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Cysteine-rich secretory protein 1 (CRISP-1) (AEG-like protein) (ARP) (Acidic epididymal glycoprotein homolog)

 CRIS1_HUMAN             Reviewed;         249 AA.
P54107; B5BU98; O00698; Q13248; Q14082; Q96SF6;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
05-DEC-2018, entry version 151.
RecName: Full=Cysteine-rich secretory protein 1;
Short=CRISP-1;
AltName: Full=AEG-like protein;
AltName: Full=ARP;
AltName: Full=Acidic epididymal glycoprotein homolog;
Flags: Precursor;
Name=CRISP1; Synonyms=AEGL1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND PROTEIN
SEQUENCE OF 22-41.
PubMed=8665901; DOI=10.1111/j.1432-1033.1996.t01-1-00827.x;
Kraetzschmar J., Haendler B., Eberspaecher U., Roostermann D.,
Donner P., Schleuning W.-D.;
"The human cysteine-rich secretory protein (CRISP) family. Primary
structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.";
Eur. J. Biochem. 236:827-836(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
PubMed=8543280;
Hayashi M.;
"Analysis of the human acidic epididymal glycoprotein-like molecule:
isolation of cDNA and tissue localization.";
Hokkaido Igaku Zasshi 70:743-753(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), AND CHARACTERIZATION.
PubMed=8838800; DOI=10.1006/geno.1996.0131;
Hayashi M., Fujimoto S., Takano H., Ushiki T., Abe K., Ishikura H.,
Yoshida M.C., Kirchhoff C., Ishibashi T., Kasahara M.;
"Characterization of a human glycoprotein with a potential role in
sperm-egg fusion: cDNA cloning, immunohistochemical localization, and
chromosomal assignment of the gene (AEGL1).";
Genomics 32:367-374(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
PubMed=19054851; DOI=10.1038/nmeth.1273;
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H.,
Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M.,
Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T.,
Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A.,
Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K.,
Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S.,
Isogai T., Imai J., Watanabe S., Nomura N.;
"Human protein factory for converting the transcriptome into an in
vitro-expressed proteome.";
Nat. Methods 5:1011-1017(2008).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
-!- FUNCTION: May have a role in sperm-egg fusion and maturation.
-!- SUBCELLULAR LOCATION: Note=Located in the lumen and epithelium of
distal ductus efferentes and epididymal ducts, and on the
postacrosomal region of the sperm head.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=P54107-1; Sequence=Displayed;
Name=Short; Synonyms=CRISP-1 delta;
IsoId=P54107-2; Sequence=VSP_006027, VSP_006028;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Caput, corpus, and cauda regions of the
epididymis, the ductus deferens, sperm and seminal plasma.
-!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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EMBL; X95237; CAA64524.1; -; mRNA.
EMBL; X95238; CAA64525.1; -; mRNA.
EMBL; S80310; AAB35899.1; -; mRNA.
EMBL; D38451; BAA07483.1; -; mRNA.
EMBL; AB451334; BAG70148.1; -; mRNA.
EMBL; AB451479; BAG70293.1; -; mRNA.
EMBL; AL359458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS4931.1; -. [P54107-1]
CCDS; CCDS4932.1; -. [P54107-2]
PIR; S68681; S68681.
PIR; S68684; S68684.
RefSeq; NP_001122.2; NM_001131.2. [P54107-1]
RefSeq; NP_001192149.1; NM_001205220.1. [P54107-1]
RefSeq; NP_733758.1; NM_170609.1. [P54107-2]
UniGene; Hs.109620; -.
ProteinModelPortal; P54107; -.
SMR; P54107; -.
STRING; 9606.ENSP00000338276; -.
PhosphoSitePlus; P54107; -.
BioMuta; CRISP1; -.
DMDM; 1706134; -.
PaxDb; P54107; -.
PeptideAtlas; P54107; -.
PRIDE; P54107; -.
ProteomicsDB; 56644; -.
ProteomicsDB; 56645; -. [P54107-2]
DNASU; 167; -.
Ensembl; ENST00000329411; ENSP00000331317; ENSG00000124812. [P54107-2]
Ensembl; ENST00000335847; ENSP00000338276; ENSG00000124812. [P54107-1]
Ensembl; ENST00000505118; ENSP00000427589; ENSG00000124812. [P54107-1]
Ensembl; ENST00000507853; ENSP00000425020; ENSG00000124812. [P54107-2]
GeneID; 167; -.
KEGG; hsa:167; -.
UCSC; uc003ozw.3; human. [P54107-1]
CTD; 167; -.
DisGeNET; 167; -.
EuPathDB; HostDB:ENSG00000124812.14; -.
