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Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B)

 DYHC2_HUMAN             Reviewed;        4307 AA.
Q8NCM8; O00432; Q16693; Q3C1U8; Q4AC93; Q6ZMX7; Q6ZUM6; Q7Z363;
Q8N977; Q92815; Q9HAE4;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 4.
25-OCT-2017, entry version 125.
RecName: Full=Cytoplasmic dynein 2 heavy chain 1;
AltName: Full=Cytoplasmic dynein 2 heavy chain;
AltName: Full=Dynein cytoplasmic heavy chain 2;
AltName: Full=Dynein heavy chain 11;
Short=hDHC11;
AltName: Full=Dynein heavy chain isotype 1B;
Name=DYNC2H1; Synonyms=DHC1B, DHC2, DNCH2, DYH1B, KIAA1997;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 1911-2004 (ISOFORM 1).
Totoki Y., Yada T., Sakaki Y., Takeda T.;
"Identification of novel human genes predicted by combining multiple
gene finders.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1088 AND 2955-4307
(ISOFORM 1).
TISSUE=Brain, Embryo, Placenta, and Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1091-1745 (ISOFORM 1), VARIANT ARG-1413,
TOPOLOGY, AND SUBCELLULAR LOCATION.
PubMed=8666668; DOI=10.1083/jcb.133.4.831;
Vaisberg E.A., Grissom P.M., McIntosh J.R.;
"Mammalian cells express three distinct dynein heavy chains that are
localized to different cytoplasmic organelles.";
J. Cell Biol. 133:831-842(1996).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 1671-1831 (ISOFORM 1).
TISSUE=Liver;
PubMed=8186465; DOI=10.1091/mbc.5.1.57;
Gibbons B.H., Asai D.J., Tang W.-J.Y., Hays T.S., Gibbons I.R.;
"Phylogeny and expression of axonemal and cytoplasmic dynein genes in
sea urchins.";
Mol. Biol. Cell 5:57-70(1994).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 1689-1867 (ISOFORM 1).
TISSUE=Testis;
PubMed=9373155; DOI=10.1016/S0378-1119(97)00417-4;
Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J.,
Engel W., Schmid M.;
"Identification of dynein heavy chain genes expressed in human and
mouse testis: chromosomal localization of an axonemal dynein gene.";
Gene 200:193-202(1997).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2583-4307 (ISOFORM 2), AND
VARIANT GLN-2871.
TISSUE=Retina;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2623-4307 (ISOFORM 1), AND
VARIANTS GLN-2871 AND VAL-3680.
TISSUE=Brain;
PubMed=12056414; DOI=10.1093/dnares/9.2.47;
Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S.,
Takahashi Y., Kitajima S., Saga Y., Koseki H.;
"Characterization of size-fractionated cDNA libraries generated by the
in vitro recombination-assisted method.";
DNA Res. 9:47-57(2002).
[9]
SEQUENCE REVISION.
Ohara O., Nagase T., Yamakawa H., Kikuno R.;
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[10]
NOMENCLATURE.
PubMed=16440056; DOI=10.1371/journal.pgen.0020001;
Pfister K.K., Shah P.R., Hummerich H., Russ A., Cotton J.,
Annuar A.A., King S.M., Fisher E.M.C.;
"Genetic analysis of the cytoplasmic dynein subunit families.";
PLoS Genet. 2:11-26(2006).
[11]
INVOLVEMENT IN DIGENIC SHORT-RIB THORACIC DYSPLASIA 3/6 WITH
POLYDACTYLY, AND VARIANT ASP-3909.
PubMed=21211617; DOI=10.1016/j.ajhg.2010.12.004;
Thiel C., Kessler K., Giessl A., Dimmler A., Shalev S.A.,
von der Haar S., Zenker M., Zahnleiter D., Stoess H., Beinder E.,
Abou Jamra R., Ekici A.B., Schroeder-Kress N., Aigner T., Kirchner T.,
Reis A., Brandstaetter J.H., Rauch A.;
"NEK1 mutations cause short-rib polydactyly syndrome type majewski.";
Am. J. Hum. Genet. 88:106-114(2011).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[13]
VARIANTS SRTD3 ILE-209; CYS-587 AND HIS-2205.
PubMed=19361615; DOI=10.1016/j.ajhg.2009.03.015;
Merrill A.E., Merriman B., Farrington-Rock C., Camacho N.,
Sebald E.T., Funari V.A., Schibler M.J., Firestein M.H., Cohn Z.A.,
Priore M.A., Thompson A.K., Rimoin D.L., Nelson S.F., Cohn D.H.,
Krakow D.;
"Ciliary abnormalities due to defects in the retrograde transport
protein DYNC2H1 in short-rib polydactyly syndrome.";
Am. J. Hum. Genet. 84:542-549(2009).
[14]
VARIANTS SRTD3 THR-1240; ALA-1987; LEU-1991; VAL-2461; GLY-3015 AND
VAL-3762.
PubMed=19442771; DOI=10.1016/j.ajhg.2009.04.016;
Dagoneau N., Goulet M., Genevieve D., Sznajer Y., Martinovic J.,
Smithson S., Huber C., Baujat G., Flori E., Tecco L., Cavalcanti D.,
Delezoide A.-L., Serre V., Le Merrer M., Munnich A., Cormier-Daire V.;
"DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short
rib-polydactyly syndrome, type III.";
Am. J. Hum. Genet. 84:706-711(2009).
[15]
VARIANTS SRTD3 CYS-330; GLY-338; CYS-430; ARG-495; CYS-1423; SER-2496
AND GLN-2662.
PubMed=22499340; DOI=10.1136/jmedgenet-2011-100717;
El Hokayem J., Huber C., Couve A., Aziza J., Baujat G., Bouvier R.,
Cavalcanti D.P., Collins F.A., Cordier M.P., Delezoide A.L.,
Gonzales M., Johnson D., Le Merrer M., Levy-Mozziconacci A., Loget P.,
Martin-Coignard D., Martinovic J., Mortier G.R., Perez M.J., Roume J.,
Scarano G., Munnich A., Cormier-Daire V.;
"NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski
type but not in Beemer Langer cases.";
J. Med. Genet. 49:227-233(2012).
[16]
VARIANTS SRTD3 CYS-330; PRO-871; ILE-1228; THR-1240; VAL-1379;
ASP-1442; LYS-1991; VAL-2227; THR-2304; SER-2362; GLN-2481; TRP-2532;
MET-2555; CYS-2573; THR-2640; MET-2819; GLY-3015; LEU-3381; CYS-3806;
GLY-3847 AND ARG-4232.
