Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Cytosolic Fe-S cluster assembly factor CFD1 (Cytosolic Fe-S cluster-deficient protein 1) (Ribosomal export protein 19)

 CFD1_YEAST              Reviewed;         293 AA.
P40558; D6VVS7;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
05-DEC-2018, entry version 155.
RecName: Full=Cytosolic Fe-S cluster assembly factor CFD1 {ECO:0000255|HAMAP-Rule:MF_03039};
AltName: Full=Cytosolic Fe-S cluster-deficient protein 1 {ECO:0000255|HAMAP-Rule:MF_03039};
AltName: Full=Ribosomal export protein 19;
Name=CFD1 {ECO:0000255|HAMAP-Rule:MF_03039}; Synonyms=DRE3, RIX19;
OrderedLocusNames=YIL003W; ORFNames=YIA3W;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7762303; DOI=10.1002/yea.320110109;
Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S.,
Schwager C., Zimmermann J., Sander C., Ansorge W.;
"Nucleotide sequence and analysis of the centromeric region of yeast
chromosome IX.";
Yeast 11:61-78(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169870;
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N.,
Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G.,
Moule S., Odell C., Pearson D., Rajandream M.A., Rice P., Rowley N.,
Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
Nature 387:84-87(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12970194; DOI=10.1093/emboj/cdg455;
Roy A., Solodovnikova N., Nicholson T., Antholine W., Walden W.E.;
"A novel eukaryotic factor for cytosolic Fe-S cluster assembly.";
EMBO J. 22:4826-4835(2003).
[6]
FUNCTION.
PubMed=15660135; DOI=10.1038/sj.emboj.7600540;
Yarunin A., Panse V.G., Petfalski E., Dez C., Tollervey D., Hurt E.C.;
"Functional link between ribosome formation and biogenesis of iron-
sulfur proteins.";
EMBO J. 24:580-588(2005).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ADR376;
PubMed=17330950; DOI=10.1021/pr060559j;
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
Elias J.E., Gygi S.P.;
"Large-scale phosphorylation analysis of alpha-factor-arrested
Saccharomyces cerevisiae.";
J. Proteome Res. 6:1190-1197(2007).
[8]
FUNCTION, INTERACTION WITH NBP35, AND EPR SPECTROSCOPY OF IRON-SULFUR
CLUSTER.
PubMed=17401378; DOI=10.1038/nchembio872;
Netz D.J.A., Pierik A.J., Stuempfig M., Muehlenhoff U., Lill R.;
"The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein
assembly in the yeast cytosol.";
Nat. Chem. Biol. 3:278-286(2007).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides
insights into evolution.";
Science 325:1682-1686(2009).
[10]
FUNCTION, SUBUNIT, AND MUTAGENESIS OF CYS-182; CYS-201; CYS-204 AND
CYS-207.
PubMed=22362766; DOI=10.1074/jbc.M111.328914;
Netz D.J., Pierik A.J., Stumpfig M., Bill E., Sharma A.K.,
Pallesen L.J., Walden W.E., Lill R.;
"A bridging [4Fe-4S] cluster and nucleotide binding are essential for
function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur
protein maturation.";
J. Biol. Chem. 287:12365-12378(2012).
-!- FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein
assembly (CIA) machinery. Required for maturation of
extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer
forms a Fe-S scaffold complex, mediating the de novo assembly of
an Fe-S cluster and its transfer to target apoproteins. Nucleotide
binding/hydrolysis seems to be critcal for loading of Fe-S
clusters onto CFD1 and NBP35. Required for biogenesis and export
of both ribosomal subunits, which may reflect a role in assembly
of the Fe/S clusters in RLI1, a protein which performs rRNA
processing and ribosome export. {ECO:0000255|HAMAP-Rule:MF_03039,
ECO:0000269|PubMed:12970194, ECO:0000269|PubMed:15660135,
ECO:0000269|PubMed:17401378, ECO:0000269|PubMed:22362766}.
-!- COFACTOR:
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two
stable clusters in the N-termini of NBP35 and two labile, bridging
clusters between subunits of the NBP35-CFD1 heterotetramer.;
-!- SUBUNIT: Heterotetramer of 2 NBP35 and 2 CFD1 chains.
{ECO:0000255|HAMAP-Rule:MF_03039, ECO:0000269|PubMed:22362766}.
-!- INTERACTION:
P52920:NBP35; NbExp=9; IntAct=EBI-24924, EBI-11880;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03039,
ECO:0000269|PubMed:12970194}.
