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Cytotoxin 2 (Toxin 12A)

 3SB2_HEMHA              Reviewed;          61 AA.
P24776;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
05-JUL-2017, entry version 77.
RecName: Full=Cytotoxin 2;
AltName: Full=Toxin 12A {ECO:0000303|PubMed:404150};
Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Hemachatus.
NCBI_TaxID=8626;
[1]
PROTEIN SEQUENCE, LETHAL DOSE, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
PubMed=404150; DOI=10.1111/j.1432-1033.1977.tb11403.x;
Joubert F.J.;
"Snake venom toxins. The amino-acid sequences of three toxins (9B, 11
and 12A) from Hemachatus haemachatus (Ringhals) venom.";
Eur. J. Biochem. 74:387-396(1977).
-!- FUNCTION: This protein lyses red blood cells, has cytotoxic
activity and induces hypotension, but is not neurotoxic. In
addition, it induces direct paralysis of the muscle fiber.
{ECO:0000303|PubMed:404150}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:404150}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- TOXIC DOSE: LD(50) is 3.8 mg/kg by intravenous injection into
mice. {ECO:0000269|PubMed:404150}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type IB cytotoxin sub-subfamily. {ECO:0000305}.
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ProteinModelPortal; P24776; -.
SMR; P24776; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0044179; P:hemolysis in other organism; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Cardiotoxin; Cytolysis; Direct protein sequencing; Disulfide bond;
Hemolysis; Hypotensive agent; Secreted; Toxin.
CHAIN 1 61 Cytotoxin 2.
/FTId=PRO_0000093477.
DISULFID 3 22 {ECO:0000250}.
DISULFID 15 39 {ECO:0000250}.
DISULFID 43 54 {ECO:0000250}.
DISULFID 55 60 {ECO:0000250}.
SEQUENCE 61 AA; 6800 MW; A40D1FED3390014B CRC64;
LKCHNKVVPF LSKTCPEGKN LCYKMTLKKV PKIPIKRGCT DACPKSSLLV NVMCCKTDKC
N


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