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Cytochrome c oxidase polypeptide VIII, mitochondrial (EC 1.9.3.1)

 COX8_YEAST              Reviewed;          78 AA.
P04039; D6VZ30;
01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
20-JUN-2018, entry version 157.
RecName: Full=Cytochrome c oxidase polypeptide VIII, mitochondrial;
EC=1.9.3.1;
Flags: Precursor;
Name=COX8; OrderedLocusNames=YLR395C; ORFNames=L8084.14;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3023386;
Patterson T.E., Poyton R.O.;
"COX8, the structural gene for yeast cytochrome c oxidase subunit
VIII. DNA sequence and gene disruption indicate that subunit VIII is
required for maximal levels of cellular respiration and is derived
from a precursor which is extended at both its NH2 and COOH termini.";
J. Biol. Chem. 261:17192-17197(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169871;
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
PROTEIN SEQUENCE OF 28-74.
PubMed=6327685;
Power S.D., Lochrie M.A., Patterson T.E., Poyton R.O.;
"The nuclear-coded subunits of yeast cytochrome c oxidase. II. The
amino acid sequence of subunit VIII and a model for its disposition in
the inner mitochondrial membrane.";
J. Biol. Chem. 259:6571-6574(1984).
[6]
PROTEIN SEQUENCE OF 28-42, AND COMPOSITION OF THE CYTOCHROME C OXIDASE
COMPLEX.
PubMed=7851399; DOI=10.1111/j.1432-1033.1995.tb20388.x;
Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U.,
Von Jagow G.;
"Kinetic properties and ligand binding of the eleven-subunit
cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a
novel large-scale purification method.";
Eur. J. Biochem. 227:296-302(1995).
[7]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
-!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
ferricytochrome c + 2 H(2)O.
-!- SUBUNIT: Cytochrome c oxidase is composed of 11 subunits: one copy
each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9,
COX12, COX13 and two copies of COX8.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
-!- MISCELLANEOUS: Present with 672 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the cytochrome c oxidase VIIc family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; J02634; AAA34522.1; -; Genomic_DNA.
EMBL; U19729; AAB82353.1; -; Genomic_DNA.
EMBL; AY558228; AAS56554.1; -; Genomic_DNA.
EMBL; BK006945; DAA09696.1; -; Genomic_DNA.
PIR; A25353; A25353.
RefSeq; NP_013499.1; NM_001182283.1.
ProteinModelPortal; P04039; -.
SMR; P04039; -.
BioGrid; 31654; 180.
ComplexPortal; CPX-1721; Mitochondrial respiratory chain complex IV variant 1.
ComplexPortal; CPX-1722; Mitochondrial electron transport complex IV variant 2.
DIP; DIP-5445N; -.
IntAct; P04039; 1.
STRING; 4932.YLR395C; -.
TCDB; 3.D.4.8.1; the proton-translocating cytochrome oxidase (cox) superfamily.
MaxQB; P04039; -.
PaxDb; P04039; -.
PRIDE; P04039; -.
EnsemblFungi; YLR395C; YLR395C; YLR395C.
GeneID; 851111; -.
KEGG; sce:YLR395C; -.
EuPathDB; FungiDB:YLR395C; -.
SGD; S000004387; COX8.
HOGENOM; HOG000001142; -.
InParanoid; P04039; -.
KO; K02272; -.
OMA; HFKEGVY; -.
OrthoDB; EOG092C5VOM; -.
BioCyc; MetaCyc:YLR395C-MONOMER; -.
BioCyc; YEAST:YLR395C-MONOMER; -.
PRO; PR:P04039; -.
Proteomes; UP000002311; Chromosome XII.
GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IPI:SGD.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IDA:SGD.
CDD; cd00929; Cyt_c_Oxidase_VIIc; 1.
Gene3D; 4.10.49.10; -; 1.
InterPro; IPR004202; COX7C/Cox8.
InterPro; IPR036636; COX7C/Cox8_sf.
PANTHER; PTHR13313; PTHR13313; 1.
Pfam; PF02935; COX7C; 1.
SUPFAM; SSF81427; SSF81427; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Membrane; Mitochondrion;
Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
Transit peptide.
TRANSIT 1 27 Mitochondrion.
{ECO:0000269|PubMed:6327685,
ECO:0000269|PubMed:7851399}.
CHAIN 28 74 Cytochrome c oxidase polypeptide VIII,
mitochondrial.
/FTId=PRO_0000006173.
PROPEP 75 78
/FTId=PRO_0000006174.
CONFLICT 47 47 T -> C (in Ref. 5; AA sequence).
{ECO:0000305}.
CONFLICT 68 68 C -> T (in Ref. 5; AA sequence).
{ECO:0000305}.
SEQUENCE 78 AA; 8907 MW; 61ABE6001BDABDD0 CRC64;
MLCQQMIRTT AKRSSNIMTR PIIMKRSVHF KDGVYENIPF KVKGRKTPYA LSHFGFFAIG
FAVPFVACYV QLKKSGAF


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