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Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1)

 CP1A1_HUMAN             Reviewed;         512 AA.
P04798; A4F3V9; A4F3W0; Q53G18;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
25-OCT-2017, entry version 201.
RecName: Full=Cytochrome P450 1A1;
EC=1.14.14.1;
AltName: Full=CYPIA1;
AltName: Full=Cytochrome P450 form 6;
AltName: Full=Cytochrome P450-C;
AltName: Full=Cytochrome P450-P1;
Name=CYP1A1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2989797; DOI=10.1093/nar/13.12.4503;
Jaiswal A.K., Gonzales F.J., Nebert D.W.;
"Human P1-450 gene sequence and correlation of mRNA with genetic
differences in benzo[a]pyrene metabolism.";
Nucleic Acids Res. 13:4503-4520(1985).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=3838385; DOI=10.1126/science.3838385;
Jaiswal A.K., Gonzalez F.J., Nebert D.W.;
"Human dioxin-inducible cytochrome P1-450: complementary DNA and amino
acid sequence.";
Science 228:80-83(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=3019683; DOI=10.1111/j.1432-1033.1986.tb09857.x;
Kawajiri K., Watanabe J., Gotoh O., Tagashira Y., Sogawa K.,
Fujii-Kuriyama Y.;
"Structure and drug inducibility of the human cytochrome P-450c
gene.";
Eur. J. Biochem. 159:219-225(1986).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11207026; DOI=10.1097/00008571-200102000-00001;
Corchero J., Pimprale S., Kimura S., Gonzalez F.J.;
"Organization of the CYP1A cluster on human chromosome 15:
implications for gene regulation.";
Pharmacogenetics 11:1-6(2001).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
TISSUE=Blood;
Graebsch C., Bauer M.;
"Cloning and sequencing of new alternative splicing variants of human
CYP1A1 gene.";
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
ASP-45.
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16572171; DOI=10.1038/nature04601;
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
Nusbaum C.;
"Analysis of the DNA sequence and duplication history of human
chromosome 15.";
Nature 440:671-675(2006).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Cervix;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 282-425 (ISOFORM 1).
TISSUE=Brain;
PubMed=9500998; DOI=10.1006/bbrc.1998.8171;
Yun C.H., Park H.J., Kim S.J., Kim H.K.;
"Identification of cytochrome P450 1A1 in human brain.";
Biochem. Biophys. Res. Commun. 243:808-810(1998).
[10]
NUCLEOTIDE SEQUENCE [MRNA] OF 295-484 (ISOFORM 1).
PubMed=3000715; DOI=10.1089/dna.1985.4.395;
Quattrochi L.C., Okino S.T., Pendurthi U.R., Tukey R.H.;
"Cloning and isolation of human cytochrome P-450 cDNAs homologous to
dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.";
DNA 4:395-400(1985).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[12]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 35-512 IN COMPLEX WITH HEME
AND INHIBITOR ALPHA-NAPHTOFLAVONE, AND COFACTOR.
PubMed=23508959; DOI=10.1074/jbc.M113.452953;
Walsh A.A., Szklarz G.D., Scott E.E.;
"Human cytochrome P450 1A1 structure and utility in understanding drug
and xenobiotic metabolism.";
J. Biol. Chem. 288:12932-12943(2013).
[13]
VARIANT VAL-462.
PubMed=1722803; DOI=10.1093/oxfordjournals.jbchem.a123594;
Hayashi S., Watanabe J., Nakachi K., Kawajiri K.;
"Genetic linkage of lung cancer-associated MspI polymorphisms with
amino acid replacement in the heme binding region of the human
cytochrome P450IA1 gene.";
J. Biochem. 110:407-411(1991).
[14]
VARIANT ASN-461.
PubMed=8895751;
Cascorbi I., Brockmoller J., Roots I.;
"A C4887A polymorphism in exon 7 of human CYP1A1: population
frequency, mutation linkages, and impact on lung cancer
susceptibility.";
Cancer Res. 56:4965-4969(1996).
[15]
VARIANT TRP-279.
PubMed=10739168; DOI=10.1097/00008571-200002000-00003;
Smart J., Daly A.K.;
"Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah
receptor and GSTM1 polymorphisms.";
Pharmacogenetics 10:11-24(2000).
[16]
VARIANTS ILE-331 AND SER-464.
