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Cyclin-dependent kinase inhibitor 1 (Inhibitor/interactor of CDK protein 1) (KIP-related protein 1)

 KRP1_ARATH              Reviewed;         191 AA.
Q67Y93; O04154; O82809; Q8LDX1;
10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
10-JUL-2007, sequence version 2.
27-SEP-2017, entry version 71.
RecName: Full=Cyclin-dependent kinase inhibitor 1;
AltName: Full=Inhibitor/interactor of CDK protein 1;
AltName: Full=KIP-related protein 1;
Name=KRP1; Synonyms=ICK1; OrderedLocusNames=At2g23430;
ORFNames=F26B6.8;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH CDKA-1.
STRAIN=cv. Columbia;
PubMed=9087400; DOI=10.1038/386451a0;
Wang H., Fowke L.C., Crosby W.L.;
"A plant cyclin-dependent kinase inhibitor gene.";
Nature 386:451-452(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY,
INDUCTION, AND INTERACTION WITH CDKA-1 AND CYCD3-1.
STRAIN=cv. Columbia;
PubMed=9753775; DOI=10.1046/j.1365-313X.1998.00231.x;
Wang H., Qi Q., Schorr P., Cutler A.J., Crosby W.L., Fowke L.C.;
"ICK1, a cyclin-dependent protein kinase inhibitor from Arabidopsis
thaliana interacts with both Cdc2a and CycD3, and its expression is
induced by abscisic acid.";
Plant J. 15:501-510(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
Hayashizaki Y., Shinozaki K.;
"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
"Arabidopsis ORF clones.";
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[8]
FUNCTION.
PubMed=11123800; DOI=10.1046/j.1365-313x.2000.00899.x;
Wang H., Zhou Y., Gilmer S., Whitwill S., Fowke L.C.;
"Expression of the plant cyclin-dependent kinase inhibitor ICK1
affects cell division, plant growth and morphology.";
Plant J. 24:613-623(2000).
[9]
INTERACTION WITH CDKA-1.
PubMed=11449057; DOI=10.1105/tpc.13.7.1653;
de Veylder L., Beeckman T., Beemster G.T.S., Krols L., Terras F.,
Landrieu I., van der Schueren E., Maes S., Naudts M., Inze D.;
"Functional analysis of cyclin-dependent kinase inhibitors of
Arabidopsis.";
Plant Cell 13:1653-1667(2001).
[10]
FUNCTION.
PubMed=12029474; DOI=10.1007/s00425-002-0752-2;
Zhou Y., Wang H., Gilmer S., Whitwill S., Keller W., Fowke L.C.;
"Control of petal and pollen development by the plant cyclin-dependent
kinase inhibitor ICK1 in transgenic Brassica plants.";
Planta 215:248-257(2002).
[11]
DEVELOPMENTAL STAGE.
PubMed=12000456; DOI=10.1046/j.1365-313X.2002.01274.x;
Menges M., Murray J.A.H.;
"Synchronous Arabidopsis suspension cultures for analysis of cell-
cycle gene activity.";
Plant J. 30:203-212(2002).
[12]
GENE FAMILY, AND NOMENCLATURE.
PubMed=11971144; DOI=10.1105/tpc.010445;
Vandepoele K., Raes J., de Veylder L., Rouze P., Rombauts S., Inze D.;
"Genome-wide analysis of core cell cycle genes in Arabidopsis.";
Plant Cell 14:903-916(2002).
[13]
DEVELOPMENTAL STAGE.
PubMed=12368490; DOI=10.1105/tpc.004960;
Himanen K., Boucheron E., Vanneste S., de Almeida Engler J., Inze D.,
Beeckman T.;
"Auxin-mediated cell cycle activation during early lateral root
initiation.";
Plant Cell 14:2339-2351(2002).
[14]
INTERACTION WITH CYCD2-1.
