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Cyclosporine synthetase

 Q09164_TOLIN            Unreviewed;     15281 AA.
Q09164;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
20-DEC-2017, entry version 96.
SubName: Full=Cyclosporine synthetase {ECO:0000313|EMBL:CAA82227.1};
Name=simA {ECO:0000313|EMBL:CAA82227.1};
Tolypocladium inflatum (Cyclosporin fungus) (Tolypocladium niveum).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae;
Tolypocladium.
NCBI_TaxID=29910 {ECO:0000313|EMBL:CAA82227.1};
[1] {ECO:0000313|EMBL:CAA82227.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ATCC34921 {ECO:0000313|EMBL:CAA82227.1};
PubMed=8001164; DOI=10.1007/BF00313798;
Weber G., Schorgendorfer K., Schneider-Scherzer E., Leitner E.;
"The peptide synthetase catalyzing cyclosporine production in
Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading
frame.";
Curr. Genet. 26:120-125(1994).
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EMBL; Z28383; CAA82227.1; -; Genomic_DNA.
PIR; S45487; S41309.
ProteinModelPortal; Q09164; -.
MINT; MINT-1203757; -.
GO; GO:0003824; F:catalytic activity; IEA:InterPro.
GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
GO; GO:0008152; P:metabolic process; IEA:InterPro.
Gene3D; 1.10.1200.10; -; 11.
InterPro; IPR010071; AA_adenyl_domain.
InterPro; IPR036736; ACP-like_sf.
InterPro; IPR025110; AMP-bd_C.
InterPro; IPR020845; AMP-binding_CS.
InterPro; IPR000873; AMP-dep_Synth/Lig.
InterPro; IPR001242; Condensatn.
InterPro; IPR020806; PKS_PP-bd.
InterPro; IPR009081; PP-bd_ACP.
InterPro; IPR006162; Ppantetheine_attach_site.
InterPro; IPR029063; SAM-dependent_MTases.
Pfam; PF00501; AMP-binding; 11.
Pfam; PF13193; AMP-binding_C; 4.
Pfam; PF00668; Condensation; 12.
Pfam; PF00550; PP-binding; 11.
SMART; SM00823; PKS_PP; 11.
SUPFAM; SSF47336; SSF47336; 11.
SUPFAM; SSF53335; SSF53335; 7.
TIGRFAMs; TIGR01733; AA-adenyl-dom; 11.
PROSITE; PS00455; AMP_BINDING; 10.
PROSITE; PS50075; CARRIER; 11.
PROSITE; PS00012; PHOSPHOPANTETHEINE; 9.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils}.
DOMAIN 1026 1100 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 2524 2598 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 4011 4085 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 5503 5577 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 7000 7074 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 8060 8134 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 9555 9629 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 11052 11126 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 12124 12198 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 13620 13694 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 14695 14769 Carrier. {ECO:0000259|PROSITE:PS50075}.