PubMed=11295847; DOI=10.1002/humu.48;
Chevalier D., Allorge D., Lo-Guidice J.-M., Cauffiez C., Lhermitte M.,
Lafitte J.-J., Broly F.;
"Detection of known and two novel (M331I and R464S) missense mutations
in the human CYP1A1 gene in a French Caucasian population.";
Hum. Mutat. 17:355-355(2001).
[17]
VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492.
PubMed=15618738; DOI=10.2133/dmpk.18.218;
Saito M., Egashira M., Kiyotani K., Fujieda M., Yamazaki H.,
Kiyohara C., Kunitoh H., Kamataki T.;
"Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.";
Drug Metab. Pharmacokinet. 18:218-222(2003).
[18]
VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND
ARG-492.
PubMed=15469410; DOI=10.1517/14622416.5.7.895;
Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q.,
McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.;
"Genetic variation in eleven phase I drug metabolism genes in an
ethnically diverse population.";
Pharmacogenomics 5:895-931(2004).
[19]
VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462.
PubMed=15643613; DOI=10.1002/humu.20134;
Jiang Z., Dalton T.P., Jin L., Wang B., Tsuneoka Y., Shertzer H.G.,
Deka R., Nebert D.W.;
"Toward the evaluation of function in genetic variability:
characterizing human SNP frequencies and establishing BAC-transgenic
mice carrying the human CYP1A1_CYP1A2 locus.";
Hum. Mutat. 25:196-206(2005).
[20]
VARIANT [LARGE SCALE ANALYSIS] TRP-477.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Cytochromes P450 are a group of heme-thiolate
monooxygenases. In liver microsomes, this enzyme is involved in an
NADPH-dependent electron transport pathway. It oxidizes a variety
of structurally unrelated compounds, including steroids, fatty
acids, and xenobiotics.
-!- CATALYTIC ACTIVITY: RH + [reduced NADPH--hemoprotein reductase] +
O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
Evidence={ECO:0000269|PubMed:23508959};
-!- INTERACTION:
Q96DZ9:CMTM5; NbExp=3; IntAct=EBI-10194262, EBI-2548702;
Q96DZ9-2:CMTM5; NbExp=3; IntAct=EBI-10194262, EBI-11522780;
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
membrane protein. Microsome membrane; Peripheral membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P04798-1; Sequence=Displayed;
Name=2;
IsoId=P04798-2; Sequence=VSP_053364, VSP_053365;
Note=No experimental confirmation available.;
Name=3;
IsoId=P04798-3; Sequence=VSP_053363, VSP_053366;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
-!- INDUCTION: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee;
Note=CYP1A1 alleles;
URL="http://www.cypalleles.ki.se/cyp1a1.htm";
-!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and
polymorphism database;
URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1";
-!- WEB RESOURCE: Name=Wikipedia; Note=CYP1A1 entry;
URL="https://en.wikipedia.org/wiki/CYP1A1";
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EMBL; X02612; CAA26458.1; -; Genomic_DNA.
EMBL; K03191; AAA52139.1; -; mRNA.
EMBL; X04300; CAA27843.1; -; Genomic_DNA.
EMBL; AF253322; AAK25727.1; -; Genomic_DNA.
EMBL; AM233518; CAJ80721.1; -; mRNA.
EMBL; AM233519; CAJ80722.1; -; mRNA.
EMBL; AM233520; CAJ80723.1; -; mRNA.
EMBL; AK223113; BAD96833.1; -; mRNA.
EMBL; AC091230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC023019; AAH23019.1; -; mRNA.
EMBL; M12079; AAA52152.1; -; mRNA.
EMBL; AF040259; AAD10199.1; -; mRNA.
CCDS; CCDS10268.1; -. [P04798-1]
PIR; A24797; O4HU6.
RefSeq; NP_000490.1; NM_000499.4. [P04798-1]
RefSeq; NP_001306145.1; NM_001319216.1.
RefSeq; NP_001306146.1; NM_001319217.1. [P04798-1]
UniGene; Hs.72912; -.
PDB; 4I8V; X-ray; 2.60 A; A/B/C/D=35-512.
PDBsum; 4I8V; -.
ProteinModelPortal; P04798; -.
SMR; P04798; -.
BioGrid; 107923; 76.
IntAct; P04798; 1.
STRING; 9606.ENSP00000369050; -.
BindingDB; P04798; -.
ChEMBL; CHEMBL2231; -.
DrugBank; DB02342; 2-Methoxyestradiol.