PubMed=12569402; DOI=10.1007/s00425-002-0935-x;
Zhou Y., Wang H., Gilmer S., Whitwill S., Fowke L.C.;
"Effects of co-expressing the plant CDK inhibitor ICK1 and D-type
cyclin genes on plant growth, cell size and ploidy in Arabidopsis
thaliana.";
Planta 216:604-613(2003).
[15]
FUNCTION, AND INTERACTION WITH CDKA-1 AND CYCD3-1.
PubMed=12566574; DOI=10.1105/tpc.008342;
Schnittger A., Weinl C., Bouyer D., Schoebinger U., Huelskamp M.;
"Misexpression of the cyclin-dependent kinase inhibitor ICK1/KRP1 in
single-celled Arabidopsis trichomes reduces endoreduplication and cell
size and induces cell death.";
Plant Cell 15:303-315(2003).
[16]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12904210; DOI=10.1046/j.1365-313X.2003.01821.x;
Zhou Y., Li G., Brandizzi F., Fowke L.C., Wang H.;
"The plant cyclin-dependent kinase inhibitor ICK1 has distinct
functional domains for in vivo kinase inhibition, protein instability
and nuclear localization.";
Plant J. 35:476-489(2003).
[17]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15749764; DOI=10.1105/tpc.104.030486;
Weinl C., Marquardt S., Kuijt S.J.H., Nowack M.K., Jakoby M.J.,
Huelskamp M., Schnittger A.;
"Novel functions of plant cyclin-dependent kinase inhibitors,
ICK1/KRP1, can act non-cell-autonomously and inhibit entry into
mitosis.";
Plant Cell 17:1704-1722(2005).
[18]
FUNCTION.
PubMed=16376885; DOI=10.1016/j.febslet.2005.12.018;
Nakai T., Kato K., Shinmyo A., Sekine M.;
"Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-
associated kinases, including plant-specific B-type cyclin-dependent
kinase.";
FEBS Lett. 580:336-340(2006).
[19]
SUBCELLULAR LOCATION, INTERACTION WITH CDKA-1, AND MUTAGENESIS OF
LYS-84 AND LYS-86.
PubMed=16845478; DOI=10.1007/s11103-006-9019-9;
Zhou Y., Niu H., Brandizzi F., Fowke L.C., Wang H.;
"Molecular control of nuclear and subnuclear targeting of the plant
CDK inhibitor ICK1 and ICK1-mediated nuclear transport of CDKA.";
Plant Mol. Biol. 62:261-278(2006).
[20]
FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF ARG-80; ARG-81;
LYS-84 AND LYS-86.
PubMed=16766674; DOI=10.1104/pp.106.081406;
Jakoby M.J., Weinl C., Pusch S., Kuijt S.J.H., Merkle T.,
Dissmeyer N., Schnittger A.;
"Analysis of the subcellular localization, function, and proteolytic
control of the Arabidopsis cyclin-dependent kinase inhibitor
ICK1/KRP1.";
Plant Physiol. 141:1293-1305(2006).
[21]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=17253089; DOI=10.1007/s00299-006-0294-3;
Bird D.A., Buruiana M.M., Zhou Y., Fowke L.C., Wang H.;
"Arabidopsis cyclin-dependent kinase inhibitors are nuclear-localized
and show different localization patterns within the nucleoplasm.";
Plant Cell Rep. 26:861-872(2007).
[22]
TISSUE SPECIFICITY, INTERACTION WITH CDKA-1 AND CYCD2-1,
UBIQUITINATION, AND DISRUPTION PHENOTYPE.
PubMed=18005227; DOI=10.1111/j.1365-313X.2007.03370.x;
Ren H., Santner A., del Pozo J.C., Murray J.A., Estelle M.;
"Degradation of the cyclin-dependent kinase inhibitor KRP1 is
regulated by two different ubiquitin E3 ligases.";
Plant J. 53:705-716(2008).
