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Cyclin D1

 F6YP86_ORNAN            Unreviewed;       253 AA.
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
05-DEC-2018, entry version 56.
SubName: Full=Cyclin D1 {ECO:0000313|Ensembl:ENSOANP00000011805};
Name=CCND1 {ECO:0000313|Ensembl:ENSOANP00000011805};
Ornithorhynchus anatinus (Duckbill platypus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011805, ECO:0000313|Proteomes:UP000002279};
[1] {ECO:0000313|Ensembl:ENSOANP00000011805, ECO:0000313|Proteomes:UP000002279}
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011805,
PubMed=18464734; DOI=10.1038/nature06936;
Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
Wilson R.K.;
"Genome analysis of the platypus reveals unique signatures of
Nature 453:175-183(2008).
[2] {ECO:0000313|Ensembl:ENSOANP00000011805}
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011805};
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the cyclin family.
{ECO:0000256|RuleBase:RU000383, ECO:0000256|SAAS:SAAS00861960}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AAPN01069998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPN01069999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPN01070000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPN01070001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPN01070002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPN01070003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPN01070004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9258.ENSOANP00000011805; -.
Ensembl; ENSOANT00000011807; ENSOANP00000011805; ENSOANG00000007416.
eggNOG; KOG0656; Eukaryota.
GeneTree; ENSGT00940000157816; -.
InParanoid; F6YP86; -.
OrthoDB; EOG091G0URX; -.
TreeFam; TF101004; -.
Proteomes; UP000002279; Chromosome 3.
Bgee; ENSOANG00000007416; Expressed in 7 organ(s), highest expression level in brain.
GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0017053; C:transcriptional repressor complex; IEA:Ensembl.
GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0070064; F:proline-rich region binding; IEA:Ensembl.
GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0097421; P:liver regeneration; IEA:Ensembl.
GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
GO; GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
GO; GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:Ensembl.
GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:Ensembl.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045787; P:positive regulation of cell cycle; IBA:GO_Central.
GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central.
GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0007088; P:regulation of mitotic nuclear division; IBA:GO_Central.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0044321; P:response to leptin; IEA:Ensembl.
GO; GO:0070141; P:response to UV-A; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
CDD; cd00043; CYCLIN; 1.
InterPro; IPR039361; Cyclin.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR004367; Cyclin_C-dom.
InterPro; IPR015451; Cyclin_D.
InterPro; IPR006671; Cyclin_N.
PANTHER; PTHR10177; PTHR10177; 1.
PANTHER; PTHR10177:SF67; PTHR10177:SF67; 1.
Pfam; PF02984; Cyclin_C; 1.
Pfam; PF00134; Cyclin_N; 1.
PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
SMART; SM00385; CYCLIN; 1.
SMART; SM01332; Cyclin_C; 1.
SUPFAM; SSF47954; SSF47954; 2.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002279};
Cyclin {ECO:0000256|RuleBase:RU000383, ECO:0000256|SAAS:SAAS00862020};
Reference proteome {ECO:0000313|Proteomes:UP000002279}.
DOMAIN 23 107 CYCLIN. {ECO:0000259|SMART:SM00385}.
DOMAIN 116 241 Cyclin_C. {ECO:0000259|SMART:SM01332}.
SEQUENCE 253 AA; 28712 MW; B82F9E370B90157C CRC64;

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