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Cytochrome c oxidase subunit 2

 D7PM88_PHOVR            Unreviewed;       227 AA.
D7PM88;
10-AUG-2010, integrated into UniProtKB/TrEMBL.
10-AUG-2010, sequence version 1.
10-MAY-2017, entry version 47.
RecName: Full=Cytochrome c oxidase subunit 2 {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709560};
Name=COX2 {ECO:0000313|EMBL:ADH95500.1};
Phoca vitulina richardii (Pacific harbor seal).
Mitochondrion {ECO:0000313|EMBL:ADH95500.1}.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Phocidae;
Phoca.
NCBI_TaxID=271025 {ECO:0000313|EMBL:ADH95500.1};
[1] {ECO:0000313|EMBL:ADH95500.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Hs1838 {ECO:0000313|EMBL:ADH95590.1},
Pacific harbor seal 12 {ECO:0000313|EMBL:ADH95616.1},
Pacific harbor seal 13 {ECO:0000313|EMBL:ADH95618.1},
Pacific harbor seal 14 {ECO:0000313|EMBL:ADH95620.1},
Pacific harbor seal 16 {ECO:0000313|EMBL:ADH95622.1},
Pacific harbor seal 1691 {ECO:0000313|EMBL:ADH95504.1},
Pacific harbor seal 1727 {ECO:0000313|EMBL:ADH95516.1},
Pacific harbor seal 1739 {ECO:0000313|EMBL:ADH95520.1},
Pacific harbor seal 1746 {ECO:0000313|EMBL:ADH95524.1},
Pacific harbor seal 1755 {ECO:0000313|EMBL:ADH95530.1},
Pacific harbor seal 1758 {ECO:0000313|EMBL:ADH95534.1},
Pacific harbor seal 1762 {ECO:0000313|EMBL:ADH95536.1},
Pacific harbor seal 1765 {ECO:0000313|EMBL:ADH95538.1},
Pacific harbor seal 1772 {ECO:0000313|EMBL:ADH95540.1},
Pacific harbor seal 1776 {ECO:0000313|EMBL:ADH95542.1},
Pacific harbor seal 1778 {ECO:0000313|EMBL:ADH95544.1},
Pacific harbor seal 1779 {ECO:0000313|EMBL:ADH95546.1},
Pacific harbor seal 1795 {ECO:0000313|EMBL:ADH95548.1},
Pacific harbor seal 1796 {ECO:0000313|EMBL:ADH95550.1},
Pacific harbor seal 1797 {ECO:0000313|EMBL:ADH95552.1},
Pacific harbor seal 1798 {ECO:0000313|EMBL:ADH95554.1},
Pacific harbor seal 18 {ECO:0000313|EMBL:ADH95626.1},
Pacific harbor seal 1800 {ECO:0000313|EMBL:ADH95556.1},
Pacific harbor seal 1805 {ECO:0000313|EMBL:ADH95558.1},
Pacific harbor seal 1806 {ECO:0000313|EMBL:ADH95560.1},
Pacific harbor seal 1808 {ECO:0000313|EMBL:ADH95562.1},
Pacific harbor seal 1809 {ECO:0000313|EMBL:ADH95564.1},
Pacific harbor seal 1810 {ECO:0000313|EMBL:ADH95566.1},
Pacific harbor seal 1813 {ECO:0000313|EMBL:ADH95568.1},
Pacific harbor seal 1814 {ECO:0000313|EMBL:ADH95570.1},
Pacific harbor seal 1815 {ECO:0000313|EMBL:ADH95572.1},
Pacific harbor seal 1820 {ECO:0000313|EMBL:ADH95574.1},
Pacific harbor seal 1822 {ECO:0000313|EMBL:ADH95576.1},
Pacific harbor seal 1825 {ECO:0000313|EMBL:ADH95578.1},
Pacific harbor seal 1826 {ECO:0000313|EMBL:ADH95580.1},
Pacific harbor seal 1829 {ECO:0000313|EMBL:ADH95582.1},
Pacific harbor seal 1831 {ECO:0000313|EMBL:ADH95584.1},
Pacific harbor seal 1836 {ECO:0000313|EMBL:ADH95586.1},
Pacific harbor seal 1837 {ECO:0000313|EMBL:ADH95588.1},
Pacific harbor seal 1840 {ECO:0000313|EMBL:ADH95592.1},
Pacific harbor seal 1841 {ECO:0000313|EMBL:ADH95594.1},
Pacific harbor seal 1847 {ECO:0000313|EMBL:ADH95596.1},
Pacific harbor seal 1848 {ECO:0000313|EMBL:ADH95598.1},
Pacific harbor seal 1850 {ECO:0000313|EMBL:ADH95600.1},
Pacific harbor seal 1853 {ECO:0000313|EMBL:ADH95602.1},
Pacific harbor seal 1855 {ECO:0000313|EMBL:ADH95604.1},
Pacific harbor seal 1858 {ECO:0000313|EMBL:ADH95606.1},
Pacific harbor seal 1862 {ECO:0000313|EMBL:ADH95608.1},
Pacific harbor seal 1863 {ECO:0000313|EMBL:ADH95610.1},
Pacific harbor seal 1864 {ECO:0000313|EMBL:ADH95612.1},
Pacific harbor seal 19 {ECO:0000313|EMBL:ADH95624.1},
Pacific harbor seal 20 {ECO:0000313|EMBL:ADH95628.1},
Pacific harbor seal 21 {ECO:0000313|EMBL:ADH95630.1},
Pacific harbor seal 34 {ECO:0000313|EMBL:ADH95632.1},
Pacific harbor seal 46 {ECO:0000313|EMBL:ADH95634.1},
Pacific harbor seal 8 {ECO:0000313|EMBL:ADH95614.1},
Wild harbor seal 1560 {ECO:0000313|EMBL:ADH95500.1},
Wild harbor seal 1562 {ECO:0000313|EMBL:ADH95502.1},
Wild harbor seal 1700 {ECO:0000313|EMBL:ADH95506.1},
Wild harbor seal 1706 {ECO:0000313|EMBL:ADH95508.1},
Wild harbor seal 1716 {ECO:0000313|EMBL:ADH95510.1},
Wild harbor seal 1722 {ECO:0000313|EMBL:ADH95512.1},
Wild harbor seal 1724 {ECO:0000313|EMBL:ADH95514.1},
Wild harbor seal 1736 {ECO:0000313|EMBL:ADH95518.1},
Wild harbor seal 1740 {ECO:0000313|EMBL:ADH95522.1},
Wild harbor seal 1747 {ECO:0000313|EMBL:ADH95526.1},
Wild harbor seal 1754 {ECO:0000313|EMBL:ADH95528.1}, and
Wild harbor seal 1758 {ECO:0000313|EMBL:ADH95532.1};
PubMed=20361967; DOI=10.1016/j.ijpara.2010.02.015;
Lasek-Nesselquist E., Welch D.M., Sogin M.L.;
"The identification of a new Giardia duodenalis assemblage in marine
vertebrates and a preliminary analysis of G. duodenalis population
biology in marine systems.";
Int. J. Parasitol. 40:1063-1074(2010).
-!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
chain that catalyzes the reduction of oxygen to water. Subunits 1-
3 form the functional core of the enzyme complex. Subunit 2
transfers the electrons from cytochrome c via its binuclear copper
A center to the bimetallic center of the catalytic subunit 1.
{ECO:0000256|RuleBase:RU000457}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
{ECO:0000256|SAAS:SAAS00709542}; Multi-pass membrane protein
{ECO:0000256|SAAS:SAAS00709542}.
-!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
{ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709553}.
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EMBL; GU733611; ADH95500.1; -; Genomic_DNA.
EMBL; GU733612; ADH95502.1; -; Genomic_DNA.
EMBL; GU733613; ADH95504.1; -; Genomic_DNA.
EMBL; GU733614; ADH95506.1; -; Genomic_DNA.
EMBL; GU733615; ADH95508.1; -; Genomic_DNA.
EMBL; GU733616; ADH95510.1; -; Genomic_DNA.
EMBL; GU733617; ADH95512.1; -; Genomic_DNA.
EMBL; GU733618; ADH95514.1; -; Genomic_DNA.
EMBL; GU733619; ADH95516.1; -; Genomic_DNA.
EMBL; GU733620; ADH95518.1; -; Genomic_DNA.
EMBL; GU733621; ADH95520.1; -; Genomic_DNA.
EMBL; GU733622; ADH95522.1; -; Genomic_DNA.
EMBL; GU733623; ADH95524.1; -; Genomic_DNA.
EMBL; GU733624; ADH95526.1; -; Genomic_DNA.
EMBL; GU733625; ADH95528.1; -; Genomic_DNA.
EMBL; GU733626; ADH95530.1; -; Genomic_DNA.
EMBL; GU733627; ADH95532.1; -; Genomic_DNA.
EMBL; GU733628; ADH95534.1; -; Genomic_DNA.
EMBL; GU733629; ADH95536.1; -; Genomic_DNA.
EMBL; GU733630; ADH95538.1; -; Genomic_DNA.
EMBL; GU733631; ADH95540.1; -; Genomic_DNA.
EMBL; GU733632; ADH95542.1; -; Genomic_DNA.
EMBL; GU733633; ADH95544.1; -; Genomic_DNA.
EMBL; GU733634; ADH95546.1; -; Genomic_DNA.
EMBL; GU733635; ADH95548.1; -; Genomic_DNA.
EMBL; GU733636; ADH95550.1; -; Genomic_DNA.
EMBL; GU733637; ADH95552.1; -; Genomic_DNA.
EMBL; GU733638; ADH95554.1; -; Genomic_DNA.
EMBL; GU733639; ADH95556.1; -; Genomic_DNA.
EMBL; GU733640; ADH95558.1; -; Genomic_DNA.
EMBL; GU733641; ADH95560.1; -; Genomic_DNA.
EMBL; GU733642; ADH95562.1; -; Genomic_DNA.
EMBL; GU733643; ADH95564.1; -; Genomic_DNA.