PubMed=23456818; DOI=10.1136/jmedgenet-2012-101284;
Schmidts M., Arts H.H., Bongers E.M., Yap Z., Oud M.M., Antony D.,
Duijkers L., Emes R.D., Stalker J., Yntema J.B., Plagnol V.,
Hoischen A., Gilissen C., Forsythe E., Lausch E., Veltman J.A.,
Roeleveld N., Superti-Furga A., Kutkowska-Kazmierczak A.,
Kamsteeg E.J., Elcioglu N., van Maarle M.C., Graul-Neumann L.M.,
Devriendt K., Smithson S.F., Wellesley D., Verbeek N.E.,
Hennekam R.C., Kayserili H., Scambler P.J., Beales P.L., Knoers N.V.,
Roepman R., Mitchison H.M.;
"Exome sequencing identifies DYNC2H1 mutations as a common cause of
asphyxiating thoracic dystrophy (Jeune syndrome) without major
polydactyly, renal or retinal involvement.";
J. Med. Genet. 50:309-323(2013).
-!- FUNCTION: May function as a motor for intraflagellar retrograde
transport. Functions in cilia biogenesis. May play a role in
transport between endoplasmic reticulum and Golgi or organization
of the Golgi in cells (By similarity). {ECO:0000250}.
-!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by
a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light
intermediate chains. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
{ECO:0000250|UniProtKB:Q9JJ79}. Cell membrane
{ECO:0000250|UniProtKB:Q45VK7}; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q45VK7}. Cytoplasm
{ECO:0000250|UniProtKB:Q9JJ79}. Note=Localizes to the apical
cytoplasm (By similarity). According to PubMed:8666668, it
localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic
reticulum (PubMed:8666668). {ECO:0000250|UniProtKB:Q9JJ79,
ECO:0000269|PubMed:8666668}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q8NCM8-1; Sequence=Displayed;
Name=2;
IsoId=Q8NCM8-2; Sequence=VSP_031283;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q8NCM8-3; Sequence=VSP_031282;
Note=No experimental confirmation available.;
-!- DISEASE: Short-rib thoracic dysplasia 3 with or without
polydactyly (SRTD3) [MIM:613091]: A form of short-rib thoracic
dysplasia, a group of autosomal recessive ciliopathies that are
characterized by a constricted thoracic cage, short ribs,
shortened tubular bones, and a 'trident' appearance of the
acetabular roof. Polydactyly is variably present. Non-skeletal
involvement can include cleft lip/palate as well as anomalies of
major organs such as the brain, eye, heart, kidneys, liver,
pancreas, intestines, and genitalia. Some forms of the disease are
lethal in the neonatal period due to respiratory insufficiency
secondary to a severely restricted thoracic cage, whereas others
are compatible with life. Disease spectrum encompasses Ellis-van
Creveld syndrome, asphyxiating thoracic dystrophy (Jeune
syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly
syndrome. {ECO:0000269|PubMed:19361615,
ECO:0000269|PubMed:19442771, ECO:0000269|PubMed:22499340,
ECO:0000269|PubMed:23456818}. Note=The disease is caused by
mutations affecting the gene represented in this entry. In some
cases DYNC2H1 mutations result in disease phenotype in the
presence of mutations in NEK1 indicating digenic inheritance
(digenic short rib-polydactyly syndrome 3/6 with polydactyly)
(PubMed:21211617). {ECO:0000269|PubMed:21211617}.
-!- SIMILARITY: Belongs to the dynein heavy chain family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAB13905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAC04578.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAD18598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; AB231765; BAE46899.1; -; mRNA.
EMBL; AB231766; BAE17138.1; -; mRNA.
EMBL; AP000817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AP001486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AP002829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AP002961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AP003382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AP003461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK021818; BAB13905.1; ALT_INIT; mRNA.
EMBL; AK095579; BAC04578.1; ALT_INIT; mRNA.
EMBL; AK125524; BAC86194.1; -; mRNA.
EMBL; AK131453; BAD18598.1; ALT_INIT; mRNA.
EMBL; U53531; AAB09728.1; -; mRNA.
EMBL; U20552; AAB50020.1; -; mRNA.
EMBL; Z83800; CAB06054.1; -; mRNA.
EMBL; BX538093; CAD98012.1; -; mRNA.
EMBL; AB082528; BAC02706.2; -; mRNA.
CCDS; CCDS44717.1; -. [Q8NCM8-2]
CCDS; CCDS53701.1; -. [Q8NCM8-1]
RefSeq; NP_001073932.1; NM_001080463.1. [Q8NCM8-2]
RefSeq; NP_001368.2; NM_001377.2. [Q8NCM8-1]
UniGene; Hs.503721; -.
PDB; 4RH7; X-ray; 3.41 A; A=1091-4307.
PDBsum; 4RH7; -.
ProteinModelPortal; Q8NCM8; -.
SMR; Q8NCM8; -.
BioGrid; 122785; 33.
CORUM; Q8NCM8; -.
IntAct; Q8NCM8; 19.
MINT; MINT-8188622; -.
STRING; 9606.ENSP00000381167; -.
iPTMnet; Q8NCM8; -.
PhosphoSitePlus; Q8NCM8; -.
BioMuta; DYNC2H1; -.
DMDM; 311033479; -.
EPD; Q8NCM8; -.
MaxQB; Q8NCM8; -.
PaxDb; Q8NCM8; -.
PeptideAtlas; Q8NCM8; -.
PRIDE; Q8NCM8; -.
Ensembl; ENST00000334267; ENSP00000334021; ENSG00000187240. [Q8NCM8-3]
Ensembl; ENST00000375735; ENSP00000364887; ENSG00000187240. [Q8NCM8-1]
Ensembl; ENST00000398093; ENSP00000381167; ENSG00000187240. [Q8NCM8-2]
GeneID; 79659; -.
