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Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)

 COX2_HUMAN              Reviewed;         227 AA.
P00403; Q37526;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
23-MAY-2018, entry version 194.
RecName: Full=Cytochrome c oxidase subunit 2;
AltName: Full=Cytochrome c oxidase polypeptide II;
Name=MT-CO2;
Synonyms=COII, COX2 {ECO:0000303|PubMed:29154948}, COXII, MTCO2;
Homo sapiens (Human).
Mitochondrion.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=7219534; DOI=10.1038/290457a0;
Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L.,
Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A.,
Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G.;
"Sequence and organization of the human mitochondrial genome.";
Nature 290:457-465(1981).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2550900; DOI=10.1093/nar/17.16.6734;
Power M.D., Kiefer M.C., Barr P.J., Reeves R.;
"Nucleotide sequence of human mitochondrial cytochrome c oxidase II
cDNA.";
Nucleic Acids Res. 17:6734-6734(1989).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=226894; DOI=10.1038/282189a0;
Barrell B.G., Bankier A.T., Drouin J.;
"A different genetic code in human mitochondria.";
Nature 282:189-194(1979).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=7530363; DOI=10.1073/pnas.92.2.532;
Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
"Recent African origin of modern humans revealed by complete sequences
of hominoid mitochondrial DNAs.";
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-30 AND THR-148.
PubMed=8277847;
Ruvolo M., Zehr S., von Dornum M., Pan D., Chang B., Lin J.;
"Mitochondrial COII sequences and modern human origins.";
Mol. Biol. Evol. 10:1115-1135(1993).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12949126; DOI=10.1093/molbev/msg230;
Moilanen J.S., Finnila S., Majamaa K.;
"Lineage-specific selection in human mtDNA: lack of polymorphisms in a
segment of MTND5 gene in haplogroup J.";
Mol. Biol. Evol. 20:2132-2142(2003).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11130070; DOI=10.1038/35047064;
Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
"Mitochondrial genome variation and the origin of modern humans.";
Nature 408:708-713(2000).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12840039; DOI=10.1101/gr.686603;
Ingman M., Gyllensten U.;
"Mitochondrial genome variation and evolutionary history of Australian
and New Guinean aborigines.";
Genome Res. 13:1600-1606(2003).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
Irwin J.A., Parsons T.J.;
"Single nucleotide polymorphisms over the entire mtDNA genome that
increase the power of forensic testing in Caucasians.";
Int. J. Legal Med. 118:137-146(2004).
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-227.
TISSUE=Endometrial adenocarcinoma;
Swanson K.V., Griffiss J.;
"Gonococcal microcolony formation on HEC-1-B cells alters selective
mitochondrial transcripts.";
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [MRNA] OF 42-227.
TISSUE=Fetal liver;
Dmitrenko V.V., Kavsan V.M.;
"Nucleotide sequence of mitochondrial cytochrome C oxidase II from
human fetal liver.";
Submitted (SEP-1990) to the EMBL/GenBank/DDBJ databases.
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[13]
INTERACTION WITH COX20.
PubMed=23125284; DOI=10.1093/hmg/dds473;
Szklarczyk R., Wanschers B.F., Nijtmans L.G., Rodenburg R.J.,
Zschocke J., Dikow N., van den Brand M.A., Hendriks-Franssen M.G.,
Gilissen C., Veltman J.A., Nooteboom M., Koopman W.J., Willems P.H.,
Smeitink J.A., Huynen M.A., van den Heuvel L.P.;
"A mutation in the FAM36A gene, the human ortholog of COX20, impairs
cytochrome c oxidase assembly and is associated with ataxia and muscle
hypotonia.";
Hum. Mol. Genet. 22:656-667(2013).
[14]
INTERACTION WITH COX20.
PubMed=24403053; DOI=10.1093/hmg/ddu003;
Bourens M., Boulet A., Leary S.C., Barrientos A.;
"Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote
the assembly of cytochrome c oxidase.";
Hum. Mol. Genet. 23:2901-2913(2014).
[15]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[16]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[17]
IDENTIFICATION IN A COMPLEX WITH TMEM177; COA6; COX20; COX18; SCO1 AND
SCO2, AND INTERACTION WITH TMEM177 AND COX20.
PubMed=29154948; DOI=10.1016/j.bbamcr.2017.11.010;
Lorenzi I., Oeljeklaus S., Aich A., Ronsoer C., Callegari S.,
Dudek J., Warscheid B., Dennerlein S., Rehling P.;
"The mitochondrial TMEM177 associates with COX20 during COX2
biogenesis.";
Biochim. Biophys. Acta 1865:323-333(2017).
[18]
INTERACTION WITH COX20.
PubMed=28330871; DOI=10.1074/jbc.M117.778514;
Bourens M., Barrientos A.;
"Human mitochondrial cytochrome c oxidase assembly factor COX18 acts
transiently as a membrane insertase within the subunit 2 maturation
module.";
J. Biol. Chem. 292:7774-7783(2017).
[19]
INTERACTION WITH COX16.
PubMed=29355485; DOI=10.1016/j.bbabio.2018.01.004;
Cerqua C., Morbidoni V., Desbats M.A., Doimo M., Frasson C.,
Sacconi S., Baldoin M.C., Sartori G., Basso G., Salviati L.,
Trevisson E.;
"COX16 is required for assembly of cytochrome c oxidase in human cells
and is involved in copper delivery to COX2.";
Biochim. Biophys. Acta 1859:244-252(2018).
[20]
INTERACTION WITH COX16.
PubMed=29381136; DOI=10.7554/eLife.32572;
Aich A., Wang C., Chowdhury A., Ronsoer C., Pacheu-Grau D.,
Richter-Dennerlein R., Dennerlein S., Rehling P.;
"COX16 promotes COX2 metallation and assembly during respiratory
complex IV biogenesis.";
Elife 7:0-0(2018).
[21]
VARIANTS ALA-11; PRO-123 AND MET-187.
PubMed=1757091; DOI=10.1007/BF00206061;
Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
Utthanaphol P., Byrne E.;
"Normal variants of human mitochondrial DNA and translation products:
the building of a reference data base.";
Hum. Genet. 88:139-145(1991).
[22]
VARIANT COLORECTAL CANCER MET-142.
PubMed=9806551; DOI=10.1038/3108;
Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D.,
Trush M.A., Kinzler K.W., Vogelstein B.;
"Somatic mutations of the mitochondrial genome in human colorectal
tumours.";
Nat. Genet. 20:291-293(1998).
[23]
VARIANT MT-C4D LYS-29, AND CHARACTERIZATION OF VARIANT MT-C4D LYS-29.
PubMed=10486321; DOI=10.1086/302590;
Rahman S., Taanman J.-W., Cooper J.M., Nelson I., Hargreaves I.,
Meunier B., Hanna M.G., Garcia J.J., Capaldi R.A., Lake B.D.,
Leonard J.V., Schapira A.H.V.;
"A missense mutation of cytochrome oxidase subunit II causes defective
assembly and myopathy.";
Am. J. Hum. Genet. 65:1030-1039(1999).