COILED 2228 2252 {ECO:0000256|SAM:Coils}.
COILED 5216 5236 {ECO:0000256|SAM:Coils}.
COILED 9264 9288 {ECO:0000256|SAM:Coils}.
COILED 9680 9700 {ECO:0000256|SAM:Coils}.
COILED 10758 10778 {ECO:0000256|SAM:Coils}.
COILED 11177 11197 {ECO:0000256|SAM:Coils}.
COILED 12249 12269 {ECO:0000256|SAM:Coils}.
COILED 13745 13765 {ECO:0000256|SAM:Coils}.
COILED 14892 14912 {ECO:0000256|SAM:Coils}.
MOD_RES 1060 1060 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 2558 2558 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 4045 4045 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 5537 5537 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 7034 7034 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 8094 8094 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 9589 9589 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 11086 11086 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 12158 12158 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 13654 13654 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
MOD_RES 14729 14729 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
SEQUENCE 15281 AA; 1689067 MW; E26DA7AA35324C05 CRC64;
MGAIGQDMAY DRLANPSRAS SISSNRYSEP VEQSFAQGRL WFLHQLKLGA SWDITPAAIR
LRGHLDIDAL NAASRALTQR HETLRTTFKE QDGVGVQVVH ASGLERGLRI VDASSRDLAQ
LLAEEQTMKF DLESEPAWRV ALLKVAEDHH ILSIVVHHII SDSRSLDIIQ QELGELYTAA
SQGKSISACP LGPIPIQYRD LTTWQNQDEQ VAEQERQLGY WIEQLDNNTP AELLTELPRP
AIPSGETGKI SFQIDGSVHK ELLAFCRSQQ VTAYAVLLAA FRVAHFRLTG AEDATIGAPV
ANRDRPELEN MVAPLATLQC MRVVLDEDDT FESVLRQIMS VMTEAHANRD VPFERIVSAL
LPGSTDTSRH PLVQLMFALH PAQDTGRARW GFLEAETLQS AAPTRFDMEM HLFEGDDRFD
ANVLFSTGLF DAEAIRSVVS IFREVLRRGI SEPAVHVKTM PLTDGLAAIR DMGLLDIGTT
DYPREASVVD MFQEQVALNP SATAVADASS RLSYSELDHK SDQLAAWLRR RQLKPETLIG
VLSPPSCETM VSFLGILKAH LAYLPLDINV PLARIESILS AVDGHKLVLL GSNVPQPKVD
VPDVELLRIS DALNGSQVNG LAGKQATAKP SATDLAYVIF TSGSTGKPKG VMIEHRGIVR
LVKGTNIISP AQAAVPTAHL ANIAFDLSTW EIYTPILNGG TLVCIEHSVT LDSKALEAVF
TKEGIRVAFL APALIKQCLA DRPAIFAGLD SLYAIGDRFD RRDALHAKSL VKHGVYNAYG
PTENSVVSTI YSVSEASPFV TGVPVGRAIS NSGAYVMDQD QQLVSPGVMG ELVVSGDGLA
RGYTDSALDK NRFVVVQIDG ESIRGYRTGD RARYSLKGGQ IEFFGRMDQQ VKIRGHRIEP
AEVEHALLNS DQVRDAAVVI RRQEEEEPAM IAFVTTQGTL PDHLVNINGN GHVPDGNGSK
NDQFAVHVES ELRRRLQMLL PSYMMPARIV VLDHLPLNPN GKVDRKALGQ SAKTVQKSKL
VSQRVAPRNE IEAVLCEEYR SVLGVEVGIT DNFFDLGGHS LTAMKLAARI SQRLDIQASV
ATVFEQPMLA DLAATIQRGS TLYSVIPTTE YTGPVEQSFA QGRLWFLEQL NTGASWYNVM
