Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Cytochrome P450 2C19 (EC 1.14.13.-) ((R)-limonene 6-monooxygenase) (EC 1.14.13.80) ((S)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 7-monooxygenase) (EC 1.14.13.49) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Mephenytoin 4-hydroxylase)

 CP2CJ_HUMAN             Reviewed;         490 AA.
P33261; P33259; Q8WZB1; Q8WZB2; Q9UCD4;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 3.
25-OCT-2017, entry version 171.
RecName: Full=Cytochrome P450 2C19;
EC=1.14.13.-;
AltName: Full=(R)-limonene 6-monooxygenase;
EC=1.14.13.80;
AltName: Full=(S)-limonene 6-monooxygenase;
EC=1.14.13.48;
AltName: Full=(S)-limonene 7-monooxygenase;
EC=1.14.13.49;
AltName: Full=CYPIIC17;
AltName: Full=CYPIIC19;
AltName: Full=Cytochrome P450-11A;
AltName: Full=Cytochrome P450-254C;
AltName: Full=Mephenytoin 4-hydroxylase;
Name=CYP2C19;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP2C19*1A).
TISSUE=Liver;
PubMed=2009263; DOI=10.1021/bi00227a012;
Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.;
"Cloning and expression of complementary DNAs for multiple members of
the human cytochrome P450IIC subfamily.";
Biochemistry 30:3247-3255(1991).
[2]
ERRATUM, AND SEQUENCE REVISION.
PubMed=8095407; DOI=10.1021/bi00056a025;
Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.;
Biochemistry 32:1390-1390(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-19; ASP-92;
ALA-122; HIS-144; ILE-331 AND CYS-410.
NIEHS SNPs program;
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-160 AND 274-490, AND VARIANT
ILE-331.
de Morais S.M.F., Blaisdell J.A.;
"Gene structure, upstream region and allelic variants of cyp2c19, the
s-mephenytoin hydroxylase.";
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
[6]
PROTEIN SEQUENCE OF 1-16.
TISSUE=Liver;
PubMed=8215410; DOI=10.1006/abbi.1993.1506;
Wrighton S.A., Stevens J.C., Becker G.W., VandenBranden M.;
"Isolation and characterization of human liver cytochrome P450 2C19:
correlation between 2C19 and S-mephenytoin 4'-hydroxylation.";
Arch. Biochem. Biophys. 306:240-245(1993).
[7]
CHARACTERIZATION.
PubMed=11950794; DOI=10.1124/dmd.30.5.602;
Miyazawa M., Shindo M., Shimada T.;
"Metabolism of (+)- and (-)-limonenes to respective carveols and
perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.";
Drug Metab. Dispos. 30:602-607(2002).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[9]
X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 23-489 IN COMPLEX WITH HEME
AND SYNTHETIC INHIBITOR, AND COFACTOR.
PubMed=23118231; DOI=10.1074/jbc.M112.424895;
Reynald R.L., Sansen S., Stout C.D., Johnson E.F.;
"Structural characterization of human cytochrome P450 2C19: active
site differences between P450s 2C8, 2C9, and 2C19.";
J. Biol. Chem. 287:44581-44591(2012).
[10]
INVOLVEMENT IN POOR DRUG METABOLISM, AND IDENTIFICATION OF ALLELE
CYP2C19*2A.
PubMed=8195181;
de Morais S.M.F., Wilkinson G.R., Blaisdell J., Nakamura K.,
Meyer U.A., Goldstein J.A.;
"The major genetic defect responsible for the polymorphism of S-
mephenytoin metabolism in humans.";
J. Biol. Chem. 269:15419-15422(1994).
[11]
INVOLVEMENT IN POOR DRUG METABOLISM, AND IDENTIFICATION OF ALLELE
CYP2C19*3A.
PubMed=7969038;
De Morais S.M.F., Wilkinson G.R., Blaisdell J., Meyer U.A.,
Nakamura K., Goldstein J.A.;
"Identification of a new genetic defect responsible for the
polymorphism of (S)-mephenytoin metabolism in Japanese.";
Mol. Pharmacol. 46:594-598(1994).
[12]
VARIANT TRP-433.
PubMed=9103550;
Xiao Z.S., Goldstein J.A., Xie H.G., Blaisdell J., Wang W.,
Jiang C.H., Yan F.X., He N., Huang S.L., Xu Z.H., Zhou H.H.;
"Differences in the incidence of the CYP2C19 polymorphism affecting
the S-mephenytoin phenotype in Chinese Han and Bai populations and
identification of a new rare CYP2C19 mutant allele.";
J. Pharmacol. Exp. Ther. 281:604-609(1997).
[13]
VARIANTS ASP-92 AND GLN-132.
PubMed=9732415;
Ibeanu G.C., Goldstein J.A., Meyer U.A., Benhamou S., Bouchardy C.,
Dayer P., Ghanayem B.I., Blaisdell J.;
"Identification of new human CYP2C19 alleles (CYP2C19*6 and
CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.";
J. Pharmacol. Exp. Ther. 286:1490-1495(1998).
[14]
VARIANT TRP-433.