-!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
chain that catalyzes the reduction of oxygen to water. Subunits 1-
3 form the functional core of the enzyme complex. Subunit 2
transfers the electrons from cytochrome c via its binuclear copper
A center to the bimetallic center of the catalytic subunit 1.
-!- COFACTOR:
Name=Cu cation; Xref=ChEBI:CHEBI:23378;
Note=Binds a copper A center.;
-!- SUBUNIT: Found in a complex with TMEM177, COA6, COX18, COX20, SCO1
and SCO2 (PubMed:29154948). Interacts with TMEM177 in a COX20-
dependent manner (PubMed:29154948). Interacts with COX20
(PubMed:29154948, PubMed:24403053, PubMed:23125284,
PubMed:28330871). Interacts with COX16 (PubMed:29355485,
PubMed:29381136). {ECO:0000269|PubMed:23125284,
ECO:0000269|PubMed:24403053, ECO:0000269|PubMed:28330871,
ECO:0000269|PubMed:29154948, ECO:0000269|PubMed:29355485,
ECO:0000269|PubMed:29381136}.
-!- INTERACTION:
Q9NZ94-2:NLGN3; NbExp=4; IntAct=EBI-2105756, EBI-16423037;
P49281-3:SLC11A2; NbExp=2; IntAct=EBI-2105756, EBI-10828817;
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
membrane protein.
-!- DISEASE: Mitochondrial complex IV deficiency (MT-C4D)
[MIM:220110]: A disorder of the mitochondrial respiratory chain
with heterogeneous clinical manifestations, ranging from isolated
myopathy to severe multisystem disease affecting several tissues
and organs. Features include hypertrophic cardiomyopathy,
hepatomegaly and liver dysfunction, hypotonia, muscle weakness,
exercise intolerance, developmental delay, delayed motor
development and mental retardation. Some affected individuals
manifest a fatal hypertrophic cardiomyopathy resulting in neonatal
death. A subset of patients manifest Leigh syndrome.
{ECO:0000269|PubMed:10486321}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
{ECO:0000305}.
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EMBL; V00662; CAA24029.1; -; Genomic_DNA.
EMBL; J01415; AAB58946.1; -; Genomic_DNA.
EMBL; X15759; CAA33766.1; -; mRNA.
EMBL; M25171; AAA31850.1; -; Genomic_DNA.
EMBL; D38112; BAA07293.1; -; Genomic_DNA.
EMBL; U12690; AAA20843.1; -; Genomic_DNA.
EMBL; U12691; AAA20844.1; -; Genomic_DNA.
EMBL; U12692; AAA20845.1; -; Genomic_DNA.
EMBL; U12693; AAA20846.1; -; Genomic_DNA.
EMBL; U12694; AAA20847.1; -; Genomic_DNA.
EMBL; AF004339; AAB63450.1; -; Genomic_DNA.
EMBL; AY339402; AAP89039.1; -; Genomic_DNA.
EMBL; AY339403; AAP89052.1; -; Genomic_DNA.
EMBL; AY339404; AAP89065.1; -; Genomic_DNA.
EMBL; AY339405; AAP89078.1; -; Genomic_DNA.
EMBL; AY339406; AAP89091.1; -; Genomic_DNA.
EMBL; AY339407; AAP89104.1; -; Genomic_DNA.
EMBL; AY339408; AAP89117.1; -; Genomic_DNA.
EMBL; AY339409; AAP89130.1; -; Genomic_DNA.
EMBL; AY339410; AAP89143.1; -; Genomic_DNA.
EMBL; AY339411; AAP89156.1; -; Genomic_DNA.
EMBL; AY339412; AAP89169.1; -; Genomic_DNA.
EMBL; AY339413; AAP89182.1; -; Genomic_DNA.
EMBL; AY339414; AAP89195.1; -; Genomic_DNA.
EMBL; AY339415; AAP89208.1; -; Genomic_DNA.
EMBL; AY339416; AAP89221.1; -; Genomic_DNA.
EMBL; AY339417; AAP89234.1; -; Genomic_DNA.
EMBL; AY339418; AAP89247.1; -; Genomic_DNA.
EMBL; AY339419; AAP89260.1; -; Genomic_DNA.
EMBL; AY339420; AAP89273.1; -; Genomic_DNA.
EMBL; AY339421; AAP89286.1; -; Genomic_DNA.
EMBL; AY339422; AAP89299.1; -; Genomic_DNA.
EMBL; AY339423; AAP89312.1; -; Genomic_DNA.
EMBL; AY339424; AAP89325.1; -; Genomic_DNA.
EMBL; AY339425; AAP89338.1; -; Genomic_DNA.
EMBL; AY339426; AAP89351.1; -; Genomic_DNA.
EMBL; AY339427; AAP89364.1; -; Genomic_DNA.
EMBL; AY339428; AAP89377.1; -; Genomic_DNA.
EMBL; AY339429; AAP89390.1; -; Genomic_DNA.
EMBL; AY339430; AAP89403.1; -; Genomic_DNA.
EMBL; AY339431; AAP89416.1; -; Genomic_DNA.
EMBL; AY339432; AAP89429.1; -; Genomic_DNA.
EMBL; AY339433; AAP89442.1; -; Genomic_DNA.
EMBL; AY339434; AAP89455.1; -; Genomic_DNA.
EMBL; AY339435; AAP89468.1; -; Genomic_DNA.
EMBL; AY339436; AAP89481.1; -; Genomic_DNA.
EMBL; AY339437; AAP89494.1; -; Genomic_DNA.
EMBL; AY339438; AAP89507.1; -; Genomic_DNA.
EMBL; AY339439; AAP89520.1; -; Genomic_DNA.
EMBL; AY339440; AAP89533.1; -; Genomic_DNA.
EMBL; AY339441; AAP89546.1; -; Genomic_DNA.
EMBL; AY339442; AAP89559.1; -; Genomic_DNA.
EMBL; AY339443; AAP89572.1; -; Genomic_DNA.
EMBL; AY339444; AAP89585.1; -; Genomic_DNA.
EMBL; AY339445; AAP89598.1; -; Genomic_DNA.
EMBL; AY339446; AAP89611.1; -; Genomic_DNA.
EMBL; AY339447; AAP89624.1; -; Genomic_DNA.
EMBL; AY339448; AAP89637.1; -; Genomic_DNA.
EMBL; AY339449; AAP89650.1; -; Genomic_DNA.
EMBL; AY339450; AAP89663.1; -; Genomic_DNA.
EMBL; AY339451; AAP89676.1; -; Genomic_DNA.
EMBL; AY339452; AAP89689.1; -; Genomic_DNA.