LTVRLRGHLD VDALGTALLA LEKRHETLRT TFEERDGVGM QVVHSSLMGE LRLIDISEKS
GTAAHEALMK EQSTRFDLTR EPGWRVALLK LADHHIFSIV MHHIVSDGWS LDLLRHELGQ
LYSAALRGQD PLSRLEPLPI QYRDFAVWQK QDSQQKAAHQ RQLEYWTKQL ADSTPAELLT
DFPRPSILSG KAGKVPVAIE GSLYDTLQVF SRTHQVTSFA VLLAAFRAAH FRLTGSDNAT
IGVPSANRNR PELENVIGFF VNTQCIRITI DENDNFESLV RQVRSTTTAA QDNQDVPFEQ
VVSSLMPSSS RDASRNPLVQ LMFALHGQQD LFKIQLEGTE EEVIPTEEVT RFDIEFHLYQ
GASKLSGDII FAADLFEAET IRGVVSVFQE VLRRGLQQPQ TPIMTMPLTD GIPELERMGL
LHMVKTDYPR NMSVVDVFQQ QVRLSAEATA VIDSSSRMSY AELDQRSDQV AAWLRQRQLP
AETFVAVLAP RSCEAVIALF GILKAGHAYL PLDVNVPAAR LRAILAEVKG EKLVLLGAGE
PSPEGQSPEV SIVRIADATS PAGHASLRDG KSKPTAGSLA YVIFTSGSTG KPKGVMIEHR
GVLRLVKQTN ILSSLPPAQT FRMAHMSNLA FDASIWEVFT ALLNGGSLVC IDRFTILDAQ
ALEALFLREH INIALFPPAL LKQCLTDAAA TIKSLDLLYV GGDRLDTADA ALAKALVKSE
VYNAYGPTEN TVMSTLYSIA DTERFVNGVP IGRAVSNSGV YVMDQNQQLV PLGVMGELVV
TGDGLARGYT NPALDSDRFV DVIARGQLLR AYRTGDRARY RPKDGQVEFF GRMDHQVKVR
GHRIELAEVE HALLSSAGVH DAVVVSNSQE DNQGVEMVAF ITAQDNETLQ EAQSSNQVQE
WESHFETTAY ADITAIDQNT LGRDFTSWTS MYDGTLIDKR EMQEWLDDTM RTFLDGQAAG
HVLEIGTGTG MVLFNLGQAG LKSYIGLEPS QSAVQFVNKA AQTFPGLEGK AQVHVGTAMD
TGRLSALSPD LIVINSVAQY FPSREYLAEV VEALVRIPGV RRIFFGDMRT YATHKDFLVA
RAVHTNGSKV TRSKVQQEVA RLEELEEELL VDPAFFTSLK ESLSEEIEHV EILPKNMKVN
NELSSYRYGA VLHIRNHNQN QSRSIHKINA ESWIDFASSQ MDRQGLARLL KENKDAESIA
VFNIPYSKTI VERHIAKSLA DDHDGDDTHS SIDGVAWISA AREKASQCPS LDVHDLVQLA
EDAGFRVEVS WARQRSQNGA LDVFFHHFQP TENESRALVD FPTDYKGQQA RSLTNRPLQR
VESRRIEAQV REQLQVLLPA YMIPARIVVL QNMPLNTSGK VDRKELTLRA KVTAARTPSS
ELVAPRDSIE AIICKEFKDV LGVEVGITDN FFNVGGHSLL ATKLAARLSR QLNAQIAVKD
IFDRPVIADL AATIQQDTTE HNPILPTSYT GPVEQSFAQG RLWFLDQLNV GATWYLMPFA
VRLRGPLVVS ALAAALLALE ERHETLRTTF IEQEGIGMQV IHPFAPKELR VIDVSGEEES
TIQKILEKEQ TTPFNLASEP GFRLALLKTG EDEHILSTVM HHAISDGWSV DIFQQEIGQF
YSAILRGHDP LAQIAPLSIQ YRDFATWQRQ IFQVAEHRRQ LAYWTKQLAD NKPAELLTDF
KRPPMLSGRA GEIPVVVDGL IYEKLQDFCR IRQVTAFTVL LAAFRAAHYR MTGTEDATIG
TPIANRNRPE LEGLIGFFVN TQCMRITVDV EDSFETLVHQ VRETTLAAHA NQDVPFEQIV
SNILPGSSDT SRNPLVQLMF ALHSQQNLGK VRLEGIEEEI ISIAETTRFD IEFHLYQEAE
RLNGSIVYAA DLFVPETIQS VITIFQGILQ KGLGEPDMPV ASMALDGGLE SLRSTGLLHP
QQTDYPCDAS VVQIFKQQVA VNPDVIAVRD ESTRLSYADL DRKSDQVACW LSRRGIAPET
FVAILAPRSC ETIVAILGVL KANLAYLPLD VNVPASRLEA ILSEVSGSML VLVGAETPIP
EGMAEAETIR ITEILADAKT DDINGLAASQ PTAASLAYVI FTSGSTGRPK GVMVEHRGIV
RLTKQTNITS KLPESFHMAH ISNLAFDASV WEVFTTLLNG GTLVCIDYFT LLESTALEKV
FFDQRVNVAL LPPALLKQCL DNSPALVKTL SVLYIGGDRL DASDAAKARG LVQTQAFNAY
GPTENTVMST IYPIAEDPFI NGVPIGHAVS NSGAFVMDQN QQITPPGAMG ELIVTGDGLA
RGYTTSSLNT GRFINVDIDG EQVRAYRTGD RVRYRPKDLQ IEFFGRIDHQ VKIRGHRIEP
AEVEYALLSH DLVTDAAVVT HSQENQDLEM VGFVAARVAD VREDESSNQV QEWQTHFDSI
