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Cytochrome P450 26A1 (EC 1 14 13 -) (Retinoic acid-degrading enzyme CYP26)

 CP26A_CHICK             Reviewed;         492 AA.
Q9PUB4; Q9PUG2;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-NOV-2018, entry version 105.
RecName: Full=Cytochrome P450 26A1;
EC=1.14.13.- {ECO:0000269|PubMed:10588879};
AltName: Full=Retinoic acid-degrading enzyme CYP26;
Name=CYP26A1; Synonyms=CYP26;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, INDUCTION,
AND DEVELOPMENTAL STAGE.
TISSUE=Embryonic spinal cord;
PubMed=10588879; DOI=10.1006/dbio.1999.9487;
Swindell E.C., Thaller C., Sockanathan S., Petkovich M., Jessell T.M.,
Eichele G.;
"Complementary domains of retinoic acid production and degradation in
the early chick embryo.";
Dev. Biol. 216:282-296(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 368-474.
Martinez-Ceballos E., Burdsal C.A.;
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays a key role in retinoic acid metabolism. Appears to
be involved in the specific inactivation of all-trans-retinoic
acid (RA). Responsible for generation of several hydroxylated
forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA.
{ECO:0000269|PubMed:10588879}.
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
membrane protein. Microsome membrane; Peripheral membrane protein.
-!- DEVELOPMENTAL STAGE: Expressed at stage 4 in the ectoderm, stage
5-7 in the nascent notochord and at stage 7 its expression
decreases in the anterior part of the embryo. From stage 7-10 its
expression is restricted to the dorsal folds of the neural tube
and to rhombomere 2. At stage 10, it is expressed in the lateral
plate endoderm and in the tail bud and by stage 11/12 it
disappears in the neural tube, followed by a confined expression
at stage 12 to dorsal neural tube and at stage 15 an increasing
expression in the ectoderm. {ECO:0000269|PubMed:10588879}.
-!- INDUCTION: By retinoic acid. {ECO:0000269|PubMed:10588879}.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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EMBL; AF199462; AAF09250.1; -; mRNA.
EMBL; AF185266; AAD56546.1; -; mRNA.
RefSeq; NP_001001129.1; NM_001001129.1.
UniGene; Gga.331; -.
ProteinModelPortal; Q9PUB4; -.
SMR; Q9PUB4; -.
STRING; 9031.ENSGALP00000010871; -.
PaxDb; Q9PUB4; -.
GeneID; 408183; -.
KEGG; gga:408183; -.
CTD; 1592; -.
eggNOG; KOG0157; Eukaryota.
eggNOG; COG2124; LUCA.
HOGENOM; HOG000220829; -.
HOVERGEN; HBG051099; -.
InParanoid; Q9PUB4; -.
KO; K07437; -.
PhylomeDB; Q9PUB4; -.
PRO; PR:Q9PUB4; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0008401; F:retinoic acid 4-hydroxylase activity; IDA:UniProtKB.
GO; GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO; GO:0034653; P:retinoic acid catabolic process; IDA:MGI.
GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002403; Cyt_P450_E_grp-IV.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00465; EP450IV.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane;
Metal-binding; Microsome; Monooxygenase; Oxidoreductase;
Reference proteome.
CHAIN 1 492 Cytochrome P450 26A1.
/FTId=PRO_0000051982.
METAL 437 437 Iron (heme axial ligand). {ECO:0000255}.
CONFLICT 371 371 I -> V (in Ref. 2; AAD56546).
{ECO:0000305}.
CONFLICT 472 474 GPI -> SPT (in Ref. 2; AAD56546).
{ECO:0000305}.
SEQUENCE 492 AA; 55265 MW; 7F28B72E75C232FB CRC64;
MGFSALVASA LCTFLLPLLL FLAAVRLWDL YCASGRDPSC PLPLPPGTMG LPFFGETLQM
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGAENVRHI LLGEHRLVSV QWPASVRTIL
GSGCLSNLHN GQHKHRKKVI MQAFSRDALQ HYVPVIQEEV SACLAQWLGA GPCLLVYPEV
KRLMFRIAMR ILLGFQPRQA SPDGEQQLVE AFEEMIRNLF SLPIDVPFSG LYRGLRARNI
IHAKIEENIR AKMARKEPEG GYKDALQLLM EHTQGNGEQL NMQELKESAT ELLFGGHETT
ASAATSLIAF LGLHHDVLQK VRKELQLKGL LSGPNQEKQL NMEFLEQLKY TGCVIKETLR
LSPPVPGGFR IALKTLELNG YQIPKGWNVI YSICDTHDVA DLFTDKDEFN PDRFMSPSPE
DSSRFSFIPF GGGLRSCVGK EFAKVLLKIF TVELARSCDW QLLNGPPTMK TGPIVYPVDN
LPAKFIGFSG QI


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