DrugBank; DB00316; Acetaminophen.
DrugBank; DB00518; Albendazole.
DrugBank; DB01118; Amiodarone.
DrugBank; DB00381; Amlodipine.
DrugBank; DB00613; Amodiaquine.
DrugBank; DB01169; Arsenic trioxide.
DrugBank; DB00972; Azelastine.
DrugBank; DB04957; Azimilide.
DrugBank; DB04975; Banoxantrone.
DrugBank; DB06770; Benzyl alcohol.
DrugBank; DB01393; Bezafibrate.
DrugBank; DB00201; Caffeine.
DrugBank; DB01136; Carvedilol.
DrugBank; DB00608; Chloroquine.
DrugBank; DB00356; Chlorzoxazone.
DrugBank; DB00169; Cholecalciferol.
DrugBank; DB00568; Cinnarizine.
DrugBank; DB01407; Clenbuterol.
DrugBank; DB01013; Clobetasol propionate.
DrugBank; DB00636; Clofibrate.
DrugBank; DB00882; Clomifene.
DrugBank; DB00575; Clonidine.
DrugBank; DB00363; Clozapine.
DrugBank; DB00851; Dacarbazine.
DrugBank; DB06292; Dapagliflozin.
DrugBank; DB01254; Dasatinib.
DrugBank; DB00694; Daunorubicin.
DrugBank; DB04840; Debrisoquin.
DrugBank; DB01234; Dexamethasone.
DrugBank; DB00633; Dexmedetomidine.
DrugBank; DB00586; Diclofenac.
DrugBank; DB00804; Dicyclomine.
DrugBank; DB00470; Dronabinol.
DrugBank; DB08846; Ellagic Acid.
DrugBank; DB00530; Erlotinib.
DrugBank; DB00783; Estradiol.
DrugBank; DB00655; Estrone.
DrugBank; DB00898; Ethanol.
DrugBank; DB04841; Flunarizine.
DrugBank; DB00693; Fluorescein.
DrugBank; DB00499; Flutamide.
DrugBank; DB01095; Fluvastatin.
DrugBank; DB00176; Fluvoxamine.
DrugBank; DB00317; Gefitinib.
DrugBank; DB00889; Granisetron.
DrugBank; DB00502; Haloperidol.
DrugBank; DB01064; Isoprenaline.
DrugBank; DB01167; Itraconazole.
DrugBank; DB01026; Ketoconazole.
DrugBank; DB00448; Lansoprazole.
DrugBank; DB04871; Lorcaserin.
DrugBank; DB00643; Mebendazole.
DrugBank; DB01065; Melatonin.
DrugBank; DB00170; Menadione.
DrugBank; DB00553; Methoxsalen.
DrugBank; DB01388; Mibefradil.
DrugBank; DB00184; Nicotine.
DrugBank; DB01115; Nifedipine.
DrugBank; DB00325; Nitroprusside.
DrugBank; DB01059; Norfloxacin.
DrugBank; DB00338; Omeprazole.
DrugBank; DB01092; Ouabain.
DrugBank; DB00526; Oxaliplatin.
DrugBank; DB00738; Pentamidine.
DrugBank; DB03783; Phenacetin.
DrugBank; DB01174; Phenobarbital.
DrugBank; DB00466; Picrotoxin.
DrugBank; DB00457; Prazosin.
DrugBank; DB01087; Primaquine.
DrugBank; DB00396; Progesterone.
DrugBank; DB00818; Propofol.
DrugBank; DB00571; Propranolol.
DrugBank; DB00165; Pyridoxine.
DrugBank; DB00908; Quinidine.
DrugBank; DB00468; Quinine.
DrugBank; DB01129; Rabeprazole.
DrugBank; DB02709; Resveratrol.
DrugBank; DB00740; Riluzole.
DrugBank; DB08931; Riociguat.
DrugBank; DB06176; Romidepsin.
DrugBank; DB00203; Sildenafil.
DrugBank; DB00428; Streptozocin.
DrugBank; DB00605; Sulindac.
DrugBank; DB00675; Tamoxifen.
DrugBank; DB04905; Tesmilifene.
DrugBank; DB00624; Testosterone.
DrugBank; DB01041; Thalidomide.
DrugBank; DB00277; Theophylline.
DrugBank; DB00730; Thiabendazole.
DrugBank; DB00208; Ticlopidine.
