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Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver/heart) (Cytochrome c oxidase subunit 8-2)

 COX8A_MACFA             Reviewed;          69 AA.
Q8SPI5;
16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
28-MAR-2018, entry version 72.
RecName: Full=Cytochrome c oxidase subunit 8A, mitochondrial;
AltName: Full=Cytochrome c oxidase polypeptide VIII-liver/heart;
AltName: Full=Cytochrome c oxidase subunit 8-2;
Flags: Precursor;
Name=COX8A; Synonyms=COX8, COX8L; ORFNames=QnpA-21537;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Parietal cortex;
PubMed=11991714; DOI=10.1006/geno.2002.6753;
Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S.,
Hirai M., Hashimoto K.;
"Search for genes positively selected during primate evolution by 5'-
end-sequence screening of cynomolgus monkey cDNAs.";
Genomics 79:657-662(2002).
-!- FUNCTION: This protein is one of the nuclear-coded polypeptide
chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
-!- SIMILARITY: Belongs to the cytochrome c oxidase VIII family.
{ECO:0000305}.
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EMBL; AB072015; BAB86804.1; -; mRNA.
RefSeq; XP_005577543.2; XM_005577486.2.
UniGene; Mfa.6137; -.
ProteinModelPortal; Q8SPI5; -.
SMR; Q8SPI5; -.
Ensembl; ENSMFAT00000021769; ENSMFAP00000008284; ENSMFAG00000001343.
GeneID; 102139510; -.
KEGG; mcf:102139510; -.
GeneTree; ENSGT00390000006255; -.
KO; K02273; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
Gene3D; 4.10.81.10; -; 1.
InterPro; IPR003205; Cyt_c_oxidase_su8.
InterPro; IPR036548; Cyt_c_oxidase_su8_sf.
PANTHER; PTHR16717; PTHR16717; 1.
Pfam; PF02285; COX8; 1.
SUPFAM; SSF81431; SSF81431; 1.
3: Inferred from homology;
Membrane; Mitochondrion; Mitochondrion inner membrane;
Transit peptide; Transmembrane; Transmembrane helix.
TRANSIT 1 25 Mitochondrion. {ECO:0000250}.
CHAIN 26 69 Cytochrome c oxidase subunit 8A,
mitochondrial.
/FTId=PRO_0000006188.
TOPO_DOM 26 36 Mitochondrial matrix. {ECO:0000250}.
TRANSMEM 37 60 Helical. {ECO:0000250}.
TOPO_DOM 61 69 Mitochondrial intermembrane.
{ECO:0000250}.
SEQUENCE 69 AA; 7707 MW; E3BA498555D280ED CRC64;
MSVLTSLLLR GLTGSARRLP VPRAKVHSMP PEEELGIMEK AIGLTFCFVS LFLPAGWILS
HLEDYKRPE


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