PubMed=10022751;
Ibeanu G.C., Blaisdell J., Ghanayem B.I., Beyeler C., Benhamou S.,
Bouchardy C., Wilkinson G.R., Dayer P., Daly A.K., Goldstein J.A.;
"An additional defective allele, CYP2C19*5, contributes to the S-
mephenytoin poor metabolizer phenotype in Caucasians.";
Pharmacogenetics 8:129-135(1998).
[15]
VARIANT ARG-120.
PubMed=10411572;
Ibeanu G.C., Blaisdell J., Ferguson R.J., Ghanayem B.I., Brosen K.,
Benhamou S., Bouchardy C., Wilkinson G.R., Dayer P., Goldstein J.A.;
"A novel transversion in the intron 5 donor splice junction of CYP2C19
and a sequence polymorphism in exon 3 contribute to the poor
metabolizer phenotype for the anticonvulsant drug S-mephenytoin.";
J. Pharmacol. Exp. Ther. 290:635-640(1999).
[16]
VARIANTS PRO-17; LEU-19; HIS-144; HIS-150; LEU-227 AND CYS-410.
PubMed=12464799; DOI=10.1097/00008571-200212000-00004;
Blaisdell J., Mohrenweiser H., Jackson J., Ferguson S., Coulter S.,
Chanas B., Xi T., Ghanayem B., Goldstein J.A.;
"Identification and functional characterization of new potentially
defective alleles of human CYP2C19.";
Pharmacogenetics 12:703-711(2002).
[17]
VARIANT CYS-442.
PubMed=15499191; DOI=10.2133/dmpk.19.236;
Morita J., Kobayashi K., Wanibuchi A., Kimura M., Irie S.,
Ishizaki T., Chiba K.;
"A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a
Japanese subject with lowered capacity of mephobarbital 4'-
hydroxylation.";
Drug Metab. Pharmacokinet. 19:236-238(2004).
[18]
VARIANTS THR-74; HIS-144; LEU-168 AND ILE-331.
PubMed=15469410; DOI=10.1517/14622416.5.7.895;
Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q.,
McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.;
"Genetic variation in eleven phase I drug metabolism genes in an
ethnically diverse population.";
Pharmacogenomics 5:895-931(2004).
[19]
VARIANTS GLY-51; PRO-161; HIS-329 AND ILE-331.
PubMed=16141610; DOI=10.2133/dmpk.20.300;
Fukushima-Uesaka H., Saito Y., Maekawa K., Ozawa S., Hasegawa R.,
Kajio H., Kuzuya N., Yasuda K., Kawamoto M., Kamatani N., Suzuki K.,
Yanagawa T., Tohkin M., Sawada J.;
"Genetic variations and haplotypes of CYP2C19 in a Japanese
population.";
Drug Metab. Pharmacokinet. 20:300-307(2005).
-!- FUNCTION: Responsible for the metabolism of a number of
therapeutic agents such as the anticonvulsant drug S-mephenytoin,
omeprazole, proguanil, certain barbiturates, diazepam,
propranolol, citalopram and imipramine.
-!- CATALYTIC ACTIVITY: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-
carveol + NADP(+) + H(2)O.
-!- CATALYTIC ACTIVITY: (-)-(S)-limonene + NADPH + O(2) = (-)-trans-
carveol + NADP(+) + H(2)O.
-!- CATALYTIC ACTIVITY: (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl
alcohol + NADP(+) + H(2)O.
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
Evidence={ECO:0000269|PubMed:23118231};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
membrane protein. Microsome membrane; Peripheral membrane protein.
-!- INDUCTION: P450 can be induced to high levels in liver and other
tissues by various foreign compounds, including drugs, pesticides,
and carcinogens.
-!- POLYMORPHISM: Genetic variation in CYP2C19 is responsible for poor
drug metabolism [MIM:609535]. Individuals can be characterized as
either extensive metabolizers (EM) or poor metabolizers (PM). The
PM phenotype is inherited in an autosomal recessive manner, with
the EM phenotype comprising both homozygous dominant and
heteroyzgote genotypes. There are marked interracial differences
in the frequency of this polymorphism. Poor metabolizers represent
2-5% of Caucasians, 13-23% of Asian populations, and as many as
38-79% of individuals of some of the islands of Polynesia and
Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A
CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A),
CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A
(CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3),
CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7,
CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12,
CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18,
CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are
characterized by a splice mutation and a stop codon, respectively,
and account for most of the PM alleles. The sequence shown is that
of allele CYP2C19*1B.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
-!- CAUTION: P450-254C was originally listed as a separate gene
(CYP2C17). Resequencing demonstrated that it is not a separate
gene, but a chimera. The 5'-portion corresponds to a partial 2C18
clone, and the 3'-portion corresponds to a partial 2C19 clone.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee;
Note=CYP2C19 alleles;
URL="http://www.cypalleles.ki.se/cyp2c19.htm";
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/cyp2c19/";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M61854; AAB59426.1; -; mRNA.
EMBL; M61858; AAA52145.1; ALT_SEQ; mRNA.
EMBL; L07093; AAA36660.1; ALT_SEQ; mRNA.
EMBL; AY796203; AAV41877.1; -; Genomic_DNA.
