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Cyclic nucleotide-gated ion channel 4 (AtCNGC4) (Cyclic nucleotide- and calmodulin-regulated ion channel 4) (AtHLM1)

 CNGC4_ARATH             Reviewed;         694 AA.
Q94AS9; Q9XFS2;
21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
21-NOV-2003, sequence version 2.
23-MAY-2018, entry version 132.
RecName: Full=Cyclic nucleotide-gated ion channel 4;
Short=AtCNGC4;
AltName: Full=Cyclic nucleotide- and calmodulin-regulated ion channel 4;
Short=AtHLM1;
Name=CNGC4; Synonyms=HLM1; OrderedLocusNames=At5g54250;
ORFNames=MDK4.7;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=cv. Columbia;
PubMed=10341447; DOI=10.1046/j.1365-313X.1999.00422.x;
Koehler C., Merkle T., Neuhaus G.;
"Characterisation of a novel gene family of putative cyclic
nucleotide- and calmodulin-regulated ion channels in Arabidopsis
thaliana.";
Plant J. 18:97-104(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=9679202; DOI=10.1093/dnares/5.2.131;
Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
features of the regions of 1,381,565 bp covered by twenty one
physically assigned P1 and TAC clones.";
DNA Res. 5:131-145(1998).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
GENE FAMILY, AND NOMENCLATURE.
PubMed=11500563; DOI=10.1104/pp.126.4.1646;
Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A.,
Guerinot M.L.;
"Phylogenetic relationships within cation transporter families of
Arabidopsis.";
Plant Physiol. 126:1646-1667(2001).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=12566578; DOI=10.1105/tpc.006999;
Balague C., Lin B., Alcon C., Flottes G., Malmstroem S., Koehler C.,
Neuhaus G., Pelletier G., Gaymard F., Roby D.;
"HLM1, an essential signaling component in the hypersensitive
response, is a member of the cyclic nucleotide-gated channel ion
channel family.";
Plant Cell 15:365-379(2003).
-!- FUNCTION: Acts as cyclic nucleotide-gated ion channel. Permeable
to potassium and sodium in a cyclic nucleotide-dependent fashion
(cAMP or cGMP). Might constitute a common downstream component of
the signaling pathways leading to hypersensitive response (HR).
{ECO:0000269|PubMed:12566578}.
-!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q94AS9-1; Sequence=Displayed;
Name=2;
IsoId=Q94AS9-2; Sequence=VSP_008985, VSP_008986;
Note=No experimental confirmation available.;
-!- INDUCTION: Induced by both ethylene and methyl jasmonate
treatments, or after pathogen attack.
-!- DOMAIN: The binding of calmodulin to the C-terminus might
interfere with cyclic nucleotide binding and thus channel
activation. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Loss-of-function mutation results in the
loss of the hypersensitive response leading to broad spectrum
disease resistance, and displays a lesion-mimic phenotype.
{ECO:0000269|PubMed:12566578}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Y17912; CAB40129.1; -; mRNA.
EMBL; AB010695; BAB10748.1; -; Genomic_DNA.
EMBL; CP002688; AED96473.1; -; Genomic_DNA.
EMBL; CP002688; AED96474.1; -; Genomic_DNA.
EMBL; CP002688; ANM70509.1; -; Genomic_DNA.
EMBL; AY045822; AAK76496.1; -; mRNA.
EMBL; AY057691; AAL15321.1; -; mRNA.
EMBL; AY133734; AAM91668.1; -; mRNA.
PIR; T52574; T52574.
RefSeq; NP_001332114.1; NM_001345080.1. [Q94AS9-1]
RefSeq; NP_200236.1; NM_124805.3. [Q94AS9-1]
RefSeq; NP_851188.1; NM_180857.2. [Q94AS9-1]
UniGene; At.401; -.
ProteinModelPortal; Q94AS9; -.
SMR; Q94AS9; -.
STRING; 3702.AT5G54250.1; -.
TCDB; 1.A.1.5.7; the voltage-gated ion channel (vic) superfamily.
iPTMnet; Q94AS9; -.
PaxDb; Q94AS9; -.
PRIDE; Q94AS9; -.
EnsemblPlants; AT5G54250.1; AT5G54250.1; AT5G54250. [Q94AS9-1]
EnsemblPlants; AT5G54250.2; AT5G54250.2; AT5G54250. [Q94AS9-1]
EnsemblPlants; AT5G54250.4; AT5G54250.4; AT5G54250. [Q94AS9-1]
GeneID; 835513; -.