AYADITTIDQ QSLGRDFMSW TSMYDGSLIK KSQMQEWLDD TMRSLLDSQP PGHVLEVGTG
TGMVLFNLGR EGGLQSYVGL EPSPSATAFV NKAAKSFPGL EDRIRVEVGT ATDIDRLGDD
LHAGLVVVNS VAQYFPSQDY LAQLVRDLTK VPGVERIFFG DMRSHAINRD FLVARAVHAL
GDKATKAEIQ REVVRMEESE DELLVDPAFF TSLTTQVENI KHVEILPKRM RATNELSSYR
YAAVLHVNDL AKPAHKVSPG AWVDFAATKM DRDALIRLLR GTKISDHIAI ANIPNSKTIV
ERTICESVYD LGGDAKDSND RVSWLSAARS NAVKVASLSA IDLVDIAQEA GFRVEISCAR
QWSQNGALDA VFHHLGPSPQ SSHVLIDFLT DHQGRPEEAL TNHPLHRAQS RRVERQIRER
LQTLLPAYMI PAQIMVLDKL PLNANGKVDR KQLTQRAQTV PKAKQVSAPV APRTEIERVL
CQEFSDVLGV DIGIMENFFD LGGHSLMATK LAARISRRLE THVSVKEIFD HPRVCDLVLI
VQQGSAPHDP IVSTKYTGPV PQSFAQGRLW FLDQLNFGAT WYLMPLAVRL RGAMNVHALT
AALLALERRH ELLRTTFYEQ NGVGMQKVNP VVTETLRIID LSNGDGDYLP TLKKEQTAPF
HLETEPGWRV ALLRLGPGDY ILSVVMHHII SDGWSVDVLF QELGQFYSTA VKGHDPLSQT
TPLPIHYRDF ALWQKKPTQE SEHERQLQYW VEQLVDSAPA ELLTDLPRPS ILSGQAGEMS
VTIEGALYKN LEEFCRVHRV TSFVVLLAAL RAAHYRLTGS EDATIGTPIA NRNRPELEQI
IGFFVNTQCI RITVNEDETF ESLVQQVRST ATAAFAHQDV PFEKIVSTLL PGSRDASRNP
LVQLMFAVHS QKNLGELKLE NAHSEVVPTE ITTRFDLEFH LFQQDDKLEG SILYSTDLFE
AVSVQSLLSV FQEILRRGLN GPDVPISTLP LQDGIVDLQR QGLLDVQKTE YPRDSSVVDV
FHEQVSINPD SIALIHGSEK LSYAQLDRES DRVARWLRHR SFSSDTLIAV LAPRSCETII
AFLGILKANL AYLPLDVKAP AARIDAIVSS LPGNKLILLG ANVTPPKLQE AAIDFVPIRD
TFTTLTDGTL QDGPTIERPS AQSLAYAMFT SGSTGRPKGV MVQHRNIVRL VKNSNVVAKQ
PAAARIAHIS NLAFDASSWE IYAPLLNGGA IVCADYFTTI DPQALQETFQ EHEIRGAMLP
PSLLKQCLVQ APDMISRLDI LFAAGDRFSS VDALQAQRLV GSGVFNAYGP TENTILSTIY
NVAENDSFVN GVPIGSAVSN SGAYIMDKNQ QLVPAGVMGE LVVTGDGLAR GYMDPKLDAD
RFIQLTVNGS EQVRAYRTGD RVRYRPKDFQ IEFFGRMDQQ IKIRGHRIEP AEVEQAFLND
GFVEDVAIVI RTPENQEPEM VAFVTAKGDN SAREEEATTQ IEGWEAHFEG GAYANIEEIE
SEALGYDFMG WTSMYDGTEI DKDEMREWLN DTMRSLLDGK PAGRVLEVGT GTGMIMFNLG
RSQGLERYIG LEPAPSAAEF VNNAAKSFPG LAGRAEVHVG TAADVGTLQG LTSDMAVINS
VAQYFPTPEY LAETIKSLVQ VPGMKRIYLG DMRSWAMNRD FAAARAAYSL ADNASKDRVR
QKMMELEEKE EELLVDPAFF TALASQLQDR IQHVEILPKR MKATNELSSY RYAAVLHISD
EPLPIYKIDP EAWINFEGSR LTREALAQVL KENENAESVA ISNIPYSKTV VERHIVRSLD
QEDANAPEES MDGSDWISAV RTRAQQCHTL SASDLFDIAE DAGFRVEVSW ARQHSQHGAL
DAVFHHLKPA TEDSRVLIKF PTDHQGRPLK SLTNQPLLPA QSRRAELLIR EGLQTLLPPY
MIPSQITLID RMPLNANGKV DRRELARRAK ITQKSKPVED IVPPRNSVEA TVCKGFTDVL
GVEVGITDNF FNLGGHSLMA TKLAARLGRQ LNTRISVRDV FDQPVVADLA AVIQRNSAPH
EPIKPADYTG PVPQSFAQGR LWFLDQLNVG ATWYLMPLGI RLHGSLRVDA LATAISALEQ
RHEPLRTTFH EEDGVGVQVV QDHRPKDLRI IDLSTQPKDA YLAVLKHEQT TLFDLATEPG
WRVALIRLGE EEHILSIVMH HIISDGWSVE VLFDEMHRFY SSALRQQDPM EQILPLPIQY
RDFAAWQKTE EQVAEHQRQL DYWTEHLADS TPAELLTDLP RPSILSGRAN ELPLTIEGRL
HDKLRAFCRV HQATPFVILL AALRAAHYRL TGAEDATLGT PIANRNRPEL ENMIGFFVNT
QCMRIAIEEN DNFESLVRRV RSTATSAFAN QDVPFESIVS SLLPGSRDAS RNPLVQVILA
VHSQQDLGKL TLEGLRDEAV DSAISTRFDV EFHLFEHADR LSGSVLYAKE LFKLRTIESV
VSVFLETLRR ALDQPLTPLA VLPLTDGVGE IASKGLLDVP RTDYPRDANI VEVFQQHVRA
TPDAIAVKDA TSILTYAQLD QQSDRLAIWL SRRHMMPETL VGVLAPRSCE TIIAMFGIMK
ANLAYLPLDI NSPAARLRSI LSAVDGNKLV LLGSGVTAPE QENPEVEAVG IQEILAGTGL
DKTQGSNARP SATSLAYVIF TSGSTGKPKG VMVEHRSVTR LAKPSNVISK LPQGARVAHL
ANIAFDASIW EIATTLLNGA TLVCLDYHTV LDCRTLKEVF ERESITVVTL MPALLKQCVA
EIPETLAHLD LLYTGGDRVG GHDAMRARSL VKIGMFSGYG PTENTVISTI YEVDADEMFV
NGVPIGKTVS NSGAYVMDRN QQLVPSGVVG ELVVTGDGLA RGYTDPSLNK NRFIYITVNG
ESIRAYRTGD RVRYRPHDLQ IEFFGRMDQQ VKIRGHRIEP GEVESALLSH NSVQDAAVVI
CAPADQDSGA EMVAFVAARN TEDEDTQEEE AVDQVQGWET HFETAAYSEV KDIRQSEVGN
DFMGWTSMYD GSEIDKTDMH EWLNDTMRMI LDAREPGHVL EIGTGTGMVM FNLAKCPGLQ
GYVGFEPSKS AAQFVNDAAQ SFPALKDGRS IVHVGTATDI NKAGPIQPRL VVINSVAQYF
PTPEYLFRVV EALVQIPSVE RIVFGDMRTN AINRDFVASR ALHTLGEKAN KRLVRQMIYE
LEANEEELLT DPAFFTSLRT RLGEKIKHVE ILPKTMKATN ELSKYRYAAV LHVRGSREQS
TIHQVSPNAW IDFAADGLDR QTLINLLKEH KDAGTVAIGN IPYSKTIVER FVNKSLSEDD
MEEGQNSLDG SAWVAAVRMA AQSCPSLDAM DVKEIAQEAG YQVEVSWARQ WSQNGALDAI
FHHFEPPKEG ARTLIEFPTD YEGRNVNTLT NRPLNSIQSR RLGTQIREKL QTLLPPYMIP
SRIMVLDQMP VNNNGKIDRK ELVRRAIVAP KPRSAATRVA PRNEIEAILR DEFEDVLGTE
VSVLDNFFDL GGHSLMATKL AARVSRRLDA HISIKDVFDQ PVLADLAASI QRESAPHEPI
PQRPYTGPAE QSFAQGRLWF LDQLNLGATW YLMPLAIRIR GQLRVAALSA ALFALERRHE
TLRTTFEESD GVGVQIVGEA RNSDLRVHDV STGDDGEYLE VLRREQTVPF DLSSEPGWRV
CLVKTGEEDH VLSIVMHHII YDGWSVDILR GELGQFYSAA LRGQDPLLHA NPLPIQYRDF
AAWQREAKQV EEHQRQLGYW SKQLVDSTPA ELLTDLPRPS ILSGRAGSVD VTIEGSVYGA
LQSFCRTRSV TTFVVLLTVF RIAHFRLTAV DDATIGTPIA NRNRPELETL VGCFVNTQCM
RISIADDDNF EGLVRQVRNV ATAAYANQDV PFERIVSALV PGSRNTSRNP LVQLMFAVQS
VEDYDQVRLE GLESVMMPGE ASTRFDMEFH LVPGDQKLTG SVLYSSDLFE QGTIQNFVDI
FQECLRSVLD QPLTPISVLP FSNAISNLES LDLLEMPTSD YPRDRTVVDL FREQAAICPD
SIAVKDSSSQ LTYAQLDEQS DRVAAWLHER HMPAESLVGV LSPRSCETII AYFGIMKANL
AYLPLDVYAP DARLAAILDT VEGERLLLLG AGVPQPGIQI PRLSTAYIAE ALSHATTVDV
TSIPQPSATS LAYVIFTSGS TGKPKGVMIE HRGIVRLVRD TNVNVFPESG SALPVSHFSN
LAWDAATWEI YTAVLNGGTV VCIDRDTMLD IAALNSTFRK ENVRAAFFTP AFLKQCLAET
PELVANLEIL HTAGDRLDPG DANLAGKTAK GGIFNVLGHT ENTAYSTFYP VVGEETFVNG
VPVGRGISNS HAYIIDRHQK LVPAGVMGEL ILTGDGVARG YTDSALNKDR FVYIDINGKS
TWSYRTGDKA RYRPRDGQLE FFGRMDQMVK IRGVRIEPGE VELTLLDHKS VLAATVVVRR
PPNGDPEMIA FITIDAEDDV QTHKAIYKHL QGILPAYMIP SHLVILDQMP VTDNGKVDRK
DLALRAQTVQ KRRSTAARVP PRDEVEAVLC EEYSNLLEVE VGITDGFFDL GGHSLLATKL
AARLSRQLNT RVSVKDVFDQ PILADLADII RRGSHRHDPI PATPYTGPVE QSFAQGRLWF
LEQLNLGASW YLMPFAIRMR GPLQTKALAV ALNALVHRHE ALRTTFEDHD GVGVQVIQPK
