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Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I)

 COX1_PHOVI              Reviewed;         514 AA.
Q00527; Q08H17;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 1.
28-FEB-2018, entry version 103.
RecName: Full=Cytochrome c oxidase subunit 1;
EC=1.9.3.1;
AltName: Full=Cytochrome c oxidase polypeptide I;
Name=MT-CO1; Synonyms=COI, COXI, MTCO1;
Phoca vitulina (Harbor seal).
Mitochondrion.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Phocidae;
Phoca.
NCBI_TaxID=9720;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1593642; DOI=10.1007/BF00160463;
Arnason U., Johnsson E.;
"The complete mitochondrial DNA sequence of the harbor seal, Phoca
vitulina.";
J. Mol. Evol. 34:493-505(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=16815048; DOI=10.1016/j.ympev.2006.05.022;
Arnason U., Gullberg A., Janke A., Kullberg M., Lehman N.,
Petrov E.A., Vainola R.;
"Pinniped phylogeny and a new hypothesis for their origin and
dispersal.";
Mol. Phylogenet. Evol. 41:345-354(2006).
-!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
chain that catalyzes the reduction of oxygen to water. Subunits 1-
3 form the functional core of the enzyme complex. CO I is the
catalytic subunit of the enzyme. Electrons originating in
cytochrome c are transferred via the copper A center of subunit 2
and heme A of subunit 1 to the bimetallic center formed by heme A3
and copper B.
-!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
ferricytochrome c + 2 H(2)O.
-!- PATHWAY: Energy metabolism; oxidative phosphorylation.
-!- SUBUNIT: As a newly synthesized protein, rapidly incorporates into
a multi-subunit assembly intermediate in the inner membrane,
called MITRAC (mitochondrial translation regulation assembly
intermediate of cytochrome c oxidase) complex, whose core
components are COA3/MITRAC12 and COX14. Within the MITRAC complex,
interacts with COA3 and with SMIM20/MITRAC7; the interaction with
SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its
premature turnover. Interacts with TMEM177 in a COX20-dependent
manner. {ECO:0000250|UniProtKB:P00395}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
membrane protein.
-!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
{ECO:0000305}.
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EMBL; X63726; CAA45259.1; -; Genomic_DNA.
EMBL; AM181032; CAJ57081.1; -; Genomic_DNA.
PIR; S26153; S26153.
RefSeq; NP_006930.1; NC_001325.1.
ProteinModelPortal; Q00527; -.
SMR; Q00527; -.
GeneID; 807649; -.
CTD; 4512; -.
HOVERGEN; HBG003841; -.
UniPathway; UPA00705; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
CDD; cd01663; Cyt_c_Oxidase_I; 1.
Gene3D; 1.20.210.10; -; 1.
InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
InterPro; IPR000883; Cyt_C_Oxase_1.
InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
InterPro; IPR033944; Cyt_c_oxase_su1_dom.
PANTHER; PTHR10422; PTHR10422; 1.
Pfam; PF00115; COX1; 1.
PRINTS; PR01165; CYCOXIDASEI.
SUPFAM; SSF81442; SSF81442; 1.
PROSITE; PS50855; COX1; 1.
PROSITE; PS00077; COX1_CUB; 1.
3: Inferred from homology;
Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
Respiratory chain; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 514 Cytochrome c oxidase subunit 1.
/FTId=PRO_0000183388.
TRANSMEM 17 37 Helical. {ECO:0000255}.
TRANSMEM 56 76 Helical. {ECO:0000255}.
TRANSMEM 102 122 Helical. {ECO:0000255}.
TRANSMEM 145 165 Helical. {ECO:0000255}.
TRANSMEM 183 203 Helical. {ECO:0000255}.
TRANSMEM 234 254 Helical. {ECO:0000255}.
TRANSMEM 268 288 Helical. {ECO:0000255}.
TRANSMEM 310 330 Helical. {ECO:0000255}.
TRANSMEM 338 358 Helical. {ECO:0000255}.
TRANSMEM 380 400 Helical. {ECO:0000255}.
TRANSMEM 412 432 Helical. {ECO:0000255}.
TRANSMEM 456 476 Helical. {ECO:0000255}.
METAL 61 61 Iron (heme A axial ligand).
{ECO:0000305}.
METAL 240 240 Copper B. {ECO:0000305}.
METAL 244 244 Copper B. {ECO:0000305}.
METAL 290 290 Copper B. {ECO:0000305}.
METAL 291 291 Copper B. {ECO:0000305}.
METAL 376 376 Iron (heme A3 axial ligand).
{ECO:0000305}.
METAL 378 378 Iron (heme A axial ligand).
{ECO:0000305}.
CROSSLNK 240 244 1'-histidyl-3'-tyrosine (His-Tyr).
{ECO:0000250}.
SEQUENCE 514 AA; 56983 MW; 05C73521837AA09A CRC64;
MFMNRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGALLGD DQIYNVIVTA
HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLLASSMVEA
GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMSQYQ
TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH
PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV GGLTGIVLAN
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF SGYMLDDTWA KIHFTIMFVG
VNMTFFPQHF LGLSGMPRRY SDYPDAYTTW NTVSSMGSFI SLTAVMLMVF MIWEAFASKR
EVAAVELTTT NIEWLHGCPP PYHTFEEPTY VVLK


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