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Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2)

 CNGA2_HUMAN             Reviewed;         664 AA.
Q16280; A0AVD0;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
12-DEC-2006, sequence version 2.
30-AUG-2017, entry version 146.
RecName: Full=Cyclic nucleotide-gated olfactory channel;
AltName: Full=Cyclic nucleotide-gated cation channel 2;
AltName: Full=Cyclic nucleotide-gated channel alpha-2;
Short=CNG channel alpha-2;
Short=CNG-2;
Short=CNG2;
Name=CNGA2; Synonyms=CNCA, CNCA1, CNCG2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-552.
PubMed=7532814; DOI=10.1016/0028-3908(94)90027-2;
Distler M., Biel M., Flockerzi V., Hofmann F.;
"Expression of cyclic nucleotide-gated cation channels in non-sensory
tissues and cells.";
Neuropharmacology 33:1275-1282(1994).
[3]
VARIANTS [LARGE SCALE ANALYSIS] HIS-97 AND GLN-399.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Odorant signal transduction is probably mediated by a G-
protein coupled cascade using cAMP as second messenger. The
olfactory channel can be shown to be activated by cyclic
nucleotides which leads to a depolarization of olfactory sensory
neurons.
-!- SUBUNIT: Heterotetramer composed of two subunits of CNGA2, one of
CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-
gated (CNG) channel of olfactory sensory neurons (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- DOMAIN: The C-terminal coiled-coil domain mediates trimerization
of CNGA subunits. {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. CNGA2 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; BC126302; AAI26303.1; -; mRNA.
EMBL; BC126304; AAI26305.1; -; mRNA.
EMBL; S76067; AAD14207.1; -; Genomic_DNA.
CCDS; CCDS14701.1; -.
PIR; I78559; I78559.
RefSeq; NP_005131.1; NM_005140.1.
UniGene; Hs.447360; -.
ProteinModelPortal; Q16280; -.
SMR; Q16280; -.
STRING; 9606.ENSP00000328478; -.
GuidetoPHARMACOLOGY; 395; -.
iPTMnet; Q16280; -.
PhosphoSitePlus; Q16280; -.
BioMuta; CNGA2; -.
DMDM; 119370323; -.
PaxDb; Q16280; -.
PeptideAtlas; Q16280; -.
PRIDE; Q16280; -.
Ensembl; ENST00000329903; ENSP00000328478; ENSG00000183862.
GeneID; 1260; -.
KEGG; hsa:1260; -.
UCSC; uc065bqd.1; human.
CTD; 1260; -.
DisGeNET; 1260; -.
GeneCards; CNGA2; -.
HGNC; HGNC:2149; CNGA2.
HPA; HPA015065; -.
MalaCards; CNGA2; -.
MIM; 300338; gene.
neXtProt; NX_Q16280; -.
OpenTargets; ENSG00000183862; -.
PharmGKB; PA26659; -.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
GeneTree; ENSGT00760000118772; -.
HOGENOM; HOG000007898; -.
HOVERGEN; HBG000281; -.
InParanoid; Q16280; -.
KO; K04949; -.
OMA; EAKVIRW; -.
OrthoDB; EOG091G03EW; -.
PhylomeDB; Q16280; -.
TreeFam; TF319048; -.
Reactome; R-HSA-5620916; VxPx cargo-targeting to cilium.
GeneWiki; Cyclic_nucleotide-gated_channel_alpha_2; -.
GenomeRNAi; 1260; -.
PRO; PR:Q16280; -.
Proteomes; UP000005640; Chromosome X.
Bgee; ENSG00000183862; -.
CleanEx; HS_CNGA2; -.
GO; GO:0060170; C:ciliary membrane; TAS:Reactome.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0030660; C:Golgi-associated vesicle membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
2: Evidence at transcript level;
Calmodulin-binding; cAMP; cAMP-binding; Coiled coil;
Complete proteome; Glycoprotein; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Nucleotide-binding; Olfaction;
Polymorphism; Reference proteome; Sensory transduction; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 664 Cyclic nucleotide-gated olfactory
channel.
/FTId=PRO_0000219312.
TOPO_DOM 1 138 Cytoplasmic. {ECO:0000255}.
TRANSMEM 139 159 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 160 171 Extracellular. {ECO:0000255}.
TRANSMEM 172 192 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 193 224 Cytoplasmic. {ECO:0000255}.
TRANSMEM 225 245 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 246 274 Extracellular. {ECO:0000255}.
TRANSMEM 275 295 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 296 350 Cytoplasmic. {ECO:0000255}.
TRANSMEM 351 371 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 372 453 Extracellular. {ECO:0000255}.
TRANSMEM 454 474 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 475 662 Cytoplasmic. {ECO:0000255}.
NP_BIND 454 577 cAMP. {ECO:0000250}.
COILED 597 640 {ECO:0000250}.
BINDING 521 521 cAMP. {ECO:0000250}.
BINDING 536 536 cAMP. {ECO:0000250}.
CARBOHYD 379 379 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 97 97 R -> H (in a breast cancer sample;
somatic mutation; dbSNP:rs561786347).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036603.
VARIANT 118 118 D -> H (in dbSNP:rs6627455).
/FTId=VAR_048748.
VARIANT 139 139 W -> L (in dbSNP:rs35350051).
/FTId=VAR_061107.
VARIANT 399 399 R -> Q (in a breast cancer sample;
somatic mutation; dbSNP:rs150539917).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036604.
VARIANT 663 663 E -> K (in dbSNP:rs714147).
/FTId=VAR_048749.
SEQUENCE 664 AA; 76048 MW; E8FB934468429CE5 CRC64;
MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL QRLADVDAPQ
QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG PELQTVTTQE GDGKGDKDGE
DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP VLYNWCLLVA RACFSDLQKG YYLVWLVLDY
VSDVVYIADL FIRLRTGFLE QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI
HSPEVRFNRL LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY LFVIFDFLIG
VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK VSKGMEAKVI RWFDYLWTNK
KTVDEREILK NLPAKLRAEI AINVHLSTLK KVRIFHDCEA GLLVELVLKL RPQVFSPGDY
ICRKGDIGKE MYIIKEGKLA VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI
RSLGYSDLFC LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK
LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS DGMNSPELAA
ADEP


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