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Cyclic nucleotide-gated channel CNGA5 (Cyclic nucleotide-gated channel alpha 5)

 Q0GFG2_DANRE            Unreviewed;       673 AA.
Q0GFG2;
03-OCT-2006, integrated into UniProtKB/TrEMBL.
03-OCT-2006, sequence version 1.
22-NOV-2017, entry version 94.
SubName: Full=Cyclic nucleotide-gated channel CNGA5 {ECO:0000313|EMBL:ABI22055.1};
SubName: Full=Cyclic nucleotide-gated channel alpha 5 {ECO:0000313|Ensembl:ENSDARP00000136862};
Name=cnga5 {ECO:0000313|Ensembl:ENSDARP00000136862,
ECO:0000313|ZFIN:ZDB-GENE-061005-1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:ABI22055.1};
[1] {ECO:0000313|EMBL:ABI22055.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Brain {ECO:0000313|EMBL:ABI22055.1};
PubMed=16887101; DOI=10.1016/j.bbrc.2006.07.074;
Tetreault M.L., Henry D., Horrigan D.M., Matthews G., Zimmerman A.L.;
"Characterization of a novel cyclic nucleotide-gated channel from
zebrafish brain.";
Biochem. Biophys. Res. Commun. 348:441-449(2006).
[2] {ECO:0000313|EMBL:ABI22055.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Brain {ECO:0000313|EMBL:ABI22055.1};
Matthews G.G., Henry D.L.;
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSDARP00000136862, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136862,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[4] {ECO:0000313|Ensembl:ENSDARP00000136862}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136862};
Ensembl;
Submitted (NOV-2015) to UniProtKB.
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EMBL; CR376767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; DQ866815; ABI22055.1; -; mRNA.
RefSeq; NP_001038211.1; NM_001044746.1.
UniGene; Dr.74129; -.
STRING; 7955.ENSDARP00000079201; -.
Ensembl; ENSDART00000157406; ENSDARP00000136862; ENSDARG00000102968.
GeneID; 751786; -.
CTD; 751786; -.
ZFIN; ZDB-GENE-061005-1; cnga5.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
GeneTree; ENSGT00900000140801; -.
HOGENOM; HOG000007898; -.
HOVERGEN; HBG000281; -.
OMA; EAKVIRW; -.
OrthoDB; EOG091G03EW; -.
TreeFam; TF319048; -.
Reactome; R-DRE-5620916; VxPx cargo-targeting to cilium.
Proteomes; UP000000437; Chromosome 14.
GO; GO:0016021; C:integral component of membrane; IDA:ZFIN.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005216; F:ion channel activity; IDA:ZFIN.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
GO; GO:0006811; P:ion transport; IDA:ZFIN.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Ion transport {ECO:0000256|SAAS:SAAS00502700};
Membrane {ECO:0000256|SAAS:SAAS00137754, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Transmembrane {ECO:0000256|SAAS:SAAS00137754,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502700}.
TRANSMEM 144 164 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 176 192 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 229 249 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 276 300 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 354 377 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 458 572 Cyclic nucleotide-binding.
{ECO:0000259|PROSITE:PS50042}.
COILED 598 643 {ECO:0000256|SAM:Coils}.
SEQUENCE 673 AA; 77222 MW; 1E39C4442E1D78C9 CRC64;
MTCQLLLESM DLSPHRLSVK TSIEDESEPA DCTFSRDQSI CDDTSSELQR VATLEQQRLN
SFRDRGALSR LVNMVVTLRE WAHKSLQEEE ERPDSFLERF RGPELQIATS RLSISRHDIQ
DGNTSAKTKK KSDVFILSPA DDLYYRWLFV IASAVLYNWC FVVARACFNE LQTRNFILWL
FLDYLSDVIY ILDTCVRLRT GFLEQGLLVK DLIKLRESYF HTLQFKLDLL SIIPTDLGYI
VIGIHVPELR LNRLMRFSRL FEFFDRTETR TSYPNLFRIC NLVLYILVII HWNACIYFAI
SKSLGFGSDQ WVYPNISDPK FGTLTRGYVY CLYWSTLTLT TIGEMPAPVQ DEEYLFVVFD
FLVGVLIFAT IVGNVGAMIS NMNATRAEFQ GQIDAIKHYM KFRKVSKELE ARVIKWFDYL
WTNKKTIDEQ DVLKNLPNKL RAEIAINVHL ETLKKVRIFQ DCEAGLLVEL VLKLRPQVFS
PGDYICRKGD IGKEMYIIKE GCLAVVADDG VTQYAHLTAG SCFGEISILN IRGSKMGNRR
TANIRSIGYS DLFCLSKGDL MEAVMEYPDA KKVLEEKGRQ ILIKEGLLEE VEADGIGVED
IEKRVERMED TIEILQTRFA RLLAQYTATQ QHLKQRLTTL ECRTNHSGSG FLSDGNESTI
DGDGTNSEVN IHL


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