-!- SIMILARITY: Belongs to the Mrp/NBP35 ATP-binding proteins family.
NUBP2/CFD1 subfamily. {ECO:0000255|HAMAP-Rule:MF_03039}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X79743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; Z38113; CAA86248.1; -; Genomic_DNA.
EMBL; Z38062; CAA86200.1; -; Genomic_DNA.
EMBL; AY558297; AAS56623.1; -; Genomic_DNA.
EMBL; BK006942; DAA08543.1; -; Genomic_DNA.
PIR; S58704; S58704.
RefSeq; NP_012263.1; NM_001179353.1.
ProteinModelPortal; P40558; -.
SMR; P40558; -.
BioGrid; 34989; 250.
ComplexPortal; CPX-385; CFD1-NBP35 complex.
IntAct; P40558; 3.
STRING; 4932.YIL003W; -.
iPTMnet; P40558; -.
MaxQB; P40558; -.
PaxDb; P40558; -.
PRIDE; P40558; -.
EnsemblFungi; YIL003W_mRNA; YIL003W_mRNA; YIL003W.
GeneID; 854814; -.
KEGG; sce:YIL003W; -.
SGD; S000001265; CFD1.
GeneTree; ENSGT00940000153844; -.
HOGENOM; HOG000079916; -.
InParanoid; P40558; -.
OMA; HCSECSN; -.
OrthoDB; EOG092C4BLN; -.
BioCyc; YEAST:G3O-31282-MONOMER; -.
Reactome; R-SCE-2564818; Cytosolic iron-sulfur cluster assembly (yeast).
PRO; PR:P40558; -.
Proteomes; UP000002311; Chromosome IX.
GO; GO:0005737; C:cytoplasm; IDA:SGD.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:1904564; C:Nbp35-Cfd1 ATPase complex; IDA:SGD.
GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:SGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016887; F:ATPase activity; TAS:SGD.
GO; GO:0051536; F:iron-sulfur cluster binding; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016226; P:iron-sulfur cluster assembly; IDA:SGD.
GO; GO:0002098; P:tRNA wobble uridine modification; IMP:SGD.
CDD; cd02037; MRP-like; 1.
HAMAP; MF_02040; Mrp_NBP35; 1.
HAMAP; MF_03039; NUBP2; 1.
InterPro; IPR019591; Mrp/NBP35_ATP-bd.
InterPro; IPR000808; Mrp_CS.
InterPro; IPR028600; NUBP2/Cfd1_eukaryotes.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033756; YlxH/NBP35.
PANTHER; PTHR23264; PTHR23264; 1.
Pfam; PF10609; ParA; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS01215; MRP; 1.
1: Evidence at protein level;
4Fe-4S; ATP-binding; Complete proteome; Cytoplasm; Iron; Iron-sulfur;
Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome.
CHAIN 1 293 Cytosolic Fe-S cluster assembly factor
CFD1.
/FTId=PRO_0000184952.
NP_BIND 25 32 ATP. {ECO:0000255|HAMAP-Rule:MF_03039}.
METAL 201 201 Iron-sulfur (4Fe-4S); shared with dimeric
partner.
METAL 204 204 Iron-sulfur (4Fe-4S); shared with dimeric
partner.
MOD_RES 291 291 Phosphoserine.
{ECO:0000244|PubMed:17330950,
ECO:0000244|PubMed:19779198}.
MUTAGEN 31 31 K->A: Loss of function.
MUTAGEN 86 86 T->A: Loss of function.
MUTAGEN 182 182 C->A: Does not impair function.
{ECO:0000269|PubMed:22362766}.
MUTAGEN 201 201 C->A: Loss of function and disrupts
heterotetramer formation.
{ECO:0000269|PubMed:22362766}.
MUTAGEN 204 204 C->A: Loss of function and disrupts
heterotetramer formation.
{ECO:0000269|PubMed:22362766}.
MUTAGEN 207 207 C->A: Does not impair function.
{ECO:0000269|PubMed:22362766}.