-!- FUNCTION: Binds and inhibits CYCD2-1/CDKA-1 kinase complex
activity. Regulates cell division which is crucial for plant
growth, development and morphogenesis. Functions in turning cells
from a mitotic to an endoreplicating cell cycle mode. Acts
cell- and non-cell-autonomously to regulate endoreduplication by
allowing S phase progression, but blocking entry into mitosis.
Keeps on the one hand the plant cell cycle locally controlled, and
on the other hand provides a possibility of linking cell cycle
control in single cells with the supracellular organization of a
tissue or an organ. May target specifically CDKA-1.
{ECO:0000269|PubMed:11123800, ECO:0000269|PubMed:12029474,
ECO:0000269|PubMed:12566574, ECO:0000269|PubMed:12904210,
ECO:0000269|PubMed:15749764, ECO:0000269|PubMed:16376885,
ECO:0000269|PubMed:16766674, ECO:0000269|PubMed:17253089,
ECO:0000269|PubMed:9087400, ECO:0000269|PubMed:9753775}.
-!- SUBUNIT: Specifically interacts with CDKA-1, but not with CDKB1-1.
Interacts with CYCD2-1 and CYCD3-1. {ECO:0000269|PubMed:11449057,
ECO:0000269|PubMed:12566574, ECO:0000269|PubMed:12569402,
ECO:0000269|PubMed:16845478, ECO:0000269|PubMed:18005227,
ECO:0000269|PubMed:9087400, ECO:0000269|PubMed:9753775}.
-!- INTERACTION:
P24100:CDKA-1; NbExp=10; IntAct=EBI-1636730, EBI-371713;
-!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
{ECO:0000269|PubMed:12904210, ECO:0000269|PubMed:15749764,
ECO:0000269|PubMed:16766674, ECO:0000269|PubMed:16845478,
ECO:0000269|PubMed:17253089}. Note=Distributed in a ponctuate
pattern and in heterochromatic chromocenters.
-!- TISSUE SPECIFICITY: Expressed at low levels in roots, stems,
leaves and flowers. {ECO:0000269|PubMed:18005227,
ECO:0000269|PubMed:9753775}.
-!- DEVELOPMENTAL STAGE: Highly expressed in root pericycle and cell
suspension culture during cell cycle arrest. Expressed early in
the G1 phase, disappears quickly and starts to increase again to
reach a peak before mitosis. {ECO:0000269|PubMed:12000456,
ECO:0000269|PubMed:12368490}.
-!- INDUCTION: By abscisic acid (ABA). {ECO:0000269|PubMed:9753775}.
-!- PTM: Ubiquitinated independently by RKP and SCF (SKP1-CUL1-
FBL5/SKP2B) protein ligase complex, leading to proteasomal
degradation. {ECO:0000269|PubMed:18005227}.
-!- DISRUPTION PHENOTYPE: No visible phenotype.
{ECO:0000269|PubMed:18005227}.
-!- MISCELLANEOUS: Plants overexpressing ICK1/KRP1 show altered
morphology (including flowers) with a reduction in plant size,
cell numbers, pollen germination, seed production and CDK kinase
activity. Trichome cells misexpressing ICK1/KRP1 show reduced
endoreduplication and cell size, and undergo cell death. ICK1/KRP1
degradation is regulated by the AXR1-dependent RUB conjugation
pathway that is required for the function of the SCF complexes.
-!- SIMILARITY: Belongs to the CDI family. ICK/KRP subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAD43255.1; Type=Frameshift; Positions=157; Evidence={ECO:0000305};
Sequence=BAD44338.1; Type=Frameshift; Positions=157; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U94772; AAC49698.1; -; mRNA.
EMBL; AF079587; AAC34660.1; -; Genomic_DNA.
EMBL; AC003040; AAC23758.1; -; Genomic_DNA.
EMBL; CP002685; AEC07454.1; -; Genomic_DNA.
EMBL; AK175492; BAD43255.1; ALT_FRAME; mRNA.
