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Cytochrome P450 family 26 subfamily A member 1

 F6ZB62_HORSE            Unreviewed;       497 AA.
F6ZB62;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
07-NOV-2018, entry version 47.
SubName: Full=Cytochrome P450 family 26 subfamily A member 1 {ECO:0000313|Ensembl:ENSECAP00000019834};
Name=CYP26A1 {ECO:0000313|Ensembl:ENSECAP00000019834,
ECO:0000313|VGNC:VGNC:50428};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019834, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000019834, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019834,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000019834}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019834};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the cytochrome P450 family.
{ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS00578476}.
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RefSeq; XP_001502548.1; XM_001502498.4.
STRING; 9796.ENSECAP00000019834; -.
PaxDb; F6ZB62; -.
Ensembl; ENSECAT00000023903; ENSECAP00000019834; ENSECAG00000022244.
GeneID; 100061805; -.
KEGG; ecb:100061805; -.
CTD; 1592; -.
VGNC; VGNC:50428; CYP26A1.
eggNOG; KOG0157; Eukaryota.
eggNOG; COG2124; LUCA.
GeneTree; ENSGT00800000124060; -.
InParanoid; F6ZB62; -.
KO; K07437; -.
OMA; DAQIADN; -.
OrthoDB; EOG091G0K6Z; -.
TreeFam; TF105093; -.
Proteomes; UP000002281; Chromosome 1.
Bgee; ENSECAG00000022244; Expressed in 2 organ(s), highest expression level in liver.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:Ensembl.
GO; GO:0008401; F:retinoic acid 4-hydroxylase activity; IEA:Ensembl.
GO; GO:0001972; F:retinoic acid binding; IEA:Ensembl.
GO; GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO; GO:0034653; P:retinoic acid catabolic process; IEA:Ensembl.
GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
GO; GO:0006805; P:xenobiotic metabolic process; IEA:Ensembl.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002403; Cyt_P450_E_grp-IV.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00465; EP450IV.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Heme {ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS01092997};
Iron {ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS01092997};
Metal-binding {ECO:0000256|RuleBase:RU000461,
ECO:0000256|SAAS:SAAS01092997};
Monooxygenase {ECO:0000256|RuleBase:RU000461,
ECO:0000256|SAAS:SAAS00966021};
Oxidoreductase {ECO:0000256|RuleBase:RU000461,
ECO:0000256|SAAS:SAAS00966021};
Reference proteome {ECO:0000313|Proteomes:UP000002281}.
SEQUENCE 497 AA; 56349 MW; 2615520CEE38BDCC CRC64;
MGLLALLASA LCTFVLPLLL FLAAIKLWDL YCVSSRDRSC ALPLPPGTMG FPFFGETLQM
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL
GSGCLSNLHD SSHKQRKKVI MRAFSREALQ CYVPVIAEEV GNSLEQWLSC GERGLLVYPQ
VKRLMFRIAM RILLGCEPRL ANGGDAEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR
NLIHARIEEN IRAKICRLRA AEAGEGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG
GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYTGCVI
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVADIFTN KEEFNPDRFM
LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWRLLNG PPTMKTSPTV
YPVDDLPARF TRFQGEI


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