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Cyclic-AMP response element binding protein B, isoform O

 M9PHW9_DROME            Unreviewed;       281 AA.
M9PHW9;
26-JUN-2013, integrated into UniProtKB/TrEMBL.
26-JUN-2013, sequence version 1.
28-MAR-2018, entry version 42.
SubName: Full=Cyclic-AMP response element binding protein B, isoform O {ECO:0000313|EMBL:AGB95520.1};
Name=CrebB {ECO:0000313|EMBL:AGB95520.1,
ECO:0000313|FlyBase:FBgn0265784};
Synonyms=CRE-BP {ECO:0000313|EMBL:AGB95520.1},
CREB {ECO:0000313|EMBL:AGB95520.1},
Creb {ECO:0000313|EMBL:AGB95520.1},
Creb B 17A {ECO:0000313|EMBL:AGB95520.1},
CREB-B {ECO:0000313|EMBL:AGB95520.1},
CREB-b {ECO:0000313|EMBL:AGB95520.1},
Creb17A {ECO:0000313|EMBL:AGB95520.1},
CREB2 {ECO:0000313|EMBL:AGB95520.1},
Creb2 {ECO:0000313|EMBL:AGB95520.1},
Creb2-b {ECO:0000313|EMBL:AGB95520.1},
Creb2.b {ECO:0000313|EMBL:AGB95520.1},
CREB2a {ECO:0000313|EMBL:AGB95520.1},
CREB2b {ECO:0000313|EMBL:AGB95520.1},
Creb2b {ECO:0000313|EMBL:AGB95520.1},
CrebB-17A {ECO:0000313|EMBL:AGB95520.1},
CrebB-17B {ECO:0000313|EMBL:AGB95520.1},
CrebB17-A {ECO:0000313|EMBL:AGB95520.1},
dCbz {ECO:0000313|EMBL:AGB95520.1},
dCREB {ECO:0000313|EMBL:AGB95520.1},
dCREB-2 {ECO:0000313|EMBL:AGB95520.1},
dCREB-2a {ECO:0000313|EMBL:AGB95520.1},
dCREB-B {ECO:0000313|EMBL:AGB95520.1},
dCREB2 {ECO:0000313|EMBL:AGB95520.1},
dCreb2 {ECO:0000313|EMBL:AGB95520.1},
dCREB2-a {ECO:0000313|EMBL:AGB95520.1},
dCREB2-b {ECO:0000313|EMBL:AGB95520.1},
dCreb2-b {ECO:0000313|EMBL:AGB95520.1},
dcreb2-b {ECO:0000313|EMBL:AGB95520.1},
dCREB2a {ECO:0000313|EMBL:AGB95520.1},
dCREB2b {ECO:0000313|EMBL:AGB95520.1},
dCrebB2 {ECO:0000313|EMBL:AGB95520.1},
DM9 {ECO:0000313|EMBL:AGB95520.1},
Dmel\CG6103 {ECO:0000313|EMBL:AGB95520.1},
l(1)17Af {ECO:0000313|EMBL:AGB95520.1},
S162 {ECO:0000313|EMBL:AGB95520.1};
ORFNames=CG6103 {ECO:0000313|EMBL:AGB95520.1,
ECO:0000313|FlyBase:FBgn0265784},
Dmel_CG6103 {ECO:0000313|EMBL:AGB95520.1};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803};
[1] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537568;
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
"Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence.";
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
[3] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537573;
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
Ashburner M., Celniker S.E.;
"The transposable elements of the Drosophila melanogaster euchromatin:
a genomics perspective.";
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
[5] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537574;
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
Karpen G.H.;
"Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly.";
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
[6] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
Ashburner M., Anxolabehere D.;
"Combined evidence annotation of transposable elements in genome
sequences.";
PLoS Comput. Biol. 1:166-175(2005).
[7] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569856; DOI=10.1126/science.1139815;
Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
"The Release 5.1 annotation of Drosophila melanogaster
heterochromatin.";
Science 316:1586-1591(2007).
[8] {ECO:0000313|EMBL:AGB95520.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569867; DOI=10.1126/science.1139816;
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
Dimitri P., Karpen G.H., Celniker S.E.;
"Sequence finishing and mapping of Drosophila melanogaster
heterochromatin.";
Science 316:1625-1628(2007).
-----------------------------------------------------------------------
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EMBL; AE014298; AGB95520.1; -; Genomic_DNA.
RefSeq; NP_001097016.2; NM_001103546.3.
RefSeq; NP_001097018.1; NM_001103548.4.
RefSeq; NP_001259678.1; NM_001272749.2.
UniGene; Dm.26256; -.
ProteinModelPortal; M9PHW9; -.
SMR; M9PHW9; -.
EnsemblMetazoa; FBtr0112879; FBpp0111792; FBgn0265784.
EnsemblMetazoa; FBtr0310341; FBpp0302024; FBgn0265784.
EnsemblMetazoa; FBtr0346093; FBpp0311927; FBgn0265784.
GeneID; 32817; -.
CTD; 32817; -.
FlyBase; FBgn0265784; CrebB.
OrthoDB; EOG091G0LR9; -.
ChiTaRS; CrebA; fly.
GenomeRNAi; 32817; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0265784; -.
ExpressionAtlas; M9PHW9; differential.
GO; GO:0005634; C:nucleus; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
InterPro; IPR004827; bZIP.
InterPro; IPR003102; Coactivator_CBP_pKID.
InterPro; IPR001630; Leuzip_CREB.
Pfam; PF00170; bZIP_1; 1.
Pfam; PF02173; pKID; 1.
PRINTS; PR00041; LEUZIPPRCREB.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
PROSITE; PS50953; KID; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000803};
Reference proteome {ECO:0000313|Proteomes:UP000000803}.
DOMAIN 166 225 KID. {ECO:0000259|PROSITE:PS50953}.
DOMAIN 222 281 BZIP. {ECO:0000259|PROSITE:PS50217}.
COILED 240 274 {ECO:0000256|SAM:Coils}.
SEQUENCE 281 AA; 29756 MW; 6D1A15E7B5D1083C CRC64;
MDNSIVEENG NSSAASGSND VVDVVAQQAA AAVGGGGGGG GGGGGGNPQQ QQQNPQSTTA
GGPTGATNNA QGGGVSSVLT TTANCNIQYP IQTLAQHGLQ VQSVIQANPS GVIQTAAGTQ
QQQQALAAAT AMQKVVYVAK PPNSTVIHTT PGNAVQIPPT FPCKIKPEPN TQHPEDSDES
LSDDDSQHHR SELTRRPSYN KIFTEISGPD MSDNSGIAED QTRKREIRLQ KNREAARECR
RKKKEYIKCL ENRVAVLENQ NKALIEELKS LKELYCQTKN D


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