Gramene; AT5G54250.1; AT5G54250.1; AT5G54250. [Q94AS9-1]
Gramene; AT5G54250.2; AT5G54250.2; AT5G54250. [Q94AS9-1]
Gramene; AT5G54250.4; AT5G54250.4; AT5G54250. [Q94AS9-1]
KEGG; ath:AT5G54250; -.
Araport; AT5G54250; -.
TAIR; locus:2162605; AT5G54250.
eggNOG; KOG0498; Eukaryota.
eggNOG; ENOG410XPSE; LUCA.
HOGENOM; HOG000238338; -.
InParanoid; Q94AS9; -.
OMA; WGETINA; -.
OrthoDB; EOG0936045S; -.
PhylomeDB; Q94AS9; -.
PRO; PR:Q94AS9; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; Q94AS9; baseline and differential.
Genevisible; Q94AS9; AT.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0016020; C:membrane; IDA:TAIR.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0008324; F:cation transmembrane transporter activity; IDA:TAIR.
GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0009626; P:plant-type hypersensitive response; IMP:TAIR.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF00520; Ion_trans; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
2: Evidence at transcript level;
Alternative splicing; Calmodulin-binding; cAMP; cAMP-binding;
Cell membrane; cGMP; cGMP-binding; Complete proteome;
Hypersensitive response; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Nucleotide-binding; Plant defense;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 694 Cyclic nucleotide-gated ion channel 4.
/FTId=PRO_0000219332.
TOPO_DOM 1 92 Cytoplasmic. {ECO:0000255}.
TRANSMEM 93 113 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 114 126 Extracellular. {ECO:0000255}.
TRANSMEM 127 147 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 148 187 Cytoplasmic. {ECO:0000255}.
TRANSMEM 188 208 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 209 216 Extracellular. {ECO:0000255}.
TRANSMEM 217 237 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 238 251 Cytoplasmic. {ECO:0000255}.
TRANSMEM 252 272 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 273 392 Extracellular. {ECO:0000255}.
TRANSMEM 393 413 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 414 694 Cytoplasmic. {ECO:0000255}.
DOMAIN 631 660 IQ.
NP_BIND 496 626 cNMP.
REGION 610 626 Calmodulin-binding. {ECO:0000250}.
COMPBIAS 25 52 Glu-rich.
BINDING 565 565 cNMP. {ECO:0000250}.
VAR_SEQ 274 293 AAGACWYLLGVQRSAKCLKE -> VSYLINCFVLLNILVNT
KFQ (in isoform 2).
{ECO:0000303|PubMed:14593172}.
/FTId=VSP_008985.
VAR_SEQ 294 694 Missing (in isoform 2).
{ECO:0000303|PubMed:14593172}.
/FTId=VSP_008986.
SEQUENCE 694 AA; 80081 MW; E3F843AE1B0F1EA0 CRC64;
MATEQEFTRA SRFSRDSSSV GYYSEEDNTE EEDEEEEEME EIEEEEEEEE EEDPRIGLTC
GGRRNGSSNN NKWMMLGRIL DPRSKWVREW NKVFLLVCAT GLFVDPLFLY TLSVSDTCMC
LLVDGWLALT VTALRSMTDL LHLWNIWIQF KIARRWPYPG GDSDGDTNKG GGTRGSTRVA
PPYVKKNGFF FDLFVILPLP QVVLWVVIPS LLKRGSVTLV VSVLLVTFLF QYLPKIYHSI
RHLRRNATLS GYIFGTVWWG IALNMIAYFV AAHAAGACWY LLGVQRSAKC LKEQCENTIG
CDLRMLSCKE PVYYGTTVMV LDRARLAWAQ NHQARSVCLD INTNYTYGAY QWTIQLVSSE
SRLEKILFPI FWGLMTLSTF GNLESTTEWS EVVFNIIVLT SGLLLVTMLI GNIKVFLHAT
TSKKQAMHLK MRNIEWWMKK RHLPIGFRQR VRNYERQRWA AMRGVDECEM VQNLPEGLRR
DIKYHLCLDL VRQVPLFQHM DDLVLENICD RVKSLIFTKG ETIQKEGDAV QRMLFVVRGH
LQSSQLLRDG VKSCCMLGPG NFSGDELLSW CLRRPFVERL PPSSSTLVTL ETTEAFGLDA
EDVKYVTQHF RYTFVNEKVK RSARYYSPGW RTWAAVAVQL AWRRYKHRLT LTSLSFIRPR
RPLSRCASLG EDKLRLYAAI LTSPKPNPDD FDDY


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