EMBL; AY339453; AAP89702.1; -; Genomic_DNA.
EMBL; AY339454; AAP89715.1; -; Genomic_DNA.
EMBL; AY339455; AAP89728.1; -; Genomic_DNA.
EMBL; AY339456; AAP89741.1; -; Genomic_DNA.
EMBL; AY339457; AAP89754.1; -; Genomic_DNA.
EMBL; AY339458; AAP89767.1; -; Genomic_DNA.
EMBL; AY339459; AAP89780.1; -; Genomic_DNA.
EMBL; AY339460; AAP89793.1; -; Genomic_DNA.
EMBL; AY339461; AAP89806.1; -; Genomic_DNA.
EMBL; AY339462; AAP89819.1; -; Genomic_DNA.
EMBL; AY339463; AAP89832.1; -; Genomic_DNA.
EMBL; AY339464; AAP89845.1; -; Genomic_DNA.
EMBL; AY339465; AAP89858.1; -; Genomic_DNA.
EMBL; AY339466; AAP89871.1; -; Genomic_DNA.
EMBL; AY339467; AAP89884.1; -; Genomic_DNA.
EMBL; AY339468; AAP89897.1; -; Genomic_DNA.
EMBL; AY339469; AAP89910.1; -; Genomic_DNA.
EMBL; AY339470; AAP89923.1; -; Genomic_DNA.
EMBL; AY339471; AAP89936.1; -; Genomic_DNA.
EMBL; AY339472; AAP89949.1; -; Genomic_DNA.
EMBL; AY339473; AAP89962.1; -; Genomic_DNA.
EMBL; AY339474; AAP89975.1; -; Genomic_DNA.
EMBL; AY339475; AAP89988.1; -; Genomic_DNA.
EMBL; AY339476; AAP90001.1; -; Genomic_DNA.
EMBL; AY339477; AAP90014.1; -; Genomic_DNA.
EMBL; AY339478; AAP90027.1; -; Genomic_DNA.
EMBL; AY339479; AAP90040.1; -; Genomic_DNA.
EMBL; AY339480; AAP90053.1; -; Genomic_DNA.
EMBL; AY339481; AAP90066.1; -; Genomic_DNA.
EMBL; AY339482; AAP90079.1; -; Genomic_DNA.
EMBL; AY339483; AAP90092.1; -; Genomic_DNA.
EMBL; AY339484; AAP90105.1; -; Genomic_DNA.
EMBL; AY339485; AAP90118.1; -; Genomic_DNA.
EMBL; AY339486; AAP90131.1; -; Genomic_DNA.
EMBL; AY339487; AAP90144.1; -; Genomic_DNA.
EMBL; AY339488; AAP90157.1; -; Genomic_DNA.
EMBL; AY339489; AAP90170.1; -; Genomic_DNA.
EMBL; AY339490; AAP90183.1; -; Genomic_DNA.
EMBL; AY339492; AAP90209.1; -; Genomic_DNA.
EMBL; AY339493; AAP90222.1; -; Genomic_DNA.
EMBL; AY339494; AAP90235.1; -; Genomic_DNA.
EMBL; AY339495; AAP90248.1; -; Genomic_DNA.
EMBL; AY339496; AAP90261.1; -; Genomic_DNA.
EMBL; AY339498; AAP90287.1; -; Genomic_DNA.
EMBL; AY339499; AAP90300.1; -; Genomic_DNA.
EMBL; AY339500; AAP90313.1; -; Genomic_DNA.
EMBL; AY339501; AAP90326.1; -; Genomic_DNA.
EMBL; AY339502; AAP90339.1; -; Genomic_DNA.
EMBL; AY339503; AAP90352.1; -; Genomic_DNA.
EMBL; AY339504; AAP90365.1; -; Genomic_DNA.
EMBL; AY339505; AAP90378.1; -; Genomic_DNA.
EMBL; AY339506; AAP90391.1; -; Genomic_DNA.
EMBL; AY339507; AAP90404.1; -; Genomic_DNA.
EMBL; AY339508; AAP90417.1; -; Genomic_DNA.
EMBL; AY339509; AAP90430.1; -; Genomic_DNA.
EMBL; AY339510; AAP90443.1; -; Genomic_DNA.
EMBL; AY339511; AAP90456.1; -; Genomic_DNA.
EMBL; AY339512; AAP90469.1; -; Genomic_DNA.
EMBL; AY339513; AAP90482.1; -; Genomic_DNA.
EMBL; AY339514; AAP90495.1; -; Genomic_DNA.
EMBL; AY339515; AAP90508.1; -; Genomic_DNA.
EMBL; AY339516; AAP90521.1; -; Genomic_DNA.
EMBL; AY339517; AAP90534.1; -; Genomic_DNA.
EMBL; AY339518; AAP90547.1; -; Genomic_DNA.
EMBL; AY339519; AAP90560.1; -; Genomic_DNA.
EMBL; AY339520; AAP90573.1; -; Genomic_DNA.
EMBL; AY339521; AAP90586.1; -; Genomic_DNA.
EMBL; AY339522; AAP90599.1; -; Genomic_DNA.
EMBL; AY339523; AAP90612.1; -; Genomic_DNA.
EMBL; AY339524; AAP90625.1; -; Genomic_DNA.
EMBL; AY339525; AAP90638.1; -; Genomic_DNA.
EMBL; AY339526; AAP90651.1; -; Genomic_DNA.
EMBL; AY339527; AAP90664.1; -; Genomic_DNA.
EMBL; AY339528; AAP90677.1; -; Genomic_DNA.
EMBL; AY339529; AAP90690.1; -; Genomic_DNA.
EMBL; AY339530; AAP90703.1; -; Genomic_DNA.
EMBL; AY339531; AAP90716.1; -; Genomic_DNA.
EMBL; AY339532; AAP90729.1; -; Genomic_DNA.
EMBL; AY339533; AAP90742.1; -; Genomic_DNA.
EMBL; AY339534; AAP90755.1; -; Genomic_DNA.
EMBL; AY339535; AAP90768.1; -; Genomic_DNA.
EMBL; AY339536; AAP90781.1; -; Genomic_DNA.
EMBL; AY339537; AAP90794.1; -; Genomic_DNA.
EMBL; AY339538; AAP90807.1; -; Genomic_DNA.
EMBL; AY339539; AAP90820.1; -; Genomic_DNA.
EMBL; AY339540; AAP90833.1; -; Genomic_DNA.
EMBL; AY339541; AAP90846.1; -; Genomic_DNA.
EMBL; AY339543; AAP90872.1; -; Genomic_DNA.
EMBL; AY339544; AAP90885.1; -; Genomic_DNA.
EMBL; AY339545; AAP90898.1; -; Genomic_DNA.
EMBL; AY339546; AAP90911.1; -; Genomic_DNA.
EMBL; AY339547; AAP90924.1; -; Genomic_DNA.
