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Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I)

 COX1_HUMAN              Reviewed;         513 AA.
P00395; Q34770;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
12-SEP-2018, entry version 195.
RecName: Full=Cytochrome c oxidase subunit 1;
EC=1.9.3.1;
AltName: Full=Cytochrome c oxidase polypeptide I;
Name=MT-CO1; Synonyms=COI, COXI, MTCO1;
Homo sapiens (Human).
Mitochondrion.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=7219534; DOI=10.1038/290457a0;
Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L.,
Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A.,
Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G.;
"Sequence and organization of the human mitochondrial genome.";
Nature 290:457-465(1981).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-235 AND ALA-415.
TISSUE=Placenta;
PubMed=7530363; DOI=10.1073/pnas.92.2.532;
Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
"Recent African origin of modern humans revealed by complete sequences
of hominoid mitochondrial DNAs.";
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12949126; DOI=10.1093/molbev/msg230;
Moilanen J.S., Finnila S., Majamaa K.;
"Lineage-specific selection in human mtDNA: lack of polymorphisms in a
segment of MTND5 gene in haplogroup J.";
Mol. Biol. Evol. 20:2132-2142(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11130070; DOI=10.1038/35047064;
Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
"Mitochondrial genome variation and the origin of modern humans.";
Nature 408:708-713(2000).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12840039; DOI=10.1101/gr.686603;
Ingman M., Gyllensten U.;
"Mitochondrial genome variation and evolutionary history of Australian
and New Guinean aborigines.";
Genome Res. 13:1600-1606(2003).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
Irwin J.A., Parsons T.J.;
"Single nucleotide polymorphisms over the entire mtDNA genome that
increase the power of forensic testing in Caucasians.";
Int. J. Legal Med. 118:137-146(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187.
PubMed=6260957; DOI=10.1016/0022-2836(80)90196-5;
Sanger F., Coulson A.R., Barrell B.G., Smith A.J.H., Roe B.A.;
"Cloning in single-stranded bacteriophage as an aid to rapid DNA
sequencing.";
J. Mol. Biol. 143:161-178(1980).
[8]
INVOLVEMENT IN DFNM.
PubMed=10577941; DOI=10.1086/302658;
Pandya A., Xia X.J., Erdenetungalag R., Amendola M., Landa B.,
Radnaabazar J., Dangaasuren B., Van Tuyle G., Nance W.E.;
"Heterogenous point mutations in the mitochondrial tRNA Ser(UCN)
precursor coexisting with the A1555G mutation in deaf students from
Mongolia.";
Am. J. Hum. Genet. 65:1803-1806(1999).
[9]
INTERACTION WITH COA3 AND SMIM20.
PubMed=26321642; DOI=10.1016/j.celrep.2015.08.009;
Dennerlein S., Oeljeklaus S., Jans D., Hellwig C., Bareth B.,
Jakobs S., Deckers M., Warscheid B., Rehling P.;
"MITRAC7 acts as a COX1-specific chaperone and reveals a checkpoint
during cytochrome c oxidase assembly.";
Cell Rep. 12:1644-1655(2015).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[11]
INTERACTION WITH TMEM177.
PubMed=29154948; DOI=10.1016/j.bbamcr.2017.11.010;
Lorenzi I., Oeljeklaus S., Aich A., Ronsoer C., Callegari S.,
Dudek J., Warscheid B., Dennerlein S., Rehling P.;
"The mitochondrial TMEM177 associates with COX20 during COX2
biogenesis.";
Biochim. Biophys. Acta 1865:323-333(2017).
[12]
VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305.
PubMed=1757091; DOI=10.1007/BF00206061;
Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
Utthanaphol P., Byrne E.;
"Normal variants of human mitochondrial DNA and translation products:
the building of a reference data base.";
Hum. Genet. 88:139-145(1991).
[13]
VARIANT LHON LYS-GLN-LYS-513 INS.
PubMed=1322638;
Brown M.D., Yang C.-C., Trounce I., Torroni A., Lott M.T.,
Wallace D.C.;
"A mitochondrial DNA variant, identified in Leber hereditary optic
neuropathy patients, which extends the amino acid sequence of
cytochrome c oxidase subunit I.";
Am. J. Hum. Genet. 51:378-385(1992).
[14]
VARIANTS THR-273 AND THR-280, AND POSSIBLE INVOLVEMENT IN ACQUIRED
IDIOPATHIC SIDEROBLASTIC ANEMIA.
PubMed=9389715;
Gattermann N., Retzlaff S., Wang Y.L., Hofhaus G., Heinisch J.,
Aul C., Schneider W.;
"Heteroplasmic point mutations of mitochondrial DNA affecting subunit
I of cytochrome c oxidase in two patients with acquired idiopathic
sideroblastic anemia.";
Blood 90:4961-4972(1997).
[15]
VARIANTS THR-273 AND THR-280, AND POSSIBLE INVOLVEMENT IN ACQUIRED
IDIOPATHIC SIDEROBLASTIC ANEMIA.
PubMed=9851701; DOI=10.1046/j.1432-1327.1998.2580132.x;
Broker S., Meunier B., Rich P., Gattermann N., Hofhaus G.;
"MtDNA mutations associated with sideroblastic anaemia cause a defect
of mitochondrial cytochrome c oxidase.";
Eur. J. Biochem. 258:132-138(1998).
[16]
INVOLVEMENT IN RM-MT.
PubMed=10980727; DOI=10.1212/WNL.55.5.644;
Karadimas C.L., Greenstein P., Sue C.M., Joseph J.T., Tanji K.,
Haller R.G., Taivassalo T., Davidson M.M., Shanske S., Bonilla E.,
DiMauro S.;
"Recurrent myoglobinuria due to a nonsense mutation in the COX I gene
of mitochondrial DNA.";
Neurology 55:644-649(2000).
[17]
VARIANT MT-C4D ILE-196.
PubMed=12140182; DOI=10.1093/hmg/11.16.1797;
Varlamov D.A., Kudin A.P., Vielhaber S., Schroeder R., Sassen R.,
Becker A., Kunz D., Haug K., Rebstock J., Heils A., Elger C.E.,
Kunz W.S.;
"Metabolic consequences of a novel missense mutation of the mtDNA CO I
gene.";
Hum. Mol. Genet. 11:1797-1805(2002).
[18]
VARIANT MT-C4D PHE-142, AND CHARACTERIZATION OF VARIANT MT-C4D
PHE-142.
PubMed=16284789; DOI=10.1007/s10048-005-0015-z;
Lucioli S., Hoffmeier K., Carrozzo R., Tessa A., Ludwig B.,
Santorelli F.M.;
"Introducing a novel human mtDNA mutation into the Paracoccus
denitrificans COX I gene explains functional deficits in a patient.";
Neurogenetics 7:51-57(2006).
[19]
VARIANTS CRC ASP-125 AND PRO-458.
PubMed=16407113; DOI=10.1073/pnas.0505903103;
Greaves L.C., Preston S.L., Tadrous P.J., Taylor R.W., Barron M.J.,
Oukrif D., Leedham S.J., Deheragoda M., Sasieni P., Novelli M.R.,
Jankowski J.A.Z., Turnbull D.M., Wright N.A., McDonald S.A.C.;
"Mitochondrial DNA mutations are established in human colonic stem
cells, and mutated clones expand by crypt fission.";
Proc. Natl. Acad. Sci. U.S.A. 103:714-719(2006).