EMBL; GU733644; ADH95566.1; -; Genomic_DNA.
EMBL; GU733645; ADH95568.1; -; Genomic_DNA.
EMBL; GU733646; ADH95570.1; -; Genomic_DNA.
EMBL; GU733647; ADH95572.1; -; Genomic_DNA.
EMBL; GU733648; ADH95574.1; -; Genomic_DNA.
EMBL; GU733649; ADH95576.1; -; Genomic_DNA.
EMBL; GU733650; ADH95578.1; -; Genomic_DNA.
EMBL; GU733651; ADH95580.1; -; Genomic_DNA.
EMBL; GU733652; ADH95582.1; -; Genomic_DNA.
EMBL; GU733653; ADH95584.1; -; Genomic_DNA.
EMBL; GU733654; ADH95586.1; -; Genomic_DNA.
EMBL; GU733655; ADH95588.1; -; Genomic_DNA.
EMBL; GU733656; ADH95590.1; -; Genomic_DNA.
EMBL; GU733657; ADH95592.1; -; Genomic_DNA.
EMBL; GU733658; ADH95594.1; -; Genomic_DNA.
EMBL; GU733659; ADH95596.1; -; Genomic_DNA.
EMBL; GU733660; ADH95598.1; -; Genomic_DNA.
EMBL; GU733661; ADH95600.1; -; Genomic_DNA.
EMBL; GU733662; ADH95602.1; -; Genomic_DNA.
EMBL; GU733663; ADH95604.1; -; Genomic_DNA.
EMBL; GU733664; ADH95606.1; -; Genomic_DNA.
EMBL; GU733665; ADH95608.1; -; Genomic_DNA.
EMBL; GU733666; ADH95610.1; -; Genomic_DNA.
EMBL; GU733667; ADH95612.1; -; Genomic_DNA.
EMBL; GU733668; ADH95614.1; -; Genomic_DNA.
EMBL; GU733669; ADH95616.1; -; Genomic_DNA.
EMBL; GU733670; ADH95618.1; -; Genomic_DNA.
EMBL; GU733671; ADH95620.1; -; Genomic_DNA.
EMBL; GU733672; ADH95622.1; -; Genomic_DNA.
EMBL; GU733673; ADH95624.1; -; Genomic_DNA.
EMBL; GU733674; ADH95626.1; -; Genomic_DNA.
EMBL; GU733675; ADH95628.1; -; Genomic_DNA.
EMBL; GU733676; ADH95630.1; -; Genomic_DNA.
EMBL; GU733677; ADH95632.1; -; Genomic_DNA.
EMBL; GU733678; ADH95634.1; -; Genomic_DNA.
ProteinModelPortal; D7PM88; -.
SMR; D7PM88; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO; GO:0005507; F:copper ion binding; IEA:InterPro.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
GO; GO:0022900; P:electron transport chain; IEA:InterPro.
CDD; cd13912; CcO_II_C; 1.
Gene3D; 2.60.40.420; -; 1.
InterPro; IPR002429; CcO_II-like_C.
InterPro; IPR034210; CcO_II_C.
InterPro; IPR001505; Copper_CuA.
InterPro; IPR008972; Cupredoxin.
InterPro; IPR014222; Cyt_c_oxidase_su2.
InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
Pfam; PF00116; COX2; 1.
Pfam; PF02790; COX2_TM; 1.
SUPFAM; SSF49503; SSF49503; 1.
SUPFAM; SSF81464; SSF81464; 1.
TIGRFAMs; TIGR02866; CoxB; 1.
PROSITE; PS00078; COX2; 1.
PROSITE; PS50857; COX2_CUA; 1.
PROSITE; PS50999; COX2_TM; 1.
3: Inferred from homology;
Copper {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00517791};
Electron transport {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00709567};
Membrane {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00709564, ECO:0000256|SAAS:SAAS00809553,
ECO:0000256|SAM:Phobius};
Metal-binding {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00517846};
Mitochondrion {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00709564};
Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00709564};
Respiratory chain {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00709567};
Transmembrane {ECO:0000256|SAAS:SAAS00809553,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00809553,
ECO:0000256|SAM:Phobius};
Transport {ECO:0000256|RuleBase:RU000457,
ECO:0000256|SAAS:SAAS00709567}.
TRANSMEM 27 46 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 66 85 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 1 91 COX2_TM. {ECO:0000259|PROSITE:PS50999}.
DOMAIN 92 225 COX2_CUA. {ECO:0000259|PROSITE:PS50857}.
SEQUENCE 227 AA; 26047 MW; 80F75AADF226E1CC CRC64;
MAYPLQMGLQ DATSPIMEEL LHFHDHTLMI VFLISSLVLY IISLMLTTKL THTSTMDAQE
VETVWTILPA IILILIALPS LRILYMMDEI NNPSLTVKTM GHQWYWSYEY TDYEDLNFDS
YMIPTQELKP GELRLLEVDN RVVLPMEMTI RMLISSEDVL HSWAVPSLGL KTDAIPGRLN
QTTLMAMRPG LYYGQCSEIC GSNHSFMPIV LELVPLSHFE KWSTSML


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