Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Cyclin mcs2 (Mitotic catastrophe suppressor 2)

 CGM2_SCHPO              Reviewed;         322 AA.
P36613;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
25-OCT-2017, entry version 143.
RecName: Full=Cyclin mcs2;
AltName: Full=Mitotic catastrophe suppressor 2;
Name=mcs2; ORFNames=SPBP16F5.02;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=8467814;
Molz L., Beach D.;
"Characterization of the fission yeast mcs2 cyclin and its associated
protein kinase activity.";
EMBO J. 12:1723-1732(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
INTERACTION WITH CRK1/MCS6.
STRAIN=972 / ATCC 24843;
PubMed=8557037;
Buck V., Russell P., Millar J.B.A.;
"Identification of a cdk-activating kinase in fission yeast.";
EMBO J. 14:6173-6183(1995).
[4]
INTERACTION WITH CRK1/MCS6.
PubMed=8557036;
Damagnez V., Makela T.P., Cottarel G.;
"Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.";
EMBO J. 14:6164-6172(1995).
[5]
SUBUNIT.
PubMed=14534314; DOI=10.1074/jbc.M306750200;
Spaehr H., Khorosjutina O., Baraznenok V., Linder T., Samuelsen C.O.,
Hermand D., Maekelae T.P., Holmberg S., Gustafsson C.M.;
"Mediator influences Schizosaccharomyces pombe RNA polymerase II-
dependent transcription in vitro.";
J. Biol. Chem. 278:51301-51306(2003).
[6]
INTERACTION WITH SKP1 AND CRK1/MCS6.
STRAIN=972 / ATCC 24843;
PubMed=15555586; DOI=10.1016/j.bbrc.2004.10.190;
Bamps S., Westerling T., Pihlak A., Tafforeau L., Vandenhaute J.,
Maekelae T.P., Hermand D.;
"Mcs2 and a novel CAK subunit Pmh1 associate with Skp1 in fission
yeast.";
Biochem. Biophys. Res. Commun. 325:1424-1432(2004).
[7]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND IDENTIFICATION
BY MASS SPECTROMETRY.
PubMed=18257517; DOI=10.1021/pr7006335;
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
-!- FUNCTION: Essential for progression through the cell cycle.
Posseses kinase activity that can be detected when myelin basic
protein (MBP) is provided as an exogenous substrate.
{ECO:0000269|PubMed:8467814}.
-!- SUBUNIT: One of the nine subunits forming the core-TFIIH basal
transcription factor. Interacts with crk1 and skp1.
{ECO:0000269|PubMed:14534314, ECO:0000269|PubMed:15555586,
ECO:0000269|PubMed:8557036, ECO:0000269|PubMed:8557037}.
-!- INTERACTION:
Q9Y709:skp1; NbExp=3; IntAct=EBI-1168694, EBI-1172248;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372,
ECO:0000269|PubMed:8467814}.
-!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; S59895; AAB26193.1; -; Genomic_DNA.
EMBL; CU329671; CAC08541.1; -; Genomic_DNA.
PIR; S35380; S35380.
RefSeq; NP_595776.1; NM_001021676.2.
ProteinModelPortal; P36613; -.
SMR; P36613; -.
BioGrid; 277082; 171.
IntAct; P36613; 3.
MINT; MINT-4543612; -.
STRING; 4896.SPBP16F5.02.1; -.
iPTMnet; P36613; -.
MaxQB; P36613; -.
PRIDE; P36613; -.
EnsemblFungi; SPBP16F5.02.1; SPBP16F5.02.1:pep; SPBP16F5.02.
GeneID; 2540555; -.
KEGG; spo:SPBP16F5.02; -.
EuPathDB; FungiDB:SPBP16F5.02; -.
PomBase; SPBP16F5.02; mcs2.
HOGENOM; HOG000197843; -.
InParanoid; P36613; -.
KO; K06634; -.
OMA; NYYLTIH; -.
OrthoDB; EOG092C3VA4; -.
PhylomeDB; P36613; -.
Reactome; R-SPO-113418; Formation of the Early Elongation Complex.
Reactome; R-SPO-5696395; Formation of Incision Complex in GG-NER.
Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
Reactome; R-SPO-6781823; Formation of TC-NER Pre-Incision Complex.
Reactome; R-SPO-6782135; Dual incision in TC-NER.
Reactome; R-SPO-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
Reactome; R-SPO-6796648; TP53 Regulates Transcription of DNA Repair Genes.
Reactome; R-SPO-72086; mRNA Capping.
Reactome; R-SPO-73776; RNA Polymerase II Promoter Escape.
Reactome; R-SPO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
Reactome; R-SPO-75953; RNA Polymerase II Transcription Initiation.
Reactome; R-SPO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
Reactome; R-SPO-77075; RNA Pol II CTD phosphorylation and interaction with CE.
PRO; PR:P36613; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
GO; GO:0005675; C:holo TFIIH complex; ISS:PomBase.
GO; GO:0005634; C:nucleus; IDA:PomBase.
GO; GO:0070985; C:TFIIK complex; IDA:PomBase.
GO; GO:0019914; F:cyclin-dependent protein kinase activating kinase regulator activity; IDA:PomBase.
GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IDA:PomBase.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:1901409; P:positive regulation of phosphorylation of RNA polymerase II C-terminal domain; IDA:PomBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:PomBase.
CDD; cd00043; CYCLIN; 1.
Gene3D; 1.10.472.10; -; 2.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR031658; Cyclin_C_2.
InterPro; IPR006671; Cyclin_N.
InterPro; IPR027081; CyclinH/Ccl1.
Pfam; PF16899; Cyclin_C_2; 1.
Pfam; PF00134; Cyclin_N; 1.
SMART; SM00385; CYCLIN; 1.
SUPFAM; SSF47954; SSF47954; 2.
TIGRFAMs; TIGR00569; ccl1; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Complete proteome; Cyclin; Nucleus;
Phosphoprotein; Reference proteome.
CHAIN 1 322 Cyclin mcs2.
/FTId=PRO_0000080505.
MOD_RES 310 310 Phosphoserine.
{ECO:0000269|PubMed:18257517}.
SEQUENCE 322 AA; 37674 MW; 09B8DDB46563727C CRC64;
MSADKFRDST HYRDWIFTEE DLSKTRAKVN EKFTNIVRER MLEELSLQNK EASLEVLPPT
LTVEEELELV NYYSFQLNAL SSALSLPTHI RSTAILFFKR FYLINSVMEY SPKIISFTSL
FLATKCNDHY ISIEQFCKNM PKTTPEEVLE YEFNVCQSLK WDLYVWLPFR PLQGFLLDCQ
TVLPKVAVEK FYECHDLSKK FLIETLHSDI YFLHSPSIIA LGAIYHTNPT ICLQYIEAKK
IPELQPLIIS ISANLKATKK FKIEKKKAQD YGRKLYFCMN PLRNKSSALY LKRKAEEEST
NNNKWAKKFS TSSNVLDKNP FE


Related products :

Catalog number Product name Quantity
18-003-43097 RNA exonuclease 4 - EC 3.1.-.-; Exonuclease XPMC2; hPMC2; Prevents mitotic catastrophe 2 protein homolog Polyclonal 0.05 mg Aff Pur
18-003-43366 RNA exonuclease 4 - EC 3.1.-.-; Exonuclease XPMC2; hPMC2; Prevents mitotic catastrophe 2 protein homolog Polyclonal 0.1 mg Protein A
EIAAB34334 Exonuclease XPMC2,Gm111,Mouse,Mus musculus,Pmc2,Prevents mitotic catastrophe 2 protein homolog,Rexo4,RNA exonuclease 4,Xpmc2h
EIAAB34333 Exonuclease XPMC2,Homo sapiens,hPMC2,Human,PMC2,Prevents mitotic catastrophe 2 protein homolog,REXO4,RNA exonuclease 4,XPMC2H
CCNB3_CHICK Chicken ELISA Kit FOR G2 per mitotic-specific cyclin-B3 96T
E10868r Bovine ELISA Kit FOR G2 per mitotic-specific cyclin-B1 96T
E2026Rb Chicken ELISA Kit FOR G2 per mitotic-specific cyclin-B2 96T
E1491m Bovine ELISA Kit FOR G2 per mitotic-specific cyclin-B2 96T
CCNB3_MOUSE Mouse ELISA Kit FOR G2 per mitotic-specific cyclin-B3 96T
CSB-EL004806MO Mouse G2 per mitotic-specific cyclin-B1(CCNB1) ELISA kit 96T
32-172 p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 _ Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malign 0.1 mL
CCNB1_MOUSE ELISA Kit FOR G2 per mitotic-specific cyclin-B1; organism: Mouse; gene name: Ccnb1 96T
CCNB3_MOUSE ELISA Kit FOR G2 per mitotic-specific cyclin-B3; organism: Mouse; gene name: Ccnb3 96T
CCNB2_MOUSE ELISA Kit FOR G2 per mitotic-specific cyclin-B2; organism: Mouse; gene name: Ccnb2 96T
BMDV10001 p15INK4b (Cyclin Dependent Kinase Inhibitor), Mitotic Inhibitor_Suppressor Protein (MTS2), 15kD, Rabbit anti_Human, NO X w_Mouse or Rat; IF_IP 0.5 ml.
15-288-21185 Cyclin-dependent kinase inhibitor 2A. isoforms 1_2_3 - Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4; p16-INK4a; Multiple tumor suppressor 1; MTS1 Polyclonal 0.1 mg
15-288-21185 Cyclin-dependent kinase inhibitor 2A. isoforms 1_2_3 - Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4; p16-INK4a; Multiple tumor suppressor 1; MTS1 Polyclonal 0.05 mg
E0794h ELISA kit CDK4I,CDKN2,CDKN2A,Cyclin-dependent kinase 4 inhibitor A,Cyclin-dependent kinase inhibitor 2A, isoforms 1_2_3,Homo sapiens,Human,MTS1,MTS-1,Multiple tumor suppressor 1,p16-INK4,p16INK4A,p16 96T
U0794h CLIA CDK4I,CDKN2,CDKN2A,Cyclin-dependent kinase 4 inhibitor A,Cyclin-dependent kinase inhibitor 2A, isoforms 1_2_3,Homo sapiens,Human,MTS1,MTS-1,Multiple tumor suppressor 1,p16-INK4,p16INK4A,p16-INK4a 96T
ABP-BM-sIRESMC pORB-MCS1-sIRES-MCS2 5 ug
E0794h ELISA CDK4I,CDKN2,CDKN2A,Cyclin-dependent kinase 4 inhibitor A,Cyclin-dependent kinase inhibitor 2A, isoforms 1_2_3,Homo sapiens,Human,MTS1,MTS-1,Multiple tumor suppressor 1,p16-INK4,p16INK4A,p16-INK4 96T
MN100B-1 Minicircle Technology pMC.BESPX-MCS2 (empty vector) 10 ug
ABP-PVL-BICISIRES Bicistronic Expression pCHAC-MCS1-IRES-MCS2 5 ug
CD501A-1 Lentiviral Technology pCDH-CMV-MCS2 cDNA Cloning and Expression Vector 10 ug
CD110B-1 Lentiviral Technology pCDF1-MCS2-EF1-Puro cDNA Cloning and Expression Lentivector 10 ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur