargets; ENSG00000070729; -.
Orphanet; 791; Retinitis pigmentosa.
PharmGKB; PA26662; -.
eggNOG; KOG0499; Eukaryota.
eggNOG; ENOG410ZJ5U; LUCA.
GeneTree; ENSGT00900000140801; -.
HOGENOM; HOG000231425; -.
HOVERGEN; HBG051038; -.
InParanoid; Q14028; -.
KO; K04952; -.
OMA; WEDAHQD; -.
OrthoDB; EOG091G03EW; -.
PhylomeDB; Q14028; -.
TreeFam; TF318250; -.
Reactome; R-HSA-2485179; Activation of the phototransduction cascade.
Reactome; R-HSA-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
Reactome; R-HSA-5620916; VxPx cargo-targeting to cilium.
GeneWiki; CNGB1; -.
GenomeRNAi; 1258; -.
PRO; PR:Q14028; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000070729; -.
CleanEx; HS_CNGB1; -.
ExpressionAtlas; Q14028; baseline and differential.
Genevisible; Q14028; HS.
GO; GO:0060170; C:ciliary membrane; TAS:Reactome.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0030660; C:Golgi-associated vesicle membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IEA:Ensembl.
GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
GO; GO:1902495; C:transmembrane transporter complex; IDA:UniProtKB.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0030553; F:cGMP binding; IDA:UniProtKB.
GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IEA:Ensembl.
GO; GO:0005223; F:intracellular cGMP activated cation channel activity; IDA:UniProtKB.
GO; GO:0015276; F:ligand-gated ion channel activity; TAS:ProtInc.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0006812; P:cation transport; IDA:UniProtKB.
GO; GO:0050908; P:detection of light stimulus involved in visual perception; IMP:UniProtKB.
GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
GO; GO:0035845; P:photoreceptor cell outer segment organization; IEA:Ensembl.
GO; GO:0051290; P:protein heterotetramerization; IEA:Ensembl.
GO; GO:0033365; P:protein localization to organelle; IEA:Ensembl.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0022400; P:regulation of rhodopsin mediated signaling pathway; TAS:Reactome.
GO; GO:0001895; P:retina homeostasis; IMP:UniProtKB.
GO; GO:0016056; P:rhodopsin mediated signaling pathway; TAS:Reactome.
GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
GO; GO:0006810; P:transport; TAS:ProtInc.
GO; GO:0007601; P:visual perception; TAS:ProtInc.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032944; CNGB1.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
PANTHER; PTHR10217:SF386; PTHR10217:SF386; 1.
Pfam; PF00027; cNMP_binding; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
1: Evidence at protein level;
Alternative splicing; cAMP; cAMP-binding; Complete proteome;
Disease mutation; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Nucleotide-binding; Olfaction;
Polymorphism; Reference proteome; Retinitis pigmentosa;
Sensory transduction; Transmembrane; Transmembrane helix; Transport;
Vision.
CHAIN 1 1251 Cyclic nucleotide-gated cation channel
beta-1.
/FTId=PRO_0000219323.
TOPO_DOM 343 656 Cytoplasmic. {ECO:0000255}.
TRANSMEM 657 675 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 676 689 Extracellular. {ECO:0000255}.
TRANSMEM 690 708 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 709 733 Cytoplasmic. {ECO:0000255}.
TRANSMEM 734 753 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 754 790 Extracellular. {ECO:0000255}.
TRANSMEM 791 813 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 814 857 Cytoplasmic. {ECO:0000255}.
TRANSMEM 858 877 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 878 961 Extracellular. {ECO:0000255}.
TRANSMEM 962 982 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 983 1251 Cytoplasmic. {ECO:0000255}.
NP_BIND 970 1109 cAMP. {ECO:0000250}.
MOTIF 568 578 IQ-like.
COMPBIAS 23 63 Glu-rich.
COMPBIAS 171 252 Pro-rich.
COMPBIAS 351 371 Poly-Glu.
BINDING 1030 1030 cAMP. {ECO:0000255}.
BINDING 1042 1042 cAMP. {ECO:0000255}.
VAR_SEQ 1 628 Missing (in isoform RCNC2A).
{ECO:0000305}.
/FTId=VSP_001110.
VAR_SEQ 189 194 Missing (in isoform 4). {ECO:0000305}.
/FTId=VSP_053421.
VAR_SEQ 292 299 ISILPGGQ -> RVMGAGGL (in isoform GARP2).
{ECO:0000303|PubMed:7590744}.
/FTId=VSP_037921.
VAR_SEQ 300 1251 Missing (in isoform GARP2).
{ECO:0000303|PubMed:7590744}.