[20]
CHARACTERIZATION OF VARIANTS CRC ASP-125 AND PRO-458.
PubMed=19218458; DOI=10.1073/pnas.0811450106;
Namslauer I., Brzezinski P.;
"A mitochondrial DNA mutation linked to colon cancer results in proton
leaks in cytochrome c oxidase.";
Proc. Natl. Acad. Sci. U.S.A. 106:3402-3407(2009).
-!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
chain that catalyzes the reduction of oxygen to water. Subunits 1-
3 form the functional core of the enzyme complex. CO I is the
catalytic subunit of the enzyme. Electrons originating in
cytochrome c are transferred via the copper A center of subunit 2
and heme A of subunit 1 to the bimetallic center formed by heme A3
and copper B.
-!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
ferricytochrome c + 2 H(2)O.
-!- PATHWAY: Energy metabolism; oxidative phosphorylation.
-!- SUBUNIT: As a newly synthesized protein, rapidly incorporates into
a multi-subunit assembly intermediate in the inner membrane,
called MITRAC (mitochondrial translation regulation assembly
intermediate of cytochrome c oxidase) complex, whose core
components are COA3/MITRAC12 and COX14. Within the MITRAC complex,
interacts with COA3 and with SMIM20/MITRAC7; the interaction with
SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its
premature turnover (PubMed:26321642). Interacts with TMEM177 in a
COX20-dependent manner (PubMed:29154948).
{ECO:0000269|PubMed:26321642, ECO:0000269|PubMed:29154948}.
-!- INTERACTION:
Q9Y2R0:COA3; NbExp=11; IntAct=EBI-2117234, EBI-6570446;
P13073:COX4I1; NbExp=2; IntAct=EBI-2117234, EBI-1056574;
Q9BVV7:TIMM21; NbExp=3; IntAct=EBI-2117234, EBI-6570759;
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
membrane protein.
-!- DISEASE: Leber hereditary optic neuropathy (LHON) [MIM:535000]: A
maternally inherited disease resulting in acute or subacute loss
of central vision, due to optic nerve dysfunction. Cardiac
conduction defects and neurological defects have also been
described in some patients. LHON results from primary
mitochondrial DNA mutations affecting the respiratory chain
complexes. {ECO:0000269|PubMed:1322638}. Note=The disease is
caused by mutations affecting the gene represented in this entry.
-!- DISEASE: Note=MT-CO1 may play a role in the pathogenesis of
acquired idiopathic sideroblastic anemia, a disease characterized
by inadequate formation of heme and excessive accumulation of iron
in mitochondria. Mitochondrial iron overload may be attributable
to mutations of mitochondrial DNA because these can cause
respiratory chain dysfunction, thereby impairing reduction of
ferric iron to ferrous iron. The reduced form of iron is essential
to the last step of mitochondrial heme biosynthesis.
{ECO:0000269|PubMed:9389715, ECO:0000269|PubMed:9851701}.
-!- DISEASE: Mitochondrial complex IV deficiency (MT-C4D)
[MIM:220110]: A disorder of the mitochondrial respiratory chain
with heterogeneous clinical manifestations, ranging from isolated
myopathy to severe multisystem disease affecting several tissues
and organs. Features include hypertrophic cardiomyopathy,
hepatomegaly and liver dysfunction, hypotonia, muscle weakness,
exercise intolerance, developmental delay, delayed motor
development and mental retardation. Some affected individuals
manifest a fatal hypertrophic cardiomyopathy resulting in neonatal
death. A subset of patients manifest Leigh syndrome.
{ECO:0000269|PubMed:12140182, ECO:0000269|PubMed:16284789}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- DISEASE: Recurrent myoglobinuria mitochondrial (RM-MT)
[MIM:550500]: Recurrent myoglobinuria is characterized by
recurrent attacks of rhabdomyolysis (necrosis or disintegration of
skeletal muscle) associated with muscle pain and weakness, and
followed by excretion of myoglobin in the urine.
{ECO:0000269|PubMed:10980727}. Note=The gene represented in this
entry may be involved in disease pathogenesis.
-!- DISEASE: Deafness, sensorineural, mitochondrial (DFNM)
[MIM:500008]: A form of non-syndromic deafness with maternal
inheritance. Affected individuals manifest progressive,
postlingual, sensorineural hearing loss involving high
frequencies. {ECO:0000269|PubMed:10577941}. Note=The disease is
caused by mutations affecting the gene represented in this entry.
-!- DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease
characterized by malignant lesions arising from the inner wall of
the large intestine (the colon) and the rectum. Genetic
alterations are often associated with progression from
premalignant lesion (adenoma) to invasive adenocarcinoma. Risk
factors for cancer of the colon and rectum include colon polyps,
long-standing ulcerative colitis, and genetic family history.
{ECO:0000269|PubMed:16407113, ECO:0000269|PubMed:19218458}.
Note=The gene represented in this entry may be involved in disease
pathogenesis.
-!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
{ECO:0000305}.
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EMBL; V00662; CAA24028.1; -; Genomic_DNA.
EMBL; J01415; AAB58945.1; -; Genomic_DNA.
EMBL; D38112; BAA07292.1; -; Genomic_DNA.
EMBL; AY339402; AAP89038.1; -; Genomic_DNA.
EMBL; AY339403; AAP89051.1; -; Genomic_DNA.
EMBL; AY339404; AAP89064.1; -; Genomic_DNA.
EMBL; AY339405; AAP89077.1; -; Genomic_DNA.
EMBL; AY339406; AAP89090.1; -; Genomic_DNA.
EMBL; AY339407; AAP89103.1; -; Genomic_DNA.
EMBL; AY339408; AAP89116.1; -; Genomic_DNA.
EMBL; AY339409; AAP89129.1; -; Genomic_DNA.
EMBL; AY339410; AAP89142.1; -; Genomic_DNA.
EMBL; AY339411; AAP89155.1; -; Genomic_DNA.
EMBL; AY339412; AAP89168.1; -; Genomic_DNA.
EMBL; AY339421; AAP89285.1; -; Genomic_DNA.
EMBL; AY339422; AAP89298.1; -; Genomic_DNA.
EMBL; AY339423; AAP89311.1; -; Genomic_DNA.
EMBL; AY339424; AAP89324.1; -; Genomic_DNA.
EMBL; AY339425; AAP89337.1; -; Genomic_DNA.
EMBL; AY339426; AAP89350.1; -; Genomic_DNA.
EMBL; AY339427; AAP89363.1; -; Genomic_DNA.
EMBL; AY339428; AAP89376.1; -; Genomic_DNA.
EMBL; AY339429; AAP89389.1; -; Genomic_DNA.
EMBL; AY339430; AAP89402.1; -; Genomic_DNA.
EMBL; AY339431; AAP89415.1; -; Genomic_DNA.
EMBL; AY339432; AAP89428.1; -; Genomic_DNA.
EMBL; AY339433; AAP89441.1; -; Genomic_DNA.
EMBL; AY339434; AAP89454.1; -; Genomic_DNA.
EMBL; AY339435; AAP89467.1; -; Genomic_DNA.
