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Cystine transporter (ERD suppressor) (Transmembrane protein ERS1)

 ERS1_YEAST              Reviewed;         260 AA.
P17261; D6VR77;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
28-FEB-2018, entry version 142.
RecName: Full=Cystine transporter;
AltName: Full=ERD suppressor;
AltName: Full=Transmembrane protein ERS1;
Name=ERS1; OrderedLocusNames=YCR075C; ORFNames=YCR75C;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2186379; DOI=10.1093/nar/18.8.2177;
Hardwick K., Pelham H.;
"ERS1 a seven transmembrane domain protein from Saccharomyces
cerevisiae.";
Nucleic Acids Res. 18:2177-2177(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=1574125; DOI=10.1038/357038a0;
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M.,
Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W.,
Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H.,
Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V.,
Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A.,
de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H.,
Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K.,
Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B.,
Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A.,
Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y.,
Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R.,
Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G.,
Tzermia M., Urrestarazu L.A., Valle G., Vetter I.,
van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H.,
Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C.,
Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.;
"The complete DNA sequence of yeast chromosome III.";
Nature 357:38-46(1992).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=15885099; DOI=10.1111/j.1742-4658.2005.04670.x;
Gao X.-D., Wang J., Keppler-Ross S., Dean N.;
"ERS1 encodes a functional homologue of the human lysosomal cystine
transporter.";
FEBS J. 272:2497-2511(2005).
-!- FUNCTION: Transport cystine out of vacuoles/endodomes.
{ECO:0000269|PubMed:15885099}.
-!- SUBCELLULAR LOCATION: Endosome membrane
{ECO:0000269|PubMed:15885099}; Multi-pass membrane protein
{ECO:0000269|PubMed:15885099}. Vacuole membrane
{ECO:0000269|PubMed:15885099}; Multi-pass membrane protein
{ECO:0000269|PubMed:15885099}.
-!- SIMILARITY: Belongs to the cystinosin family. {ECO:0000305}.
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EMBL; X52468; CAA36706.1; -; Genomic_DNA.
EMBL; X59720; CAA42264.1; -; Genomic_DNA.
EMBL; BK006937; DAA07546.1; -; Genomic_DNA.
PIR; S22850; S22850.
RefSeq; NP_010000.1; NM_001178784.1.
ProteinModelPortal; P17261; -.
BioGrid; 31050; 138.
DIP; DIP-8250N; -.
IntAct; P17261; 4.
MINT; P17261; -.
STRING; 4932.YCR075C; -.
TCDB; 2.A.43.1.3; the lysosomal cystine transporter (lct) family.
PaxDb; P17261; -.
PRIDE; P17261; -.
EnsemblFungi; CAA42264; CAA42264; CAA42264.
EnsemblFungi; YCR075C; YCR075C; YCR075C.
GeneID; 850438; -.
KEGG; sce:YCR075C; -.
EuPathDB; FungiDB:YCR075C; -.
SGD; S000000671; ERS1.
GeneTree; ENSGT00390000005338; -.
HOGENOM; HOG000000908; -.
InParanoid; P17261; -.
KO; K12386; -.
OMA; FFIQHFC; -.
OrthoDB; EOG092C4BRM; -.
BioCyc; YEAST:G3O-29374-MONOMER; -.
Reactome; R-SCE-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
Reactome; R-SCE-5223345; Miscellaneous transport and binding events.
PRO; PR:P17261; -.
Proteomes; UP000002311; Chromosome III.
GO; GO:0005768; C:endosome; IDA:SGD.
GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0000324; C:fungal-type vacuole; IDA:SGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:SGD.
GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
GO; GO:0015184; F:L-cystine transmembrane transporter activity; IGI:SGD.
GO; GO:0015811; P:L-cystine transport; IDA:SGD.
GO; GO:0055085; P:transmembrane transport; ISS:SGD.
InterPro; IPR005282; LC_transporter.
InterPro; IPR006603; PQ-loop_rpt.
PANTHER; PTHR13131; PTHR13131; 1.
Pfam; PF04193; PQ-loop; 2.
SMART; SM00679; CTNS; 2.
TIGRFAMs; TIGR00951; 2A43; 1.
3: Inferred from homology;
Complete proteome; Endosome; Glycoprotein; Membrane;
Reference proteome; Repeat; Transmembrane; Transmembrane helix;
Transport; Vacuole.
CHAIN 1 260 Cystine transporter.
/FTId=PRO_0000205519.
TRANSMEM 7 28 Helical. {ECO:0000255}.
TRANSMEM 40 62 Helical. {ECO:0000255}.
TRANSMEM 81 102 Helical. {ECO:0000255}.
TRANSMEM 118 138 Helical. {ECO:0000255}.
TRANSMEM 151 175 Helical. {ECO:0000255}.
TRANSMEM 185 205 Helical. {ECO:0000255}.
TRANSMEM 227 247 Helical. {ECO:0000255}.
DOMAIN 1 67 PQ-loop 1.
DOMAIN 162 212 PQ-loop 2.
CARBOHYD 177 177 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 260 AA; 30116 MW; BF9E129E44D20655 CRC64;
MVSLDDILGI VYVTSWSISM YPPIITNWRH KSASAISMDF VMLNTAGYSY LVISIFLQLY
CWKMTGDESD LGRPKLTQFD FWYCLHGCLM NVVLLTQVVA GARIWRFPGK GHRKMNPWYL
RILLASLAIF SLLTVQFMYS NYWYDWHNSR TLAYCNNLFL LKISMSLIKY IPQVTHNSTR
KSMDCFPIQG VFLDVTGGIA SLLQLIWQLS NDQGFSLDTF VTNFGKVGLS MVTLIFNFIF
IMQWFVYRSR GHDLASEYPL


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