/FTId=VSP_037922.
VARIANT 100 100 R -> H (in dbSNP:rs13336595).
{ECO:0000269|PubMed:7590744,
ECO:0000269|PubMed:8766832,
ECO:0000269|PubMed:9535905}.
/FTId=VAR_058691.
VARIANT 479 479 L -> I (in dbSNP:rs2303783).
/FTId=VAR_059225.
VARIANT 535 535 V -> A (in dbSNP:rs12927214).
/FTId=VAR_059226.
VARIANT 731 731 N -> K (in dbSNP:rs376270).
/FTId=VAR_059227.
VARIANT 745 745 L -> I (in dbSNP:rs10459809).
/FTId=VAR_059228.
VARIANT 911 911 K -> R (in dbSNP:rs2303785).
/FTId=VAR_059229.
VARIANT 961 961 A -> S (in dbSNP:rs16942445).
/FTId=VAR_059230.
VARIANT 993 993 G -> V (in RP45; dbSNP:rs121918532).
{ECO:0000269|PubMed:11379879}.
/FTId=VAR_060491.
MUTAGEN 568 568 L->E: Loss of calcium/calmodulin
modulation.
{ECO:0000269|PubMed:15195096}.
CONFLICT 128 128 I -> V (in Ref. 5; AC010543).
{ECO:0000305}.
CONFLICT 1148 1149 QQ -> HE (in Ref. 2; AAB63387 and 1;
AAA65619/AAA65620). {ECO:0000305}.
CONFLICT 1207 1208 RP -> SC (in Ref. 2; AAB63387 and 1;
AAA65619/AAA65620). {ECO:0000305}.
SEQUENCE 1251 AA; 139678 MW; 7A45CB399EB2B20C CRC64;
MLGWVQRVLP QPPGTPRKTK MQEEEEVEPE PEMEAEVEPE PNPEEAETES ESMPPEESFK
EEEVAVADPS PQETKEAALT STISLRAQGA EISEMNSPSR RVLTWLMKGV EKVIPQPVHS
ITEDPAQILG HGSTGDTGCT DEPNEALEAQ DTRPGLRLLL WLEQNLERVL PQPPKSSEVW
RDEPAVATGA ASDPAPPGRP QEMGPKLQAR ETPSLPTPIP LQPKEEPKEA PAPEPQPGSQ
AQTSSLPPTR DPARLVAWVL HRLEMALPQP VLHGKIGEQE PDSPGICDVQ TISILPGGQV
EPDLVLEEVE PPWEDAHQDV STSPQGTEVV PAYEEENKAV EKMPRELSRI EEEKEDEEEE
EEEEEEEEEE EVTEVLLDSC VVSQVGVGQS EEDGTRPQST SDQKLWEEVG EEAKKEAEEK
AKEEAEEVAE EEAEKEPQDW AETKEEPEAE AEAASSGVPA TKQHPEVQVE DTDADSCPLM
AEENPPSTVL PPPSPAKSDT LIVPSSASGT HRKKLPSEDD EAEELKALSP AESPVVAWSD
PTTPKDTDGQ DRAASTASTN SAIINDRLQE LVKLFKERTE KVKEKLIDPD VTSDEESPKP
SPAKKAPEPA PDTKPAEAEP VEEEHYCDML CCKFKHRPWK KYQFPQSIDP LTNLMYVLWL
FFVVMAWNWN CWLIPVRWAF PYQTPDNIHH WLLMDYLCDL IYFLDITVFQ TRLQFVRGGD
IITDKKDMRN NYLKSRRFKM DLLSLLPLDF LYLKVGVNPL LRLPRCLKYM AFFEFNSRLE
SILSKAYVYR VIRTTAYLLY SLHLNSCLYY WASAYQGLGS THWVYDGVGN SYIRCYYFAV
KTLITIGGLP DPKTLFEIVF QLLNYFTGVF AFSVMIGQMR DVVGAATAGQ TYYRSCMDST
VKYMNFYKIP KSVQNRVKTW YEYTWHSQGM LDESELMVQL PDKMRLDLAI DVNYNIVSKV
ALFQGCDRQM IFDMLKRLRS VVYLPNDYVC KKGEIGREMY IIQAGQVQVL GGPDGKSVLV
TLKAGSVFGE ISLLAVGGGN RRTANVVAHG FTNLFILDKK DLNEILVHYP ESQKLLRKKA
RRMLRSNNKP KEEKSVLILP PRAGTPKLFN AALAMTGKMG GKGAKGGKLA HLRARLKELA
ALEAAAKQQE LVEQAKSSQD VKGEEGSAAP DQHTHPKEAA TDPPAPRTPP EPPGSPPSSP
PPASLGRPEG EEEGPAEPEE HSVRICMSPG PEPGEQILSV KMPEEREEKA E


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EIAAB08175 CNCA,CNCA1,CNCG2,CNG channel alpha-2,CNG2,CNG-2,CNGA2,Cyclic nucleotide-gated cation channel 2,Cyclic nucleotide-gated channel alpha-2,Cyclic nucleotide-gated olfactory channel,Homo sapiens,Human
EIAAB08177 Aorta CNG channel,CNCG2,CNG channel alpha-2,CNG2,CNG-2,CNGA2,Cyclic nucleotide-gated cation channel 2,Cyclic nucleotide-gated channel alpha-2,Cyclic nucleotide-gated olfactory channel,Oryctolagus cuni
