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Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2) (Cyclic nucleotide-gated olfactory channel subunit OCNC1)

 CNGA2_RAT               Reviewed;         664 AA.
Q00195; Q549G7;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 1.
22-NOV-2017, entry version 130.
RecName: Full=Cyclic nucleotide-gated olfactory channel;
AltName: Full=Cyclic nucleotide-gated cation channel 2;
AltName: Full=Cyclic nucleotide-gated channel alpha-2;
Short=CNG channel alpha-2;
Short=CNG-2;
Short=CNG2;
AltName: Full=Cyclic nucleotide-gated olfactory channel subunit OCNC1;
Name=Cnga2; Synonyms=Cncg2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Olfactory sensory neuron;
PubMed=1697649; DOI=10.1038/347184a0;
Dhallan R.S., Yau K.-W., Schrader K.A., Reed R.R.;
"Primary structure and functional expression of a cyclic nucleotide-
activated channel from olfactory neurons.";
Nature 347:184-187(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=10594674; DOI=10.1046/j.1460-9568.1999.00893.x;
Strijbos P.J., Pratt G.D., Khan S., Charles I.G., Garthwaite J.;
"Molecular characterization and in situ localization of a full-length
cyclic nucleotide-gated channel in rat brain.";
Eur. J. Neurosci. 11:4463-4467(1999).
-!- FUNCTION: Odorant signal transduction is probably mediated by a G-
protein coupled cascade using cAMP as second messenger. The
olfactory channel can be shown to be activated by cyclic
nucleotides which leads to a depolarization of olfactory sensory
neurons.
-!- SUBUNIT: Heterotetramer composed of two subunits of CNGA2, one of
CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-
gated (CNG) channel of olfactory sensory neurons (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Olfactory neurons.
-!- DOMAIN: The C-terminal coiled-coil domain mediates trimerization
of CNGA subunits. {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
(TC 1.A.1.5) family. CNGA2 subfamily. {ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; X55519; CAA39135.1; -; mRNA.
EMBL; AF126808; AAD41473.1; -; mRNA.
PIR; S11517; S11517.
RefSeq; NP_037060.1; NM_012928.1.
RefSeq; XP_017455916.1; XM_017600427.1.
UniGene; Rn.10384; -.
PDB; 2M0J; NMR; -; B=60-87.
PDB; 2M0K; NMR; -; B=60-87.
PDBsum; 2M0J; -.
PDBsum; 2M0K; -.
ProteinModelPortal; Q00195; -.
SMR; Q00195; -.
DIP; DIP-61291N; -.
IntAct; Q00195; 1.
STRING; 10116.ENSRNOP00000016415; -.
GuidetoPHARMACOLOGY; 395; -.
iPTMnet; Q00195; -.
PaxDb; Q00195; -.
PRIDE; Q00195; -.
GeneID; 108348053; -.
GeneID; 25411; -.
KEGG; rno:108348053; -.
KEGG; rno:25411; -.
CTD; 1260; -.
RGD; 2367; Cnga2.
eggNOG; KOG0500; Eukaryota.
eggNOG; ENOG410YWWI; LUCA.
HOGENOM; HOG000007898; -.
HOVERGEN; HBG000281; -.
InParanoid; Q00195; -.
KO; K04949; -.
PhylomeDB; Q00195; -.
PRO; PR:Q00195; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
GO; GO:0030553; F:cGMP binding; IDA:RGD.
GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IDA:RGD.
GO; GO:0005223; F:intracellular cGMP activated cation channel activity; IDA:RGD.
GO; GO:0005216; F:ion channel activity; ISO:RGD.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0051899; P:membrane depolarization; IDA:RGD.
GO; GO:0051290; P:protein heterotetramerization; IDA:RGD.
GO; GO:0051289; P:protein homotetramerization; IDA:RGD.
GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
GO; GO:0007608; P:sensory perception of smell; IEP:RGD.
CDD; cd00038; CAP_ED; 1.
Gene3D; 2.60.120.10; -; 1.
InterPro; IPR032406; CLZ_dom.
InterPro; IPR018490; cNMP-bd-like.
