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Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)

 CISH_HUMAN              Reviewed;         258 AA.
Q9NSE2; B2R9N1; G5E9R1; Q9NS38; Q9Y5R1;
21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
28-FEB-2018, entry version 153.
RecName: Full=Cytokine-inducible SH2-containing protein;
Short=CIS;
AltName: Full=CIS-1;
AltName: Full=Protein G18;
AltName: Full=Suppressor of cytokine signaling;
Short=SOCS;
Name=CISH; Synonyms=G18;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Fetal lung;
PubMed=9465889;
Uchida K., Yoshimura A., Inazawa J., Yanagisawa K., Osada H.,
Masuda A., Saito T., Takahashi T., Miyajima A., Takahashi K.;
"Molecular cloning of CISH, chromosome assignment to 3p21.3, and
analysis of expression in fetal and adult tissues.";
Cytogenet. Cell Genet. 78:209-212(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1B).
TISSUE=Placenta;
PubMed=10902923; DOI=10.3109/10425170009033983;
Jiang C., Yu L., Zhao Y., Zhang M., Liu Q., Mao N., Geng Z., Zhao S.;
"Cloning and characterization of CIS 1b (cytokine inducible SH2-
containing protein 1b), an alternative splicing form of CIS 1 gene.";
DNA Seq. 11:149-154(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1C).
Wei M.-H., Minna J.D., Lerman M.I.;
"The human G18 is an ortholog of the rodent gene CIS-2 and is located
in 3p21.3 and homozygously deleted in lung cancer.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
PubMed=11032736; DOI=10.1006/bbrc.2000.3678;
Yousefi S., Cooper P.R., Mueck B., Potter S.L., Jarai G.;
"cDNA representational difference analysis of human neutrophils
stimulated by GM-CSF.";
Biochem. Biophys. Res. Commun. 277:401-409(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Placenta;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16641997; DOI=10.1038/nature04728;
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Colon, and Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
INTERACTION WITH EPOR, AND UBIQUITINATION.
PubMed=9774439; DOI=10.1074/jbc.273.43.28185;
Verdier F., Chretien S., Muller O., Varlet P., Yoshimura A.,
Gisselbrecht S., Lacombe C., Mayeux P.;
"Proteasomes regulate erythropoietin receptor and signal transducer
and activator of transcription 5 (STAT5) activation. Possible
involvement of the ubiquitinated CIS protein.";
J. Biol. Chem. 273:28185-28190(1998).
[10]
POLYMORPHISM, AND INVOLVEMENT IN SUSCEPTIBILITY TO TUBERCULOSIS;
MALARIA AND BACTS2.
PubMed=20484391; DOI=10.1056/NEJMoa0905606;
Khor C.C., Vannberg F.O., Chapman S.J., Guo H., Wong S.H.,
Walley A.J., Vukcevic D., Rautanen A., Mills T.C., Chang K.C.,
Kam K.M., Crampin A.C., Ngwira B., Leung C.C., Tam C.M., Chan C.Y.,
Sung J.J., Yew W.W., Toh K.Y., Tay S.K., Kwiatkowski D., Lienhardt C.,
Hien T.T., Day N.P., Peshu N., Marsh K., Maitland K., Scott J.A.,
Williams T.N., Berkley J.A., Floyd S., Tang N.L., Fine P.E., Goh D.L.,
Hill A.V.;
"CISH and susceptibility to infectious diseases.";
N. Engl. J. Med. 362:2092-2101(2010).
-!- FUNCTION: SOCS family proteins form part of a classical negative
feedback system that regulates cytokine signal transduction. CIS
is involved in the negative regulation of cytokines that signal
through the JAK-STAT5 pathway such as erythropoietin, prolactin
and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation
by suppressing its tyrosine phosphorylation. May be a substrate-
recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-
box protein) E3 ubiquitin-protein ligase complex which mediates
the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity). {ECO:0000250}.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Stably associated with the tyrosine-phosphorylated IL3
receptor beta chain and tyrosine-phosphorylated EPO receptor
(EPOR).
-!- INTERACTION:
P00533:EGFR; NbExp=3; IntAct=EBI-617866, EBI-297353;
P04626:ERBB2; NbExp=4; IntAct=EBI-617866, EBI-641062;
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q9NSE2-1; Sequence=Displayed;
Name=1B;
IsoId=Q9NSE2-2; Sequence=VSP_006194;
Name=1C;
IsoId=Q9NSE2-3; Sequence=VSP_006195;
-!- TISSUE SPECIFICITY: Expressed in various epithelial tissues.
Abundantly expressed in liver and kidney, and to a lesser extent
in lung. The tissue distribution of isoforms 1 and 1B is distinct.
{ECO:0000269|PubMed:11032736}.
-!- INDUCTION: By a subset of cytokines including EPO/erythropoietin.
-!- PTM: Association with EPOR may target the protein for proteolysis
by the ubiquitin-dependent proteasome pathway. CIS is mainly
monubiquitinated (37 kDa form) but may also exist in a
polyubiquitinated form (45 kDa). {ECO:0000269|PubMed:9774439}.
-!- POLYMORPHISM: Note=CISH polymorphisms are involved in
susceptibilty to malaria [MIM:611162].
{ECO:0000269|PubMed:20484391}.
-!- POLYMORPHISM: Note=Genetic variations in CISH are involved in
susceptibilty to tuberculosis [MIM:607948].
{ECO:0000269|PubMed:20484391}.