SSQDLRIIDL SDAVDDTAYL AALKREQTTA FDLTSEPGWR VSLLRLGDDD YILSIVMHHI
ISDGWTVDVL RQELGQFYSA AIRGQEPLSQ AKSLPIQYRD FAVWQRQENQ IKEQAKQLKY
WSQQLADSTP CEFLTDLPRP SILSGEADAV PMVIDGTVYQ LLTDFCRTHQ VTSFSVLLAA
FRTAHYRLTG TLDATVGTPI ANRNRPELEG LIGFFVNTQC MRMAISETET FESLVQQVRL
TTTEAFANQD VPFEQIVSTL LPGSRDTSRN PLVQVMFALQ SQQDLGRIQL EGMTDEALET
PLSTRLDLEV HLFQEVGKLS GSLLYSTDLF EVETIRGIVD VFLEILRRGL EQPKQRLMAM
PITDGITKLR DQGLLTVAKP AYPRESSVID LFRQQVAAAP DAIAVWDSSS TLTYADLDGQ
SNKLAHWLCQ RNMAPETLVA VFAPRSCLTI VAFLGVLKAN LAYLPLDVNA PAARIEAILS
AVPGHKLVLV QAHGPELGLT MADTELVQID EALASSSSGD HEQIHASGPT ATSLAYVMFT
SGSTGKPKGV MIDHRSIIRL VKNSDVVATL PTPVRMANVS NLAFDISVQE IYTALLNGGT
LVCLDYLTLL DSKILYNVFV EAQVNAAMFT PVLLKQCLGN MPAIISRLSV LFNVGDRLDA
HDAVAASGLI QDAVYNAYGP TENGMQSTMY KVDVNEPFVN GVPIGRSITN SGAYVMDGNQ
QLVSPGVMGE IVVTGDGLAR GYTDSALDED RFVHVTIDGE ENIKAYRTGD RVRYRPKDFE
IEFFGRMDQQ VKIRGHRIEP AEVEHALLGH DLVHDAAVVL RKPANQEPEM IAFITSQEDE
TIEQHESNKQ VQGWGEHFDV SRYADIKDLD TSTFGHDFLG WTSMYDGVDI PVNEMKEWLD
ETTASLLDNR PPGHILEIGA GTGMILSNLG KVDGLQKYVG LDPAPSAAIF VNEAVKSLPS
LAGKARVLVG TALDIGSLDK NEIQPELVVI NSVAQYFPTS EYLIKVVKAV VEVPSVKRVF
FGDIRSQALN RDFLAARAVR ALGDNASKEQ IREKIAELEE SEEELLVDPA FFVSLRSQLP
NIKHVEVLPK LMKATNELSS YRYAAVLHIS HNEEEQLLIQ DIDPTAWVDF AATQKDSQGL
RNLLQQGRDD VMIAVGNIPY SKTIVERHIM NSLDQDHVNS LDGTSWISDA RSAAAICTSF
DAPALTQLAK EEGFRVELSW ARQRSQNGAL DAVFHRLATD ANCERSRVLV HFPTDHQGRQ
LRTLTNRPLQ RAQSRRIESQ VFEALQTALP AYMIPSRIIV LPQMPTNANG KVDRKQLARR
AQVVAKRKAV SARVAPRNDT EIVLCEEYAD ILGTEVGITD NFFDMGGHSL MATKLAARLS
RRLDTRVTVK EVFDKPVLAD LAASIEQGST PHLPIASSVY SGPVEQSYAQ GRLWFLDQFN
LNATWYHMSL AMRLLGPLNM DALDVALRAL EQRHETLRTT FEAQKDIGVQ VVHEAGMKRL
KVLDLSDKNE KEHMAVLENE QMRPFTLASE PGWKGHLARL GPTEYILSLV MHHMFSDGWS
VDILRQELGQ FYSAALRGRD PLSQVKPLPI QYRDFAAWQK EAAQVAEHER QLAYWENQLA
DSTPGELLTD FPRPQFLSGK AGVIPVTIEG PVYEKLLKFS KERQVTLFSV LLTAFRATHF
RLTGAEDATI GTPIANRNRP ELEHIIGFFV NTQCMRLLLD TGSTFESLVQ HVRSVATDAY
SNQDIPFERI VSALLPGSRD ASRSPLIQLM FALHSQPDLG NITLEGLEHE RLPTSVATRF
DMEFHLFQEP NKLSGSILFA DELFQPETIN SVVTVFQEIL RRGLDQPQVS ISTMPLTDGL
IDLEKLGLLE IESSNFPRDY SVVDVFRQQV AANPNAPAVV DSETSMSYTS LDQKSEQIAA
WLHAQGLRPE SLICVMAPRS FETIVSLFGI LKAGYAYLPL DVNSPAARIQ PILSEVEGKR
LVLLGSGIDM PQSDRMDVET ARIQDILTNT KVERSDPMSR PSATSLAYVI FTSGSTGRPK
GVMIEHRNIL RLVKQSNVTS QLPQDLRMAH ISNLAFDASI WEIFTAILNG GALICIDYFT
LLDSQALRTT FEKARVNATL FAPALLKECL NHAPTLFEDL KVLYIGGDRL DATDAAKIQA
LVKGTVYNAY GPTENTVMST IYRLTDGESY ANGVPIGNAV SSSGAYIMDQ KQRLVPPGVM
GELVVSGDGL ARGYTNSTLN ADRFVDIVIN DQKARAYRTG DRTRYRPKDG SIEFFGRMDQ
QVKIRGHRVE PAEVEQAMLG NKAIHDAAVV VQAVDGQETE MIGFVSMASD RFSEGEEEIT
NQVQEWEDHF ESTAYAGIEA IDQATLGRDF TSWTSMYNGN LIDKAEMEEW LDDTMQSLLD
