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Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB)

 5NT1B_MOUSE             Reviewed;         573 AA.
Q91YE9; E9QNH2; Q91Y48;
10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
28-JUN-2011, sequence version 2.
28-FEB-2018, entry version 110.
RecName: Full=Cytosolic 5'-nucleotidase 1B;
Short=cN1B;
EC=3.1.3.5;
AltName: Full=Autoimmune infertility-related protein;
AltName: Full=Cytosolic 5'-nucleotidase IB;
Short=cN-IB;
Name=Nt5c1b; Synonyms=Airp;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
SPECIFICITY.
TISSUE=Testis;
PubMed=11690631; DOI=10.1016/S0167-4781(01)00278-0;
Sala-Newby G.B., Newby A.C.;
"Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene
related to human autoimmune infertility-related protein.";
Biochim. Biophys. Acta 1521:12-18(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=CD-1; TISSUE=Testis;
Setiady Y.Y., Pujianto D.A., Ekowati A.L., Harahap A., Marzuki S.;
"Isolation of a novel human testis cDNA encoding a polypeptide related
to autoimmune infertility.";
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
-!- FUNCTION: Dephosphorylates the 5' and 2'(3')-phosphates of
deoxyribonucleotides. Helps to regulate adenosine levels.
{ECO:0000269|PubMed:11690631}.
-!- CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside
+ phosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
-!- ENZYME REGULATION: Activated by ADP.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q91YE9-1; Sequence=Displayed;
Name=2;
IsoId=Q91YE9-2; Sequence=VSP_010204, VSP_010205;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Highly expressed in testis and brain. Detected
at lower levels in skeletal muscle, heart and kidney.
{ECO:0000269|PubMed:11690631}.
-!- SIMILARITY: Belongs to the 5'-nucleotidase type 3 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAK39109.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AJ295253; CAC44364.1; -; mRNA.
EMBL; AF356186; AAK39109.1; ALT_INIT; mRNA.
EMBL; AC157570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS25810.1; -. [Q91YE9-1]
CCDS; CCDS79106.1; -. [Q91YE9-2]
RefSeq; NP_081864.2; NM_027588.3. [Q91YE9-1]
UniGene; Mm.272843; -.
ProteinModelPortal; Q91YE9; -.
STRING; 10090.ENSMUSP00000002456; -.
iPTMnet; Q91YE9; -.
PhosphoSitePlus; Q91YE9; -.
PaxDb; Q91YE9; -.
PRIDE; Q91YE9; -.
Ensembl; ENSMUST00000002456; ENSMUSP00000002456; ENSMUSG00000020622. [Q91YE9-1]
Ensembl; ENSMUST00000118657; ENSMUSP00000112694; ENSMUSG00000020622. [Q91YE9-2]
GeneID; 70881; -.
KEGG; mmu:70881; -.
UCSC; uc007nap.2; mouse. [Q91YE9-1]
CTD; 93034; -.
MGI; MGI:1918131; Nt5c1b.
eggNOG; ENOG410IE01; Eukaryota.
eggNOG; ENOG410XPRD; LUCA.
GeneTree; ENSGT00390000017767; -.
HOGENOM; HOG000243802; -.
HOVERGEN; HBG050426; -.
InParanoid; Q91YE9; -.
KO; K01081; -.
OMA; PKPKHAI; -.
OrthoDB; EOG091G0EZE; -.
TreeFam; TF329831; -.
Reactome; R-MMU-74259; Purine catabolism.
SABIO-RK; Q91YE9; -.
ChiTaRS; Nt5c1b; mouse.
PRO; PR:Q91YE9; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000020622; -.
CleanEx; MM_NT5C1B; -.
ExpressionAtlas; Q91YE9; baseline and differential.
Genevisible; Q91YE9; MM.
GO; GO:0005829; C:cytosol; IDA:MGI.
GO; GO:0008253; F:5'-nucleotidase activity; IDA:MGI.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
GO; GO:0046085; P:adenosine metabolic process; IEA:Ensembl.
GO; GO:0009116; P:nucleoside metabolic process; IDA:MGI.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
InterPro; IPR010394; 5-nucleotidase.
PANTHER; PTHR31367; PTHR31367; 1.
Pfam; PF06189; 5-nucleotidase; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Cytoplasm; Hydrolase;
Magnesium; Nucleotide metabolism; Reference proteome.
CHAIN 1 573 Cytosolic 5'-nucleotidase 1B.
/FTId=PRO_0000144797.
ACT_SITE 428 428 Nucleophile. {ECO:0000250}.
VAR_SEQ 88 89 Missing (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_010204.
VAR_SEQ 247 262 Missing (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_010205.
CONFLICT 103 103 S -> F (in Ref. 2; AAK39109).
{ECO:0000305}.
CONFLICT 121 121 I -> T (in Ref. 1; CAC44364 and 2;
AAK39109). {ECO:0000305}.
CONFLICT 162 162 A -> V (in Ref. 1; CAC44364).
{ECO:0000305}.
CONFLICT 185 185 E -> Q (in Ref. 1; CAC44364).
{ECO:0000305}.
CONFLICT 228 228 Q -> H (in Ref. 1; CAC44364).
{ECO:0000305}.
SEQUENCE 573 AA; 65002 MW; 948868F505D6B965 CRC64;
MSQTSLKHKK KNEPGMRYSK ESLDAEKRKD SDKTGARLST QGSQELPLHN TDSRGYVVRN
QWSRTSRSPS TGAPSVDEPR SRNTAIKVEA PNSSTTSRTS SASPSQHETS PPPQTSEKSS
IQQTPQNRPI TQLESQPPTP PETEPNSRRT SAKMYTGSDP WAHRENREPR DLQLRDYAYS
CDSREGMPKT REYPRTPPTE WKPYAQRRLQ YGTSVDMEPE YISDGPQQRQ RQQTEEDEVD
EAYWTSVSML YEKIPSCARP RPPKPKHAIT IAVSSRALFN MVDDRKIYEE EGLEKYMEYQ
LTNENVILTP GPAFRFVKAL QHVNSRLRDL YPDEQDLFDI VLMTNNHAQV GVRLINSVNH
YGLLIDRFCL TGGKSPIGYL KAYLTNLYLS ADSEKVQEAI KEGIASATMY AGAKDMAYCD
TQLRVAFDGD AVLFSDESEH IAKDHGLDKF FQHETLFENK PLAQGPLKSF LEDLGKLQKK
FYAKDERLLC PIRTYLVTAR SAASSGARVL KTLRRWGLEI DEALFLAGAP KGPILVKIRP
HIFFDDQMFH IESAQKFGTI TAHVPYGIAQ KRN


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