EMBL; AY339436; AAP89480.1; -; Genomic_DNA.
EMBL; AY339437; AAP89493.1; -; Genomic_DNA.
EMBL; AY339438; AAP89506.1; -; Genomic_DNA.
EMBL; AY339439; AAP89519.1; -; Genomic_DNA.
EMBL; AY339440; AAP89532.1; -; Genomic_DNA.
EMBL; AY339441; AAP89545.1; -; Genomic_DNA.
EMBL; AY339442; AAP89558.1; -; Genomic_DNA.
EMBL; AY339443; AAP89571.1; -; Genomic_DNA.
EMBL; AY339444; AAP89584.1; -; Genomic_DNA.
EMBL; AY339445; AAP89597.1; -; Genomic_DNA.
EMBL; AY339451; AAP89675.1; -; Genomic_DNA.
EMBL; AY339452; AAP89688.1; -; Genomic_DNA.
EMBL; AY339453; AAP89701.1; -; Genomic_DNA.
EMBL; AY339454; AAP89714.1; -; Genomic_DNA.
EMBL; AY339455; AAP89727.1; -; Genomic_DNA.
EMBL; AY339456; AAP89740.1; -; Genomic_DNA.
EMBL; AY339457; AAP89753.1; -; Genomic_DNA.
EMBL; AY339458; AAP89766.1; -; Genomic_DNA.
EMBL; AY339459; AAP89779.1; -; Genomic_DNA.
EMBL; AY339460; AAP89792.1; -; Genomic_DNA.
EMBL; AY339461; AAP89805.1; -; Genomic_DNA.
EMBL; AY339462; AAP89818.1; -; Genomic_DNA.
EMBL; AY339463; AAP89831.1; -; Genomic_DNA.
EMBL; AY339464; AAP89844.1; -; Genomic_DNA.
EMBL; AY339465; AAP89857.1; -; Genomic_DNA.
EMBL; AY339466; AAP89870.1; -; Genomic_DNA.
EMBL; AY339467; AAP89883.1; -; Genomic_DNA.
EMBL; AY339468; AAP89896.1; -; Genomic_DNA.
EMBL; AY339469; AAP89909.1; -; Genomic_DNA.
EMBL; AY339470; AAP89922.1; -; Genomic_DNA.
EMBL; AY339471; AAP89935.1; -; Genomic_DNA.
EMBL; AY339472; AAP89948.1; -; Genomic_DNA.
EMBL; AY339473; AAP89961.1; -; Genomic_DNA.
EMBL; AY339474; AAP89974.1; -; Genomic_DNA.
EMBL; AY339475; AAP89987.1; -; Genomic_DNA.
EMBL; AY339476; AAP90000.1; -; Genomic_DNA.
EMBL; AY339477; AAP90013.1; -; Genomic_DNA.
EMBL; AY339478; AAP90026.1; -; Genomic_DNA.
EMBL; AY339479; AAP90039.1; -; Genomic_DNA.
EMBL; AY339480; AAP90052.1; -; Genomic_DNA.
EMBL; AY339481; AAP90065.1; -; Genomic_DNA.
EMBL; AY339482; AAP90078.1; -; Genomic_DNA.
EMBL; AY339483; AAP90091.1; -; Genomic_DNA.
EMBL; AY339484; AAP90104.1; -; Genomic_DNA.
EMBL; AY339485; AAP90117.1; -; Genomic_DNA.
EMBL; AY339486; AAP90130.1; -; Genomic_DNA.
EMBL; AY339487; AAP90143.1; -; Genomic_DNA.
EMBL; AY339488; AAP90156.1; -; Genomic_DNA.
EMBL; AY339489; AAP90169.1; -; Genomic_DNA.
EMBL; AY339490; AAP90182.1; -; Genomic_DNA.
EMBL; AY339491; AAP90195.1; -; Genomic_DNA.
EMBL; AY339492; AAP90208.1; -; Genomic_DNA.
EMBL; AY339493; AAP90221.1; -; Genomic_DNA.
EMBL; AY339494; AAP90234.1; -; Genomic_DNA.
EMBL; AY339495; AAP90247.1; -; Genomic_DNA.
EMBL; AY339496; AAP90260.1; -; Genomic_DNA.
EMBL; AY339497; AAP90273.1; -; Genomic_DNA.
EMBL; AY339498; AAP90286.1; -; Genomic_DNA.
EMBL; AY339499; AAP90299.1; -; Genomic_DNA.
EMBL; AY339500; AAP90312.1; -; Genomic_DNA.
EMBL; AY339501; AAP90325.1; -; Genomic_DNA.
EMBL; AY339502; AAP90338.1; -; Genomic_DNA.
EMBL; AY339503; AAP90351.1; -; Genomic_DNA.
EMBL; AY339504; AAP90364.1; -; Genomic_DNA.
EMBL; AY339505; AAP90377.1; -; Genomic_DNA.
EMBL; AY339506; AAP90390.1; -; Genomic_DNA.
EMBL; AY339507; AAP90403.1; -; Genomic_DNA.
EMBL; AY339508; AAP90416.1; -; Genomic_DNA.
EMBL; AY339509; AAP90429.1; -; Genomic_DNA.
EMBL; AY339510; AAP90442.1; -; Genomic_DNA.
EMBL; AY339511; AAP90455.1; -; Genomic_DNA.
EMBL; AY339512; AAP90468.1; -; Genomic_DNA.
EMBL; AY339513; AAP90481.1; -; Genomic_DNA.
EMBL; AY339514; AAP90494.1; -; Genomic_DNA.
EMBL; AY339515; AAP90507.1; -; Genomic_DNA.
EMBL; AY339516; AAP90520.1; -; Genomic_DNA.
EMBL; AY339517; AAP90533.1; -; Genomic_DNA.
EMBL; AY339518; AAP90546.1; -; Genomic_DNA.
EMBL; AY339519; AAP90559.1; -; Genomic_DNA.
EMBL; AY339520; AAP90572.1; -; Genomic_DNA.
EMBL; AY339521; AAP90585.1; -; Genomic_DNA.
EMBL; AY339522; AAP90598.1; -; Genomic_DNA.
EMBL; AY339523; AAP90611.1; -; Genomic_DNA.
EMBL; AY339524; AAP90624.1; -; Genomic_DNA.
EMBL; AY339525; AAP90637.1; -; Genomic_DNA.
EMBL; AY339526; AAP90650.1; -; Genomic_DNA.
EMBL; AY339527; AAP90663.1; -; Genomic_DNA.
EMBL; AY339528; AAP90676.1; -; Genomic_DNA.
EMBL; AY339529; AAP90689.1; -; Genomic_DNA.
EMBL; AY339530; AAP90702.1; -; Genomic_DNA.
EMBL; AY339531; AAP90715.1; -; Genomic_DNA.
EMBL; AY339532; AAP90728.1; -; Genomic_DNA.
EMBL; AY339533; AAP90741.1; -; Genomic_DNA.
EMBL; AY339534; AAP90754.1; -; Genomic_DNA.
EMBL; AY339535; AAP90767.1; -; Genomic_DNA.
EMBL; AY339536; AAP90780.1; -; Genomic_DNA.
EMBL; AY339537; AAP90793.1; -; Genomic_DNA.
EMBL; AY339538; AAP90806.1; -; Genomic_DNA.
