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Cystatin-related protein 1 (CRP-1) (Androgen-regulated 20 kDa protein) (Prostatic 22 kDa glycoprotein P22K16/P22K20)

 22P1_RAT                Reviewed;         176 AA.
P22282; Q63674;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
10-MAY-2017, entry version 108.
RecName: Full=Cystatin-related protein 1;
Short=CRP-1;
AltName: Full=Androgen-regulated 20 kDa protein;
AltName: Full=Prostatic 22 kDa glycoprotein P22K16/P22K20;
Flags: Precursor;
Name=Andpro; Synonyms=Crp1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Prostate;
PubMed=2280780; DOI=10.1210/mend-4-4-657;
Winderickx J., Hemschoote K., de Clercq N., van Dijck P., Peeters B.,
Rombauts W., Verhoeven G., Heyns W.;
"Tissue-specific expression and androgen regulation of different genes
encoding rat prostatic 22-kilodalton glycoproteins homologous to human
and rat cystatin.";
Mol. Endocrinol. 4:657-667(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 32-81.
PubMed=2477055; DOI=10.1021/bi00441a032;
Ho K.-C., Snoek R., Quarmby V., Viskochil D.H., Rennie P.S.,
Wilson E.M., French F.S., Bruchovsky N.;
"Primary structure and androgen regulation of a 20-kilodalton protein
specific to rat ventral prostate.";
Biochemistry 28:6367-6373(1989).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Wistar;
Vercaeren I., Winderickx J., Devos A., Peeters B., Heyns W.;
"An effect of androgens on the length of the poly(A)-tail and
alternative splicing cause size heterogeneity of the messenger
ribonucleic acids encoding cystatin-related protein.";
Endocrinology 131:2496-2502(1992).
[4]
ERRATUM.
PubMed=7679983; DOI=10.1210/endo.132.3.7679983;
Vercaeren I., Winderickx J., Devos A., Peeters B., Heyns W.;
Endocrinology 132:2496-2502(1993).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8462870; DOI=10.1016/0378-1119(93)90323-U;
Devos A., de Clercq N., Vercaeren I., Heyns W., Rombauts W.,
Peeters B.;
"Structure of rat genes encoding androgen-regulated cystatin-related
proteins (CRPs): a new member of the cystatin superfamily.";
Gene 125:159-167(1993).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8262963;
Ho K.-C., Marschke K.B., Tan J.A., Power S.G.A., Wilson E.M.,
French F.S.;
"A complex response element in intron 1 of the androgen-regulated 20-
kDa protein gene displays cell type-dependent androgen receptor
specificity.";
J. Biol. Chem. 268:27226-27235(1993).
-!- TISSUE SPECIFICITY: Prostate and lacrimal gland.
-!- INDUCTION: By androgens.
-!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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EMBL; M58167; AAA63498.1; -; mRNA.
EMBL; M27901; AAA42345.1; -; mRNA.
EMBL; Z13993; CAA78384.1; -; Genomic_DNA.
EMBL; S48988; AAA12401.1; -; mRNA.
EMBL; S57980; AAB26027.1; -; Genomic_DNA.
EMBL; L12454; AAA40732.1; -; Genomic_DNA.
PIR; A49304; A49304.
RefSeq; NP_036850.1; NM_012718.2.
UniGene; Rn.9977; -.
STRING; 10116.ENSRNOP00000040184; -.
iPTMnet; P22282; -.
PhosphoSitePlus; P22282; -.
PaxDb; P22282; -.
PRIDE; P22282; -.
GeneID; 25030; -.
KEGG; rno:25030; -.
UCSC; RGD:2115; rat.
CTD; 25030; -.
RGD; 2115; Andpro.
HOGENOM; HOG000033690; -.
HOVERGEN; HBG000007; -.
InParanoid; P22282; -.
PhylomeDB; P22282; -.
TreeFam; TF340321; -.
PRO; PR:P22282; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
GO; GO:0030521; P:androgen receptor signaling pathway; IMP:RGD.
CDD; cd00042; CY; 1.
InterPro; IPR027214; Cystatin.
InterPro; IPR000010; Cystatin_dom.
PANTHER; PTHR11413; PTHR11413; 1.
SMART; SM00043; CY; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Protease inhibitor; Reference proteome; Signal;
Thiol protease inhibitor.
SIGNAL 1 26 {ECO:0000255}.
PROPEP 27 31 {ECO:0000255}.
/FTId=PRO_0000006671.
CHAIN 32 176 Cystatin-related protein 1.
/FTId=PRO_0000006672.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
DISULFID 129 139 {ECO:0000250}.
DISULFID 153 173 {ECO:0000250}.
CONFLICT 1 22 Missing (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 23 24 HA -> MQ (in Ref. 2; AAA42345).
{ECO:0000305}.
CONFLICT 157 157 V -> L (in Ref. 2; AAA42345, 3; CAA78384
and 6; AAA40732). {ECO:0000305}.
SEQUENCE 176 AA; 21060 MW; 3D5355EC56E3CBA0 CRC64;
MCKTLHGTLL LLAIFVLFLN FSHATAKRTR RGMEIFEKNF IDKNKLKDVY DVFKYLYNTH
SADTYLSNIK NESFTMNIWG FGEIEMVKTK CRKIDSDFYK CSFQREFYNL KRTPGETMYY
ISLPGSVRCR KLLSKLDNCP FEEQTEQLKR EICYFVVYPD YIEQNIHAVR FDCYTK


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