DrugBank; DB00539; Toremifene.
DrugBank; DB00755; Tretinoin.
DrugBank; DB00197; Troglitazone.
DrugBank; DB00162; Vitamin A.
DrugBank; DB00682; Warfarin.
GuidetoPHARMACOLOGY; 1318; -.
SwissLipids; SLP:000001329; -.
iPTMnet; P04798; -.
PhosphoSitePlus; P04798; -.
BioMuta; CYP1A1; -.
DMDM; 117139; -.
MaxQB; P04798; -.
PaxDb; P04798; -.
PeptideAtlas; P04798; -.
PRIDE; P04798; -.
DNASU; 1543; -.
Ensembl; ENST00000379727; ENSP00000369050; ENSG00000140465. [P04798-1]
Ensembl; ENST00000395048; ENSP00000378488; ENSG00000140465. [P04798-1]
Ensembl; ENST00000562201; ENSP00000455340; ENSG00000140465. [P04798-2]
Ensembl; ENST00000564596; ENSP00000457668; ENSG00000140465. [P04798-3]
Ensembl; ENST00000567032; ENSP00000456585; ENSG00000140465. [P04798-1]
Ensembl; ENST00000569630; ENSP00000455051; ENSG00000140465. [P04798-2]
GeneID; 1543; -.
KEGG; hsa:1543; -.
UCSC; uc002ayp.4; human. [P04798-1]
CTD; 1543; -.
DisGeNET; 1543; -.
EuPathDB; HostDB:ENSG00000140465.13; -.
GeneCards; CYP1A1; -.
HGNC; HGNC:2595; CYP1A1.
HPA; CAB018654; -.
MIM; 108330; gene.
neXtProt; NX_P04798; -.
OpenTargets; ENSG00000140465; -.
PharmGKB; PA27092; -.
eggNOG; KOG0156; Eukaryota.
eggNOG; COG2124; LUCA.
GeneTree; ENSGT00900000140831; -.
HOGENOM; HOG000036991; -.
HOVERGEN; HBG106944; -.
InParanoid; P04798; -.
KO; K07408; -.
OMA; NNWQDYI; -.
OrthoDB; EOG091G0BT8; -.
PhylomeDB; P04798; -.
TreeFam; TF105095; -.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-211981; Xenobiotics.
Reactome; R-HSA-2142670; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
Reactome; R-HSA-2142816; Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RK; P04798; -.
SIGNOR; P04798; -.
ChiTaRS; CYP1A1; human.
GeneWiki; Cytochrome_P450,_family_1,_member_A1; -.
GenomeRNAi; 1543; -.
PRO; PR:P04798; -.
Proteomes; UP000005640; Chromosome 15.
Bgee; ENSG00000140465; -.
CleanEx; HS_CYP1A1; -.
ExpressionAtlas; P04798; baseline and differential.
Genevisible; P04798; HS.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
GO; GO:0032451; F:demethylase activity; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0101020; F:estrogen 16-alpha-hydroxylase activity; IDA:BHF-UCL.
GO; GO:0016711; F:flavonoid 3'-monooxygenase activity; IEA:Ensembl.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0004497; F:monooxygenase activity; TAS:Reactome.
GO; GO:0016491; F:oxidoreductase activity; IDA:BHF-UCL.
GO; GO:0016679; F:oxidoreductase activity, acting on diphenols and related substances as donors; IEA:Ensembl.
GO; GO:0019825; F:oxygen binding; TAS:Reactome.
GO; GO:0070576; F:vitamin D 24-hydroxylase activity; IDA:BHF-UCL.
GO; GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Ensembl.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0009308; P:amine metabolic process; IEA:Ensembl.
GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0071280; P:cellular response to copper ion; IEA:Ensembl.
GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
GO; GO:0009804; P:coumarin metabolic process; IEA:Ensembl.
GO; GO:0019341; P:dibenzo-p-dioxin catabolic process; IEA:Ensembl.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0017144; P:drug metabolic process; IDA:BHF-UCL.
GO; GO:0019373; P:epoxygenase P450 pathway; TAS:Reactome.
GO; GO:0009692; P:ethylene metabolic process; TAS:Reactome.
GO; GO:0009812; P:flavonoid metabolic process; IEA:Ensembl.
GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
GO; GO:0050665; P:hydrogen peroxide biosynthetic process; IEA:Ensembl.
GO; GO:0017143; P:insecticide metabolic process; IEA:Ensembl.