EMBL; AY339539; AAP90819.1; -; Genomic_DNA.
EMBL; AY339540; AAP90832.1; -; Genomic_DNA.
EMBL; AY339541; AAP90845.1; -; Genomic_DNA.
EMBL; AY339542; AAP90858.1; -; Genomic_DNA.
EMBL; AY339543; AAP90871.1; -; Genomic_DNA.
EMBL; AY339544; AAP90884.1; -; Genomic_DNA.
EMBL; AY339545; AAP90897.1; -; Genomic_DNA.
EMBL; AY339546; AAP90910.1; -; Genomic_DNA.
EMBL; AY339547; AAP90923.1; -; Genomic_DNA.
EMBL; AY339548; AAP90936.1; -; Genomic_DNA.
EMBL; AY339549; AAP90949.1; -; Genomic_DNA.
EMBL; AY339550; AAP90962.1; -; Genomic_DNA.
EMBL; AY339551; AAP90975.1; -; Genomic_DNA.
EMBL; AY339552; AAP90988.1; -; Genomic_DNA.
EMBL; AY339553; AAP91001.1; -; Genomic_DNA.
EMBL; AY339554; AAP91014.1; -; Genomic_DNA.
EMBL; AY339555; AAP91027.1; -; Genomic_DNA.
EMBL; AY339556; AAP91040.1; -; Genomic_DNA.
EMBL; AY339557; AAP91053.1; -; Genomic_DNA.
EMBL; AY339558; AAP91066.1; -; Genomic_DNA.
EMBL; AY339559; AAP91079.1; -; Genomic_DNA.
EMBL; AY339560; AAP91092.1; -; Genomic_DNA.
EMBL; AY339563; AAP91131.1; -; Genomic_DNA.
EMBL; AY339564; AAP91144.1; -; Genomic_DNA.
EMBL; AY339566; AAP91170.1; -; Genomic_DNA.
EMBL; AY339567; AAP91183.1; -; Genomic_DNA.
EMBL; AY339568; AAP91196.1; -; Genomic_DNA.
EMBL; AY339569; AAP91209.1; -; Genomic_DNA.
EMBL; AY339570; AAP91222.1; -; Genomic_DNA.
EMBL; AY339571; AAP91235.1; -; Genomic_DNA.
EMBL; AY339572; AAP91248.1; -; Genomic_DNA.
EMBL; AY339573; AAP91261.1; -; Genomic_DNA.
EMBL; AY339574; AAP91274.1; -; Genomic_DNA.
EMBL; AY339575; AAP91287.1; -; Genomic_DNA.
EMBL; AY339576; AAP91300.1; -; Genomic_DNA.
EMBL; AY339577; AAP91313.1; -; Genomic_DNA.
EMBL; AY339578; AAP91326.1; -; Genomic_DNA.
EMBL; AY339579; AAP91339.1; -; Genomic_DNA.
EMBL; AY339580; AAP91352.1; -; Genomic_DNA.
EMBL; AY339581; AAP91365.1; -; Genomic_DNA.
EMBL; AY339582; AAP91378.1; -; Genomic_DNA.
EMBL; AY339583; AAP91391.1; -; Genomic_DNA.
EMBL; AY339584; AAP91404.1; -; Genomic_DNA.
EMBL; AY339585; AAP91417.1; -; Genomic_DNA.
EMBL; AY339586; AAP91430.1; -; Genomic_DNA.
EMBL; AY339587; AAP91443.1; -; Genomic_DNA.
EMBL; AY339588; AAP91456.1; -; Genomic_DNA.
EMBL; AY339589; AAP91469.1; -; Genomic_DNA.
EMBL; AY339590; AAP91482.1; -; Genomic_DNA.
EMBL; AY339591; AAP91495.1; -; Genomic_DNA.
EMBL; AY339592; AAP91508.1; -; Genomic_DNA.
EMBL; AY339593; AAP91521.1; -; Genomic_DNA.
EMBL; AF346963; AAK17209.1; -; Genomic_DNA.
EMBL; AF346964; AAK17222.1; -; Genomic_DNA.
EMBL; AF346965; AAK17235.1; -; Genomic_DNA.
EMBL; AF346966; AAK17248.1; -; Genomic_DNA.
EMBL; AF346967; AAK17261.1; -; Genomic_DNA.
EMBL; AF346970; AAK17300.1; -; Genomic_DNA.
EMBL; AF346971; AAK17313.1; -; Genomic_DNA.
EMBL; AF346972; AAK17326.1; -; Genomic_DNA.
EMBL; AF346973; AAK17339.1; -; Genomic_DNA.
EMBL; AF346974; AAK17352.1; -; Genomic_DNA.
EMBL; AF346975; AAK17365.1; -; Genomic_DNA.
EMBL; AF346976; AAK17378.1; -; Genomic_DNA.
EMBL; AF346977; AAK17391.1; -; Genomic_DNA.
EMBL; AF346978; AAK17404.1; -; Genomic_DNA.
EMBL; AF346979; AAK17417.1; -; Genomic_DNA.
EMBL; AF346980; AAK17430.1; -; Genomic_DNA.
EMBL; AF346981; AAK17443.1; -; Genomic_DNA.
EMBL; AF346982; AAK17456.1; -; Genomic_DNA.
EMBL; AF346983; AAK17469.1; -; Genomic_DNA.
EMBL; AF346984; AAK17482.1; -; Genomic_DNA.
EMBL; AF346988; AAK17534.1; -; Genomic_DNA.
EMBL; AF346989; AAK17547.1; -; Genomic_DNA.
EMBL; AF346990; AAK17560.1; -; Genomic_DNA.
EMBL; AF346991; AAK17573.1; -; Genomic_DNA.
EMBL; AF346993; AAK17599.1; -; Genomic_DNA.
EMBL; AF346994; AAK17612.1; -; Genomic_DNA.
EMBL; AF346995; AAK17625.1; -; Genomic_DNA.
EMBL; AF346998; AAK17664.1; -; Genomic_DNA.
EMBL; AF347000; AAK17690.1; -; Genomic_DNA.
EMBL; AF347001; AAK17703.1; -; Genomic_DNA.
EMBL; AF347003; AAK17729.1; -; Genomic_DNA.
EMBL; AF347004; AAK17742.1; -; Genomic_DNA.
EMBL; AF347007; AAK17781.1; -; Genomic_DNA.
EMBL; AF347010; AAK17820.1; -; Genomic_DNA.
EMBL; AF347011; AAK17833.1; -; Genomic_DNA.
EMBL; AF347012; AAK17846.1; -; Genomic_DNA.
EMBL; AF347013; AAK17859.1; -; Genomic_DNA.
EMBL; AF347014; AAK17872.1; -; Genomic_DNA.
EMBL; AF347015; AAK17885.1; -; Genomic_DNA.
EMBL; AY289051; AAP47882.1; -; Genomic_DNA.
EMBL; AY289052; AAP47895.1; -; Genomic_DNA.
EMBL; AY289053; AAP47908.1; -; Genomic_DNA.
EMBL; AY289055; AAP47934.1; -; Genomic_DNA.
EMBL; AY289056; AAP47947.1; -; Genomic_DNA.
EMBL; AY289057; AAP47960.1; -; Genomic_DNA.