SEQUENCE 293 AA; 31922 MW; 5CDD563B51229D14 CRC64;
MEEQEIGVPA ASLAGIKHII LILSGKGGVG KSSVTTQTAL TLCSMGFKVG VLDIDLTGPS
LPRMFGLENE SIYQGPEGWQ PVKVETNSTG SLSVISLGFL LGDRGNSVIW RGPKKTSMIK
QFISDVAWGE LDYLLIDTPP GTSDEHISIA EELRYSKPDG GIVVTTPQSV ATADVKKEIN
FCKKVDLKIL GIIENMSGFV CPHCAECTNI FSSGGGKRLS EQFSVPYLGN VPIDPKFVEM
IENQVSSKKT LVEMYRESSL CPIFEEIMKK LRKQDTTTPV VDKHEQPQIE SPK


Related products :

Catalog number Product name Quantity
EIAAB26389 Cytosolic Fe-S cluster assembly factor NARFL,Homo sapiens,Human,IOP1,Iron-only hydrogenase-like protein 1,NARFL,Nuclear prelamin A recognition factor-like protein,PRN,Protein related to Narf
EIAAB26390 Cytosolic Fe-S cluster assembly factor NARFL,IOP1,Iron-only hydrogenase-like protein 1,Mouse,Mus musculus,Narfl,Nuclear prelamin A recognition factor-like protein
EIAAB26391 Bos taurus,Bovine,Cytosolic Fe-S cluster assembly factor NARFL,IOP1,Iron-only hydrogenase-like protein 1,NARFL,Nuclear prelamin A recognition factor-like protein
EIAAB26388 Cytosolic Fe-S cluster assembly factor NARFL,IOP1,Iron-only hydrogenase-like protein 1,Narfl,Nuclear prelamin A recognition factor-like protein,Rat,Rattus norvegicus
EIAAB28174 Bos taurus,Bovine,Cytosolic Fe-S cluster assembly factor NUBP2,NBP 2,NUBP2,Nucleotide-binding protein 2
EIAAB28176 Cytosolic Fe-S cluster assembly factor NUBP2,Mouse,Mus musculus,NBP 2,Nubp2,Nucleotide-binding protein 2
EIAAB28173 Bos taurus,Bovine,Cytosolic Fe-S cluster assembly factor NUBP1,NBP 1,NUBP1,Nucleotide-binding protein 1
EIAAB28171 Cytosolic Fe-S cluster assembly factor NUBP1,Mouse,Mus musculus,NBP 1,Nubp1,Nucleotide-binding protein 1
EIAAB28178 Cytosolic Fe-S cluster assembly factor NUBP2,NBP 2,Nubp2,Nucleotide-binding protein 2,Rat,Rattus norvegicus
EIAAB28170 Cytosolic Fe-S cluster assembly factor NUBP1,NBP 1,Nubp1,Nucleotide-binding protein 1,Rat,Rattus norvegicus
EIAAB28177 Cytosolic Fe-S cluster assembly factor NUBP2,Homo sapiens,Human,NBP 2,NUBP2,Nucleotide-binding protein 2
E15041h Rat ELISA Kit FOR Cytosolic Fe-S cluster assembly factor NUBP1 96T
EIAAB28172 Cytosolic Fe-S cluster assembly factor NUBP1,Homo sapiens,Human,NBP,NBP 1,NBP1,NUBP1,Nucleotide-binding protein 1
NUBP1_BOVIN Bovine ELISA Kit FOR Cytosolic Fe-S cluster assembly factor NUBP1 96T
EIAAB28175 Chicken,Cytosolic Fe-S cluster assembly factor NUBP2,Gallus gallus,NBP 2,NUBP2,Nucleotide-binding protein 2,RCJMB04_9a23
CSB-EL016142MO Mouse Cytosolic Fe-S cluster assembly factor NUBP1(NUBP1) ELISA kit 96T
CSB-EL015455MO Mouse Cytosolic Fe-S cluster assembly factor NARFL(NARFL) ELISA kit 96T
CSB-EL015455HU Human Cytosolic Fe-S cluster assembly factor NARFL(NARFL) ELISA kit 96T
CSB-EL016142HU Human Cytosolic Fe-S cluster assembly factor NUBP1(NUBP1) ELISA kit 96T
CSB-EL016143HU Human Cytosolic Fe-S cluster assembly factor NUBP2(NUBP2) ELISA kit 96T
CSB-EL016143BO Bovine Cytosolic Fe-S cluster assembly factor NUBP2(NUBP2) ELISA kit 96T
CSB-EL015455RA Rat Cytosolic Fe-S cluster assembly factor NARFL(NARFL) ELISA kit SpeciesRat 96T
CSB-EL016143RA Rat Cytosolic Fe-S cluster assembly factor NUBP2(NUBP2) ELISA kit SpeciesRat 96T
CSB-EL015455BO Bovine Cytosolic Fe-S cluster assembly factor NARFL(NARFL) ELISA kit 96T
CSB-EL016143CH Chicken Cytosolic Fe-S cluster assembly factor NUBP2(NUBP2) ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur