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Cystatin-8 (Cystatin-related epididymal spermatogenic protein) (Cystatin-related epididymal-specific protein)

 CST8_MOUSE              Reviewed;         142 AA.
P32766; O89102; Q543A7;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
05-DEC-2018, entry version 137.
RecName: Full=Cystatin-8;
AltName: Full=Cystatin-related epididymal spermatogenic protein;
AltName: Full=Cystatin-related epididymal-specific protein;
Flags: Precursor;
Name=Cst8; Synonyms=Cres;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=C3H/HeJ, and CD-1;
PubMed=10229662; DOI=10.1042/bj3400085;
Cornwall G.A., Hsia N., Sutton H.G.;
"Structure, alternative splicing and chromosomal localization of the
cystatin-related epididymal spermatogenic gene.";
Biochem. J. 340:85-93(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-142.
TISSUE=Epididymis;
PubMed=1280328; DOI=10.1210/mend.6.10.1280328;
Cornwall G.A., Orgebin-Crist M.-C., Hann S.R.;
"The CRES gene: a unique testis-regulated gene related to the cystatin
family is highly restricted in its expression to the proximal region
of the mouse epididymis.";
Mol. Endocrinol. 6:1653-1664(1992).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Performs a specialized role during sperm development and
maturation.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Proximal caput region of the epididymis. Lower
expression in the testis. Within the testis it is localized to the
elongating spermatids, whereas within the epididymis it is
exclusively synthesized by the proximal caput epithelium.
-!- INDUCTION: Testicular factors or hormones other than androgens
present in the testicular fluid may be involved in the regulation
of CRES gene expression.
-!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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EMBL; AF091503; AAC61754.1; -; Genomic_DNA.
EMBL; AK018943; BAB31489.1; -; mRNA.
EMBL; AK054409; BAC35768.1; -; mRNA.
EMBL; AK161808; BAE36585.1; -; mRNA.
EMBL; BC049753; AAH49753.1; -; mRNA.
EMBL; AF090691; AAC36316.1; -; mRNA.
EMBL; S49926; AAC35390.1; -; mRNA.
CCDS; CCDS16848.1; -.
PIR; A45361; A45361.
RefSeq; NP_034108.1; NM_009978.2.
RefSeq; XP_006498721.1; XM_006498658.3.
RefSeq; XP_006498722.1; XM_006498659.3.
UniGene; Mm.20435; -.
ProteinModelPortal; P32766; -.
SMR; P32766; -.
STRING; 10090.ENSMUSP00000028931; -.
MEROPS; I25.027; -.
PhosphoSitePlus; P32766; -.
PaxDb; P32766; -.
PRIDE; P32766; -.
Ensembl; ENSMUST00000028931; ENSMUSP00000028931; ENSMUSG00000027442.
Ensembl; ENSMUST00000109947; ENSMUSP00000105573; ENSMUSG00000027442.
GeneID; 13012; -.
KEGG; mmu:13012; -.
UCSC; uc008mto.1; mouse.
CTD; 10047; -.
MGI; MGI:107161; Cst8.
eggNOG; ENOG410IXH4; Eukaryota.
eggNOG; ENOG41113F6; LUCA.
GeneTree; ENSGT00940000162294; -.
HOGENOM; HOG000231754; -.
HOVERGEN; HBG095685; -.
InParanoid; P32766; -.
KO; K13904; -.
OMA; KQCLWFA; -.
OrthoDB; EOG091G0TP1; -.
PhylomeDB; P32766; -.
PRO; PR:P32766; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027442; Expressed in 60 organ(s), highest expression level in testis.
Genevisible; P32766; MM.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
CDD; cd00042; CY; 1.
InterPro; IPR027214; Cystatin.
InterPro; IPR000010; Cystatin_dom.
PANTHER; PTHR11413; PTHR11413; 1.
Pfam; PF00031; Cystatin; 1.
SMART; SM00043; CY; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Protease inhibitor;
Reference proteome; Secreted; Signal; Thiol protease inhibitor.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 142 Cystatin-8.
/FTId=PRO_0000006654.
MOTIF 77 81 Secondary area of contact. {ECO:0000255}.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 100 100 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 95 105 {ECO:0000250}.
DISULFID 119 139 {ECO:0000250}.
CONFLICT 4 15 PLWLSLILFIIP -> GTRDEQVGESQK (in Ref. 4;
AAC35390). {ECO:0000305}.
SEQUENCE 142 AA; 16288 MW; 50B446E98F66673E CRC64;
MAKPLWLSLI LFIIPVALAV GVDQSKNEVK AQNYFGSINI SNANVKQCVW FAMKEYNKES
EDKYVFLVDK ILHAKLQITD RMEYQIDVQI SRSNCKKPLN NTENCIPQKK PELEKKMSCS
FLVGALPWNG EFNLLSKECK DV


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