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Cyclic nucleotide-gated cation channel subunit A (Cyclic nucleotide-gated ion channel subunit A) (CNG channel)

 CNGA_DROME              Reviewed;         665 AA.
Q24278; Q9V7L5;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
18-OCT-2001, sequence version 2.
25-OCT-2017, entry version 141.
RecName: Full=Cyclic nucleotide-gated cation channel subunit A;
AltName: Full=Cyclic nucleotide-gated ion channel subunit A;
Short=CNG channel;
Name=CngA; Synonyms=Cng; ORFNames=CG7779;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
PubMed=7957070;
Baumann A., Frings S., Godde M., Seifert R., Kaupp U.B.;
"Primary structure and functional expression of a Drosophila cyclic
nucleotide-gated channel present in eyes and antennae.";
EMBO J. 13:5040-5050(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
-!- FUNCTION: Approximately 50-fold more sensitive to cGMP than to
cAMP. May be involved in transduction cascades of both
invertebrate photoreceptors and olfactory sensillae.
{ECO:0000269|PubMed:7957070}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in antennae and the visual system.
{ECO:0000269|PubMed:7957070}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X89601; CAA61760.1; -; mRNA.
EMBL; AE013599; AAF58033.1; -; Genomic_DNA.
RefSeq; NP_477116.1; NM_057768.3.
ProteinModelPortal; Q24278; -.
SMR; Q24278; -.
IntAct; Q24278; 2.
STRING; 7227.FBpp0292051; -.
TCDB; 1.A.1.5.18; the voltage-gated ion channel (vic) superfamily.
PaxDb; Q24278; -.
PRIDE; Q24278; -.
EnsemblMetazoa; FBtr0302924; FBpp0292050; FBgn0261612.
GeneID; 36806; -.
KEGG; dme:Dmel_CG42701; -.
CTD; 36806; -.
FlyBase; FBgn0261612; CngA.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
GeneTree; ENSGT00900000140801; -.
InParanoid; Q24278; -.
KO; K04950; -.
OrthoDB; EOG091G03EW; -.
PhylomeDB; Q24278; -.
Reactome; R-DME-2485179; Activation of the phototransduction cascade.
Reactome; R-DME-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
Reactome; R-DME-5620916; VxPx cargo-targeting to cilium.
GenomeRNAi; 36806; -.
PRO; PR:Q24278; -.
Proteomes; UP000000803; Chromosome 2R.
Bgee; FBgn0261612; -.
ExpressionAtlas; Q24278; differential.
Genevisible; Q24278; DM.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IDA:FlyBase.
GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
GO; GO:0005221; F:intracellular cyclic nucleotide activated cation channel activity; IDA:FlyBase.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0006812; P:cation transport; IDA:FlyBase.
GO; GO:0019934; P:cGMP-mediated signaling; IDA:FlyBase.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0001666; P:response to hypoxia; IMP:FlyBase.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
2: Evidence at transcript level;
cGMP; cGMP-binding; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Ligand-gated ion channel; Membrane; Nucleotide-binding;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 665 Cyclic nucleotide-gated cation channel
subunit A.
/FTId=PRO_0000219327.
TOPO_DOM 1 110 Cytoplasmic. {ECO:0000255}.
TRANSMEM 111 131 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 132 138 Extracellular. {ECO:0000255}.
TRANSMEM 139 159 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 160 186 Cytoplasmic. {ECO:0000255}.
TRANSMEM 187 207 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 208 253 Extracellular. {ECO:0000255}.
TRANSMEM 254 274 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 275 325 Cytoplasmic. {ECO:0000255}.
TRANSMEM 326 346 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 347 481 Extracellular. {ECO:0000255}.
TRANSMEM 482 502 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 503 665 Cytoplasmic. {ECO:0000255}.
NP_BIND 437 559 cGMP. {ECO:0000250}.
BINDING 496 496 cGMP. {ECO:0000255}.
BINDING 511 511 cGMP. {ECO:0000255}.
CARBOHYD 135 135 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 73 73 G -> R (in Ref. 1; CAA61760).
{ECO:0000305}.
SEQUENCE 665 AA; 75823 MW; 6EFFC9A7CA243660 CRC64;
MRHFKVKAMV QSLDISAITG QQTDAEPSKR SKPSALRRTL QALRQRLTKR NRPKPPDWFL
EKFSNTTNTD KIGKGCPAME DAALSSEIRG SSVLCNRLSV DPTLQSHYRW LAIVSLAVLY
NIIFVVGRAV FWEINKSAPA FWYTLDYLCD FIYLLDTLVH MHEGFLDQGL LVRDAFRLRR
HYFHTKGWYL DVLSMLPTDL AYIWWPPETC SSLYLPCPVI VRLNRLLRIN RLWEWFDRTE
TATGYPNAFR ICKVVLAILV LIHWNACMYF AISYEIGFSS DSWVYNLNGT RNNTLQRQYI
YSFYWSTLTL TTIGETPTPE NDVEYLFVVA DFLAGVLIFA TIVGNIGSMI SNMNVARVEF
QNRMDGVKQY MAFRRVGHEL EARVIRWFAY TWSQSGALDE ERVLAALPDK LKAEIAIQVH
MDTLKQVRIF HDTEPGLLEA LVLKLKLQVF SPGDYICRKG DVGKEMYIVK RGKLSVVGDD
GITVLATLGA GSVFGEVSVL EIAGNRTGNR RTANVRSLGY SDLFCLAKRD LWETLSDYPE
ARSTLTQRGC QLLRKDGLLD EQIFADSQRV HDSIEGGIEK LELSVENLNM RLARLLAEYT
ASQAKIKQRL AKLEMNGGPG TWRLECEPQS RARSGRLYSL QPKRRPRSRP DATAKSSDAA
KQNTL


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