EIAAB08169 cGMP-gated cation channel alpha-1,CNCG,CNCG1,CNG channel alpha-1,CNG1,CNG-1,CNGA1,Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,Cyclic nucleotide-gated channel, phot
EIAAB08172 cGMP-gated cation channel alpha-1,Cncg,Cncg1,CNG channel alpha-1,CNG1,CNG-1,Cnga1,Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,Cyclic nucleotide-gated channel, phot
EIAAB08171 cGMP-gated cation channel alpha-1,Cncg,Cncg1,CNG channel alpha-1,CNG1,CNG-1,Cnga1,Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,Cyclic nucleotide-gated channel, phot
EIAAB08173 Bos taurus,Bovine,cGMP-gated cation channel alpha-1,CNCG,CNCG1,CNG channel alpha-1,CNG1,CNG-1,CNGA1,Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,Cyclic nucleotide-g
EIAAB08174 Cncg2,Cncg4,CNG channel alpha-2,CNG2,CNG-2,Cnga2,Cyclic nucleotide-gated cation channel 2,Cyclic nucleotide-gated channel alpha-2,Cyclic nucleotide-gated olfactory channel,Mouse,Mus musculus
EIAAB08187 Canis familiaris,Canis lupus familiaris,CNG channel beta-3,CNGB3,Cone photoreceptor cGMP-gated channel subunit beta,Cyclic nucleotide-gated cation channel beta-3,Cyclic nucleotide-gated cation channel
EIAAB08178 Bos taurus,Bovine,CNCG2,CNG channel alpha-2,CNG2,CNG-2,CNGA2,Cyclic nucleotide-gated cation channel 2,Cyclic nucleotide-gated channel alpha-2,Cyclic nucleotide-gated olfactory channel
EIAAB08181 CNCG3,CNG channel alpha-3,CNG3,CNG-3,CNGA3,Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated cation channel alpha-3,Cyclic nucleotide-gated channel alpha-3,Homo sapiens,Human
EIAAB08179 Bos taurus,Bovine,CNCG3,CNG channel alpha-3,CNG3,CNG-3,CNGA3,Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated cation channel alpha-3,Cyclic nucleotide-gated channel alpha-3
EIAAB08176 Cncg2,CNG channel alpha-2,CNG2,CNG-2,Cnga2,Cyclic nucleotide-gated cation channel 2,Cyclic nucleotide-gated channel alpha-2,Cyclic nucleotide-gated olfactory channel,Cyclic nucleotide-gated olfactory
EIAAB08180 CNG channel alpha-3,CNG3,Cng3,CNG-3,Cnga3,Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated cation channel alpha-3,Cyclic nucleotide-gated channel alpha-3,Mouse,Mus musculus
EIAAB08170 Canis familiaris,Canis lupus familiaris,cGMP-gated cation channel alpha-1,CNCG,CNCG1,CNG channel alpha-1,CNG1,CNG-1,CNGA1,Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha
EIAAB08183 CNG channel alpha-4,CNG4,CNG-4,CNGA4,Cyclic nucleotide-gated cation channel alpha-4,Cyclic nucleotide-gated channel alpha-4,Homo sapiens,Human
EIAAB08184 CNG channel alpha-4,CNG4,CNG-4,Cnga4,Cyclic nucleotide-gated cation channel alpha-4,Cyclic nucleotide-gated channel alpha-4,Mouse,Mus musculus
E2021h Dog ELISA Kit FOR Cyclic nucleotide-gated cation channel beta-3 96T
CSB-EL005647DO Dog Cyclic nucleotide-gated cation channel beta-3(CNGB3) ELISA kit 96T
CNGB1_BOVIN Bovine ELISA Kit FOR Cyclic nucleotide-gated cation channel beta-1 96T
CSB-EL005647RA Rat Cyclic nucleotide-gated cation channel beta-3(CNGB3) ELISA kit 96T


 

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