KEGG; hsa:79659; -.
UCSC; uc001phn.2; human. [Q8NCM8-1]
CTD; 79659; -.
DisGeNET; 79659; -.
EuPathDB; HostDB:ENSG00000187240.13; -.
GeneCards; DYNC2H1; -.
HGNC; HGNC:2962; DYNC2H1.
HPA; HPA039015; -.
HPA; HPA039016; -.
MalaCards; DYNC2H1; -.
MIM; 603297; gene.
MIM; 613091; phenotype.
neXtProt; NX_Q8NCM8; -.
OpenTargets; ENSG00000187240; -.
Orphanet; 474; Jeune syndrome.
Orphanet; 93269; Short rib-polydactyly syndrome, Majewski type.
Orphanet; 93271; Short rib-polydactyly syndrome, Verma-Naumoff type.
eggNOG; KOG3595; Eukaryota.
eggNOG; COG5245; LUCA.
GeneTree; ENSGT00760000118964; -.
HOVERGEN; HBG107832; -.
InParanoid; Q8NCM8; -.
KO; K10414; -.
OMA; ANAHRAW; -.
OrthoDB; EOG091G0313; -.
PhylomeDB; Q8NCM8; -.
TreeFam; TF315251; -.
Reactome; R-HSA-5610787; Hedgehog 'off' state.
Reactome; R-HSA-5620924; Intraflagellar transport.
ChiTaRS; DYNC2H1; human.
GeneWiki; DYNC2H1; -.
GenomeRNAi; 79659; -.
PRO; PR:Q8NCM8; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000187240; -.
ExpressionAtlas; Q8NCM8; baseline and differential.
Genevisible; Q8NCM8; HS.
GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
GO; GO:0005930; C:axoneme; IBA:GO_Central.
GO; GO:0097542; C:ciliary tip; TAS:Reactome.
GO; GO:0005929; C:cilium; TAS:Reactome.
GO; GO:0005868; C:cytoplasmic dynein complex; IDA:GO_Central.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0005874; C:microtubule; IDA:UniProtKB.
GO; GO:0031514; C:motile cilium; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016887; F:ATPase activity; IEA:InterPro.
GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
GO; GO:0003774; F:motor activity; NAS:UniProtKB.
GO; GO:0008105; P:asymmetric protein localization; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0007030; P:Golgi organization; IDA:UniProtKB.
GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
GO; GO:0035735; P:intraciliary transport involved in cilium assembly; TAS:Reactome.
GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR035699; AAA_6.
InterPro; IPR011704; ATPase_dyneun-rel_AAA.
InterPro; IPR035706; DHC_D5.
InterPro; IPR026983; DHC_fam.
InterPro; IPR026815; DYNC2H1.
InterPro; IPR024743; Dynein_HC_stalk.
InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
InterPro; IPR004273; Dynein_heavy_dom.
InterPro; IPR013594; Dynein_heavy_dom-1.
InterPro; IPR013602; Dynein_heavy_dom-2.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR10676; PTHR10676; 1.
PANTHER; PTHR10676:SF352; PTHR10676:SF352; 1.
Pfam; PF07728; AAA_5; 1.
Pfam; PF12774; AAA_6; 1.
Pfam; PF12780; AAA_8; 1.
Pfam; PF12781; AAA_9; 1.
Pfam; PF08385; DHC_N1; 1.
Pfam; PF08393; DHC_N2; 1.
Pfam; PF03028; Dynein_heavy; 1.
Pfam; PF12777; MT; 1.
SMART; SM00382; AAA; 3.
SUPFAM; SSF52540; SSF52540; 5.
1: Evidence at protein level;
3D-structure; Alternative splicing; ATP-binding; Cell membrane;
Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation;
Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton;
Developmental protein; Disease mutation; Dynein; Membrane;
Microtubule; Motor protein; Nucleotide-binding; Polymorphism;
Reference proteome.
CHAIN 1 4307 Cytoplasmic dynein 2 heavy chain 1.
/FTId=PRO_0000318743.
NP_BIND 145 152 ATP. {ECO:0000255}.
NP_BIND 1689 1696 ATP. {ECO:0000255}.
NP_BIND 1979 1986 ATP. {ECO:0000255}.
NP_BIND 2291 2298 ATP. {ECO:0000255}.
NP_BIND 2655 2662 ATP. {ECO:0000255}.
REGION 1 1650 Stem. {ECO:0000250}.
REGION 1651 1875 AAA 1. {ECO:0000250}.
REGION 1938 2161 AAA 2. {ECO:0000250}.
REGION 2251 2505 AAA 3. {ECO:0000250}.
REGION 2617 2863 AAA 4. {ECO:0000250}.
REGION 2881 3169 Stalk. {ECO:0000250}.
REGION 3244 3473 AAA 5. {ECO:0000250}.
REGION 3690 3905 AAA 6. {ECO:0000250}.
COILED 1074 1103 {ECO:0000255}.
COILED 2897 2982 {ECO:0000255}.
COILED 3109 3200 {ECO:0000255}.
COILED 3408 3442 {ECO:0000255}.
VAR_SEQ 736 4122 Missing (in isoform 3).
{ECO:0000303|Ref.1}.
/FTId=VSP_031282.
VAR_SEQ 3273 3273 Q -> QIIGLKSW (in isoform 2).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_031283.
VARIANT 209 209 F -> I (in SRTD3; dbSNP:rs771511132).
{ECO:0000269|PubMed:19361615}.
/FTId=VAR_063242.
VARIANT 302 302 T -> P (in dbSNP:rs12803695).
/FTId=VAR_038862.
VARIANT 304 304 Q -> L (in dbSNP:rs12146610).
/FTId=VAR_038863.
VARIANT 330 330 R -> C (in SRTD3; dbSNP:rs397514637).
{ECO:0000269|PubMed:22499340,
ECO:0000269|PubMed:23456818}.
/FTId=VAR_069591.
VARIANT 338 338 R -> G (in SRTD3).
{ECO:0000269|PubMed:22499340}.
/FTId=VAR_069592.
VARIANT 341 341 H -> Y (in dbSNP:rs17301182).