EMBL; AL583836; CAH74068.1; -; Genomic_DNA.
EMBL; AL133513; CAH74068.1; JOINED; Genomic_DNA.
EMBL; AL133513; CAH73444.1; -; Genomic_DNA.
EMBL; AL583836; CAH73444.1; JOINED; Genomic_DNA.
EMBL; L39098; AAL31347.1; -; Genomic_DNA.
EMBL; L39097; AAL31347.1; JOINED; Genomic_DNA.
EMBL; L39102; AAL31348.1; -; Genomic_DNA.
EMBL; L39099; AAL31348.1; JOINED; Genomic_DNA.
EMBL; L39100; AAL31348.1; JOINED; Genomic_DNA.
EMBL; L39101; AAL31348.1; JOINED; Genomic_DNA.
EMBL; L31506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L31507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L32982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L32983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS7436.1; -.
PIR; F38462; F38462.
PIR; G38462; G38462.
PIR; I52418; I52418.
RefSeq; NP_000760.1; NM_000769.2.
UniGene; Hs.282409; -.
PDB; 4GQS; X-ray; 2.87 A; A/B/C/D=23-489.
PDBsum; 4GQS; -.
ProteinModelPortal; P33261; -.
SMR; P33261; -.
BioGrid; 107935; 2.
STRING; 9606.ENSP00000360372; -.
BindingDB; P33261; -.
ChEMBL; CHEMBL3622; -.
DrugBank; DB05812; Abiraterone.
DrugBank; DB01418; Acenocoumarol.
DrugBank; DB00945; Acetylsalicylic acid.
DrugBank; DB00546; Adinazolam.
DrugBank; DB00918; Almotriptan.
DrugBank; DB06403; Ambrisentan.
DrugBank; DB00357; Aminoglutethimide.
DrugBank; DB01424; Aminophenazone.
DrugBank; DB01118; Amiodarone.
DrugBank; DB00321; Amitriptyline.
DrugBank; DB01060; Amoxicillin.
DrugBank; DB00701; Amprenavir.
DrugBank; DB01435; Antipyrine.
DrugBank; DB06605; Apixaban.
DrugBank; DB00673; Aprepitant.
DrugBank; DB01274; Arformoterol.
DrugBank; DB06413; Armodafinil.
DrugBank; DB06697; Artemether.
DrugBank; DB00289; Atomoxetine.
DrugBank; DB01076; Atorvastatin.
DrugBank; DB06626; Axitinib.
DrugBank; DB00972; Azelastine.
DrugBank; DB00245; Benzatropine.
DrugBank; DB01128; Bicalutamide.
DrugBank; DB04794; Bifonazole.
DrugBank; DB00188; Bortezomib.
DrugBank; DB01558; Bromazepam.
DrugBank; DB00835; Brompheniramine.
DrugBank; DB00297; Bupivacaine.
DrugBank; DB00921; Buprenorphine.
DrugBank; DB00564; Carbamazepine.
DrugBank; DB00748; Carbinoxamine.
DrugBank; DB00395; Carisoprodol.
DrugBank; DB00439; Cerivastatin.
DrugBank; DB00446; Chloramphenicol.
DrugBank; DB00672; Chlorpropamide.
DrugBank; DB00169; Cholecalciferol.
DrugBank; DB01166; Cilostazol.
DrugBank; DB00501; Cimetidine.
DrugBank; DB00604; Cisapride.
DrugBank; DB00215; Citalopram.
DrugBank; DB01211; Clarithromycin.
DrugBank; DB04920; Clevidipine.
DrugBank; DB00349; Clobazam.
DrugBank; DB01242; Clomipramine.
DrugBank; DB00758; Clopidogrel.
DrugBank; DB01559; Clotiazepam.
DrugBank; DB00257; Clotrimazole.
DrugBank; DB00363; Clozapine.
DrugBank; DB00531; Cyclophosphamide.
DrugBank; DB00091; Cyclosporine.
DrugBank; DB00250; Dapsone.
DrugBank; DB00705; Delavirdine.
DrugBank; DB01151; Desipramine.
DrugBank; DB00967; Desloratadine.
DrugBank; DB01234; Dexamethasone.
DrugBank; DB01191; Dexfenfluramine.
DrugBank; DB00514; Dextromethorphan.
DrugBank; DB00829; Diazepam.
DrugBank; DB00586; Diclofenac.
DrugBank; DB00343; Diltiazem.
DrugBank; DB01093; Dimethyl sulfoxide.
DrugBank; DB01075; Diphenhydramine.
DrugBank; DB00988; Dopamine.
DrugBank; DB00590; Doxazosin.
DrugBank; DB01142; Doxepin.
DrugBank; DB00470; Dronabinol.
DrugBank; DB00625; Efavirenz.
DrugBank; DB00216; Eletriptan.
DrugBank; DB00109; Enfuvirtide.
DrugBank; DB08899; Enzalutamide.
DrugBank; DB01175; Escitalopram.
DrugBank; DB09119; Eslicarbazepine acetate.
DrugBank; DB00736; Esomeprazole.
DrugBank; DB00783; Estradiol.
DrugBank; DB00898; Ethanol.
DrugBank; DB00754; Ethotoin.
DrugBank; DB01628; Etoricoxib.
DrugBank; DB06414; Etravirine.
DrugBank; DB00927; Famotidine.
DrugBank; DB00949; Felbamate.
DrugBank; DB00196; Fluconazole.
DrugBank; DB01544; Flunitrazepam.
DrugBank; DB00472; Fluoxetine.
DrugBank; DB00499; Flutamide.
DrugBank; DB01095; Fluvastatin.
DrugBank; DB00176; Fluvoxamine.
DrugBank; DB00983; Formoterol.
DrugBank; DB01320; Fosphenytoin.
DrugBank; DB00317; Gefitinib.
DrugBank; DB01241; Gemfibrozil.
DrugBank; DB01120; Gliclazide.
DrugBank; DB01296; Glucosamine.
DrugBank; DB01016; Glyburide.
DrugBank; DB01018; Guanfacine.
DrugBank; DB00502; Haloperidol.
DrugBank; DB01355; Hexobarbital.
DrugBank; DB06789; Hydroxyprogesterone caproate.
DrugBank; DB01050; Ibuprofen.
DrugBank; DB09054; Idelalisib.
DrugBank; DB01181; Ifosfamide.
DrugBank; DB00619; Imatinib.
DrugBank; DB00458; Imipramine.
DrugBank; DB00224; Indinavir.
DrugBank; DB00328; Indomethacin.
DrugBank; DB00951; Isoniazid.
DrugBank; DB09570; Ixazomib.
DrugBank; DB06738; Ketobemidone.
DrugBank; DB01026; Ketoconazole.
DrugBank; DB00448; Lansoprazole.
DrugBank; DB01259; Lapatinib.
DrugBank; DB08918; Levomilnacipran.
DrugBank; DB01601; Lopinavir.
DrugBank; DB00455; Loratadine.
DrugBank; DB04871; Lorcaserin.
DrugBank; DB00678; Losartan.
DrugBank; DB00227; Lovastatin.
DrugBank; DB08933; Luliconazole.
DrugBank; DB09280; Lumacaftor.
DrugBank; DB01283; Lumiracoxib.
DrugBank; DB08932; Macitentan.
DrugBank; DB01065; Melatonin.
DrugBank; DB01043; Memantine.
DrugBank; DB00532; Mephenytoin.
DrugBank; DB00371; Meprobamate.
DrugBank; DB00333; Methadone.
DrugBank; DB00703; Methazolamide.
DrugBank; DB00763; Methimazole.
DrugBank; DB05246; Methsuximide.
DrugBank; DB00849; Methylphenobarbital.
DrugBank; DB00264; Metoprolol.
DrugBank; DB01110; Miconazole.
DrugBank; DB01171; Moclobemide.
DrugBank; DB00745; Modafinil.
DrugBank; DB09049; Naloxegol.
DrugBank; DB00220; Nelfinavir.
DrugBank; DB00622; Nicardipine.
DrugBank; DB00184; Nicotine.
DrugBank; DB00665; Nilutamide.
DrugBank; DB06712; Nilvadipine.
DrugBank; DB00717; Norethisterone.
DrugBank; DB00540; Nortriptyline.
DrugBank; DB00334; Olanzapine.
DrugBank; DB00338; Omeprazole.
DrugBank; DB04938; Ospemifene.
DrugBank; DB00776; Oxcarbazepine.
DrugBank; DB00239; Oxiconazole.
DrugBank; DB06412; Oxymetholone.
DrugBank; DB00213; Pantoprazole.
DrugBank; DB00082; Pegvisomant.
DrugBank; DB00738; Pentamidine.
DrugBank; DB00312; Pentobarbital.
DrugBank; DB00850; Perphenazine.
DrugBank; DB00454; Pethidine.
DrugBank; DB03783; Phenacetin.
DrugBank; DB00780; Phenelzine.
DrugBank; DB01174; Phenobarbital.
DrugBank; DB00832; Phensuximide.
DrugBank; DB00252; Phenytoin.
DrugBank; DB01100; Pimozide.
DrugBank; DB01132; Pioglitazone.
DrugBank; DB01621; Pipotiazine.
DrugBank; DB01179; Podofilox.
DrugBank; DB06209; Prasugrel.
DrugBank; DB01058; Praziquantel.
DrugBank; DB00635; Prednisone.
DrugBank; DB00794; Primidone.
DrugBank; DB01032; Probenecid.
DrugBank; DB00396; Progesterone.
DrugBank; DB01131; Proguanil.
DrugBank; DB00420; Promazine.
DrugBank; DB00818; Propofol.
DrugBank; DB00571; Propranolol.
DrugBank; DB01589; Quazepam.
DrugBank; DB01224; Quetiapine.
DrugBank; DB00468; Quinine.
DrugBank; DB01129; Rabeprazole.
DrugBank; DB00980; Ramelteon.
DrugBank; DB00863; Ranitidine.
DrugBank; DB08896; Regorafenib.
DrugBank; DB01045; Rifampicin.
DrugBank; DB08864; Rilpivirine.
DrugBank; DB00503; Ritonavir.
DrugBank; DB06176; Romidepsin.
DrugBank; DB00412; Rosiglitazone.
DrugBank; DB01098; Rosuvastatin.
DrugBank; DB01232; Saquinavir.
DrugBank; DB01037; Selegiline.
DrugBank; DB01104; Sertraline.
DrugBank; DB00203; Sildenafil.
DrugBank; DB00641; Simvastatin.
DrugBank; DB06268; Sitaxentan.
DrugBank; DB00398; Sorafenib.
DrugBank; DB09118; Stiripentol.
DrugBank; DB00259; Sulfanilamide.
DrugBank; DB00675; Tamoxifen.
DrugBank; DB06204; Tapentadol.
DrugBank; DB00966; Telmisartan.
DrugBank; DB00231; Temazepam.
DrugBank; DB00444; Teniposide.
DrugBank; DB00857; Terbinafine.
DrugBank; DB00624; Testosterone.
DrugBank; DB01041; Thalidomide.
DrugBank; DB00679; Thioridazine.
DrugBank; DB00208; Ticlopidine.
DrugBank; DB00373; Timolol.
DrugBank; DB01007; Tioconazole.
DrugBank; DB00932; Tipranavir.
DrugBank; DB08895; Tofacitinib.
DrugBank; DB01124; Tolbutamide.
DrugBank; DB01036; Tolterodine.
DrugBank; DB00273; Topiramate.
DrugBank; DB00214; Torasemide.
DrugBank; DB05109; Trabectedin.
DrugBank; DB00752; Tranylcypromine.
DrugBank; DB00347; Trimethadione.
DrugBank; DB00726; Trimipramine.
DrugBank; DB00197; Troglitazone.
DrugBank; DB01361; Troleandomycin.
DrugBank; DB00580; Valdecoxib.
DrugBank; DB00313; Valproic Acid.
DrugBank; DB00285; Venlafaxine.
DrugBank; DB00661; Verapamil.
DrugBank; DB08828; Vismodegib.
DrugBank; DB00582; Voriconazole.
DrugBank; DB09068; Vortioxetine.
DrugBank; DB00682; Warfarin.
DrugBank; DB00549; Zafirlukast.
DrugBank; DB00495; Zidovudine.
DrugBank; DB00425; Zolpidem.
DrugBank; DB00909; Zonisamide.
GuidetoPHARMACOLOGY; 1328; -.
SwissLipids; SLP:000001589; -.
iPTMnet; P33261; -.
PhosphoSitePlus; P33261; -.
BioMuta; CYP2C19; -.
DMDM; 60416369; -.
PaxDb; P33261; -.
PeptideAtlas; P33261; -.
PRIDE; P33261; -.
DNASU; 1557; -.
Ensembl; ENST00000371321; ENSP00000360372; ENSG00000165841.
GeneID; 1557; -.
KEGG; hsa:1557; -.
UCSC; uc010qnz.3; human.
CTD; 1557; -.
DisGeNET; 1557; -.
EuPathDB; HostDB:ENSG00000165841.9; -.
GeneCards; CYP2C19; -.
HGNC; HGNC:2621; CYP2C19.
HPA; HPA015066; -.
MalaCards; CYP2C19; -.
MIM; 124020; gene.
MIM; 609535; phenotype.
neXtProt; NX_P33261; -.
Orphanet; 413667; Antidepressant or antipsychotics toxicity or dose selection.
Orphanet; 240935; Resistance to clopidogrel.
Orphanet; 240921; Voriconazole toxicity.
PharmGKB; PA124; -.
eggNOG; KOG0156; Eukaryota.
eggNOG; COG2124; LUCA.
HOGENOM; HOG000036992; -.
HOVERGEN; HBG015789; -.
InParanoid; P33261; -.
KO; K17721; -.
OrthoDB; EOG091G0BT8; -.
PhylomeDB; P33261; -.
TreeFam; TF352043; -.
BioCyc; MetaCyc:HS09293-MONOMER; -.
Reactome; R-HSA-211981; Xenobiotics.
Reactome; R-HSA-211999; CYP2E1 reactions.
Reactome; R-HSA-2142670; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
Reactome; R-HSA-2142816; Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RK; P33261; -.
GeneWiki; CYP2C19; -.
GenomeRNAi; 1557; -.
PRO; PR:P33261; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000165841; -.
CleanEx; HS_CYP2C19; -.
ExpressionAtlas; P33261; baseline and differential.
Genevisible; P33261; HS.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0043231; C:intracellular membrane-bounded organelle; TAS:ProtInc.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0052741; F:(R)-limonene 6-monooxygenase activity; IEA:UniProtKB-EC.
GO; GO:0018675; F:(S)-limonene 6-monooxygenase activity; IEA:UniProtKB-EC.
GO; GO:0018676; F:(S)-limonene 7-monooxygenase activity; IEA:UniProtKB-EC.
GO; GO:0008392; F:arachidonic acid epoxygenase activity; IBA:GO_Central.
GO; GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO; GO:0020037; F:heme binding; IDA:UniProtKB.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0004497; F:monooxygenase activity; IDA:BHF-UCL.
GO; GO:0016491; F:oxidoreductase activity; IDA:BHF-UCL.
GO; GO:0019825; F:oxygen binding; TAS:Reactome.
GO; GO:0008395; F:steroid hydroxylase activity; IMP:BHF-UCL.
GO; GO:0017144; P:drug metabolic process; IDA:BHF-UCL.
GO; GO:0019373; P:epoxygenase P450 pathway; IBA:GO_Central.
GO; GO:0042738; P:exogenous drug catabolic process; IDA:BHF-UCL.
GO; GO:0046483; P:heterocycle metabolic process; IDA:BHF-UCL.
GO; GO:0016098; P:monoterpenoid metabolic process; IDA:BHF-UCL.
GO; GO:0097267; P:omega-hydroxylase P450 pathway; TAS:Reactome.
GO; GO:0055114; P:oxidation-reduction process; IDA:BHF-UCL.
GO; GO:0008202; P:steroid metabolic process; IMP:BHF-UCL.
GO; GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002401; Cyt_P450_E_grp-I.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00463; EP450I.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Complete proteome;
Direct protein sequencing; Endoplasmic reticulum; Heme; Iron;
Membrane; Metal-binding; Microsome; Monooxygenase; NADP;
Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome.
CHAIN 1 490 Cytochrome P450 2C19.
/FTId=PRO_0000051708.
METAL 435 435 Iron (heme axial ligand).
MOD_RES 127 127 Phosphoserine.
{ECO:0000250|UniProtKB:P00176}.
MOD_RES 249 249 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q64458}.
MOD_RES 375 375 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q64458}.
VARIANT 17 17 L -> P (in allele CYP2C19*14;
dbSNP:rs55752064).
{ECO:0000269|PubMed:12464799}.
/FTId=VAR_021268.
VARIANT 19 19 I -> L (in allele CYP2C19*15;
dbSNP:rs17882687).
{ECO:0000269|PubMed:12464799,
ECO:0000269|Ref.3}.
/FTId=VAR_021269.
VARIANT 51 51 S -> G (in allele CYP2C19*19).
{ECO:0000269|PubMed:16141610}.
/FTId=VAR_024083.
VARIANT 74 74 M -> T (in dbSNP:rs28399505).
{ECO:0000269|PubMed:15469410}.
/FTId=VAR_024718.
VARIANT 92 92 E -> D (in dbSNP:rs17878459).
{ECO:0000269|PubMed:9732415,
ECO:0000269|Ref.3}.
/FTId=VAR_021270.
VARIANT 120 120 W -> R (in allele CYP2C19*8; loss of
activity; dbSNP:rs41291556).
{ECO:0000269|PubMed:10411572}.
/FTId=VAR_008357.
VARIANT 122 122 E -> A (in dbSNP:rs17885179).
{ECO:0000269|Ref.3}.
/FTId=VAR_021271.
VARIANT 132 132 R -> Q (in allele CYP2C19*6; loss of
activity). {ECO:0000269|PubMed:9732415}.
/FTId=VAR_008358.
VARIANT 144 144 R -> H (in allele CYP2C19*9;
dbSNP:rs17884712).
{ECO:0000269|PubMed:12464799,
ECO:0000269|PubMed:15469410,
ECO:0000269|Ref.3}.
/FTId=VAR_021272.
VARIANT 150 150 R -> H (in allele CYP2C19*11;
dbSNP:rs58973490).
{ECO:0000269|PubMed:12464799}.
/FTId=VAR_021273.
VARIANT 161 161 A -> P (in dbSNP:rs181297724).
{ECO:0000269|PubMed:16141610}.
/FTId=VAR_024084.
VARIANT 168 168 F -> L (in dbSNP:rs28399510).
{ECO:0000269|PubMed:15469410}.
/FTId=VAR_024719.
VARIANT 227 227 P -> L (in allele CYP2C19*10;
dbSNP:rs6413438).
{ECO:0000269|PubMed:12464799}.
/FTId=VAR_020123.
VARIANT 329 329 R -> H (in allele CYP2C19*18).
{ECO:0000269|PubMed:16141610}.
/FTId=VAR_024085.
VARIANT 331 331 V -> I (in allele CYP2C19*1A, allele
CYP2C19*5A, allele CYP2C19*8 and allele
CYP2C19*16; dbSNP:rs3758581).
{ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:16141610,
ECO:0000269|Ref.3, ECO:0000269|Ref.5}.
/FTId=VAR_001255.
VARIANT 410 410 R -> C (in allele CYP2C19*13;
dbSNP:rs17879685).
{ECO:0000269|PubMed:12464799,
ECO:0000269|Ref.3}.
/FTId=VAR_021274.
VARIANT 433 433 R -> W (in allele CYP2C19*5A and allele
CYP2C19*5B; loss of activity;
dbSNP:rs56337013).
{ECO:0000269|PubMed:10022751,
ECO:0000269|PubMed:9103550}.
/FTId=VAR_008359.
VARIANT 442 442 R -> C (in allele CYP2C19*16; lowered
catalytic activity; dbSNP:rs192154563).
{ECO:0000269|PubMed:15499191}.
/FTId=VAR_021275.