InterPro; IPR018488; cNMP-bd_CS.
InterPro; IPR000595; cNMP-bd_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
InterPro; IPR014710; RmlC-like_jellyroll.
Pfam; PF16526; CLZ; 1.
Pfam; PF00027; cNMP_binding; 1.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR01463; EAGCHANLFMLY.
SMART; SM00100; cNMP; 1.
SUPFAM; SSF51206; SSF51206; 1.
PROSITE; PS00888; CNMP_BINDING_1; 1.
PROSITE; PS00889; CNMP_BINDING_2; 1.
PROSITE; PS50042; CNMP_BINDING_3; 1.
1: Evidence at protein level;
3D-structure; Calmodulin-binding; cAMP; cAMP-binding; Coiled coil;
Complete proteome; Glycoprotein; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Nucleotide-binding; Olfaction;
Reference proteome; Sensory transduction; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 664 Cyclic nucleotide-gated olfactory
channel.
/FTId=PRO_0000219315.
TOPO_DOM 1 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 162 Helical; Name=H1. {ECO:0000255}.
TOPO_DOM 163 175 Extracellular. {ECO:0000255}.
TRANSMEM 176 194 Helical; Name=H2. {ECO:0000255}.
TOPO_DOM 195 218 Cytoplasmic. {ECO:0000255}.
TRANSMEM 219 238 Helical; Name=H3. {ECO:0000255}.
TOPO_DOM 239 276 Extracellular. {ECO:0000255}.
TRANSMEM 277 299 Helical; Name=H4. {ECO:0000255}.
TOPO_DOM 300 351 Cytoplasmic. {ECO:0000255}.
TRANSMEM 352 371 Helical; Name=H5. {ECO:0000255}.
TOPO_DOM 372 455 Extracellular. {ECO:0000255}.
TRANSMEM 456 476 Helical; Name=H6. {ECO:0000255}.
TOPO_DOM 477 664 Cytoplasmic. {ECO:0000255}.
NP_BIND 464 586 cAMP. {ECO:0000250}.
COILED 599 642 {ECO:0000250}.
BINDING 523 523 cAMP. {ECO:0000255}.
BINDING 538 538 cAMP. {ECO:0000255}.
CARBOHYD 381 381 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 212 212 K -> R.
STRAND 62 64 {ECO:0000244|PDB:2M0K}.
HELIX 66 82 {ECO:0000244|PDB:2M0J}.
TURN 83 85 {ECO:0000244|PDB:2M0K}.
SEQUENCE 664 AA; 76177 MW; 720806950EC27F3C CRC64;
MMTEKSNGVK SSPANNHNHH PPPSIKANGK DDHRAGSRPQ SVAADDDTSP ELQRLAEMDT
PRRGRGGFQR IVRLVGVIRD WANKNFREEE PRPDSFLERF RGPELQTVTT HQGDDKGGKD
GEGKGTKKKF ELFVLDPAGD WYYRWLFVIA MPVLYNWCLL VARACFSDLQ RNYFVVWLVL
DYFSDTVYIA DLIIRLRTGF LEQGLLVKDP KKLRDNYIHT LQFKLDVASI IPTDLIYFAV
GIHSPEVRFN RLLHFARMFE FFDRTETRTS YPNIFRISNL VLYILVIIHW NACIYYVISK
SIGFGVDTWV YPNITDPEYG YLAREYIYCL YWSTLTLTTI GETPPPVKDE EYLFVIFDFL
IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAVKHYMQF RKVSKDMEAK VIKWFDYLWT
NKKTVDEREV LKNLPAKLRA EIAINVHLST LKKVRIFQDC EAGLLVELVL KLRPQVFSPG
DYICRKGDIG KEMYIIKEGK LAVVADDGVT QYALLSAGSC FGEISILNIK GSKMGNRRTA
NIRSLGYSDL FCLSKDDLME AVTEYPDAKK VLEERGREIL MKEGLLDENE VAASMEVDVQ
EKLEQLETNM DTLYTRFARL LAEYTGAQQK LKQRITVLET KMKQNHEDDY LSDGINTPEP
TAAE


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