GO; GO:0002933; P:lipid hydroxylation; IDA:BHF-UCL.
GO; GO:0060137; P:maternal process involved in parturition; IEA:Ensembl.
GO; GO:0097267; P:omega-hydroxylase P450 pathway; TAS:Reactome.
GO; GO:0055114; P:oxidation-reduction process; IDA:BHF-UCL.
GO; GO:0006778; P:porphyrin-containing compound metabolic process; IEA:Ensembl.
GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0019216; P:regulation of lipid metabolic process; TAS:Reactome.
GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
GO; GO:0046685; P:response to arsenic-containing substance; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0032094; P:response to food; IEA:Ensembl.
GO; GO:0009635; P:response to herbicide; IEA:Ensembl.
GO; GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO; GO:0010041; P:response to iron(III) ion; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0009624; P:response to nematode; IEA:Ensembl.
GO; GO:0009615; P:response to virus; IEA:Ensembl.
GO; GO:0033189; P:response to vitamin A; IEA:Ensembl.
GO; GO:0009611; P:response to wounding; IEA:Ensembl.
GO; GO:0008202; P:steroid metabolic process; IDA:BHF-UCL.
GO; GO:0042359; P:vitamin D metabolic process; IC:BHF-UCL.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002401; Cyt_P450_E_grp-I.
InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00463; EP450I.
PRINTS; PR01683; EP450ICYP1A.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome;
Endoplasmic reticulum; Glycoprotein; Heme; Iron; Membrane;
Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Polymorphism;
Reference proteome.
CHAIN 1 512 Cytochrome P450 1A1.
/FTId=PRO_0000051627.
METAL 457 457 Iron (heme axial ligand).
{ECO:0000269|PubMed:23508959}.
BINDING 224 224 Substrate. {ECO:0000269|PubMed:23508959}.
CARBOHYD 67 67 O-linked (GlcNAc) serine. {ECO:0000250}.
VAR_SEQ 1 261 Missing (in isoform 3).
{ECO:0000303|Ref.5}.
/FTId=VSP_053363.
VAR_SEQ 189 189 Y -> T (in isoform 2).
{ECO:0000303|Ref.5}.
/FTId=VSP_053364.
VAR_SEQ 190 512 Missing (in isoform 2).
{ECO:0000303|Ref.5}.
/FTId=VSP_053365.
VAR_SEQ 419 512 Missing (in isoform 3).
{ECO:0000303|Ref.5}.
/FTId=VSP_053366.
VARIANT 45 45 G -> D (in dbSNP:rs4646422).
{ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:15643613,
ECO:0000269|Ref.6}.
/FTId=VAR_023194.
VARIANT 66 66 M -> V (in dbSNP:rs35035798).
/FTId=VAR_033817.
VARIANT 78 78 I -> T (in dbSNP:rs17861094).
{ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:15643613}.
/FTId=VAR_023195.
VARIANT 93 93 R -> W (in dbSNP:rs2229150).
{ECO:0000269|PubMed:15469410}.
/FTId=VAR_024706.
VARIANT 173 173 T -> R (in dbSNP:rs28399427).
{ECO:0000269|PubMed:15469410}.
/FTId=VAR_024707.
VARIANT 279 279 R -> W (in dbSNP:rs34260157).
{ECO:0000269|PubMed:10739168}.
/FTId=VAR_009280.
VARIANT 286 286 I -> T (in dbSNP:rs4987133).
/FTId=VAR_020122.
VARIANT 331 331 M -> I (in allele CYP1A1*6;
dbSNP:rs56313657).
{ECO:0000269|PubMed:11295847}.
/FTId=VAR_016937.
VARIANT 448 448 I -> N (in allele CYP1A1*8;
dbSNP:rs72547509).
{ECO:0000269|PubMed:15618738}.
/FTId=VAR_016938.
VARIANT 461 461 T -> N (in allele CYP1A1*4;
dbSNP:rs1799814).
{ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:15643613,
ECO:0000269|PubMed:8895751}.
/FTId=VAR_008342.
VARIANT 462 462 I -> V (in allele CYP1A1*2B and allele
CYP1A1*2C; dbSNP:rs1048943).
{ECO:0000269|PubMed:15643613,
ECO:0000269|PubMed:1722803}.
/FTId=VAR_001243.
VARIANT 464 464 R -> C (in allele CYP1A1*9;
dbSNP:rs41279188).