EMBL; AY339548; AAP90937.1; -; Genomic_DNA.
EMBL; AY339549; AAP90950.1; -; Genomic_DNA.
EMBL; AY339550; AAP90963.1; -; Genomic_DNA.
EMBL; AY339551; AAP90976.1; -; Genomic_DNA.
EMBL; AY339552; AAP90989.1; -; Genomic_DNA.
EMBL; AY339553; AAP91002.1; -; Genomic_DNA.
EMBL; AY339555; AAP91028.1; -; Genomic_DNA.
EMBL; AY339556; AAP91041.1; -; Genomic_DNA.
EMBL; AY339557; AAP91054.1; -; Genomic_DNA.
EMBL; AY339558; AAP91067.1; -; Genomic_DNA.
EMBL; AY339559; AAP91080.1; -; Genomic_DNA.
EMBL; AY339560; AAP91093.1; -; Genomic_DNA.
EMBL; AY339561; AAP91106.1; -; Genomic_DNA.
EMBL; AY339562; AAP91119.1; -; Genomic_DNA.
EMBL; AY339563; AAP91132.1; -; Genomic_DNA.
EMBL; AY339564; AAP91145.1; -; Genomic_DNA.
EMBL; AY339565; AAP91158.1; -; Genomic_DNA.
EMBL; AY339566; AAP91171.1; -; Genomic_DNA.
EMBL; AY339567; AAP91184.1; -; Genomic_DNA.
EMBL; AY339568; AAP91197.1; -; Genomic_DNA.
EMBL; AY339569; AAP91210.1; -; Genomic_DNA.
EMBL; AY339570; AAP91223.1; -; Genomic_DNA.
EMBL; AY339571; AAP91236.1; -; Genomic_DNA.
EMBL; AY339572; AAP91249.1; -; Genomic_DNA.
EMBL; AY339573; AAP91262.1; -; Genomic_DNA.
EMBL; AY339574; AAP91275.1; -; Genomic_DNA.
EMBL; AY339575; AAP91288.1; -; Genomic_DNA.
EMBL; AY339576; AAP91301.1; -; Genomic_DNA.
EMBL; AY339577; AAP91314.1; -; Genomic_DNA.
EMBL; AY339578; AAP91327.1; -; Genomic_DNA.
EMBL; AY339579; AAP91340.1; -; Genomic_DNA.
EMBL; AY339580; AAP91353.1; -; Genomic_DNA.
EMBL; AY339581; AAP91366.1; -; Genomic_DNA.
EMBL; AY339582; AAP91379.1; -; Genomic_DNA.
EMBL; AY339583; AAP91392.1; -; Genomic_DNA.
EMBL; AY339584; AAP91405.1; -; Genomic_DNA.
EMBL; AY339585; AAP91418.1; -; Genomic_DNA.
EMBL; AY339586; AAP91431.1; -; Genomic_DNA.
EMBL; AY339587; AAP91444.1; -; Genomic_DNA.
EMBL; AY339588; AAP91457.1; -; Genomic_DNA.
EMBL; AY339589; AAP91470.1; -; Genomic_DNA.
EMBL; AY339590; AAP91483.1; -; Genomic_DNA.
EMBL; AY339591; AAP91496.1; -; Genomic_DNA.
EMBL; AY339592; AAP91509.1; -; Genomic_DNA.
EMBL; AY339593; AAP91522.1; -; Genomic_DNA.
EMBL; AF346963; AAK17210.1; -; Genomic_DNA.
EMBL; AF346964; AAK17223.1; -; Genomic_DNA.
EMBL; AF346965; AAK17236.1; -; Genomic_DNA.
EMBL; AF346966; AAK17249.1; -; Genomic_DNA.
EMBL; AF346967; AAK17262.1; -; Genomic_DNA.
EMBL; AF346970; AAK17301.1; -; Genomic_DNA.
EMBL; AF346972; AAK17327.1; -; Genomic_DNA.
EMBL; AF346973; AAK17340.1; -; Genomic_DNA.
EMBL; AF346974; AAK17353.1; -; Genomic_DNA.
EMBL; AF346975; AAK17366.1; -; Genomic_DNA.
EMBL; AF346976; AAK17379.1; -; Genomic_DNA.
EMBL; AF346977; AAK17392.1; -; Genomic_DNA.
EMBL; AF346978; AAK17405.1; -; Genomic_DNA.
EMBL; AF346979; AAK17418.1; -; Genomic_DNA.
EMBL; AF346980; AAK17431.1; -; Genomic_DNA.
EMBL; AF346981; AAK17444.1; -; Genomic_DNA.
EMBL; AF346982; AAK17457.1; -; Genomic_DNA.
EMBL; AF346983; AAK17470.1; -; Genomic_DNA.
EMBL; AF346984; AAK17483.1; -; Genomic_DNA.
EMBL; AF346985; AAK17496.1; -; Genomic_DNA.
EMBL; AF346986; AAK17509.1; -; Genomic_DNA.
EMBL; AF346988; AAK17535.1; -; Genomic_DNA.
EMBL; AF346989; AAK17548.1; -; Genomic_DNA.
EMBL; AF346990; AAK17561.1; -; Genomic_DNA.
EMBL; AF346991; AAK17574.1; -; Genomic_DNA.
EMBL; AF346993; AAK17600.1; -; Genomic_DNA.
EMBL; AF346994; AAK17613.1; -; Genomic_DNA.
EMBL; AF346995; AAK17626.1; -; Genomic_DNA.
EMBL; AF346998; AAK17665.1; -; Genomic_DNA.
EMBL; AF346999; AAK17678.1; -; Genomic_DNA.
EMBL; AF347000; AAK17691.1; -; Genomic_DNA.
EMBL; AF347001; AAK17704.1; -; Genomic_DNA.
EMBL; AF347002; AAK17717.1; -; Genomic_DNA.
EMBL; AF347003; AAK17730.1; -; Genomic_DNA.
EMBL; AF347004; AAK17743.1; -; Genomic_DNA.
EMBL; AF347005; AAK17756.1; -; Genomic_DNA.
EMBL; AF347006; AAK17769.1; -; Genomic_DNA.
EMBL; AF347007; AAK17782.1; -; Genomic_DNA.
EMBL; AF347009; AAK17808.1; -; Genomic_DNA.
EMBL; AF347010; AAK17821.1; -; Genomic_DNA.
EMBL; AF347011; AAK17834.1; -; Genomic_DNA.
EMBL; AF347014; AAK17873.1; -; Genomic_DNA.
EMBL; AF347015; AAK17886.1; -; Genomic_DNA.
EMBL; AY289051; AAP47883.1; -; Genomic_DNA.
EMBL; AY289053; AAP47909.1; -; Genomic_DNA.
EMBL; AY289054; AAP47922.1; -; Genomic_DNA.
EMBL; AY289056; AAP47948.1; -; Genomic_DNA.
EMBL; AY289057; AAP47961.1; -; Genomic_DNA.
EMBL; AY289058; AAP47974.1; -; Genomic_DNA.
EMBL; AY289059; AAP47987.1; -; Genomic_DNA.
EMBL; AY289060; AAP48000.1; -; Genomic_DNA.
EMBL; AY289061; AAP48013.1; -; Genomic_DNA.
EMBL; AY289062; AAP48026.1; -; Genomic_DNA.
EMBL; AY289063; AAP48039.1; -; Genomic_DNA.
EMBL; AY289064; AAP48052.1; -; Genomic_DNA.
EMBL; AY289065; AAP48065.1; -; Genomic_DNA.
EMBL; AY289066; AAP48078.1; -; Genomic_DNA.
EMBL; AY289067; AAP48091.1; -; Genomic_DNA.
EMBL; AY289068; AAP48104.1; -; Genomic_DNA.
EMBL; AY289069; AAP48117.1; -; Genomic_DNA.
EMBL; AY289071; AAP48143.1; -; Genomic_DNA.
EMBL; AY289072; AAP48156.1; -; Genomic_DNA.
EMBL; AY289073; AAP48169.1; -; Genomic_DNA.
EMBL; AY289074; AAP48182.1; -; Genomic_DNA.
EMBL; AY289075; AAP48195.1; -; Genomic_DNA.
EMBL; AY289076; AAP48208.1; -; Genomic_DNA.
EMBL; AY289077; AAP48221.1; -; Genomic_DNA.
EMBL; AY289078; AAP48234.1; -; Genomic_DNA.
EMBL; AY289079; AAP48247.1; -; Genomic_DNA.
EMBL; AY289080; AAP48260.1; -; Genomic_DNA.
EMBL; AY289081; AAP48273.1; -; Genomic_DNA.
EMBL; AY289082; AAP48286.1; -; Genomic_DNA.
EMBL; AY289083; AAP48299.1; -; Genomic_DNA.
EMBL; AY289084; AAP48312.1; -; Genomic_DNA.
EMBL; AY289085; AAP48325.1; -; Genomic_DNA.
EMBL; AY289086; AAP48338.1; -; Genomic_DNA.
EMBL; AY289087; AAP48351.1; -; Genomic_DNA.
EMBL; AY289088; AAP48364.1; -; Genomic_DNA.
EMBL; AY289089; AAP48377.1; -; Genomic_DNA.
EMBL; AY289090; AAP48390.1; -; Genomic_DNA.
EMBL; AY289091; AAP48403.1; -; Genomic_DNA.
EMBL; AY289092; AAP48416.1; -; Genomic_DNA.
EMBL; AY289093; AAP48428.1; -; Genomic_DNA.
EMBL; AY289094; AAP48441.1; -; Genomic_DNA.
EMBL; AY289095; AAP48454.1; -; Genomic_DNA.
EMBL; AY289096; AAP48467.1; -; Genomic_DNA.
EMBL; AY289099; AAP48506.1; -; Genomic_DNA.
EMBL; AY289100; AAP48519.1; -; Genomic_DNA.
EMBL; AY289102; AAP48545.1; -; Genomic_DNA.
EMBL; AY495090; AAR92499.1; -; Genomic_DNA.
EMBL; AY495091; AAR92512.1; -; Genomic_DNA.
EMBL; AY495092; AAR92525.1; -; Genomic_DNA.
EMBL; AY495093; AAR92538.1; -; Genomic_DNA.
EMBL; AY495094; AAR92551.1; -; Genomic_DNA.
EMBL; AY495095; AAR92564.1; -; Genomic_DNA.
EMBL; AY495096; AAR92577.1; -; Genomic_DNA.
EMBL; AY495097; AAR92590.1; -; Genomic_DNA.
EMBL; AY495098; AAR92603.1; -; Genomic_DNA.
EMBL; AY495099; AAR92616.1; -; Genomic_DNA.
EMBL; AY495100; AAR92629.1; -; Genomic_DNA.
EMBL; AY495101; AAR92642.1; -; Genomic_DNA.
EMBL; AY495102; AAR92655.1; -; Genomic_DNA.
EMBL; AY495103; AAR92668.1; -; Genomic_DNA.
EMBL; AY495104; AAR92681.1; -; Genomic_DNA.
EMBL; AY495105; AAR92694.1; -; Genomic_DNA.
EMBL; AY495106; AAR92707.1; -; Genomic_DNA.
EMBL; AY495107; AAR92720.1; -; Genomic_DNA.
EMBL; AY495108; AAR92733.1; -; Genomic_DNA.
EMBL; AY495109; AAR92746.1; -; Genomic_DNA.
EMBL; AY495110; AAR92759.1; -; Genomic_DNA.
EMBL; AY495111; AAR92772.1; -; Genomic_DNA.
EMBL; AY495112; AAR92785.1; -; Genomic_DNA.
EMBL; AY495113; AAR92798.1; -; Genomic_DNA.
EMBL; AY495114; AAR92811.1; -; Genomic_DNA.
EMBL; AY495115; AAR92824.1; -; Genomic_DNA.
EMBL; AY495116; AAR92837.1; -; Genomic_DNA.
EMBL; AY495117; AAR92850.1; -; Genomic_DNA.
EMBL; AY495118; AAR92863.1; -; Genomic_DNA.
EMBL; AY495119; AAR92876.1; -; Genomic_DNA.
EMBL; AY495120; AAR92889.1; -; Genomic_DNA.
EMBL; AY495121; AAR92902.1; -; Genomic_DNA.
EMBL; AY495122; AAR92915.1; -; Genomic_DNA.
EMBL; AY495123; AAR92928.1; -; Genomic_DNA.
EMBL; AY495124; AAR92941.1; -; Genomic_DNA.
EMBL; AY495125; AAR92954.1; -; Genomic_DNA.
EMBL; AY495126; AAR92967.1; -; Genomic_DNA.
EMBL; AY495127; AAR92980.1; -; Genomic_DNA.
EMBL; AY495128; AAR92993.1; -; Genomic_DNA.
EMBL; AY495129; AAR93006.1; -; Genomic_DNA.
EMBL; AY495130; AAR93019.1; -; Genomic_DNA.
EMBL; AY495131; AAR93032.1; -; Genomic_DNA.
EMBL; AY495132; AAR93045.1; -; Genomic_DNA.
EMBL; AY495133; AAR93058.1; -; Genomic_DNA.
EMBL; AY495134; AAR93071.1; -; Genomic_DNA.
EMBL; AY495135; AAR93084.1; -; Genomic_DNA.
EMBL; AY495136; AAR93097.1; -; Genomic_DNA.
EMBL; AY495137; AAR93110.1; -; Genomic_DNA.
EMBL; AY495138; AAR93123.1; -; Genomic_DNA.
EMBL; AY495139; AAR93136.1; -; Genomic_DNA.