GeneCards; CRISP1; -.
HGNC; HGNC:304; CRISP1.
HPA; HPA028445; -.
HPA; HPA030534; -.
MIM; 601193; gene.
neXtProt; NX_P54107; -.
OpenTargets; ENSG00000124812; -.
PharmGKB; PA24605; -.
eggNOG; KOG3017; Eukaryota.
eggNOG; COG2340; LUCA.
GeneTree; ENSGT00940000162362; -.
HOGENOM; HOG000236338; -.
HOVERGEN; HBG004184; -.
InParanoid; P54107; -.
KO; K19919; -.
OMA; YICHYCH; -.
OrthoDB; EOG091G0D4V; -.
PhylomeDB; P54107; -.
TreeFam; TF316148; -.
GeneWiki; CRISP1; -.
GenomeRNAi; 167; -.
PRO; PR:P54107; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000124812; Expressed in 23 organ(s), highest expression level in cauda epididymis.
CleanEx; HS_CRISP1; -.
ExpressionAtlas; P54107; baseline and differential.
Genevisible; P54107; HS.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005634; C:nucleus; HDA:UniProtKB.
GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
GO; GO:0007339; P:binding of sperm to zona pellucida; IBA:GO_Central.
GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; TAS:ProtInc.
GO; GO:0060046; P:regulation of acrosome reaction; IEA:Ensembl.
CDD; cd05383; SCP_CRISP; 1.
Gene3D; 3.40.33.10; -; 1.
InterPro; IPR001283; Allrgn_V5/Tpx1.
InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
InterPro; IPR014044; CAP_domain.
InterPro; IPR035940; CAP_sf.
InterPro; IPR013871; Cysteine_rich_secretory.
InterPro; IPR034117; SCP_CRISP.
InterPro; IPR003582; ShKT_dom.
InterPro; IPR002413; V5_allergen.
PANTHER; PTHR10334; PTHR10334; 1.
Pfam; PF00188; CAP; 1.
Pfam; PF08562; Crisp; 1.
PRINTS; PR00838; V5ALLERGEN.
PRINTS; PR00837; V5TPXLIKE.
SMART; SM00198; SCP; 1.
SUPFAM; SSF55797; SSF55797; 1.
PROSITE; PS01009; CRISP_1; 1.
PROSITE; PS01010; CRISP_2; 1.
PROSITE; PS51670; SHKT; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; Reference proteome; Signal.
SIGNAL 1 21 {ECO:0000269|PubMed:8665901}.
CHAIN 22 249 Cysteine-rich secretory protein 1.
/FTId=PRO_0000006260.
DOMAIN 45 175 SCP.
DOMAIN 211 244 ShKT. {ECO:0000255|PROSITE-
ProRule:PRU01005}.
CARBOHYD 230 230 N-linked (GlcNAc...) asparagine.
DISULFID 195 202 {ECO:0000255|PROSITE-ProRule:PRU01005}.
DISULFID 198 207 {ECO:0000255|PROSITE-ProRule:PRU01005}.
DISULFID 211 244 {ECO:0000255|PROSITE-ProRule:PRU01005}.
DISULFID 220 238 {ECO:0000255|PROSITE-ProRule:PRU01005}.
DISULFID 229 242 {ECO:0000255|PROSITE-ProRule:PRU01005}.
VAR_SEQ 178 178 E -> D (in isoform Short).
{ECO:0000303|PubMed:19054851,
ECO:0000303|PubMed:8665901}.
/FTId=VSP_006027.
VAR_SEQ 179 249 Missing (in isoform Short).
{ECO:0000303|PubMed:19054851,
ECO:0000303|PubMed:8665901}.
/FTId=VSP_006028.
CONFLICT 22 22 K -> E (in Ref. 2; AAB35899 and 3;
BAA07483). {ECO:0000305}.
CONFLICT 97 97 T -> A (in Ref. 2; AAB35899 and 3;
BAA07483). {ECO:0000305}.
SEQUENCE 249 AA; 28481 MW; 85BED3DDEAD62A9C CRC64;
MEIKHLLFLV AAACLLPMLS MKKKSARDQF NKLVTDLPNV QEEIVNIHNA LRRRVVPPAS
NMLKMSWSEE AAQNARIFSK YCDMTESNPL ERRLPNTFCG ENMHMTSYPV SWSSVIGVWY
SESTSFKHGE WTTTDDDITT DHYTQIVWAT SYLIGCAIAS CRQQGSPRYL YVCHYCHEGN
DPETKNEPYK TGVPCEACPS NCEDKLCTNP CIYYDEYFDC DIQVHYLGCN HSTTILFCKA
TCLCDTEIK


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