{ECO:0000269|PubMed:15618738}.
/FTId=VAR_016939.
VARIANT 464 464 R -> S (in allele CYP1A1*5;
dbSNP:rs41279188).
{ECO:0000269|PubMed:11295847}.
/FTId=VAR_016940.
VARIANT 470 470 F -> V (in dbSNP:rs36121583).
/FTId=VAR_033818.
VARIANT 477 477 R -> W (in allele CYP1A1*10;
dbSNP:rs56240201).
{ECO:0000269|PubMed:15618738,
ECO:0000269|PubMed:16959974}.
/FTId=VAR_016941.
VARIANT 482 482 V -> M (in dbSNP:rs28399429).
{ECO:0000269|PubMed:15469410}.
/FTId=VAR_024708.
VARIANT 492 492 P -> R (in allele CYP1A1*11;
dbSNP:rs28399430).
{ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:15618738}.
/FTId=VAR_016942.
CONFLICT 26 26 I -> M (in Ref. 2; AAA52139).
{ECO:0000305}.
CONFLICT 235 235 D -> E (in Ref. 2; AAA52139).
{ECO:0000305}.
CONFLICT 381 381 F -> L (in Ref. 1; CAA26458).
{ECO:0000305}.
TURN 47 49 {ECO:0000244|PDB:4I8V}.
HELIX 52 55 {ECO:0000244|PDB:4I8V}.
HELIX 59 70 {ECO:0000244|PDB:4I8V}.
STRAND 72 78 {ECO:0000244|PDB:4I8V}.
STRAND 81 86 {ECO:0000244|PDB:4I8V}.
HELIX 89 96 {ECO:0000244|PDB:4I8V}.
TURN 97 99 {ECO:0000244|PDB:4I8V}.
HELIX 100 103 {ECO:0000244|PDB:4I8V}.
HELIX 110 114 {ECO:0000244|PDB:4I8V}.
HELIX 116 118 {ECO:0000244|PDB:4I8V}.
TURN 121 123 {ECO:0000244|PDB:4I8V}.
HELIX 129 145 {ECO:0000244|PDB:4I8V}.
HELIX 158 179 {ECO:0000244|PDB:4I8V}.
HELIX 186 203 {ECO:0000244|PDB:4I8V}.
HELIX 212 218 {ECO:0000244|PDB:4I8V}.
STRAND 219 221 {ECO:0000244|PDB:4I8V}.
HELIX 224 228 {ECO:0000244|PDB:4I8V}.
HELIX 233 235 {ECO:0000244|PDB:4I8V}.
HELIX 238 242 {ECO:0000244|PDB:4I8V}.
HELIX 246 271 {ECO:0000244|PDB:4I8V}.
HELIX 281 292 {ECO:0000244|PDB:4I8V}.
STRAND 296 298 {ECO:0000244|PDB:4I8V}.
STRAND 300 302 {ECO:0000244|PDB:4I8V}.
HELIX 304 308 {ECO:0000244|PDB:4I8V}.
HELIX 310 334 {ECO:0000244|PDB:4I8V}.
HELIX 337 350 {ECO:0000244|PDB:4I8V}.
HELIX 359 364 {ECO:0000244|PDB:4I8V}.
HELIX 366 379 {ECO:0000244|PDB:4I8V}.
STRAND 394 396 {ECO:0000244|PDB:4I8V}.
STRAND 399 401 {ECO:0000244|PDB:4I8V}.
STRAND 406 410 {ECO:0000244|PDB:4I8V}.
HELIX 411 415 {ECO:0000244|PDB:4I8V}.
TURN 418 420 {ECO:0000244|PDB:4I8V}.
HELIX 429 432 {ECO:0000244|PDB:4I8V}.
STRAND 435 437 {ECO:0000244|PDB:4I8V}.
HELIX 441 444 {ECO:0000244|PDB:4I8V}.
HELIX 453 455 {ECO:0000244|PDB:4I8V}.
HELIX 460 477 {ECO:0000244|PDB:4I8V}.
STRAND 478 481 {ECO:0000244|PDB:4I8V}.
STRAND 495 497 {ECO:0000244|PDB:4I8V}.
STRAND 506 510 {ECO:0000244|PDB:4I8V}.
SEQUENCE 512 AA; 58165 MW; 3C62366044148EFD CRC64;
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH
LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS
MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG
PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL
RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS
DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL
WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF
SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS


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