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Cytotoxin 6 (Cardiotoxin-6) (CTX6)

 3SA6_NAJAT              Reviewed;          82 AA.
Q98965;
02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
05-JUL-2017, entry version 66.
RecName: Full=Cytotoxin 6;
AltName: Full=Cardiotoxin-6;
Short=CTX6;
Flags: Precursor;
Naja atra (Chinese cobra).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
NCBI_TaxID=8656;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
PubMed=9192088;
Chang L.-S., Lin J., Wu P.-F.;
"cDNA sequence analysis of cardiotoxin variants from Taiwan cobra.";
Biochem. Mol. Biol. Int. 42:85-92(1997).
-!- FUNCTION: Shows cytolytic activity on many different cells by
forming pore in lipid membranes. In vivo, increases heart rate or
kills the animal by cardiac arrest. In addition, it binds to
heparin with high affinity, interacts with Kv channel-interacting
protein 1 (KCNIP1) in a calcium-independent manner, and binds to
integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
{ECO:0000250|UniProtKB:P60301, ECO:0000250|UniProtKB:P60304}.
-!- SUBUNIT: Monomer in solution; Homodimer and oligomer in the
presence of negatively charged lipids forming a pore with a size
ranging between 20 and 30 Angstroms.
{ECO:0000250|UniProtKB:P60301}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
{ECO:0000250|UniProtKB:P60301}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type IA cytotoxin sub-subfamily. {ECO:0000305}.
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EMBL; Y08727; CAA69977.1; -; mRNA.
ProteinModelPortal; Q98965; -.
SMR; Q98965; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
3: Inferred from homology;
Cardiotoxin; Cytolysis; Disulfide bond; Membrane; Secreted; Signal;
Target cell membrane; Target membrane; Toxin.
SIGNAL 1 21 {ECO:0000250}.
CHAIN 22 82 Cytotoxin 6.
/FTId=PRO_0000035381.
DISULFID 24 42 {ECO:0000250}.
DISULFID 35 59 {ECO:0000250}.
DISULFID 63 74 {ECO:0000250}.
DISULFID 75 80 {ECO:0000250}.
SEQUENCE 82 AA; 9201 MW; 4912FA608DABD307 CRC64;
MKTLLLTLVV VTIVCLDLGY TLKCNQLIPP FYKTCAAGKN LCYKMFMVAA QRFPVKRGCI
DVCPKSSLLV KYVCCNTDRC NN


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