EMBL; AY495140; AAR93149.1; -; Genomic_DNA.
EMBL; AY495141; AAR93162.1; -; Genomic_DNA.
EMBL; AY495142; AAR93175.1; -; Genomic_DNA.
EMBL; AY495143; AAR93188.1; -; Genomic_DNA.
EMBL; AY495144; AAR93201.1; -; Genomic_DNA.
EMBL; AY495145; AAR93214.1; -; Genomic_DNA.
EMBL; AY495146; AAR93227.1; -; Genomic_DNA.
EMBL; AY495147; AAR93240.1; -; Genomic_DNA.
EMBL; AY495148; AAR93253.1; -; Genomic_DNA.
EMBL; AY495149; AAR93266.1; -; Genomic_DNA.
EMBL; AY495150; AAR93279.1; -; Genomic_DNA.
EMBL; AY495151; AAR93292.1; -; Genomic_DNA.
EMBL; AY495152; AAR93305.1; -; Genomic_DNA.
EMBL; AY495153; AAR93318.1; -; Genomic_DNA.
EMBL; AY495154; AAR93331.1; -; Genomic_DNA.
EMBL; AY495155; AAR93344.1; -; Genomic_DNA.
EMBL; AY495156; AAR93357.1; -; Genomic_DNA.
EMBL; AY495157; AAR93370.1; -; Genomic_DNA.
EMBL; AY495158; AAR93383.1; -; Genomic_DNA.
EMBL; AY495159; AAR93396.1; -; Genomic_DNA.
EMBL; AY495160; AAR93409.1; -; Genomic_DNA.
EMBL; AY495161; AAR93422.1; -; Genomic_DNA.
EMBL; AY495162; AAR93435.1; -; Genomic_DNA.
EMBL; AY495163; AAR93448.1; -; Genomic_DNA.
EMBL; AY495164; AAR93461.1; -; Genomic_DNA.
EMBL; AY495166; AAR93487.1; -; Genomic_DNA.
EMBL; AY495167; AAR93500.1; -; Genomic_DNA.
EMBL; AY495168; AAR93513.1; -; Genomic_DNA.
EMBL; AY495169; AAR93526.1; -; Genomic_DNA.
EMBL; AY495170; AAR93539.1; -; Genomic_DNA.
EMBL; AY495172; AAR93565.1; -; Genomic_DNA.
EMBL; AY495173; AAR93578.1; -; Genomic_DNA.
EMBL; AY495174; AAR93591.1; -; Genomic_DNA.
EMBL; AY495175; AAR93604.1; -; Genomic_DNA.
EMBL; AY495176; AAR93617.1; -; Genomic_DNA.
EMBL; AY495177; AAR93630.1; -; Genomic_DNA.
EMBL; AY495178; AAR93643.1; -; Genomic_DNA.
EMBL; AY495179; AAR93656.1; -; Genomic_DNA.
EMBL; AY495180; AAR93669.1; -; Genomic_DNA.
EMBL; AY495181; AAR93682.1; -; Genomic_DNA.
EMBL; AY495182; AAR93695.1; -; Genomic_DNA.
EMBL; AY495183; AAR93708.1; -; Genomic_DNA.
EMBL; AY495184; AAR93721.1; -; Genomic_DNA.
EMBL; AY495185; AAR93734.1; -; Genomic_DNA.
EMBL; AY495186; AAR93747.1; -; Genomic_DNA.
EMBL; AY495187; AAR93760.1; -; Genomic_DNA.
EMBL; AY495188; AAR93773.1; -; Genomic_DNA.
EMBL; AY495189; AAR93786.1; -; Genomic_DNA.
EMBL; AY495190; AAR93799.1; -; Genomic_DNA.
EMBL; AY495191; AAR93812.1; -; Genomic_DNA.
EMBL; AY495192; AAR93825.1; -; Genomic_DNA.
EMBL; AY495193; AAR93838.1; -; Genomic_DNA.
EMBL; AY495194; AAR93851.1; -; Genomic_DNA.
EMBL; AY495195; AAR93864.1; -; Genomic_DNA.
EMBL; AY495196; AAR93877.1; -; Genomic_DNA.
EMBL; AY495197; AAR93890.1; -; Genomic_DNA.
EMBL; AY495198; AAR93903.1; -; Genomic_DNA.
EMBL; AY495199; AAR93916.1; -; Genomic_DNA.
EMBL; AY495200; AAR93929.1; -; Genomic_DNA.
EMBL; AY495201; AAR93942.1; -; Genomic_DNA.
EMBL; AY495202; AAR93955.1; -; Genomic_DNA.
EMBL; AY495203; AAR93968.1; -; Genomic_DNA.
EMBL; AY495204; AAR93981.1; -; Genomic_DNA.
EMBL; AY495205; AAR93994.1; -; Genomic_DNA.
EMBL; AY495206; AAR94007.1; -; Genomic_DNA.
EMBL; AY495207; AAR94020.1; -; Genomic_DNA.
EMBL; AY495208; AAR94033.1; -; Genomic_DNA.
EMBL; AY495209; AAR94046.1; -; Genomic_DNA.
EMBL; AY495210; AAR94059.1; -; Genomic_DNA.
EMBL; AY495211; AAR94072.1; -; Genomic_DNA.
EMBL; AY495212; AAR94085.1; -; Genomic_DNA.
EMBL; AY495213; AAR94098.1; -; Genomic_DNA.
EMBL; AY495214; AAR94111.1; -; Genomic_DNA.
EMBL; AY495215; AAR94124.1; -; Genomic_DNA.
EMBL; AY495216; AAR94137.1; -; Genomic_DNA.
EMBL; AY495217; AAR94150.1; -; Genomic_DNA.
EMBL; AY495218; AAR94163.1; -; Genomic_DNA.
EMBL; AY495219; AAR94176.1; -; Genomic_DNA.
EMBL; AY495220; AAR94189.1; -; Genomic_DNA.
EMBL; AY495221; AAR94202.1; -; Genomic_DNA.
EMBL; AY495223; AAR94228.1; -; Genomic_DNA.
EMBL; AY495224; AAR94241.1; -; Genomic_DNA.
EMBL; AY495225; AAR94254.1; -; Genomic_DNA.
EMBL; AY495226; AAR94267.1; -; Genomic_DNA.
EMBL; AY495227; AAR94280.1; -; Genomic_DNA.
EMBL; AY495228; AAR94293.1; -; Genomic_DNA.
EMBL; AY495229; AAR94306.1; -; Genomic_DNA.
EMBL; AY495230; AAR94319.1; -; Genomic_DNA.
EMBL; AY495231; AAR94332.1; -; Genomic_DNA.
EMBL; AY495232; AAR94345.1; -; Genomic_DNA.
EMBL; AY495233; AAR94358.1; -; Genomic_DNA.
EMBL; AY495234; AAR94371.1; -; Genomic_DNA.
EMBL; AY495235; AAR94384.1; -; Genomic_DNA.
EMBL; AY495236; AAR94397.1; -; Genomic_DNA.
EMBL; AY495237; AAR94410.1; -; Genomic_DNA.
EMBL; AY495238; AAR94423.1; -; Genomic_DNA.
EMBL; AY495239; AAR94436.1; -; Genomic_DNA.
EMBL; AY495240; AAR94449.1; -; Genomic_DNA.
EMBL; AY495241; AAR94462.1; -; Genomic_DNA.
EMBL; AY495242; AAR94475.1; -; Genomic_DNA.
EMBL; AY495243; AAR94488.1; -; Genomic_DNA.
EMBL; AY495244; AAR94501.1; -; Genomic_DNA.
EMBL; AY495245; AAR94514.1; -; Genomic_DNA.
EMBL; AY495246; AAR94527.1; -; Genomic_DNA.
EMBL; AY495247; AAR94540.1; -; Genomic_DNA.
EMBL; AY495248; AAR94553.1; -; Genomic_DNA.
EMBL; AY495249; AAR94566.1; -; Genomic_DNA.
EMBL; AY495250; AAR94579.1; -; Genomic_DNA.
EMBL; AY495251; AAR94592.1; -; Genomic_DNA.
EMBL; AY495252; AAR94605.1; -; Genomic_DNA.
EMBL; AY495253; AAR94618.1; -; Genomic_DNA.
EMBL; AY495254; AAR94631.1; -; Genomic_DNA.
EMBL; AY495255; AAR94644.1; -; Genomic_DNA.
EMBL; AY495256; AAR94657.1; -; Genomic_DNA.
EMBL; AY495257; AAR94670.1; -; Genomic_DNA.
EMBL; AY495258; AAR94683.1; -; Genomic_DNA.
EMBL; AY495259; AAR94696.1; -; Genomic_DNA.
EMBL; AY495260; AAR94709.1; -; Genomic_DNA.
EMBL; AY495261; AAR94722.1; -; Genomic_DNA.
EMBL; AY495262; AAR94735.1; -; Genomic_DNA.
EMBL; AY495263; AAR94748.1; -; Genomic_DNA.
EMBL; AY495264; AAR94761.1; -; Genomic_DNA.
EMBL; AY495265; AAR94774.1; -; Genomic_DNA.
EMBL; AY495266; AAR94787.1; -; Genomic_DNA.
EMBL; AY495267; AAR94800.1; -; Genomic_DNA.
EMBL; AY495268; AAR94813.1; -; Genomic_DNA.
EMBL; AY495269; AAR94826.1; -; Genomic_DNA.
EMBL; AY495270; AAR94839.1; -; Genomic_DNA.
EMBL; AY495271; AAR94852.1; -; Genomic_DNA.
EMBL; AY495272; AAR94865.1; -; Genomic_DNA.
EMBL; AY495273; AAR94878.1; -; Genomic_DNA.
EMBL; AY495274; AAR94891.1; -; Genomic_DNA.
EMBL; AY495275; AAR94904.1; -; Genomic_DNA.
EMBL; AY495276; AAR94917.1; -; Genomic_DNA.
EMBL; AY495277; AAR94930.1; -; Genomic_DNA.
EMBL; AY495278; AAR94943.1; -; Genomic_DNA.
EMBL; AY495279; AAR94956.1; -; Genomic_DNA.
EMBL; AY495280; AAR94969.1; -; Genomic_DNA.
EMBL; AY495281; AAR94982.1; -; Genomic_DNA.
EMBL; AY495282; AAR94995.1; -; Genomic_DNA.
EMBL; AY495283; AAR95008.1; -; Genomic_DNA.
EMBL; AY495284; AAR95021.1; -; Genomic_DNA.
EMBL; AY495285; AAR95034.1; -; Genomic_DNA.
EMBL; AY495286; AAR95047.1; -; Genomic_DNA.
EMBL; AY495287; AAR95060.1; -; Genomic_DNA.
EMBL; AY495288; AAR95073.1; -; Genomic_DNA.
EMBL; AY495289; AAR95086.1; -; Genomic_DNA.
EMBL; AY495290; AAR95099.1; -; Genomic_DNA.
EMBL; AY495291; AAR95112.1; -; Genomic_DNA.
EMBL; AY495292; AAR95125.1; -; Genomic_DNA.
EMBL; AY495293; AAR95138.1; -; Genomic_DNA.
EMBL; AY495294; AAR95151.1; -; Genomic_DNA.
EMBL; AY495295; AAR95164.1; -; Genomic_DNA.
EMBL; AY495296; AAR95177.1; -; Genomic_DNA.
EMBL; AY495297; AAR95190.1; -; Genomic_DNA.
EMBL; AY495298; AAR95203.1; -; Genomic_DNA.
EMBL; AY495299; AAR95216.1; -; Genomic_DNA.
EMBL; AY495300; AAR95229.1; -; Genomic_DNA.
EMBL; AY495301; AAR95242.1; -; Genomic_DNA.
EMBL; AY495302; AAR95255.1; -; Genomic_DNA.
EMBL; AY495303; AAR95268.1; -; Genomic_DNA.
EMBL; AY495304; AAR95281.1; -; Genomic_DNA.
EMBL; AY495305; AAR95294.1; -; Genomic_DNA.
EMBL; AY495306; AAR95307.1; -; Genomic_DNA.
EMBL; AY495307; AAR95320.1; -; Genomic_DNA.
EMBL; AY495308; AAR95333.1; -; Genomic_DNA.
EMBL; AY495309; AAR95346.1; -; Genomic_DNA.
EMBL; AY495310; AAR95359.1; -; Genomic_DNA.
EMBL; AY495311; AAR95372.1; -; Genomic_DNA.
EMBL; AY495312; AAR95385.1; -; Genomic_DNA.
EMBL; AY495313; AAR95398.1; -; Genomic_DNA.
EMBL; AY495314; AAR95411.1; -; Genomic_DNA.
EMBL; AY495315; AAR95424.1; -; Genomic_DNA.
EMBL; AY495316; AAR95437.1; -; Genomic_DNA.
EMBL; AY495317; AAR95450.1; -; Genomic_DNA.
EMBL; AY495318; AAR95463.1; -; Genomic_DNA.
EMBL; AY495319; AAR95476.1; -; Genomic_DNA.
EMBL; AY495320; AAR95489.1; -; Genomic_DNA.
EMBL; AY495321; AAR95502.1; -; Genomic_DNA.
EMBL; AY495322; AAR95515.1; -; Genomic_DNA.
EMBL; AY495323; AAR95528.1; -; Genomic_DNA.
EMBL; AY495325; AAR95554.1; -; Genomic_DNA.
EMBL; AY495326; AAR95567.1; -; Genomic_DNA.
