GENTAUR Molecular Products.

 A0A0B5EAW1_RADBA        Unreviewed;       194 AA.
 A0A0B5EAW1;
 01-APR-2015, integrated into UniProtKB/TrEMBL.
 01-APR-2015, sequence version 1.
 23-MAY-2018, entry version 11.
 RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369};
          EC=1.9.3.1 {ECO:0000256|RuleBase:RU000369};
 Flags: Fragment;
 Name=COI {ECO:0000313|EMBL:AJE70540.1};
 Radix balthica (Wandering pond snail) (Radix ovata).
 Mitochondrion {ECO:0000313|EMBL:AJE70540.1}.
 Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
 Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
 Lymnaeidae; Radix.
 NCBI_TaxID=582868 {ECO:0000313|EMBL:AJE70540.1};
 [1] {ECO:0000313|EMBL:AJE70540.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=FEL4 {ECO:0000313|EMBL:AJE70540.1};
 PubMed=25533031; DOI=10.1111/mec.13049;
 Patel S., Schell T., Eifert C., Feldmeyer B., Pfenninger M.;
 "Characterizing a hybrid zone between a cryptic species pair of
 freshwater snails.";
 Mol. Ecol. 24:643-655(2015).
 -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
     chain that catalyzes the reduction of oxygen to water. Subunits 1-
     3 form the functional core of the enzyme complex. CO I is the
     catalytic subunit of the enzyme. Electrons originating in
     cytochrome c are transferred via the copper A center of subunit 2
     and heme A of subunit 1 to the bimetallic center formed by heme A3
     and copper B. {ECO:0000256|RuleBase:RU000369}.
 -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
     ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU000369}.
 -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
     {ECO:0000256|RuleBase:RU000369}.
 -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
     {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein
     {ECO:0000256|RuleBase:RU000369}.
 -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
     {ECO:0000256|RuleBase:RU000369}.
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 EMBL; KP242572; AJE70540.1; -; Genomic_DNA.
 UniPathway; UPA00705; -.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
 GO; GO:0020037; F:heme binding; IEA:InterPro.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
 GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
 Gene3D; 1.20.210.10; -; 1.
 InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
 InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
 InterPro; IPR000883; Cyt_C_Oxase_1.
 PANTHER; PTHR10422; PTHR10422; 1.
 Pfam; PF00115; COX1; 1.
 PRINTS; PR01165; CYCOXIDASEI.
 SUPFAM; SSF81442; SSF81442; 1.
 PROSITE; PS50855; COX1; 1.
 3: Inferred from homology;
 Copper {ECO:0000256|RuleBase:RU000369};
 Electron transport {ECO:0000256|RuleBase:RU000369};
 Heme {ECO:0000256|RuleBase:RU000369};
 Iron {ECO:0000256|RuleBase:RU000369};
 Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius};
 Metal-binding {ECO:0000256|RuleBase:RU000369};
 Mitochondrion {ECO:0000256|RuleBase:RU000369};
 Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369};
 Oxidoreductase {ECO:0000256|RuleBase:RU000369};
 Respiratory chain {ECO:0000256|RuleBase:RU000369};
 Transmembrane {ECO:0000256|SAM:Phobius};
 Transmembrane helix {ECO:0000256|SAM:Phobius};
 Transport {ECO:0000256|RuleBase:RU000369}.
 TRANSMEM     34     62       Helical. {ECO:0000256|SAM:Phobius}.
 TRANSMEM     83    107       Helical. {ECO:0000256|SAM:Phobius}.
 TRANSMEM    127    152       Helical. {ECO:0000256|SAM:Phobius}.
 TRANSMEM    164    191       Helical. {ECO:0000256|SAM:Phobius}.
 DOMAIN        1    194       COX1. {ECO:0000259|PROSITE:PS50855}.
 NON_TER       1      1       {ECO:0000313|EMBL:AJE70540.1}.
 NON_TER     194    194       {ECO:0000313|EMBL:AJE70540.1}.
 SEQUENCE   194 AA;  21081 MW;  E1F6EF3CC1512BA7 CRC64;
 YMIFGVWCGL VGTGLSLLIR LELGTSMVLI DEHFYNVIVT AHAFVMIFFM VMPMMIGGFG
 NWMVPLLIGA PDMSFPRMNN MSFWLLPPSF VLLLCSSMVE GGVGTGWTVY PPLSGPIAHG
 GSSVDLAIFS LHLAGLSSIL GAINFITTIF NMRSPGITLE RMSLFVWSVL ITAFLLLLSL
 PVLAGAITML LTDR

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