/FTId=VAR_038864.
VARIANT 430 430 R -> C (in SRTD3; dbSNP:rs374073337).
{ECO:0000269|PubMed:22499340}.
/FTId=VAR_069593.
VARIANT 456 456 R -> Q (in dbSNP:rs17099969).
/FTId=VAR_038865.
VARIANT 495 495 K -> R (in SRTD3).
{ECO:0000269|PubMed:22499340}.
/FTId=VAR_069594.
VARIANT 587 587 R -> C (in SRTD3; dbSNP:rs137853030).
{ECO:0000269|PubMed:19361615}.
/FTId=VAR_063243.
VARIANT 789 789 R -> K (in dbSNP:rs7358374).
/FTId=VAR_038866.
VARIANT 871 871 L -> P (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069595.
VARIANT 1221 1221 R -> K (in dbSNP:rs12794914).
/FTId=VAR_038867.
VARIANT 1228 1228 L -> I (in SRTD3; dbSNP:rs189806840).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069596.
VARIANT 1240 1240 I -> T (in SRTD3; dbSNP:rs137853028).
{ECO:0000269|PubMed:19442771,
ECO:0000269|PubMed:23456818}.
/FTId=VAR_063244.
VARIANT 1288 1288 T -> A (in dbSNP:rs17301750).
/FTId=VAR_038868.
VARIANT 1379 1379 M -> V (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069597.
VARIANT 1413 1413 K -> R (in dbSNP:rs688906).
{ECO:0000269|PubMed:8666668}.
/FTId=VAR_038869.
VARIANT 1423 1423 R -> C (in SRTD3; dbSNP:rs745870321).
{ECO:0000269|PubMed:22499340}.
/FTId=VAR_069598.
VARIANT 1442 1442 G -> D (in SRTD3; dbSNP:rs763571787).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069599.
VARIANT 1537 1537 Q -> R (in SRTD3; dbSNP:rs137853033).
/FTId=VAR_063245.
VARIANT 1987 1987 T -> A (in SRTD3; dbSNP:rs137853035).
{ECO:0000269|PubMed:19442771}.
/FTId=VAR_063246.
VARIANT 1991 1991 M -> K (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069600.
VARIANT 1991 1991 M -> L (in SRTD3; dbSNP:rs137853025).
{ECO:0000269|PubMed:19442771}.
/FTId=VAR_063247.
VARIANT 2205 2205 R -> H (in SRTD3; dbSNP:rs137853031).
{ECO:0000269|PubMed:19361615}.
/FTId=VAR_063248.
VARIANT 2227 2227 M -> V (in SRTD3; dbSNP:rs750249486).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069601.
VARIANT 2304 2304 A -> T (in SRTD3; dbSNP:rs747348765).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069602.
VARIANT 2362 2362 N -> S (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069603.
VARIANT 2461 2461 G -> V (in SRTD3; dbSNP:rs137853034).
{ECO:0000269|PubMed:19442771}.
/FTId=VAR_063249.
VARIANT 2481 2481 R -> Q (in SRTD3; dbSNP:rs781326398).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069604.
VARIANT 2496 2496 P -> S (in SRTD3; dbSNP:rs397514636).
{ECO:0000269|PubMed:22499340}.
/FTId=VAR_069605.
VARIANT 2532 2532 R -> W (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069606.
VARIANT 2555 2555 V -> M (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069607.
VARIANT 2573 2573 Y -> C (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069608.
VARIANT 2640 2640 I -> T (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069609.
VARIANT 2662 2662 R -> Q (in SRTD3; dbSNP:rs397514635).
{ECO:0000269|PubMed:22499340}.
/FTId=VAR_069610.
VARIANT 2819 2819 I -> M (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069611.
VARIANT 2871 2871 R -> Q (in dbSNP:rs589623).
{ECO:0000269|PubMed:12056414,
ECO:0000269|PubMed:17974005}.
/FTId=VAR_038870.
VARIANT 3015 3015 D -> G (in SRTD3; dbSNP:rs137853027).
{ECO:0000269|PubMed:19442771,
ECO:0000269|PubMed:23456818}.
/FTId=VAR_063250.
VARIANT 3381 3381 P -> L (in SRTD3; dbSNP:rs368631447).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069612.
VARIANT 3680 3680 A -> V (in dbSNP:rs10895391).
{ECO:0000269|PubMed:12056414}.
/FTId=VAR_038871.
VARIANT 3762 3762 L -> V (in SRTD3).
{ECO:0000269|PubMed:19442771}.
/FTId=VAR_063251.
VARIANT 3806 3806 R -> C (in SRTD3; dbSNP:rs754753584).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069613.
VARIANT 3847 3847 W -> G (in SRTD3; dbSNP:rs752554582).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069614.
VARIANT 3909 3909 G -> D (probable disease-associated
mutation found in short rib-polydactyly
syndrome 3/6; digenic inheritance; the
patient also carries a mutation in NEK1;
dbSNP:rs201479015).
{ECO:0000269|PubMed:21211617}.
/FTId=VAR_069615.
VARIANT 3976 3976 S -> N (in dbSNP:rs4754914).
/FTId=VAR_038872.
VARIANT 4139 4139 Q -> P (in dbSNP:rs1793493).
/FTId=VAR_038873.
VARIANT 4232 4232 L -> R (in SRTD3).
{ECO:0000269|PubMed:23456818}.
/FTId=VAR_069616.
CONFLICT 174 174 D -> G (in Ref. 1; BAE17138).
{ECO:0000305}.
CONFLICT 178 178 F -> L (in Ref. 1; BAE17138).
{ECO:0000305}.
CONFLICT 594 594 F -> L (in Ref. 1; BAE17138).
{ECO:0000305}.
CONFLICT 1120 1120 I -> N (in Ref. 4; AAB09728).
{ECO:0000305}.
CONFLICT 1168 1168 D -> V (in Ref. 4; AAB09728).
{ECO:0000305}.
CONFLICT 1784 1784 N -> H (in Ref. 6; CAB06054).
{ECO:0000305}.
CONFLICT 1864 1864 W -> Y (in Ref. 6; CAB06054).
{ECO:0000305}.
