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Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2)

 CNGA2_MOUSE             Reviewed;         664 AA.
Q62398; Q80XH6;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
25-OCT-2017, entry version 147.
RecName: Full=Cyclic nucleotide-gated olfactory channel;
AltName: Full=Cyclic nucleotide-gated cation channel 2;
AltName: Full=Cyclic nucleotide-gated channel alpha-2;
Short=CNG channel alpha-2;
Short=CNG-2;
Short=CNG2;
Name=Cnga2; Synonyms=Cncg2, Cncg4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Heart;
PubMed=8841933; DOI=10.1006/jmcc.1996.0136;
Ruiz M.L., London B., Nadal-Ginard B.;
"Cloning and characterization of an olfactory cyclic nucleotide-gated
channel expressed in mouse heart.";
J. Mol. Cell. Cardiol. 28:1453-1461(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Odorant signal transduction is probably mediated by a G-
protein coupled cascade using cAMP as second messenger. The
olfactory channel can be shown to be activated by cyclic
nucleotides which leads to a depolarization of olfactory sensory
neurons.
-!- SUBUNIT: Heterotetramer composed of two subunits of CNGA2, one of
CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-
gated (CNG) channel of olfactory sensory neurons (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- DOMAIN: The C-terminal coiled-coil domain mediates trimerization
of CNGA subunits. {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. CNGA2 subfamily. {ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
{ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; U49391; AAC52712.1; -; Genomic_DNA.
EMBL; AK132574; BAE21237.1; -; mRNA.
EMBL; CH466624; EDL26564.1; -; Genomic_DNA.
EMBL; BC048775; AAH48775.1; -; mRNA.
CCDS; CCDS30184.1; -.
RefSeq; NP_031750.2; NM_007724.3.
RefSeq; XP_006527824.1; XM_006527761.1.
UniGene; Mm.5097; -.
ProteinModelPortal; Q62398; -.
SMR; Q62398; -.
STRING; 10090.ENSMUSP00000006020; -.
TCDB; 1.A.1.5.4; the voltage-gated ion channel (vic) superfamily.
PhosphoSitePlus; Q62398; -.
PaxDb; Q62398; -.
PRIDE; Q62398; -.
Ensembl; ENSMUST00000006020; ENSMUSP00000006020; ENSMUSG00000005864.
GeneID; 12789; -.
KEGG; mmu:12789; -.
UCSC; uc009tkk.1; mouse.
CTD; 1260; -.
MGI; MGI:108040; Cnga2.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
GeneTree; ENSGT00900000140801; -.
HOGENOM; HOG000007898; -.
HOVERGEN; HBG000281; -.
InParanoid; Q62398; -.
KO; K04949; -.
OMA; EAKVIRW; -.
OrthoDB; EOG091G03EW; -.
TreeFam; TF319048; -.
Reactome; R-MMU-5620916; VxPx cargo-targeting to cilium.
PRO; PR:Q62398; -.
Proteomes; UP000000589; Chromosome X.
Bgee; ENSMUSG00000005864; -.
CleanEx; MM_CNGA2; -.
ExpressionAtlas; Q62398; baseline and differential.
Genevisible; Q62398; MM.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0005216; F:ion channel activity; IMP:MGI.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR01463; EAGCHANLFMLY.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
2: Evidence at transcript level;
Calmodulin-binding; cAMP; cAMP-binding; Coiled coil;
Complete proteome; Glycoprotein; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Nucleotide-binding; Olfaction;
Reference proteome; Sensory transduction; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 664 Cyclic nucleotide-gated olfactory
channel.
/FTId=PRO_0000219313.
TOPO_DOM 1 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 163 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 164 175 Extracellular. {ECO:0000255}.
TRANSMEM 176 194 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 195 218 Cytoplasmic. {ECO:0000255}.
TRANSMEM 219 238 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 239 276 Extracellular. {ECO:0000255}.
TRANSMEM 277 299 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 300 351 Cytoplasmic. {ECO:0000255}.
TRANSMEM 352 371 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 372 455 Extracellular. {ECO:0000255}.
TRANSMEM 456 476 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 477 664 Cytoplasmic. {ECO:0000255}.
NP_BIND 464 586 cAMP. {ECO:0000250}.
COILED 599 642 {ECO:0000250}.
BINDING 523 523 cAMP. {ECO:0000255}.
BINDING 538 538 cAMP. {ECO:0000255}.
CARBOHYD 381 381 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 110 110 T -> P (in Ref. 1; AAC52712).
{ECO:0000305}.
CONFLICT 355 355 V -> F (in Ref. 1; AAC52712).
{ECO:0000305}.
CONFLICT 540 541 AN -> GT (in Ref. 1; AAC52712).
{ECO:0000305}.
SEQUENCE 664 AA; 76193 MW; 34F8DF3B372C0D9C CRC64;
MMTEKSNGVK SSPANNHNHH PPPSIKANGK DDHRAGSRPQ SVAADDDTSS ELQRLAEMDT
PRRGRGGFRR IVRLVGIIRD WANKNFREEE PRPDSFLERF RGPELQTVTT HQGDGKGDKD
GEGKGTKKKF ELFVLDPAGD WYYRWLFVIA MPVLYNWCLL VARACFSDLQ RNYFVVWLVL
DYFSDTVYIA DLIIRLRTGF LEQGLLVKDP KKLRDNYIHT LQFKLDVASI IPTDLIYFAV
GIHSPEVRFN RLLHFARMFE FFDRTETRTS YPNIFRISNL VLYILVIIHW NACIYYAISK
SIGFGVDTWV YPNITDPEYG YLAREYIYCL YWSTLTLTTI GETPPPVKDE EYLFVIFDFL
IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAVKHYMQF RKVSKDMEAK VIKWFDYLWT
NKKTVDEREV LKNLPAKLRA EIAINVHLST LKKVRIFQDC EAGLLVELVL KLRPQVFSPG
DYICRKGDIG KEMYIIKEGK LAVVADDGVT QYALLSAGSC FGEISILNIK GSKMGNRRTA
NIRSLGYSDL FCLSKDDLME AVTEYPDAKK VLEERGREIL MKEGLLDENE VAASMEVDVQ
EKLEQLETNM ETLYTRFARL LAEYTGAQQK LKQRITVLET KMKQNHEDDY LSDGINTPEP
AVAE


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