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Cytotoxin 3 (Cytotoxin IIa)

 3SA3_NAJNA              Reviewed;          60 AA.
P24780;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
22-NOV-2017, entry version 73.
RecName: Full=Cytotoxin 3;
AltName: Full=Cytotoxin IIa;
Naja naja (Indian cobra).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
NCBI_TaxID=35670;
[1]
PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND LETHAL DOSE.
TISSUE=Venom;
PubMed=6525197;
Kaneda N., Takechi M., Sasaki T., Hayashi K.;
"Amino acid sequence of cytotoxin IIa isolated from the venom of the
Indian cobra (Naja naja).";
Biochem. Int. 9:603-610(1984).
-!- FUNCTION: Shows cytolytic activity on many different cells by
forming pore in lipid membranes. In vivo, increases heart rate or
kills the animal by cardiac arrest. In addition, it binds to
heparin with high affinity, interacts with Kv channel-interacting
protein 1 (KCNIP1) in a calcium-independent manner, and binds to
integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
{ECO:0000250|UniProtKB:P60301, ECO:0000250|UniProtKB:P60304}.
-!- SUBUNIT: Monomer in solution; Homodimer and oligomer in the
presence of negatively charged lipids forming a pore with a size
ranging between 20 and 30 Angstroms.
{ECO:0000250|UniProtKB:P60301}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6525197}.
Target cell membrane {ECO:0000250|UniProtKB:P60301}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- TOXIC DOSE: LD(50) is 40 to 55 mg/kg by subcutaneous injection.
{ECO:0000269|PubMed:6525197}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type IA cytotoxin sub-subfamily. {ECO:0000305}.
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ProteinModelPortal; P24780; -.
SMR; P24780; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Cardiotoxin; Cytolysis; Direct protein sequencing; Disulfide bond;
Membrane; Secreted; Target cell membrane; Target membrane; Toxin.
CHAIN 1 60 Cytotoxin 3.
/FTId=PRO_0000093512.
DISULFID 3 21 {ECO:0000250}.
DISULFID 14 38 {ECO:0000250}.
DISULFID 42 53 {ECO:0000250}.
DISULFID 54 59 {ECO:0000250}.
SEQUENCE 60 AA; 6745 MW; 84125AC1BE4F45E2 CRC64;
LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID VCPKNSLVLK YVCCNTDRCN


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