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Cytotoxin 10 (Toxin CM-4a)

 3SAA_NAJHA              Reviewed;          60 AA.
P01453;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
05-JUL-2017, entry version 78.
RecName: Full=Cytotoxin 10;
AltName: Full=Toxin CM-4a;
Naja annulifera (Banded Egyptian cobra) (Naja haje annulifera).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
NCBI_TaxID=96794;
[1]
PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND LETHAL DOSE.
TISSUE=Venom;
PubMed=1017800;
Joubert F.J.;
"Snake venom toxins. The amino acid sequence of three toxins (CM-2e,
CM-4a and CM-) from Naja haje annulifera (Egyptian cobra) venom.";
Hoppe-Seyler's Z. Physiol. Chem. 357:1735-1750(1976).
-!- FUNCTION: Shows cytolytic activity on many different cells by
forming pore in lipid membranes. In vivo, increases heart rate or
kills the animal by cardiac arrest. In addition, it binds to
heparin with high affinity, interacts with Kv channel-interacting
protein 1 (KCNIP1) in a calcium-independent manner, and binds to
integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
{ECO:0000250|UniProtKB:P60301, ECO:0000250|UniProtKB:P60304}.
-!- SUBUNIT: Monomer in solution; Homodimer and oligomer in the
presence of negatively charged lipids forming a pore with a size
ranging between 20 and 30 Angstroms.
{ECO:0000250|UniProtKB:P60301}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1017800}.
Target cell membrane {ECO:0000250|UniProtKB:P60301}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- TOXIC DOSE: LD(50) is 4.14 mg/kg by intravenous injection.
{ECO:0000269|PubMed:1017800}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type IA cytotoxin sub-subfamily. {ECO:0000305}.
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PIR; A01718; H3NJ0E.
ProteinModelPortal; P01453; -.
SMR; P01453; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Cardiotoxin; Cytolysis; Direct protein sequencing; Disulfide bond;
Membrane; Secreted; Target cell membrane; Target membrane; Toxin.
CHAIN 1 60 Cytotoxin 10.
/FTId=PRO_0000093494.
DISULFID 3 21 {ECO:0000250}.
DISULFID 14 38 {ECO:0000250}.
DISULFID 42 53 {ECO:0000250}.
DISULFID 54 59 {ECO:0000250}.
SEQUENCE 60 AA; 6682 MW; 0FC405A2233EE28D CRC64;
LECNQLIPIA HKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKNSALVK YVCCNTDRCN


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