KEDARPCAEI GTGTGMVLFN LPKNDGLESY VGIEPSRSAA LFVDKAAQDF PGLQGKTQIL
VGTAEDIKLV KDFHPDVVVI NSVAQYFPSR SYLVQIASEL IHMTSVKTIF FGDMRSWATN
RDFLVSRALY TLGDKATKDQ IRQEVARLEE NEDELLVDPA FFTSLTSQWP GKVKHVEILP
KRMRTSNELS SYRYAAVLHI CRDGEGRNRY GRRVHSVEEN AWIDFASSGM DRHALVQMLD
ERRDAKTVAI GNIPHSNTIN ERHFTTSLDT EGEGIAQDSL DGSAWQSATK AMAARCPCLS
VTELVEIGQA AGFRVEVSWA RQRSQHGALD VVFHHLEDDR VGRVLINFPT DFERLPPSTG
LTSRPLQRIQ NRRFESQIRE QLQTLLPPYM VPSRIVVLER MPLNANSKVD RKELARKART
LQTIKPSATR VAPRNDIEAV LCDEFQAVLG VTVGVMDNFF ELGGHSLMAT KLAARLSRRL
DTRVSVKDIF NQPILQDLAD VVQTGSAPHE AIPSTPYSGP VEQSFSQGRL WFLDQLNLNA
SWYHMPLASR LRGPLRIEAL QSALATIEAR HESLRTTFEE QDGVPVQIVR AARNKQLRII
DVSGTEDAYL AALKQEQDAA FDLTAEPGWR VALLRLGPDD HVLSIVMHHI ISDGWSVDIL
RQELGQLYSN ASSQPAPLPI QYRDFAIWQK QDSQIAEHQK QLNYWKRQLV NSKPAELLAD
FTRPKALSGD ADVIPIEIDD QVYQNLRSFC RARHVTSFVA LLAAFRAAHY RLTGAEDATI
GSPIANRNRP ELEGLIGCFV NTQCLRIPVK SEDTFDTLVK QARETATEAQ DNQDVPFERI
VSSMVASSRD TSRNPLVQVM FAVHSQHDLG NIRLEGVEGK PVSMAASTRF DAEMHLFEDQ
GMLGGNVVFS KDLFESETIR SVVAVFQETL RRGLANPHAN LATLPLTDGL PSLRSLCLQV
NQPDYPRDAS VIDVFREQVA SIPKSIAVID ASSQLTYTEL DERSSQLATW LRRQVTVPEE
LVGVLAPRSC ETIIAFLGII KANLAYLPLD VNAPAGRIET ILSSLPGNRL ILLGSDTQAV
KLHANSVRFT RISDALVESG SPPTEELSTR PTAQSLAYVM FTSGSTGVPK GVMVEHRGIT
RLVKNSNVVA KQPAAAAIAH LSNIAFDASS WEIYAPLLNG GTVVCIDYYT TIDIKALEAV
FKQHHIRGAM LPPALLKQCL VSAPTMISSL EILFAAGDRL SSQDAILARR AVGSGVYNAY
GPTENTVLST IHNIGENEAF SNGVPIGNAV SNSGAFVMDQ NQQLVSAGVI GELVVTGDGL
ARGYTDSKLR VDRFIYITLD GNRVRAYRTG DRVRHRPKDG QIEFFGRMDQ QIKIRGHRIE
PAEVEQALAR DPAISDSAVI TQLTDEEEPE LVAFFSLKGN ANGTNGVNGV SDQEKIDGDE
QHALLMENKI RHNLQALLPT YMIPSRIIHV DQLPVNANGK IDRNELAVRA QATPRTSSVS
TYVAPRNDIE TIICKEFADI LSVRVGITDN FFDLGGHSLI ATKLAARLSR RLDTRVSVRD
VFDTPVVGQL AASIQQGSTP HEAIPALSHS GPVQQSFAQG RLWFLDRFNL NAAWYIMPFG
VRLRGPLRVD ALQTALRALE ERHELLRTTF EEQDGVGMQI VHSPRMRDIC VVDISGANED
LAKLKEEQQA PFNLSTEVAW RVALFKAGEN HHILSIVMHH IISDGWSVDI FQQELAQFYS
VAVRGHDPLS QVKPLPIHYR DFAVWQRQDK QVAVHESQLQ YWIEQLADST PAEILSDFNR
PEVLSGEAGT VPIVIEDEVY EKLSLFCRNH QVTSFVVLLA AFRVAHYRLT GAEDATIGTP
IANRNRPELE DLIGFFVNTQ CMRIALEEHD NFLSVVRRVR STAASAFENQ DVPFERLVSA
LLPGSRDASR NPLVQLMFVV HSQRNLGKLQ LEGLEGEPTP YTATTRFDVE FHLFEQDKGL
AGNVVFAADL FEAATIRSVV EVFHEILRRG LDQPDIAIST MPLVDGLAAL NSRNLPAVED
IEPDFATEAS VVDVFQTQVV ANPDALAVTD TSTKLTYAEL DQQSDHVAAW LSKQKLPAES
IVVVLAPRSS ETIVACIGIL KANLAYLPMD SNVPEARRQA ILSEIPGEKF VLLGAGVPIP
DNKTADVRMV FISDIVASKT DKSYSPGTRP SASSLAYVIF TSGSTGRPKG VMVEHRGVIS
LVKQNASRIP QSLRMAHVSN LAFDASVWEI FTTLLNGGTL FCISYFTVLD SKALSAAFSD
HRINITLLPP ALLKQCLADA PSVLSSLESL YIGGDRLDGA DATKVKDLVK GKAYNAYGPT