-!- POLYMORPHISM: Note=Genetic variations in CISH are associated with
susceptibility to bacterial invasion of the blood and define the
bacteremia susceptibility locus 2 (BACTS2) [MIM:614383].
{ECO:0000269|PubMed:20484391}.
-!- SEQUENCE CAUTION:
Sequence=AAD28471.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; D83532; BAA92328.1; -; mRNA.
EMBL; AF035947; AAF97410.1; -; mRNA.
EMBL; AF132297; AAD28471.2; ALT_INIT; mRNA.
EMBL; AK313850; BAG36578.1; -; mRNA.
EMBL; AC096920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471055; EAW65128.1; -; Genomic_DNA.
EMBL; CH471055; EAW65129.1; -; Genomic_DNA.
EMBL; BC031590; AAH31590.1; -; mRNA.
EMBL; BC064354; AAH64354.1; -; mRNA.
CCDS; CCDS2831.1; -. [Q9NSE2-1]
CCDS; CCDS46834.1; -. [Q9NSE2-3]
PIR; JC7512; JC7512.
RefSeq; NP_037456.5; NM_013324.5. [Q9NSE2-3]
RefSeq; NP_659508.1; NM_145071.2. [Q9NSE2-1]
RefSeq; XP_011531631.1; XM_011533329.2. [Q9NSE2-2]
UniGene; Hs.655334; -.
ProteinModelPortal; Q9NSE2; -.
SMR; Q9NSE2; -.
BioGrid; 107574; 26.
IntAct; Q9NSE2; 9.
MINT; Q9NSE2; -.
STRING; 9606.ENSP00000409346; -.
iPTMnet; Q9NSE2; -.
PhosphoSitePlus; Q9NSE2; -.
BioMuta; CISH; -.
DMDM; 13124022; -.
MaxQB; Q9NSE2; -.
PaxDb; Q9NSE2; -.
PeptideAtlas; Q9NSE2; -.
PRIDE; Q9NSE2; -.
DNASU; 1154; -.
Ensembl; ENST00000348721; ENSP00000294173; ENSG00000114737. [Q9NSE2-1]
Ensembl; ENST00000443053; ENSP00000409346; ENSG00000114737. [Q9NSE2-3]
GeneID; 1154; -.
KEGG; hsa:1154; -.
UCSC; uc003dax.4; human. [Q9NSE2-1]
CTD; 1154; -.
DisGeNET; 1154; -.
EuPathDB; HostDB:ENSG00000114737.15; -.
GeneCards; CISH; -.
HGNC; HGNC:1984; CISH.
HPA; CAB034039; -.
HPA; HPA040812; -.
MalaCards; CISH; -.
MIM; 602441; gene.
MIM; 607948; phenotype.
MIM; 611162; phenotype.
MIM; 614383; phenotype.
neXtProt; NX_Q9NSE2; -.
OpenTargets; ENSG00000114737; -.
PharmGKB; PA26521; -.
eggNOG; KOG4566; Eukaryota.
eggNOG; ENOG4111V4J; LUCA.
GeneTree; ENSGT00760000119136; -.
HOGENOM; HOG000236320; -.
HOVERGEN; HBG002457; -.
InParanoid; Q9NSE2; -.
KO; K04701; -.
OMA; QHYVTSC; -.
OrthoDB; EOG091G0J75; -.
PhylomeDB; Q9NSE2; -.
TreeFam; TF321368; -.
Reactome; R-HSA-1266695; Interleukin-7 signaling.
Reactome; R-HSA-8951664; Neddylation.
Reactome; R-HSA-982772; Growth hormone receptor signaling.
SignaLink; Q9NSE2; -.
UniPathway; UPA00143; -.
ChiTaRS; CISH; human.
GeneWiki; CISH; -.
GenomeRNAi; 1154; -.
PRO; PR:Q9NSE2; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000114737; -.
CleanEx; HS_CISH; -.
Genevisible; Q9NSE2; HS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0038111; P:interleukin-7-mediated signaling pathway; TAS:Reactome.
GO; GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0046426; P:negative regulation of JAK-STAT cascade; IBA:GO_Central.
GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
GO; GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
CDD; cd10718; SH2_CIS; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR028425; CIS.
InterPro; IPR035887; CIS_SH2.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001496; SOCS_box.
InterPro; IPR036036; SOCS_box-like_dom_sf.
PANTHER; PTHR44649; PTHR44649; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF07525; SOCS_box; 1.
PRINTS; PR00401; SH2DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00253; SOCS; 1.
SMART; SM00969; SOCS_box; 1.
SUPFAM; SSF158235; SSF158235; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50225; SOCS; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Growth regulation;
Reference proteome; SH2 domain; Signal transduction inhibitor;
Ubl conjugation; Ubl conjugation pathway.
CHAIN 1 258 Cytokine-inducible SH2-containing
protein.
/FTId=PRO_0000181231.
DOMAIN 82 163 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 209 257 SOCS box. {ECO:0000255|PROSITE-
ProRule:PRU00194}.
VAR_SEQ 1 7 MVLCVQG -> MGPPLTAHPLPSR (in isoform 1B).
{ECO:0000303|PubMed:10902923}.
/FTId=VSP_006194.
VAR_SEQ 1 7 MVLCVQG -> MYLEHTSHCPHHDDDTAMDTPLPR (in
isoform 1C). {ECO:0000303|Ref.3}.
/FTId=VSP_006195.
SEQUENCE 258 AA; 28663 MW; 0BA97804E3B0F608 CRC64;
MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV
LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV
KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP
TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC
LPLPRRMADY LRQYPFQL


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Genprice Inc, Invoices and accounting
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