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Cytosolic inhibitor of Nrf2 (Kelch-like ECH-associated protein 1)

 G7NL03_MACMU            Unreviewed;       624 AA.
G7NL03; F7C3R9;
25-JAN-2012, integrated into UniProtKB/TrEMBL.
25-JAN-2012, sequence version 1.
12-SEP-2018, entry version 50.
SubName: Full=Cytosolic inhibitor of Nrf2 {ECO:0000313|EMBL:EHH29625.1};
SubName: Full=Kelch-like ECH-associated protein 1 {ECO:0000313|EMBL:AFE81090.1, ECO:0000313|Ensembl:ENSMMUP00000006905};
Name=KEAP1 {ECO:0000313|EMBL:AFE81090.1,
ECO:0000313|Ensembl:ENSMMUP00000006905};
ORFNames=EGK_10100 {ECO:0000313|EMBL:EHH29625.1};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH29625.1};
[1] {ECO:0000313|Ensembl:ENSMMUP00000006905, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000006905,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|EMBL:EHH29625.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CR-5 {ECO:0000313|EMBL:EHH29625.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[3] {ECO:0000313|Ensembl:ENSMMUP00000006905}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000006905};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[4] {ECO:0000313|EMBL:AFE81090.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Caudate {ECO:0000313|EMBL:AFE81090.1}, and
Thymus {ECO:0000313|EMBL:AFH34845.1};
PubMed=25319552; DOI=10.1186/1745-6150-9-20;
Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
"A new rhesus macaque assembly and annotation for next-generation
sequencing analyses.";
Biol. Direct 9:20-20(2014).
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EMBL; JSUE03020726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JSUE03020727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JSUE03020728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JU337339; AFE81090.1; -; mRNA.
EMBL; JU478041; AFH34845.1; -; mRNA.
EMBL; CM001271; EHH29625.1; -; Genomic_DNA.
RefSeq; XP_014978344.1; XM_015122858.1.
RefSeq; XP_014978345.1; XM_015122859.1.
RefSeq; XP_014978346.1; XM_015122860.1.
RefSeq; XP_014978347.1; XM_015122861.1.
UniGene; Mmu.25641; -.
STRING; 9544.ENSMMUP00000006905; -.
Ensembl; ENSMMUT00000007347; ENSMMUP00000006905; ENSMMUG00000005218.
GeneID; 720514; -.
KEGG; mcc:720514; -.
CTD; 9817; -.
eggNOG; KOG4441; Eukaryota.
eggNOG; ENOG410XNX8; LUCA.
GeneTree; ENSGT00760000118931; -.
KO; K10456; -.
OrthoDB; EOG091G02T3; -.
TreeFam; TF329218; -.
Proteomes; UP000006718; Chromosome 19.
Bgee; ENSMMUG00000005218; Expressed in 13 organ(s), highest expression level in cerebellum.
ExpressionAtlas; G7NL03; baseline.
GO; GO:0005884; C:actin filament; IEA:Ensembl.
GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005815; C:microtubule organizing center; IEA:Ensembl.
GO; GO:0030496; C:midbody; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
GO; GO:0045604; P:regulation of epidermal cell differentiation; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:Ensembl.
Gene3D; 2.120.10.80; -; 1.
InterPro; IPR011705; BACK.
InterPro; IPR017096; BTB-kelch_protein.
InterPro; IPR000210; BTB/POZ_dom.
InterPro; IPR030563; KEAP1.
InterPro; IPR015915; Kelch-typ_b-propeller.
InterPro; IPR006652; Kelch_1.
InterPro; IPR011333; SKP1/BTB/POZ_sf.
PANTHER; PTHR24412:SF162; PTHR24412:SF162; 1.
Pfam; PF07707; BACK; 1.
Pfam; PF00651; BTB; 1.
Pfam; PF01344; Kelch_1; 6.
PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
SMART; SM00875; BACK; 1.
SMART; SM00225; BTB; 1.
SMART; SM00612; Kelch; 6.
SUPFAM; SSF117281; SSF117281; 1.
SUPFAM; SSF54695; SSF54695; 1.
PROSITE; PS50097; BTB; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000006718};
Kelch repeat {ECO:0000256|SAAS:SAAS00752720};
Reference proteome {ECO:0000313|Proteomes:UP000006718};
Repeat {ECO:0000256|SAAS:SAAS00752774}.
DOMAIN 77 149 BTB. {ECO:0000259|PROSITE:PS50097}.
SEQUENCE 624 AA; 69818 MW; CE4615E47D01A43F CRC64;
MQPDPKPSRA GACSRFLPLR SQCPEGSGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT
KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM
EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD
PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR
CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY
LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV
PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV
IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG
TNRLNSAERY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE
TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG
RSGVGVAVTM EPCRKQIDQQ NCTC


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