ENSVMSTIYT IEHETFANGV PIGTSLGPKS KAYIMDQDQQ LVPAGVMGEL VVAGDGLARG
YTDPSLNTGR FIHITIDGKQ VQAYRTGDRV RYRPRDYQIE FFGRLDQQIK IRGHRIEPAE
VEQALLSDSS INDAVVVSAQ NKEGLEMVGY ITTQAAQSVD KEEASNKVQE WEAHFDSTAY
ANIGGIDRDA LGQDFLSWTS MYDGSLIPRE EMQEWLNDTM RSLLDNQPPG KVLEIGTGTG
MVLFNLGKVE GLQSYAGLEP SRSVTAWVNK AIETFPSLAG SARVHVGTAE DISSIDGLRS
DLVVINSVAQ YFPSREYLAE LTANLIRLPG VKRIFFGDMR TYATNKDFLV ARAVHTLGSN
ASKAMVRQQV AKLEDDEEEL LVDPAFFTSL SDQFPDEIKH VEILPKRMAA TNELSSYRYA
AVIHVGGHQM PNGEDEDKQW AVKDINPKAW VDFAGTRMDR QALLQLLQDR QRGDDVVAVS
NIPYSKTIME RHLSQSLDDD EDGTSAVDGT AWISRTQSRA KECPALSVAD LIEIGKGIGF
EVEASWARQH SQRGGLDAVF HRFEPPRHSG HVMFRFPTEH KGRSSSSLTN RPLHLLQSRR
LEAKVRERLQ SLLPPYMIPS RITLLDQMPL TSNGKVDRKK LARQARVIPR SAASTLDFVA
PRTEIEVVLC EEFTDLLGVK VGITDNFFEL GGHSLLATKL SARLSRRLDA GITVKQVFDQ
PVLADLAASI LQGSSRHRSI PSLPYEGPVE QSFAQGRLWF LDQFNIDALW YLIPFALRMR
GPLQVDALAA ALVALEERHE SLRTTFEERD GVGIQVVQPL RTTKDIRIID VSGMRDDDAY
LEPLQKEQQT PFDLASEPGW RVALLKLGKD DHILSIVMHH IISDGWSTEV LQRELGQFYL
AAKSGKAPLS QVAPLPIQYR DFAVWQRQEE QVAESQRQLD YWKKQLADSS PAELLADYTR
PNVLSGEAGS VSFVINDSVY KSLVSFCRSR QVTTFTTLLA AFRAAHYRMT GSDDATIGTP
IANRNRPELE NLIGCFVNTQ CMRITIGDDE TFESLVQQVR STTATAFENQ DVPFERIVST
LSAGSRDTSR NPLVQLLFAV HSQQGLGRIQ LDGVVDEPVL STVSTRFDLE FHAFQEADRL
NGSVMFATDL FQPETIQGFV AVVEEVLQRG LEQPQSPIAT MPLAEGIAQL RDAGALQMPK
SDYPRNASLV DVFQQQAMAS PSTVAVTDST SKLTYAELDR LSDQAASYLR RQQLPAETMV
AVLAPRSCET IIAFLAILKA NLAYMPLDVN TPSARMEAII SSVPGRRLIL VGSGVRHADI
NVPNAKTMLI SDTVTGTDAI GTPEPLVVRP SATSLAYVIF TSGSTGKPKG VMVEHRAIMR
LVKDSNVVTH MPPATRMAHV TNIAFDVSLF EMCATLLNGG TLVCIDYLTL LDSTMLRETF
EREQVRAAIF PPALLRQCLV NMPDAIGMLE AVYVAGDRFH SRDARATQAL AGPRVYNAYG
PTENAILSTI YNIDKHDPYV NGVPIGSAVS NSGAYVMDRN QQLLPPGVMG ELVVTGEGVA
RGYTDASLDT DRFVTVTIDG QRQRAYRTGD RVRYRPKGFQ IEFFGRLDQQ AKIRGHRVEL
GEVEHALLSE NSVTDAAVVL RTMEEEDPQL VAFVTTDHEY RSGSSNEEED PYATQAAGDM
RKRLRSLLPY YMVPSRVTIL RQMPLNANGK VDRKDLARRA QMTPTASSSG PVHVAPRNET
EAAICDEFET ILGVKVGITD NFFELGGHSL LATKLAARLS RRMGLRISVK DLFDDPVPVS
LAGKLEQQQG FSGEDESSTV GIVPFQLLPA EMSREIIQRD VVPQIENGHS TPLDMYPATQ
TQIFFLHDKA TGHPATPPLF SLDFPETADC RRLASACAAL VQHFDIFRTV FVSRGGRFYQ
VVLAHLDVPV EVIETEQELD EVALALHEAD KQQPLRLGRA MLRIAILKRP GAKMRLVLRM
SHSLYDGLSL EHIVNALHAL YSDKHLAQAP KFGLYMHHMA SRRAEGYNFW RSILQGSSMT
SLKRSVGALE AMTPSAGTWQ TSKSIRIPPA ALKNGITQAT LFTAAVSLLL AKHTKSTDVV
FGRVVSGRQD LSINCQDIVG PCINEVPVRV RIDEGDDMGG LLRAIQDQYT SSFRHETLGL
QEVKENCTDW TDATKEFSCC IAFQNLNLHP EAEIEGQQIR LEGLPAKDQA RQANGHAPNG
TNGTNGTNGT NGANGTNGTN GTNGTHANGI NGSNGVNGRD SNVVSAAGDQ APVHDLDIVG
IPEPDGSVKI GIGASRQILG EKVVGSMLNE LCETMLALSR T


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