EMBL; AY289058; AAP47973.1; -; Genomic_DNA.
EMBL; AY289059; AAP47986.1; -; Genomic_DNA.
EMBL; AY289060; AAP47999.1; -; Genomic_DNA.
EMBL; AY289061; AAP48012.1; -; Genomic_DNA.
EMBL; AY289062; AAP48025.1; -; Genomic_DNA.
EMBL; AY289064; AAP48051.1; -; Genomic_DNA.
EMBL; AY289065; AAP48064.1; -; Genomic_DNA.
EMBL; AY289066; AAP48077.1; -; Genomic_DNA.
EMBL; AY289067; AAP48090.1; -; Genomic_DNA.
EMBL; AY289068; AAP48103.1; -; Genomic_DNA.
EMBL; AY289069; AAP48116.1; -; Genomic_DNA.
EMBL; AY289070; AAP48129.1; -; Genomic_DNA.
EMBL; AY289071; AAP48142.1; -; Genomic_DNA.
EMBL; AY289073; AAP48168.1; -; Genomic_DNA.
EMBL; AY289074; AAP48181.1; -; Genomic_DNA.
EMBL; AY289075; AAP48194.1; -; Genomic_DNA.
EMBL; AY289076; AAP48207.1; -; Genomic_DNA.
EMBL; AY289077; AAP48220.1; -; Genomic_DNA.
EMBL; AY289078; AAP48233.1; -; Genomic_DNA.
EMBL; AY289079; AAP48246.1; -; Genomic_DNA.
EMBL; AY289080; AAP48259.1; -; Genomic_DNA.
EMBL; AY289081; AAP48272.1; -; Genomic_DNA.
EMBL; AY289082; AAP48285.1; -; Genomic_DNA.
EMBL; AY289083; AAP48298.1; -; Genomic_DNA.
EMBL; AY289084; AAP48311.1; -; Genomic_DNA.
EMBL; AY289085; AAP48324.1; -; Genomic_DNA.
EMBL; AY289086; AAP48337.1; -; Genomic_DNA.
EMBL; AY289088; AAP48363.1; -; Genomic_DNA.
EMBL; AY289089; AAP48376.1; -; Genomic_DNA.
EMBL; AY289090; AAP48389.1; -; Genomic_DNA.
EMBL; AY289092; AAP48415.1; -; Genomic_DNA.
EMBL; AY289093; AAP48427.1; -; Genomic_DNA.
EMBL; AY289094; AAP48440.1; -; Genomic_DNA.
EMBL; AY289095; AAP48453.1; -; Genomic_DNA.
EMBL; AY289096; AAP48466.1; -; Genomic_DNA.
EMBL; AY289097; AAP48479.1; -; Genomic_DNA.
EMBL; AY289098; AAP48492.1; -; Genomic_DNA.
EMBL; AY289099; AAP48505.1; -; Genomic_DNA.
EMBL; AY289100; AAP48518.1; -; Genomic_DNA.
EMBL; AY289101; AAP48531.1; -; Genomic_DNA.
EMBL; AY289102; AAP48544.1; -; Genomic_DNA.
EMBL; AY495090; AAR92498.1; -; Genomic_DNA.
EMBL; AY495091; AAR92511.1; -; Genomic_DNA.
EMBL; AY495092; AAR92524.1; -; Genomic_DNA.
EMBL; AY495093; AAR92537.1; -; Genomic_DNA.
EMBL; AY495094; AAR92550.1; -; Genomic_DNA.
EMBL; AY495095; AAR92563.1; -; Genomic_DNA.
EMBL; AY495096; AAR92576.1; -; Genomic_DNA.
EMBL; AY495097; AAR92589.1; -; Genomic_DNA.
EMBL; AY495098; AAR92602.1; -; Genomic_DNA.
EMBL; AY495099; AAR92615.1; -; Genomic_DNA.
EMBL; AY495100; AAR92628.1; -; Genomic_DNA.
EMBL; AY495101; AAR92641.1; -; Genomic_DNA.
EMBL; AY495102; AAR92654.1; -; Genomic_DNA.
EMBL; AY495103; AAR92667.1; -; Genomic_DNA.
EMBL; AY495104; AAR92680.1; -; Genomic_DNA.
EMBL; AY495105; AAR92693.1; -; Genomic_DNA.
EMBL; AY495106; AAR92706.1; -; Genomic_DNA.
EMBL; AY495107; AAR92719.1; -; Genomic_DNA.
EMBL; AY495108; AAR92732.1; -; Genomic_DNA.
EMBL; AY495109; AAR92745.1; -; Genomic_DNA.
EMBL; AY495110; AAR92758.1; -; Genomic_DNA.
EMBL; AY495111; AAR92771.1; -; Genomic_DNA.
EMBL; AY495112; AAR92784.1; -; Genomic_DNA.
EMBL; AY495113; AAR92797.1; -; Genomic_DNA.
EMBL; AY495114; AAR92810.1; -; Genomic_DNA.
EMBL; AY495116; AAR92836.1; -; Genomic_DNA.
EMBL; AY495117; AAR92849.1; -; Genomic_DNA.
EMBL; AY495118; AAR92862.1; -; Genomic_DNA.
EMBL; AY495119; AAR92875.1; -; Genomic_DNA.
EMBL; AY495120; AAR92888.1; -; Genomic_DNA.
EMBL; AY495121; AAR92901.1; -; Genomic_DNA.
EMBL; AY495122; AAR92914.1; -; Genomic_DNA.
EMBL; AY495123; AAR92927.1; -; Genomic_DNA.
EMBL; AY495124; AAR92940.1; -; Genomic_DNA.
EMBL; AY495125; AAR92953.1; -; Genomic_DNA.
EMBL; AY495126; AAR92966.1; -; Genomic_DNA.
EMBL; AY495127; AAR92979.1; -; Genomic_DNA.
EMBL; AY495128; AAR92992.1; -; Genomic_DNA.
EMBL; AY495129; AAR93005.1; -; Genomic_DNA.
EMBL; AY495130; AAR93018.1; -; Genomic_DNA.
EMBL; AY495131; AAR93031.1; -; Genomic_DNA.
EMBL; AY495132; AAR93044.1; -; Genomic_DNA.
EMBL; AY495133; AAR93057.1; -; Genomic_DNA.
EMBL; AY495134; AAR93070.1; -; Genomic_DNA.
EMBL; AY495135; AAR93083.1; -; Genomic_DNA.
EMBL; AY495136; AAR93096.1; -; Genomic_DNA.
EMBL; AY495137; AAR93109.1; -; Genomic_DNA.
EMBL; AY495138; AAR93122.1; -; Genomic_DNA.
EMBL; AY495139; AAR93135.1; -; Genomic_DNA.
EMBL; AY495140; AAR93148.1; -; Genomic_DNA.
EMBL; AY495141; AAR93161.1; -; Genomic_DNA.
EMBL; AY495142; AAR93174.1; -; Genomic_DNA.
EMBL; AY495143; AAR93187.1; -; Genomic_DNA.
EMBL; AY495144; AAR93200.1; -; Genomic_DNA.
EMBL; AY495145; AAR93213.1; -; Genomic_DNA.
EMBL; AY495147; AAR93239.1; -; Genomic_DNA.