CONFLICT 1866 1867 LR -> FS (in Ref. 6; CAB06054).
{ECO:0000305}.
CONFLICT 1930 1930 E -> K (in Ref. 1; BAE46899).
{ECO:0000305}.
CONFLICT 3095 3095 A -> V (in Ref. 7; CAD98012).
{ECO:0000305}.
CONFLICT 3665 3665 L -> P (in Ref. 7; CAD98012).
{ECO:0000305}.
CONFLICT 4258 4258 C -> R (in Ref. 3; BAB13905).
{ECO:0000305}.
HELIX 1257 1273 {ECO:0000244|PDB:4RH7}.
STRAND 1278 1281 {ECO:0000244|PDB:4RH7}.
STRAND 1289 1292 {ECO:0000244|PDB:4RH7}.
HELIX 1295 1314 {ECO:0000244|PDB:4RH7}.
HELIX 1316 1321 {ECO:0000244|PDB:4RH7}.
HELIX 1322 1358 {ECO:0000244|PDB:4RH7}.
HELIX 1362 1384 {ECO:0000244|PDB:4RH7}.
HELIX 1389 1392 {ECO:0000244|PDB:4RH7}.
HELIX 1397 1425 {ECO:0000244|PDB:4RH7}.
HELIX 1427 1431 {ECO:0000244|PDB:4RH7}.
HELIX 1434 1442 {ECO:0000244|PDB:4RH7}.
HELIX 1447 1454 {ECO:0000244|PDB:4RH7}.
TURN 1455 1457 {ECO:0000244|PDB:4RH7}.
STRAND 1458 1460 {ECO:0000244|PDB:4RH7}.
STRAND 1462 1464 {ECO:0000244|PDB:4RH7}.
STRAND 1475 1477 {ECO:0000244|PDB:4RH7}.
STRAND 1483 1485 {ECO:0000244|PDB:4RH7}.
HELIX 1496 1523 {ECO:0000244|PDB:4RH7}.
STRAND 1524 1526 {ECO:0000244|PDB:4RH7}.
TURN 1531 1533 {ECO:0000244|PDB:4RH7}.
HELIX 1536 1557 {ECO:0000244|PDB:4RH7}.
HELIX 1561 1580 {ECO:0000244|PDB:4RH7}.
STRAND 1583 1586 {ECO:0000244|PDB:4RH7}.
HELIX 1593 1616 {ECO:0000244|PDB:4RH7}.
HELIX 1624 1628 {ECO:0000244|PDB:4RH7}.
STRAND 1631 1634 {ECO:0000244|PDB:4RH7}.
STRAND 1640 1644 {ECO:0000244|PDB:4RH7}.
STRAND 1647 1650 {ECO:0000244|PDB:4RH7}.
HELIX 1666 1681 {ECO:0000244|PDB:4RH7}.
STRAND 1684 1688 {ECO:0000244|PDB:4RH7}.
HELIX 1695 1705 {ECO:0000244|PDB:4RH7}.
STRAND 1710 1714 {ECO:0000244|PDB:4RH7}.
HELIX 1721 1734 {ECO:0000244|PDB:4RH7}.
STRAND 1737 1742 {ECO:0000244|PDB:4RH7}.
HELIX 1748 1767 {ECO:0000244|PDB:4RH7}.
STRAND 1770 1774 {ECO:0000244|PDB:4RH7}.
STRAND 1777 1780 {ECO:0000244|PDB:4RH7}.
STRAND 1786 1791 {ECO:0000244|PDB:4RH7}.
TURN 1796 1798 {ECO:0000244|PDB:4RH7}.
HELIX 1806 1809 {ECO:0000244|PDB:4RH7}.
STRAND 1812 1816 {ECO:0000244|PDB:4RH7}.
HELIX 1823 1833 {ECO:0000244|PDB:4RH7}.
HELIX 1838 1855 {ECO:0000244|PDB:4RH7}.
HELIX 1866 1886 {ECO:0000244|PDB:4RH7}.
HELIX 1891 1906 {ECO:0000244|PDB:4RH7}.
TURN 1907 1909 {ECO:0000244|PDB:4RH7}.
HELIX 1912 1925 {ECO:0000244|PDB:4RH7}.
TURN 1927 1929 {ECO:0000244|PDB:4RH7}.
HELIX 1938 1950 {ECO:0000244|PDB:4RH7}.
HELIX 1956 1971 {ECO:0000244|PDB:4RH7}.
STRAND 1973 1978 {ECO:0000244|PDB:4RH7}.
HELIX 1985 1999 {ECO:0000244|PDB:4RH7}.
STRAND 2004 2008 {ECO:0000244|PDB:4RH7}.
TURN 2010 2012 {ECO:0000244|PDB:4RH7}.
HELIX 2015 2019 {ECO:0000244|PDB:4RH7}.
STRAND 2021 2023 {ECO:0000244|PDB:4RH7}.
TURN 2024 2027 {ECO:0000244|PDB:4RH7}.
STRAND 2028 2030 {ECO:0000244|PDB:4RH7}.
HELIX 2033 2043 {ECO:0000244|PDB:4RH7}.
STRAND 2050 2056 {ECO:0000244|PDB:4RH7}.
HELIX 2060 2063 {ECO:0000244|PDB:4RH7}.
HELIX 2064 2066 {ECO:0000244|PDB:4RH7}.
HELIX 2067 2070 {ECO:0000244|PDB:4RH7}.
STRAND 2071 2073 {ECO:0000244|PDB:4RH7}.
STRAND 2090 2097 {ECO:0000244|PDB:4RH7}.
HELIX 2104 2109 {ECO:0000244|PDB:4RH7}.
STRAND 2110 2114 {ECO:0000244|PDB:4RH7}.
TURN 2117 2119 {ECO:0000244|PDB:4RH7}.
HELIX 2122 2132 {ECO:0000244|PDB:4RH7}.
HELIX 2138 2159 {ECO:0000244|PDB:4RH7}.
HELIX 2168 2177 {ECO:0000244|PDB:4RH7}.
HELIX 2185 2197 {ECO:0000244|PDB:4RH7}.
HELIX 2202 2215 {ECO:0000244|PDB:4RH7}.