EMBL; AK176575; BAD44338.1; ALT_FRAME; mRNA.
EMBL; BT028986; ABI93895.1; -; mRNA.
EMBL; AY085749; AAM62967.1; -; mRNA.
PIR; T01132; T01132.
RefSeq; NP_179924.1; NM_127907.4.
UniGene; At.24577; -.
ProteinModelPortal; Q67Y93; -.
SMR; Q67Y93; -.
BioGrid; 2227; 27.
IntAct; Q67Y93; 6.
STRING; 3702.AT2G23430.1; -.
PaxDb; Q67Y93; -.
EnsemblPlants; AT2G23430.1; AT2G23430.1; AT2G23430.
GeneID; 816875; -.
Gramene; AT2G23430.1; AT2G23430.1; AT2G23430.
KEGG; ath:AT2G23430; -.
Araport; AT2G23430; -.
TAIR; locus:2046778; AT2G23430.
eggNOG; ENOG410J46P; Eukaryota.
eggNOG; ENOG410Y3ZZ; LUCA.
HOGENOM; HOG000113262; -.
InParanoid; Q67Y93; -.
OMA; TYMQLRS; -.
PRO; PR:Q67Y93; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; Q67Y93; baseline and differential.
Genevisible; Q67Y93; AT.
GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IDA:TAIR.
GO; GO:0007050; P:cell cycle arrest; IEA:InterPro.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:TAIR.
GO; GO:0048527; P:lateral root development; IMP:TAIR.
GO; GO:0010311; P:lateral root formation; IMP:TAIR.
GO; GO:0048366; P:leaf development; IMP:TAIR.
GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:TAIR.
GO; GO:0045740; P:positive regulation of DNA replication; IMP:TAIR.
GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
GO; GO:0048367; P:shoot system development; IMP:TAIR.
InterPro; IPR003175; CDI.
PANTHER; PTHR10265; PTHR10265; 1.
Pfam; PF02234; CDI; 1.
PIRSF; PIRSF017811; CDK_inhib_pln; 1.
1: Evidence at protein level;
Cell cycle; Complete proteome; Nucleus; Protein kinase inhibitor;
Reference proteome; Ubl conjugation.
CHAIN 1 191 Cyclin-dependent kinase inhibitor 1.
/FTId=PRO_0000294087.
REGION 162 191 Required for inhibitory function and
interaction with CDK kinase complexes.
MUTAGEN 80 80 R->A: Slightly affects transport to
nucleus; when associated with A-81.
{ECO:0000269|PubMed:16766674}.
MUTAGEN 81 81 R->A: Slightly affects transport to
nucleus; when associated with A-80.
{ECO:0000269|PubMed:16766674}.
MUTAGEN 84 84 K->A: Affects transport to nucleus, but
does not abolish it; when associated with
A-86. {ECO:0000269|PubMed:16766674,
ECO:0000269|PubMed:16845478}.
MUTAGEN 86 86 K->A: Affects transport to nucleus, but
does not abolish it; when associated with
A-84. {ECO:0000269|PubMed:16766674,
ECO:0000269|PubMed:16845478}.
CONFLICT 88 88 F -> C (in Ref. 1; AAC49698).
{ECO:0000305}.
CONFLICT 191 191 E -> Q (in Ref. 7; AAM62967).
{ECO:0000305}.
SEQUENCE 191 AA; 22283 MW; 0477A91E277C46B2 CRC64;
MVRKYRKAKG IVEAGVSSTY MQLRSRRIVY VRSEKSSSVS VVGDNGVSSS CSGSNEYKKK
ELIHLEEEDK DGDTETSTYR RGTKRKLFEN LREEEKEELS KSMENYSSEF ESAVKESLDC
CCSGRKTMEE TVTAEEEEKA KLMTEMPTES EIEDFFVEAE KQLKEKFKKK YNFDFEKEKP
LEGRYEWVKL E


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