EMBL; AY495148; AAR93252.1; -; Genomic_DNA.
EMBL; AY495149; AAR93265.1; -; Genomic_DNA.
EMBL; AY495150; AAR93278.1; -; Genomic_DNA.
EMBL; AY495151; AAR93291.1; -; Genomic_DNA.
EMBL; AY495152; AAR93304.1; -; Genomic_DNA.
EMBL; AY495153; AAR93317.1; -; Genomic_DNA.
EMBL; AY495154; AAR93330.1; -; Genomic_DNA.
EMBL; AY495155; AAR93343.1; -; Genomic_DNA.
EMBL; AY495156; AAR93356.1; -; Genomic_DNA.
EMBL; AY495157; AAR93369.1; -; Genomic_DNA.
EMBL; AY495158; AAR93382.1; -; Genomic_DNA.
EMBL; AY495159; AAR93395.1; -; Genomic_DNA.
EMBL; AY495160; AAR93408.1; -; Genomic_DNA.
EMBL; AY495161; AAR93421.1; -; Genomic_DNA.
EMBL; AY495162; AAR93434.1; -; Genomic_DNA.
EMBL; AY495163; AAR93447.1; -; Genomic_DNA.
EMBL; AY495164; AAR93460.1; -; Genomic_DNA.
EMBL; AY495165; AAR93473.1; -; Genomic_DNA.
EMBL; AY495166; AAR93486.1; -; Genomic_DNA.
EMBL; AY495167; AAR93499.1; -; Genomic_DNA.
EMBL; AY495168; AAR93512.1; -; Genomic_DNA.
EMBL; AY495169; AAR93525.1; -; Genomic_DNA.
EMBL; AY495170; AAR93538.1; -; Genomic_DNA.
EMBL; AY495171; AAR93551.1; -; Genomic_DNA.
EMBL; AY495172; AAR93564.1; -; Genomic_DNA.
EMBL; AY495173; AAR93577.1; -; Genomic_DNA.
EMBL; AY495174; AAR93590.1; -; Genomic_DNA.
EMBL; AY495175; AAR93603.1; -; Genomic_DNA.
EMBL; AY495176; AAR93616.1; -; Genomic_DNA.
EMBL; AY495177; AAR93629.1; -; Genomic_DNA.
EMBL; AY495178; AAR93642.1; -; Genomic_DNA.
EMBL; AY495179; AAR93655.1; -; Genomic_DNA.
EMBL; AY495180; AAR93668.1; -; Genomic_DNA.
EMBL; AY495181; AAR93681.1; -; Genomic_DNA.
EMBL; AY495182; AAR93694.1; -; Genomic_DNA.
EMBL; AY495183; AAR93707.1; -; Genomic_DNA.
EMBL; AY495184; AAR93720.1; -; Genomic_DNA.
EMBL; AY495185; AAR93733.1; -; Genomic_DNA.
EMBL; AY495186; AAR93746.1; -; Genomic_DNA.
EMBL; AY495187; AAR93759.1; -; Genomic_DNA.
EMBL; AY495188; AAR93772.1; -; Genomic_DNA.
EMBL; AY495189; AAR93785.1; -; Genomic_DNA.
EMBL; AY495190; AAR93798.1; -; Genomic_DNA.
EMBL; AY495191; AAR93811.1; -; Genomic_DNA.
EMBL; AY495192; AAR93824.1; -; Genomic_DNA.
EMBL; AY495193; AAR93837.1; -; Genomic_DNA.
EMBL; AY495194; AAR93850.1; -; Genomic_DNA.
EMBL; AY495195; AAR93863.1; -; Genomic_DNA.
EMBL; AY495196; AAR93876.1; -; Genomic_DNA.
EMBL; AY495197; AAR93889.1; -; Genomic_DNA.
EMBL; AY495198; AAR93902.1; -; Genomic_DNA.
EMBL; AY495199; AAR93915.1; -; Genomic_DNA.
EMBL; AY495200; AAR93928.1; -; Genomic_DNA.
EMBL; AY495201; AAR93941.1; -; Genomic_DNA.
EMBL; AY495202; AAR93954.1; -; Genomic_DNA.
EMBL; AY495203; AAR93967.1; -; Genomic_DNA.
EMBL; AY495204; AAR93980.1; -; Genomic_DNA.
EMBL; AY495205; AAR93993.1; -; Genomic_DNA.
EMBL; AY495206; AAR94006.1; -; Genomic_DNA.
EMBL; AY495207; AAR94019.1; -; Genomic_DNA.
EMBL; AY495208; AAR94032.1; -; Genomic_DNA.
EMBL; AY495209; AAR94045.1; -; Genomic_DNA.
EMBL; AY495210; AAR94058.1; -; Genomic_DNA.
EMBL; AY495211; AAR94071.1; -; Genomic_DNA.
EMBL; AY495212; AAR94084.1; -; Genomic_DNA.
EMBL; AY495213; AAR94097.1; -; Genomic_DNA.
EMBL; AY495214; AAR94110.1; -; Genomic_DNA.
EMBL; AY495215; AAR94123.1; -; Genomic_DNA.
EMBL; AY495216; AAR94136.1; -; Genomic_DNA.
EMBL; AY495217; AAR94149.1; -; Genomic_DNA.
EMBL; AY495218; AAR94162.1; -; Genomic_DNA.
EMBL; AY495219; AAR94175.1; -; Genomic_DNA.
EMBL; AY495220; AAR94188.1; -; Genomic_DNA.
EMBL; AY495221; AAR94201.1; -; Genomic_DNA.
EMBL; AY495222; AAR94214.1; -; Genomic_DNA.
EMBL; AY495223; AAR94227.1; -; Genomic_DNA.
EMBL; AY495224; AAR94240.1; -; Genomic_DNA.
EMBL; AY495225; AAR94253.1; -; Genomic_DNA.
EMBL; AY495226; AAR94266.1; -; Genomic_DNA.
EMBL; AY495228; AAR94292.1; -; Genomic_DNA.
EMBL; AY495230; AAR94318.1; -; Genomic_DNA.
EMBL; AY495231; AAR94331.1; -; Genomic_DNA.
EMBL; AY495232; AAR94344.1; -; Genomic_DNA.
EMBL; AY495233; AAR94357.1; -; Genomic_DNA.
EMBL; AY495234; AAR94370.1; -; Genomic_DNA.
EMBL; AY495235; AAR94383.1; -; Genomic_DNA.
EMBL; AY495236; AAR94396.1; -; Genomic_DNA.
EMBL; AY495237; AAR94409.1; -; Genomic_DNA.
EMBL; AY495239; AAR94435.1; -; Genomic_DNA.
EMBL; AY495240; AAR94448.1; -; Genomic_DNA.
EMBL; AY495241; AAR94461.1; -; Genomic_DNA.
EMBL; AY495242; AAR94474.1; -; Genomic_DNA.
EMBL; AY495243; AAR94487.1; -; Genomic_DNA.
EMBL; AY495244; AAR94500.1; -; Genomic_DNA.
EMBL; AY495245; AAR94513.1; -; Genomic_DNA.
EMBL; AY495246; AAR94526.1; -; Genomic_DNA.
EMBL; AY495247; AAR94539.1; -; Genomic_DNA.
