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Cytoplasmic envelopment protein 2

 CEP2_HHV11              Reviewed;         373 AA.
P10200;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
15-FEB-2017, entry version 64.
RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
Name=UL16;
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
1).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Simplexvirus.
NCBI_TaxID=10299;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
McNab D., Perry L.J., Scott J.E., Taylor P.;
"The complete DNA sequence of the long unique region in the genome of
herpes simplex virus type 1.";
J. Gen. Virol. 69:1531-1574(1988).
[2]
INTERACTION WITH CYTOPLASMIC ENVELOPMENT PROTEIN 3.
STRAIN=KOS;
PubMed=14557627; DOI=10.1128/JVI.77.21.11417-11424.2003;
Loomis J.S., Courtney R.J., Wills J.W.;
"Binding partners for the UL11 tegument protein of herpes simplex
virus type 1.";
J. Virol. 77:11417-11424(2003).
[3]
INTERACTION WITH CAPSID, AND SUBCELLULAR LOCATION.
STRAIN=KOS;
PubMed=17855514; DOI=10.1128/JVI.01306-07;
Meckes D.G. Jr., Wills J.W.;
"Dynamic interactions of the UL16 tegument protein with the capsid of
herpes simplex virus.";
J. Virol. 81:13028-13036(2007).
[4]
FUNCTION.
STRAIN=KOS;
PubMed=18715922; DOI=10.1128/JVI.01223-08;
Meckes D.G. Jr., Wills J.W.;
"Structural rearrangement within an enveloped virus upon binding to
the host cell.";
J. Virol. 82:10429-10435(2008).
[5]
INTERACTION WITH CYTOPLASMIC ENVELOPMENT PROTEIN 3, AND MUTAGENESIS OF
CYS-221; CYS-244; CYS-247; CYS-269; CYS-271 AND CYS-275.
STRAIN=KOS;
PubMed=18715918; DOI=10.1128/JVI.01230-08;
Yeh P.-C., Meckes D.G. Jr., Wills J.W.;
"Analysis of the interaction between the UL11 and UL16 tegument
proteins of herpes simplex virus.";
J. Virol. 82:10693-10700(2008).
-!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
Participates in the final step of tegumentation and envelope
acquisition within the host cytoplasm by directly interacting with
the capsid. Upon virion binding to target cell, a signaling
cascade is triggered to disrupt the interaction with the capsid,
thereby preparing capsid uncoating. {ECO:0000255|HAMAP-
Rule:MF_04039, ECO:0000269|PubMed:18715922}.
-!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with
the capsid. {ECO:0000255|HAMAP-Rule:MF_04039,
ECO:0000269|PubMed:14557627, ECO:0000269|PubMed:17855514,
ECO:0000269|PubMed:18715918}.
-!- INTERACTION:
P04289:UL11; NbExp=3; IntAct=EBI-7044955, EBI-7044930;
-!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
Rule:MF_04039, ECO:0000269|PubMed:17855514}. Host cytoplasm
{ECO:0000255|HAMAP-Rule:MF_04039, ECO:0000269|PubMed:17855514}.
Host nucleus {ECO:0000255|HAMAP-Rule:MF_04039,
ECO:0000269|PubMed:17855514}. Note=Localizes in the host nucleus
up to 18 hours postinfection, but at later times localizes to
punctate, cytoplasmic structures. {ECO:0000255|HAMAP-
Rule:MF_04039, ECO:0000269|PubMed:17855514}.
-!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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EMBL; X14112; CAA32328.1; -; Genomic_DNA.
PIR; G30083; WMBET6.
RefSeq; YP_009137090.1; NC_001806.2.
IntAct; P10200; 2.
MINT; MINT-6732685; -.
PRIDE; P10200; -.
GeneID; 24271465; -.
KEGG; vg:24271465; -.
OrthoDB; VOG090000ON; -.
Proteomes; UP000009294; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
HAMAP; MF_04039; HSV_CEP2; 1.
InterPro; IPR004286; Herpes_UL16/UL94.
Pfam; PF03044; Herpes_UL16; 1.
1: Evidence at protein level;
Complete proteome; Host cytoplasm; Host nucleus; Late protein;
Reference proteome; Virion; Virion tegument.
CHAIN 1 373 Cytoplasmic envelopment protein 2.
/FTId=PRO_0000115949.
MUTAGEN 221 221 C->S: No effect on the interaction with
UL11. {ECO:0000269|PubMed:18715918}.
MUTAGEN 244 244 C->S: No effect on the interaction with
UL11. {ECO:0000269|PubMed:18715918}.
MUTAGEN 247 247 C->S: Complete loss of interaction with
UL11. {ECO:0000269|PubMed:18715918}.
MUTAGEN 269 269 C->S: Complete loss of interaction with
UL11. {ECO:0000269|PubMed:18715918}.
MUTAGEN 271 271 C->S: Complete loss of interaction with
UL11. {ECO:0000269|PubMed:18715918}.
MUTAGEN 275 275 C->S: Complete loss of interaction with
UL11. {ECO:0000269|PubMed:18715918}.
SEQUENCE 373 AA; 40443 MW; 85D9914C533FE34B CRC64;
MAQLGPRRPL APPGPPGTLP RPDSRAGARG TRDRVDDLGT DVDSIARIVN SVFVWRVVRA
DERLKIFRCL TVLTEPLCQV ALPNPDPGRA LFCEIFLYLT RPKALRLPPN TFFALFFFNR
ERRYCAIVHL RSVTHPLTPL LCTLTFARIR AATPPEETPD PTTEQLAEEP VVGELDGAYL
VPAKTPPEPG ACCALGPGAW WHLPSGQIYC WAMDSDLGSL CPPGSRARHL GWLLARITNH
PGGCESCAPP PHIDSANALW LSSVVTESCP CVAPCLWAKM AQCTLAVQGD ASLCPLLFGH
PVDTVTLLQA PRRPCITDRL QEVVGGRCGA DNIPPTSAGW RLCVFSSYIS RLFATSCPTV
ARAVARASSS DPE


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