STRAND 2216 2218 {ECO:0000244|PDB:4RH7}.
HELIX 2226 2228 {ECO:0000244|PDB:4RH7}.
TURN 2233 2235 {ECO:0000244|PDB:4RH7}.
TURN 2251 2254 {ECO:0000244|PDB:4RH7}.
STRAND 2256 2259 {ECO:0000244|PDB:4RH7}.
HELIX 2266 2279 {ECO:0000244|PDB:4RH7}.
HELIX 2281 2283 {ECO:0000244|PDB:4RH7}.
STRAND 2287 2290 {ECO:0000244|PDB:4RH7}.
HELIX 2297 2307 {ECO:0000244|PDB:4RH7}.
STRAND 2312 2316 {ECO:0000244|PDB:4RH7}.
HELIX 2324 2332 {ECO:0000244|PDB:4RH7}.
STRAND 2341 2343 {ECO:0000244|PDB:4RH7}.
STRAND 2348 2350 {ECO:0000244|PDB:4RH7}.
STRAND 2352 2359 {ECO:0000244|PDB:4RH7}.
HELIX 2373 2384 {ECO:0000244|PDB:4RH7}.
STRAND 2385 2388 {ECO:0000244|PDB:4RH7}.
STRAND 2390 2392 {ECO:0000244|PDB:4RH7}.
STRAND 2394 2397 {ECO:0000244|PDB:4RH7}.
STRAND 2401 2406 {ECO:0000244|PDB:4RH7}.
HELIX 2419 2422 {ECO:0000244|PDB:4RH7}.
STRAND 2425 2429 {ECO:0000244|PDB:4RH7}.
HELIX 2435 2452 {ECO:0000244|PDB:4RH7}.
STRAND 2455 2461 {ECO:0000244|PDB:4RH7}.
HELIX 2463 2483 {ECO:0000244|PDB:4RH7}.
TURN 2486 2488 {ECO:0000244|PDB:4RH7}.
HELIX 2496 2504 {ECO:0000244|PDB:4RH7}.
HELIX 2505 2508 {ECO:0000244|PDB:4RH7}.
HELIX 2520 2534 {ECO:0000244|PDB:4RH7}.
TURN 2535 2538 {ECO:0000244|PDB:4RH7}.
HELIX 2542 2559 {ECO:0000244|PDB:4RH7}.
STRAND 2560 2562 {ECO:0000244|PDB:4RH7}.
STRAND 2571 2577 {ECO:0000244|PDB:4RH7}.
HELIX 2579 2581 {ECO:0000244|PDB:4RH7}.
STRAND 2599 2603 {ECO:0000244|PDB:4RH7}.
HELIX 2604 2621 {ECO:0000244|PDB:4RH7}.
HELIX 2631 2645 {ECO:0000244|PDB:4RH7}.
STRAND 2651 2654 {ECO:0000244|PDB:4RH7}.
HELIX 2661 2672 {ECO:0000244|PDB:4RH7}.
STRAND 2675 2677 {ECO:0000244|PDB:4RH7}.
HELIX 2687 2702 {ECO:0000244|PDB:4RH7}.
STRAND 2708 2713 {ECO:0000244|PDB:4RH7}.
HELIX 2714 2716 {ECO:0000244|PDB:4RH7}.
HELIX 2721 2732 {ECO:0000244|PDB:4RH7}.
TURN 2736 2738 {ECO:0000244|PDB:4RH7}.
HELIX 2741 2758 {ECO:0000244|PDB:4RH7}.
HELIX 2764 2775 {ECO:0000244|PDB:4RH7}.
STRAND 2776 2782 {ECO:0000244|PDB:4RH7}.
STRAND 2784 2786 {ECO:0000244|PDB:4RH7}.
HELIX 2789 2795 {ECO:0000244|PDB:4RH7}.
HELIX 2798 2802 {ECO:0000244|PDB:4RH7}.
STRAND 2803 2807 {ECO:0000244|PDB:4RH7}.
HELIX 2813 2825 {ECO:0000244|PDB:4RH7}.
HELIX 2849 2862 {ECO:0000244|PDB:4RH7}.
TURN 2863 2865 {ECO:0000244|PDB:4RH7}.
HELIX 2869 2994 {ECO:0000244|PDB:4RH7}.
HELIX 2998 3004 {ECO:0000244|PDB:4RH7}.
HELIX 3011 3023 {ECO:0000244|PDB:4RH7}.
HELIX 3031 3038 {ECO:0000244|PDB:4RH7}.
HELIX 3043 3046 {ECO:0000244|PDB:4RH7}.
TURN 3047 3049 {ECO:0000244|PDB:4RH7}.
HELIX 3057 3070 {ECO:0000244|PDB:4RH7}.
TURN 3071 3073 {ECO:0000244|PDB:4RH7}.
HELIX 3076 3080 {ECO:0000244|PDB:4RH7}.
TURN 3084 3087 {ECO:0000244|PDB:4RH7}.
HELIX 3088 3197 {ECO:0000244|PDB:4RH7}.
HELIX 3200 3214 {ECO:0000244|PDB:4RH7}.
HELIX 3219 3233 {ECO:0000244|PDB:4RH7}.
HELIX 3240 3244 {ECO:0000244|PDB:4RH7}.
HELIX 3247 3255 {ECO:0000244|PDB:4RH7}.
HELIX 3262 3270 {ECO:0000244|PDB:4RH7}.
STRAND 3275 3281 {ECO:0000244|PDB:4RH7}.
HELIX 3286 3295 {ECO:0000244|PDB:4RH7}.
STRAND 3301 3303 {ECO:0000244|PDB:4RH7}.
HELIX 3310 3320 {ECO:0000244|PDB:4RH7}.
STRAND 3324 3327 {ECO:0000244|PDB:4RH7}.
HELIX 3334 3336 {ECO:0000244|PDB:4RH7}.
HELIX 3337 3340 {ECO:0000244|PDB:4RH7}.
STRAND 3344 3347 {ECO:0000244|PDB:4RH7}.
STRAND 3350 3355 {ECO:0000244|PDB:4RH7}.
STRAND 3358 3362 {ECO:0000244|PDB:4RH7}.
STRAND 3370 3375 {ECO:0000244|PDB:4RH7}.
HELIX 3381 3384 {ECO:0000244|PDB:4RH7}.
STRAND 3387 3391 {ECO:0000244|PDB:4RH7}.
HELIX 3396 3411 {ECO:0000244|PDB:4RH7}.
HELIX 3413 3446 {ECO:0000244|PDB:4RH7}.
STRAND 3447 3449 {ECO:0000244|PDB:4RH7}.
TURN 3451 3453 {ECO:0000244|PDB:4RH7}.
HELIX 3455 3490 {ECO:0000244|PDB:4RH7}.
HELIX 3493 3512 {ECO:0000244|PDB:4RH7}.
HELIX 3520 3532 {ECO:0000244|PDB:4RH7}.
HELIX 3540 3562 {ECO:0000244|PDB:4RH7}.
HELIX 3565 3579 {ECO:0000244|PDB:4RH7}.
STRAND 3582 3584 {ECO:0000244|PDB:4RH7}.
HELIX 3588 3593 {ECO:0000244|PDB:4RH7}.
STRAND 3616 3618 {ECO:0000244|PDB:4RH7}.
HELIX 3620 3632 {ECO:0000244|PDB:4RH7}.
HELIX 3634 3640 {ECO:0000244|PDB:4RH7}.
TURN 3641 3644 {ECO:0000244|PDB:4RH7}.
HELIX 3647 3653 {ECO:0000244|PDB:4RH7}.
HELIX 3658 3660 {ECO:0000244|PDB:4RH7}.
HELIX 3663 3668 {ECO:0000244|PDB:4RH7}.
HELIX 3673 3681 {ECO:0000244|PDB:4RH7}.
HELIX 3683 3698 {ECO:0000244|PDB:4RH7}.
HELIX 3710 3714 {ECO:0000244|PDB:4RH7}.
STRAND 3723 3726 {ECO:0000244|PDB:4RH7}.
HELIX 3734 3744 {ECO:0000244|PDB:4RH7}.
STRAND 3751 3754 {ECO:0000244|PDB:4RH7}.
HELIX 3759 3773 {ECO:0000244|PDB:4RH7}.
STRAND 3776 3780 {ECO:0000244|PDB:4RH7}.
HELIX 3782 3784 {ECO:0000244|PDB:4RH7}.
TURN 3786 3788 {ECO:0000244|PDB:4RH7}.
HELIX 3789 3798 {ECO:0000244|PDB:4RH7}.
STRAND 3806 3811 {ECO:0000244|PDB:4RH7}.
HELIX 3819 3823 {ECO:0000244|PDB:4RH7}.
STRAND 3824 3829 {ECO:0000244|PDB:4RH7}.
HELIX 3836 3846 {ECO:0000244|PDB:4RH7}.
HELIX 3849 3852 {ECO:0000244|PDB:4RH7}.
TURN 3855 3860 {ECO:0000244|PDB:4RH7}.
HELIX 3861 3877 {ECO:0000244|PDB:4RH7}.
TURN 3881 3884 {ECO:0000244|PDB:4RH7}.
HELIX 3893 3908 {ECO:0000244|PDB:4RH7}.
STRAND 3909 3911 {ECO:0000244|PDB:4RH7}.
HELIX 3916 3925 {ECO:0000244|PDB:4RH7}.
TURN 3928 3930 {ECO:0000244|PDB:4RH7}.
HELIX 3934 3948 {ECO:0000244|PDB:4RH7}.
TURN 3967 3969 {ECO:0000244|PDB:4RH7}.
HELIX 3977 3986 {ECO:0000244|PDB:4RH7}.
HELIX 3993 3996 {ECO:0000244|PDB:4RH7}.
HELIX 4001 4020 {ECO:0000244|PDB:4RH7}.
HELIX 4031 4036 {ECO:0000244|PDB:4RH7}.
HELIX 4041 4051 {ECO:0000244|PDB:4RH7}.
HELIX 4055 4059 {ECO:0000244|PDB:4RH7}.
HELIX 4071 4102 {ECO:0000244|PDB:4RH7}.
HELIX 4109 4120 {ECO:0000244|PDB:4RH7}.
HELIX 4125 4130 {ECO:0000244|PDB:4RH7}.
HELIX 4137 4159 {ECO:0000244|PDB:4RH7}.
TURN 4163 4165 {ECO:0000244|PDB:4RH7}.
HELIX 4170 4172 {ECO:0000244|PDB:4RH7}.
HELIX 4176 4191 {ECO:0000244|PDB:4RH7}.
HELIX 4195 4197 {ECO:0000244|PDB:4RH7}.
STRAND 4198 4202 {ECO:0000244|PDB:4RH7}.
STRAND 4204 4206 {ECO:0000244|PDB:4RH7}.
STRAND 4212 4217 {ECO:0000244|PDB:4RH7}.
STRAND 4221 4228 {ECO:0000244|PDB:4RH7}.
STRAND 4231 4233 {ECO:0000244|PDB:4RH7}.
STRAND 4237 4239 {ECO:0000244|PDB:4RH7}.
STRAND 4241 4244 {ECO:0000244|PDB:4RH7}.
STRAND 4248 4254 {ECO:0000244|PDB:4RH7}.
TURN 4263 4265 {ECO:0000244|PDB:4RH7}.
STRAND 4266 4276 {ECO:0000244|PDB:4RH7}.
STRAND 4279 4287 {ECO:0000244|PDB:4RH7}.
HELIX 4292 4298 {ECO:0000244|PDB:4RH7}.
STRAND 4301 4303 {ECO:0000244|PDB:4RH7}.
SEQUENCE 4307 AA; 492622 MW; 54B60DEE419B7E9D CRC64;
MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI
SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML
LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI
EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH
DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH
LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR
VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA
FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS
EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR
DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK
SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD
GLQELRTGLA TVEAQGFQAS DMHAWKQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLT
YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSIMID RNASGFLTIF
SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLFTVH DWEKNFKALK IKGKEVERLP
SAVKVDCLNI NCNPVKTVID DLIQKLFDLL VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP
QSVEEIGDAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL
MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQHNTLDKSA
KLIKEKKIEF DDLEVTRKKL VDDCHHFRLE EPNFSLASSI SKDIESCAQI WAFYEEFQQG
FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKVEEHSVMT VKLQSEVDKY KIVIPILKYV
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VAKAADLKDL NSRAQGEVTI
REALRELDLW GVGAVFTLID YEDSQSRTMK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG
FEDKVSIWER KLAELDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNR VDEDFRSIMT
DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI
LGQSTNPSVI QSHLKKLFAG INSVCFDEKS KHITAMKSLE GEVVPFKNKV PLSNNVETWL
NDLALEMKKT LEQLLKECVT TGRSSQGAVD PSLFPSQILC LAEQIKFTED VENAIKDHSL
HQIETQLVNK LEQYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQIQVHT
TEDWAWKKQL RFYMKSDHTC CVQMVDSEFQ YTYEYQGNAS KLVYTPLTDK CYLTLTQAMK
MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF
DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE VNSNSGIFIT MNPAGKGYGG
RQKLPDNLKQ LFRPVAMSHP DNELIAEVIL YSEGFKDAKV LSRKLVAIFN LSRELLTPQQ
HYDWGLRALK TVLRGSGNLL RQLNKSGTTQ NANESHIVVQ ALRLNTMSKF TFTDCTRFDA
LIKDVFPGIE LKEVEYDELS AALKQVFEEA NYEIIPNQIK KALELYEQLC QRMGVVIVGP
SGAGKSTLWR MLRAALCKTG KVVKQYTMNP KAMPRYQLLG HIDMDTREWS DGVLTNSARQ
VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPAEYRNN LENWIGDYFE KALQWVLKQN
DYVVETSLVG TVMNGLSHLH GCRDHDEFII NLIRGLGGNL NMKSRLEFTK EVFHWARESP
PDFHKPMDTY YDSTRGRLAT YVLKKPEDLT ADDFSNGLTL PVIQTPDMQR GLDYFKPWLS
SDTKQPFILV GPEGCGKGML LRYAFSQLRS TQIATVHCSA QTTSRHLLQK LSQTCMVIST
NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI
QIVASMSAGG RLGRHKLTTR FTSIVRLCSI DYPEREQLQT IYGAYLEPVL HKNLKNHSIW
GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL
DYVLEIVAYE ARRLFRDKIV GAKELHLFDI ILTSVFQGDW GSDILDNMSD SFYVTWGARH
NSGARAAPGQ PLPPHGKPLG KLNSTDLKDV IKKGLIHYGR DNQNLDILLF HEVLEYMSRI
DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKQF KNDLKHVLQL
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF
FGPVFNYFTY RIQQNLHIVL IMDSANSNFM INCESNPALH KKCQVLWMEG WSNSSMKKIP
EMLFSETGGG EKYNDKKRKE EKKKNSVDPD FLKSFLLIHE SCKAYGATPS RYMTFLHVYS
AISSSKKKEL LKRQSHLQAG VSKLNEAKAL VDELNRKAGE QSVLLKTKQD EADAALQMIT
VSMQDASEQK TELERLKHRI AEEVVKIEER KNKIDDELKE VQPLVNEAKL AVGNIKPESL
SEIRSLRMPP DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVREDIATF DARNISKEIR
ESVEELLFKN KGSFDPKNAK RASTAAAPLA AWVKANIQYS HVLERIHPLE TEQAGLESNL
KKTEDRKRKL EELLNSVGQK VSELKEKFQS RTSEAAKLEA EVSKAQETIK AAEVLINQLD
REHKRWNAQV VEITEELATL PKRAQLAAAF ITYLSAAPES LRKTCLEEWT KSAGLEKFDL
RRFLCTESEQ LIWKSEGLPS DDLSIENALV ILQSRVCPFL IDPSSQATEW LKTHLKDSRL
EVINQQDSNF ITALELAVRF GKTLIIQEMD GVEPVLYPLL RRDLVAQGPR YVVQIGDKII
DYNEEFRLFL STRNPNPFIP PDAASIVTEV NFTTTRSGLR GQLLALTIQH EKPDLEEQKT
KLLQQEEDKK IQLAKLEESL LETLATSQGN ILENKDLIES LNQTKASSAL IQESLKESYK
LQISLDQERD AYLPLAESAS KMYFIISDLS KINNMYRFSL AAFLRLFQRA LQNKQDSENT
EQRIQSLISS LQHMVYEYIC RCLFKADQLM FALHFVRGMH PELFQENEWD TFTGVVVGDM
LRKADSQQKI RDQLPSWIDQ ERSWAVATLK IALPSLYQTL CFEDAALWRT YYNNSMCEQE
FPSILAKKVS LFQQILVVQA LRPDRLQSAM ALFACKTLGL KEVSPLPLNL KRLYKETLEI
EPILIIISPG ADPSQELQEL ANAERSGECY HQVAMGQGQA DLAIQMLKEC ARNGDWLCLK
NLHLVVSWLP VLEKELNTLQ PKDTFRLWLT AEVHPNFTPI LLQSSLKITY ESPPGLKKNL
MRTYESWTPE QISKKDNTHR AHALFSLAWF HAACQERRNY IPQGWTKFYE FSLSDLRAGY
NIIDRLFDGA KDVQWEFVHG LLENAIYGGR IDNYFDLRVL QSYLKQFFNS SVIDVFNQRN
KKSIFPYSVS LPQSCSILDY RAVIEKIPED DKPSFFGLPA NIARSSQRMI SSQVISQLRI
LGRSITAGSK FDREIWSNEL SPVLNLWKKL NQNSNLIHQK VPPPNDRQGS PILSFIILEQ
FNAIRLVQSV HQSLAALSKV IRGTTLLSSE VQKLASALLN QKCPLAWQSK WEGPEDPLQY
LRGLVARALA IQNWVDKAEK QALLSETLDL SELFHPDTFL NALRQETARA VGRSVDSLKF
VASWKGRLQE AKLQIKISGL LLEGCSFDGN QLSENQLDSP SVSSVLPCFM GWIPQDACGP
YSPDECISLP VYTSAERDRV VTNIDVPCGG NQDQWIQCGA ALFLKNQ


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