EMBL; AY495248; AAR94552.1; -; Genomic_DNA.
EMBL; AY495249; AAR94565.1; -; Genomic_DNA.
EMBL; AY495250; AAR94578.1; -; Genomic_DNA.
EMBL; AY495251; AAR94591.1; -; Genomic_DNA.
EMBL; AY495252; AAR94604.1; -; Genomic_DNA.
EMBL; AY495253; AAR94617.1; -; Genomic_DNA.
EMBL; AY495254; AAR94630.1; -; Genomic_DNA.
EMBL; AY495255; AAR94643.1; -; Genomic_DNA.
EMBL; AY495256; AAR94656.1; -; Genomic_DNA.
EMBL; AY495258; AAR94682.1; -; Genomic_DNA.
EMBL; AY495259; AAR94695.1; -; Genomic_DNA.
EMBL; AY495261; AAR94721.1; -; Genomic_DNA.
EMBL; AY495262; AAR94734.1; -; Genomic_DNA.
EMBL; AY495263; AAR94747.1; -; Genomic_DNA.
EMBL; AY495264; AAR94760.1; -; Genomic_DNA.
EMBL; AY495265; AAR94773.1; -; Genomic_DNA.
EMBL; AY495266; AAR94786.1; -; Genomic_DNA.
EMBL; AY495267; AAR94799.1; -; Genomic_DNA.
EMBL; AY495268; AAR94812.1; -; Genomic_DNA.
EMBL; AY495269; AAR94825.1; -; Genomic_DNA.
EMBL; AY495270; AAR94838.1; -; Genomic_DNA.
EMBL; AY495271; AAR94851.1; -; Genomic_DNA.
EMBL; AY495272; AAR94864.1; -; Genomic_DNA.
EMBL; AY495273; AAR94877.1; -; Genomic_DNA.
EMBL; AY495274; AAR94890.1; -; Genomic_DNA.
EMBL; AY495275; AAR94903.1; -; Genomic_DNA.
EMBL; AY495276; AAR94916.1; -; Genomic_DNA.
EMBL; AY495277; AAR94929.1; -; Genomic_DNA.
EMBL; AY495278; AAR94942.1; -; Genomic_DNA.
EMBL; AY495279; AAR94955.1; -; Genomic_DNA.
EMBL; AY495280; AAR94968.1; -; Genomic_DNA.
EMBL; AY495281; AAR94981.1; -; Genomic_DNA.
EMBL; AY495282; AAR94994.1; -; Genomic_DNA.
EMBL; AY495283; AAR95007.1; -; Genomic_DNA.
EMBL; AY495284; AAR95020.1; -; Genomic_DNA.
EMBL; AY495285; AAR95033.1; -; Genomic_DNA.
EMBL; AY495286; AAR95046.1; -; Genomic_DNA.
EMBL; AY495287; AAR95059.1; -; Genomic_DNA.
EMBL; AY495288; AAR95072.1; -; Genomic_DNA.
EMBL; AY495289; AAR95085.1; -; Genomic_DNA.
EMBL; AY495290; AAR95098.1; -; Genomic_DNA.
EMBL; AY495291; AAR95111.1; -; Genomic_DNA.
EMBL; AY495292; AAR95124.1; -; Genomic_DNA.
EMBL; AY495293; AAR95137.1; -; Genomic_DNA.
EMBL; AY495294; AAR95150.1; -; Genomic_DNA.
EMBL; AY495295; AAR95163.1; -; Genomic_DNA.
EMBL; AY495297; AAR95189.1; -; Genomic_DNA.
EMBL; AY495298; AAR95202.1; -; Genomic_DNA.
EMBL; AY495299; AAR95215.1; -; Genomic_DNA.
EMBL; AY495300; AAR95228.1; -; Genomic_DNA.
EMBL; AY495301; AAR95241.1; -; Genomic_DNA.
EMBL; AY495302; AAR95254.1; -; Genomic_DNA.
EMBL; AY495303; AAR95267.1; -; Genomic_DNA.
EMBL; AY495304; AAR95280.1; -; Genomic_DNA.
EMBL; AY495305; AAR95293.1; -; Genomic_DNA.
EMBL; AY495306; AAR95306.1; -; Genomic_DNA.
EMBL; AY495307; AAR95319.1; -; Genomic_DNA.
EMBL; AY495308; AAR95332.1; -; Genomic_DNA.
EMBL; AY495309; AAR95345.1; -; Genomic_DNA.
EMBL; AY495310; AAR95358.1; -; Genomic_DNA.
EMBL; AY495311; AAR95371.1; -; Genomic_DNA.
EMBL; AY495312; AAR95384.1; -; Genomic_DNA.
EMBL; AY495313; AAR95397.1; -; Genomic_DNA.
EMBL; AY495314; AAR95410.1; -; Genomic_DNA.
EMBL; AY495315; AAR95423.1; -; Genomic_DNA.
EMBL; AY495316; AAR95436.1; -; Genomic_DNA.
EMBL; AY495317; AAR95449.1; -; Genomic_DNA.
EMBL; AY495318; AAR95462.1; -; Genomic_DNA.
EMBL; AY495319; AAR95475.1; -; Genomic_DNA.
EMBL; AY495320; AAR95488.1; -; Genomic_DNA.
EMBL; AY495322; AAR95514.1; -; Genomic_DNA.
EMBL; AY495323; AAR95527.1; -; Genomic_DNA.
EMBL; AY495324; AAR95540.1; -; Genomic_DNA.
EMBL; AY495325; AAR95553.1; -; Genomic_DNA.
EMBL; AY495326; AAR95566.1; -; Genomic_DNA.
EMBL; AY495327; AAR95579.1; -; Genomic_DNA.
EMBL; AY495328; AAR95592.1; -; Genomic_DNA.
EMBL; AY495329; AAR95605.1; -; Genomic_DNA.
EMBL; AY495330; AAR95618.1; -; Genomic_DNA.
EMBL; M10546; AAA65503.1; -; Genomic_DNA.
PIR; A00463; ODHU1.
RefSeq; YP_003024028.1; NC_012920.1.
ProteinModelPortal; P00395; -.
SMR; P00395; -.
BioGrid; 110615; 36.
CORUM; P00395; -.
IntAct; P00395; 15.
MINT; P00395; -.
STRING; 9606.ENSP00000354499; -.
BindingDB; P00395; -.
ChEMBL; CHEMBL6173; -.
DrugBank; DB02659; Cholic Acid.
DrugBank; DB04464; N-Formylmethionine.
DrugBank; DB09325; Sodium fluoride.
TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
iPTMnet; P00395; -.
PhosphoSitePlus; P00395; -.
DMDM; 116977; -.
EPD; P00395; -.
PaxDb; P00395; -.
PeptideAtlas; P00395; -.
PRIDE; P00395; -.
ProteomicsDB; 51246; -.
TopDownProteomics; P00395; -.
Ensembl; ENST00000361624; ENSP00000354499; ENSG00000198804.
GeneID; 4512; -.
KEGG; hsa:4512; -.
CTD; 4512; -.
DisGeNET; 4512; -.
EuPathDB; HostDB:ENSG00000198804.2; -.
GeneCards; MT-CO1; -.
GeneReviews; MT-CO1; -.
HGNC; HGNC:7419; MT-CO1.
HPA; CAB016241; -.
HPA; HPA069328; -.
MalaCards; MT-CO1; -.
MIM; 114500; phenotype.
MIM; 220110; phenotype.
MIM; 500008; phenotype.
MIM; 516030; gene.
MIM; 535000; phenotype.
MIM; 550500; phenotype.
neXtProt; NX_P00395; -.
OpenTargets; ENSG00000198804; -.
Orphanet; 99845; Genetic recurrent myoglobinuria.
Orphanet; 254905; Isolated cytochrome C oxidase deficiency.
Orphanet; 104; Leber hereditary optic neuropathy.
Orphanet; 255210; Maternally-inherited Leigh syndrome.
Orphanet; 550; MELAS.
Orphanet; 90641; Mitochondrial non-syndromic sensorineural deafness.
Orphanet; 168609; Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure.
PharmGKB; PA31225; -.
eggNOG; KOG4769; Eukaryota.
eggNOG; COG0843; LUCA.
GeneTree; ENSGT00390000001518; -.
HOVERGEN; HBG003841; -.
InParanoid; P00395; -.
KO; K02256; -.
OMA; MSFWLLP; -.
OrthoDB; EOG091G035B; -.
PhylomeDB; P00395; -.
TreeFam; TF353096; -.
BRENDA; 1.9.3.1; 2681.
Reactome; R-HSA-5628897; TP53 Regulates Metabolic Genes.
Reactome; R-HSA-611105; Respiratory electron transport.
UniPathway; UPA00705; -.
ChiTaRS; MT-CO1; human.
GeneWiki; MT-CO1; -.
GenomeRNAi; 4512; -.
PRO; PR:P00395; -.
Proteomes; UP000005640; Mitochondrion.
Bgee; ENSG00000198804; Expressed in 93 organ(s), highest expression level in esophagus.
ExpressionAtlas; P00395; baseline and differential.
Genevisible; P00395; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO; GO:0005750; C:mitochondrial respiratory chain complex III; IDA:UniProtKB.
GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IDA:UniProtKB.
GO; GO:0045277; C:respiratory chain complex IV; IDA:UniProtKB.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
CDD; cd01663; Cyt_c_Oxidase_I; 1.
Gene3D; 1.20.210.10; -; 1.
InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
InterPro; IPR000883; Cyt_C_Oxase_1.
InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
InterPro; IPR033944; Cyt_c_oxase_su1_dom.
PANTHER; PTHR10422; PTHR10422; 1.
Pfam; PF00115; COX1; 1.
PRINTS; PR01165; CYCOXIDASEI.
SUPFAM; SSF81442; SSF81442; 1.
PROSITE; PS50855; COX1; 1.
PROSITE; PS00077; COX1_CUB; 1.
1: Evidence at protein level;
Complete proteome; Copper; Deafness; Disease mutation;
Electron transport; Heme; Iron; Leber hereditary optic neuropathy;
Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane;
Non-syndromic deafness; Oxidoreductase; Polymorphism;
Primary mitochondrial disease; Reference proteome; Respiratory chain;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 513 Cytochrome c oxidase subunit 1.
/FTId=PRO_0000183345.
TOPO_DOM 1 19 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 20 42 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 43 56 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 57 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 99 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 100 122 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 123 146 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 147 169 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 170 181 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 182 204 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 205 235 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 236 258 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 259 270 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 271 293 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 294 302 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 303 325 Helical; Name=8. {ECO:0000255}.
TOPO_DOM 326 336 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 337 359 Helical; Name=9. {ECO:0000255}.
TOPO_DOM 360 373 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 374 396 Helical; Name=10. {ECO:0000255}.
TOPO_DOM 397 408 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 409 431 Helical; Name=11. {ECO:0000255}.
TOPO_DOM 432 450 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 451 473 Helical; Name=12. {ECO:0000255}.
TOPO_DOM 474 513 Mitochondrial matrix. {ECO:0000255}.
METAL 61 61 Iron (heme A axial ligand).
{ECO:0000305}.
METAL 240 240 Copper B. {ECO:0000305}.
METAL 244 244 Copper B. {ECO:0000305}.
METAL 290 290 Copper B. {ECO:0000305}.
METAL 291 291 Copper B. {ECO:0000305}.
METAL 376 376 Iron (heme A3 axial ligand).
{ECO:0000305}.
METAL 378 378 Iron (heme A axial ligand).
{ECO:0000305}.
CROSSLNK 240 244 1'-histidyl-3'-tyrosine (His-Tyr).
{ECO:0000250}.
VARIANT 10 10 T -> A. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008566.
VARIANT 94 94 F -> C. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008567.
VARIANT 125 125 G -> D (in CRC; displays steady-state
catalytic activity linked to proton
pumping that is approximately 34% of
wild-type; an intrinsic proton leak is
find in the enzyme, which will lead to
decreased overall energy-conversion
efficiency of the respiratory chain,
perturbing transport processes such as
protein, ion and metabolite trafficking;
dbSNP:rs281865417).
{ECO:0000269|PubMed:16407113,
ECO:0000269|PubMed:19218458}.
/FTId=VAR_064154.
VARIANT 142 142 S -> F (in MT-C4D; significant decrease
in enzyme activity; dbSNP:rs267606883).
{ECO:0000269|PubMed:16284789}.
/FTId=VAR_033055.
VARIANT 155 155 V -> L. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008568.
VARIANT 196 196 L -> I (in MT-C4D; dbSNP:rs28461189).
{ECO:0000269|PubMed:12140182}.
/FTId=VAR_033056.
VARIANT 224 224 G -> A. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008569.
VARIANT 235 235 F -> S (in dbSNP:rs2853818).
{ECO:0000269|PubMed:7530363}.
/FTId=VAR_011342.
VARIANT 273 273 M -> T (found in two patients with
acquired idiopathic sideroblastic anemia;
dbSNP:rs199476127).
{ECO:0000269|PubMed:9389715,
ECO:0000269|PubMed:9851701}.
/FTId=VAR_008385.
VARIANT 280 280 I -> T (found in two patients with
acquired idiopathic sideroblastic anemia;
dbSNP:rs199476126).
{ECO:0000269|PubMed:9389715,
ECO:0000269|PubMed:9851701}.
/FTId=VAR_008386.
VARIANT 305 305 F -> L (in dbSNP:rs368552121).
{ECO:0000269|PubMed:1757091}.
/FTId=VAR_008570.
VARIANT 415 415 T -> A (in dbSNP:rs372136420).
{ECO:0000269|PubMed:7530363}.
/FTId=VAR_011343.
VARIANT 458 458 S -> P (in CRC; the mutant is probably
not expressed, indicating that the amino
acid substitution results in a severely
altered overall structure of the enzyme;
dbSNP:rs267606884).
{ECO:0000269|PubMed:16407113,
ECO:0000269|PubMed:19218458}.
/FTId=VAR_064155.
VARIANT 513 513 S -> SKQK (in LHON; secondary mutation;
does not seem to directly cause the
disease). {ECO:0000269|PubMed:1322638}.
/FTId=VAR_008387.
SEQUENCE 513 AA; 57041 MW; DBCBFE808650AE0D CRC64;
MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA
HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA
GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ
TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH
PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG
VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR
KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS


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