EMBL; AY495327; AAR95580.1; -; Genomic_DNA.
EMBL; AY495328; AAR95593.1; -; Genomic_DNA.
EMBL; AY495329; AAR95606.1; -; Genomic_DNA.
EMBL; AY495330; AAR95619.1; -; Genomic_DNA.
EMBL; X55654; CAA39187.1; -; mRNA.
PIR; A00472; OBHU2.
RefSeq; YP_003024029.1; NC_012920.1.
PDB; 3VRJ; X-ray; 1.90 A; C=46-55.
PDBsum; 3VRJ; -.
ProteinModelPortal; P00403; -.
SMR; P00403; -.
BioGrid; 110616; 52.
CORUM; P00403; -.
IntAct; P00403; 38.
MINT; P00403; -.
STRING; 9606.ENSP00000354876; -.
BindingDB; P00403; -.
ChEMBL; CHEMBL6174; -.
DrugBank; DB02659; Cholic Acid.
DrugBank; DB04464; N-Formylmethionine.
DrugBank; DB05412; SCIO-469.
TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
iPTMnet; P00403; -.
PhosphoSitePlus; P00403; -.
SwissPalm; P00403; -.
DMDM; 117020; -.
EPD; P00403; -.
PaxDb; P00403; -.
PeptideAtlas; P00403; -.
PRIDE; P00403; -.
TopDownProteomics; P00403; -.
Ensembl; ENST00000361739; ENSP00000354876; ENSG00000198712.
GeneID; 4513; -.
KEGG; hsa:4513; -.
CTD; 4513; -.
DisGeNET; 4513; -.
EuPathDB; HostDB:ENSG00000198712.1; -.
GeneCards; MT-CO2; -.
GeneReviews; MT-CO2; -.
H-InvDB; HIX0080298; -.
HGNC; HGNC:7421; MT-CO2.
HPA; CAB016243; -.
HPA; HPA051505; -.
HPA; HPA054758; -.
MalaCards; MT-CO2; -.
MIM; 220110; phenotype.
MIM; 516040; gene.
neXtProt; NX_P00403; -.
OpenTargets; ENSG00000198712; -.
Orphanet; 254905; Isolated cytochrome C oxidase deficiency.
Orphanet; 255210; Maternally-inherited Leigh syndrome.
Orphanet; 550; MELAS.
PharmGKB; PA31227; -.
eggNOG; KOG4767; Eukaryota.
eggNOG; COG1622; LUCA.
GeneTree; ENSGT00390000017410; -.
HOGENOM; HOG000264988; -.
HOVERGEN; HBG012727; -.
InParanoid; P00403; -.
KO; K02261; -.
OMA; WSYEYTD; -.
OrthoDB; EOG091G0IO9; -.
PhylomeDB; P00403; -.
TreeFam; TF344269; -.
Reactome; R-HSA-5628897; TP53 Regulates Metabolic Genes.
Reactome; R-HSA-611105; Respiratory electron transport.
ChiTaRS; MT-CO2; human.
GeneWiki; MT-CO2; -.
GenomeRNAi; 4513; -.
PRO; PR:P00403; -.
Proteomes; UP000005640; Mitochondrion.
Bgee; ENSG00000198712; -.
ExpressionAtlas; P00403; baseline and differential.
Genevisible; P00403; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0005743; C:mitochondrial inner membrane; IDA:CAFA.
GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0045277; C:respiratory chain complex IV; IDA:UniProtKB.
GO; GO:0005507; F:copper ion binding; IEA:InterPro.
GO; GO:0004129; F:cytochrome-c oxidase activity; NAS:UniProtKB.
GO; GO:0042773; P:ATP synthesis coupled electron transport; IBA:GO_Central.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; NAS:UniProtKB.
GO; GO:2001171; P:positive regulation of ATP biosynthetic process; IEA:Ensembl.
GO; GO:0010729; P:positive regulation of hydrogen peroxide biosynthetic process; IEA:Ensembl.
GO; GO:0010940; P:positive regulation of necrotic cell death; IEA:Ensembl.
GO; GO:0009409; P:response to cold; IEA:Ensembl.
CDD; cd13912; CcO_II_C; 1.
Gene3D; 1.10.287.90; -; 1.
Gene3D; 2.60.40.420; -; 1.
InterPro; IPR002429; CcO_II-like_C.
InterPro; IPR034210; CcO_II_C.
InterPro; IPR001505; Copper_CuA.
InterPro; IPR008972; Cupredoxin.
InterPro; IPR014222; Cyt_c_oxidase_su2.
InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
InterPro; IPR036257; Cyt_c_oxidase_su2_TM_sf.
Pfam; PF00116; COX2; 1.
Pfam; PF02790; COX2_TM; 1.
SUPFAM; SSF49503; SSF49503; 1.
SUPFAM; SSF81464; SSF81464; 1.
TIGRFAMs; TIGR02866; CoxB; 1.
PROSITE; PS00078; COX2; 1.
PROSITE; PS50857; COX2_CUA; 1.
PROSITE; PS50999; COX2_TM; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Copper; Disease mutation;
Electron transport; Membrane; Metal-binding; Mitochondrion;
Mitochondrion inner membrane; Polymorphism;
Primary mitochondrial disease; Reference proteome; Respiratory chain;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 227 Cytochrome c oxidase subunit 2.
/FTId=PRO_0000183610.
TOPO_DOM 1 26 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 27 48 Helical. {ECO:0000255}.
TOPO_DOM 49 62 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 63 82 Helical. {ECO:0000255}.
TOPO_DOM 83 227 Mitochondrial intermembrane.
{ECO:0000255}.
METAL 161 161 Copper A. {ECO:0000305}.
METAL 196 196 Copper A. {ECO:0000305}.
METAL 200 200 Copper A. {ECO:0000305}.
METAL 204 204 Copper A. {ECO:0000305}.
VARIANT 11 11 D -> A. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008863.
VARIANT 29 29 M -> K (in MT-C4D; affect the stability
of the COX complex; dbSNP:rs199474827).
{ECO:0000269|PubMed:10486321}.
/FTId=VAR_035085.
VARIANT 30 30 I -> V. {ECO:0000269|PubMed:8277847}.
/FTId=VAR_011344.
VARIANT 123 123 L -> P. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008571.
VARIANT 142 142 V -> M (in colorectal cancer;
dbSNP:rs199474826).
{ECO:0000269|PubMed:9806551}.
/FTId=VAR_008390.
VARIANT 148 148 A -> T (in dbSNP:rs1116904).
{ECO:0000269|PubMed:8277847}.
/FTId=VAR_011345.
VARIANT 187 187 T -> M. {ECO:0000269|PubMed:1757091}.
/FTId=VAR_008572.
SEQUENCE 227 AA; 25565 MW; 402A3145241DDEE6 CRC64;
MAHAAQVGLQ DATSPIMEEL ITFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE
METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL


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