TURN 37 39 {ECO:0000244|PDB:4GQS}.
HELIX 42 44 {ECO:0000244|PDB:4GQS}.
HELIX 47 49 {ECO:0000244|PDB:4GQS}.
HELIX 50 61 {ECO:0000244|PDB:4GQS}.
STRAND 63 69 {ECO:0000244|PDB:4GQS}.
STRAND 72 77 {ECO:0000244|PDB:4GQS}.
HELIX 80 87 {ECO:0000244|PDB:4GQS}.
TURN 88 90 {ECO:0000244|PDB:4GQS}.
HELIX 91 94 {ECO:0000244|PDB:4GQS}.
HELIX 103 106 {ECO:0000244|PDB:4GQS}.
TURN 107 109 {ECO:0000244|PDB:4GQS}.
HELIX 117 130 {ECO:0000244|PDB:4GQS}.
STRAND 135 139 {ECO:0000244|PDB:4GQS}.
HELIX 141 158 {ECO:0000244|PDB:4GQS}.
TURN 159 161 {ECO:0000244|PDB:4GQS}.
TURN 166 168 {ECO:0000244|PDB:4GQS}.
HELIX 169 182 {ECO:0000244|PDB:4GQS}.
STRAND 183 185 {ECO:0000244|PDB:4GQS}.
HELIX 192 209 {ECO:0000244|PDB:4GQS}.
HELIX 211 218 {ECO:0000244|PDB:4GQS}.
HELIX 222 225 {ECO:0000244|PDB:4GQS}.
HELIX 228 254 {ECO:0000244|PDB:4GQS}.
HELIX 263 273 {ECO:0000244|PDB:4GQS}.
TURN 274 276 {ECO:0000244|PDB:4GQS}.
HELIX 284 297 {ECO:0000244|PDB:4GQS}.
HELIX 300 315 {ECO:0000244|PDB:4GQS}.
HELIX 317 330 {ECO:0000244|PDB:4GQS}.
STRAND 333 335 {ECO:0000244|PDB:4GQS}.
HELIX 339 344 {ECO:0000244|PDB:4GQS}.
HELIX 346 359 {ECO:0000244|PDB:4GQS}.
STRAND 377 379 {ECO:0000244|PDB:4GQS}.
STRAND 386 389 {ECO:0000244|PDB:4GQS}.
HELIX 391 395 {ECO:0000244|PDB:4GQS}.
TURN 398 400 {ECO:0000244|PDB:4GQS}.
STRAND 401 403 {ECO:0000244|PDB:4GQS}.
HELIX 409 412 {ECO:0000244|PDB:4GQS}.
STRAND 415 417 {ECO:0000244|PDB:4GQS}.
HELIX 438 455 {ECO:0000244|PDB:4GQS}.
STRAND 456 462 {ECO:0000244|PDB:4GQS}.
TURN 464 466 {ECO:0000244|PDB:4GQS}.
STRAND 475 477 {ECO:0000244|PDB:4GQS}.
STRAND 485 489 {ECO:0000244|PDB:4GQS}.
SEQUENCE 490 AA; 55931 MW; 17DB04C50A132C53 CRC64;
MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV SKSLTNLSKI
YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF PLAERANRGF GIVFSNGKRW
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS
IIFQKRFDYK DQQFLNLMEK LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM
ESDILEKVKE HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV VGRNRSPCMQ DRGHMPYTDA VVHEVQRYID
LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE FPNPEMFDPR HFLDEGGNFK
KSNYFMPFSA GKRICVGEGL ARMELFLFLT FILQNFNLKS LIDPKDLDTT PVVNGFASVP
PFYQLCFIPV


Related products :

Catalog number Product name Quantity
EIAAB08929 (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYP2C19,CYPIIC17,CYPIIC19,Cytochrome P450 2C19,Cytochrome P450-11A,Cytochrome P450-254C,Homo sapiens,Human,Mephen
EIAAB08921 (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYP2C10,CYP2C9,CYPIIC9,Cytochrome P450 2C9,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,Cytochr
EIAAB08974 Albendazole monooxygenase,Albendazole sulfoxidase,CYP3A3,CYP3A4,CYPIIIA3,CYPIIIA4,Cytochrome P450 3A3,Cytochrome P450 3A4,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Homo sapiens,Hu
EIAAB08920 CYP2C8,CYPIIC8,Cytochrome P450 2C8,Cytochrome P450 form 1,Cytochrome P450 IIC2,Cytochrome P450 MP-12,Cytochrome P450 MP-20,Homo sapiens,Human,S-mephenytoin 4-hydroxylase
E1557h ELISA kit 21-OHase,CYP21,CYP21A2,CYP21B,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Cytochrome P450-C21B,Homo sapiens,Human,Steroid 21-hydroxylase 96T
E1557h ELISA 21-OHase,CYP21,CYP21A2,CYP21B,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Cytochrome P450-C21B,Homo sapiens,Human,Steroid 21-hydroxylase 96T
U1557h CLIA 21-OHase,CYP21,CYP21A2,CYP21B,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Cytochrome P450-C21B,Homo sapiens,Human,Steroid 21-hydroxylase 96T
U0988Rb CLIA 4-nitrophenol 2-hydroxylase,CYP2E,CYP2E1,CYPIIE1,Cytochrome P450 2E1,Cytochrome P450 isozyme 3A,Cytochrome P450 LM3A,Cytochrome P450-ALC,Oryctolagus cuniculus,Rabbit 96T
E0988Rb ELISA 4-nitrophenol 2-hydroxylase,CYP2E,CYP2E1,CYPIIE1,Cytochrome P450 2E1,Cytochrome P450 isozyme 3A,Cytochrome P450 LM3A,Cytochrome P450-ALC,Oryctolagus cuniculus,Rabbit 96T
E0988Rb ELISA kit 4-nitrophenol 2-hydroxylase,CYP2E,CYP2E1,CYPIIE1,Cytochrome P450 2E1,Cytochrome P450 isozyme 3A,Cytochrome P450 LM3A,Cytochrome P450-ALC,Oryctolagus cuniculus,Rabbit 96T
EIAAB08934 Cyp2d1,Cyp2d-1,Cyp2d9,CYPIID1,Cytochrome P450 2D1,Cytochrome P450-CMF1A,Cytochrome P450-DB1,Cytochrome P450-UT-7,Debrisoquine 4-hydroxylase,Rat,Rattus norvegicus
EIAAB09012 CYP4F3,CYPIVF3,Cytochrome P450 4F3,Cytochrome P450-LTB-omega,Homo sapiens,Human,Leukotriene-B(4) 20-monooxygenase 2,Leukotriene-B(4) omega-hydroxylase 2,LTB4H
EIAAB08908 Cyp2b10,Cyp2b-10,Cyp2b20,CYPIIB10,CYPIIB20,Cytochrome P450 2B10,Cytochrome P450 2B20,Cytochrome P450 clone PF3_46,Cytochrome P450-16-alpha,Mouse,Mus musculus,P24,Testosterone 16-alpha hydroxylase
EIAAB09013 Cyp4f18,Cyp4f3,CYPIVF3,Cytochrome P450 4F3,Cytochrome P450-LTB-omega,Leukotriene-B(4) 20-monooxygenase 2,Leukotriene-B(4) omega-hydroxylase 2,Mouse,Mus musculus
EIAAB09011 Cyp4f18,Cyp4f3,CYPIVF3,Cytochrome P450 4F3,Cytochrome P450-LTB-omega,Leukotriene-B(4) 20-monooxygenase 2,Leukotriene-B(4) omega-hydroxylase 2,Rat,Rattus norvegicus
EIAAB09020 Cyp4f14,Cyp4f-14,Cytochrome P450 4F14,Cytochrome P450-LTB-omega,Leukotriene-B4 20-monooxygenase 3,Leukotriene-B4 omega-hydroxylase 3,Mouse,Mus musculus
EIAAB09010 CYP4F2,CYPIVF2,Cytochrome P450 4F2,Cytochrome P450-LTB-omega,Homo sapiens,Human,Leukotriene-B(4) 20-monooxygenase 1,Leukotriene-B(4) omega-hydroxylase 1
EIAAB08901 Cyp2b1,Cyp2b-1,CYPIIB1,Cytochrome P450 2B1,Cytochrome P450b,Cytochrome P450-B,Cytochrome P450-LM2,Cytochrome P450-PB1,Cytochrome P450-PB2,Rat,Rattus norvegicus
EIAAB08923 Cyp2c12,Cyp2c-12,Cyp2c40,CYPIIC12,Cytochrome P450 15-beta,Cytochrome P450 2C12, female-specific,Cytochrome P450I,Cytochrome P450-UT-1,Cytochrome P450-UT-I,Rat,Rattus norvegicus
E1557m ELISA 21-OHase,Cyp21,Cyp21a1,Cyp21a-1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Mouse,Mus musculus,Steroid 21-hydroxylase 96T
U1557m CLIA 21-OHase,Cyp21,Cyp21a1,Cyp21a-1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Mouse,Mus musculus,Steroid 21-hydroxylase 96T
E1557m ELISA kit 21-OHase,Cyp21,Cyp21a1,Cyp21a-1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Mouse,Mus musculus,Steroid 21-hydroxylase 96T
E2016h ELISA kit CYP17,CYP17A1,CYPXVII,Cytochrome P450 17A1,Cytochrome P450c17,Cytochrome P450-C17,Homo sapiens,Human,S17AH,Steroid 17-alpha-hydroxylase_17,20 lyase,Steroid 17-alpha-monooxygenase 96T
U2016h CLIA kit CYP17,CYP17A1,CYPXVII,Cytochrome P450 17A1,Cytochrome P450c17,Cytochrome P450-C17,Homo sapiens,Human,S17AH,Steroid 17-alpha-hydroxylase_17,20 lyase,Steroid 17-alpha-monooxygenase 96T
U2016h CLIA CYP17,CYP17A1,CYPXVII,Cytochrome P450 17A1,Cytochrome P450c17,Cytochrome P450-C17,Homo sapiens,Human,S17AH,Steroid 17-alpha-hydroxylase_17,20 lyase,Steroid 17-alpha-monooxygenase 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur