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D(1A) dopamine receptor (Dopamine D1 receptor)

 DRD1_MACMU              Reviewed;         446 AA.
O77680;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
30-AUG-2017, entry version 120.
RecName: Full=D(1A) dopamine receptor;
AltName: Full=Dopamine D1 receptor;
Name=DRD1;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1533268;
Machida C.A., Searles R.P., Nipper V., Brown J.A., Kozell L.B.,
Neve K.A.;
"Molecular cloning and expression of the rhesus macaque D1 dopamine
receptor gene.";
Mol. Pharmacol. 41:652-659(1992).
-!- FUNCTION: Dopamine receptor whose activity is mediated by G
proteins which activate adenylyl cyclase.
-!- SUBUNIT: Interacts with DNAJC14 via its C-terminus. Interacts with
DRD1IP. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Note=Transport from the endoplasmic reticulum to the cell surface
is regulated by interaction with DNAJC14. {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AF077862; AAC27328.1; -; Genomic_DNA.
RefSeq; NP_001193904.1; NM_001206975.1.
RefSeq; XP_014996937.1; XM_015141451.1.
UniGene; Mmu.30055; -.
ProteinModelPortal; O77680; -.
SMR; O77680; -.
STRING; 9544.ENSMMUP00000006816; -.
BindingDB; O77680; -.
PRIDE; O77680; -.
Ensembl; ENSMMUT00000007253; ENSMMUP00000006816; ENSMMUG00000005147.
GeneID; 697796; -.
KEGG; mcc:697796; -.
CTD; 1812; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00890000139331; -.
HOGENOM; HOG000239242; -.
HOVERGEN; HBG106962; -.
InParanoid; O77680; -.
KO; K04144; -.
OMA; SLNRMYA; -.
OrthoDB; EOG091G06VI; -.
TreeFam; TF325181; -.
Proteomes; UP000006718; Chromosome 6.
Bgee; ENSMMUG00000005147; -.
ExpressionAtlas; O77680; baseline.
GO; GO:0060170; C:ciliary membrane; IEA:Ensembl.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0035240; F:dopamine binding; IEA:Ensembl.
GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IEA:Ensembl.
GO; GO:0007190; P:activation of adenylate cyclase activity; IEA:Ensembl.
GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IBA:GO_Central.
GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO; GO:0014002; P:astrocyte development; IEA:Ensembl.
GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO; GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO; GO:1903351; P:cellular response to dopamine; IEA:Ensembl.
GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; IEA:Ensembl.
GO; GO:0001661; P:conditioned taste aversion; IEA:Ensembl.
GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
GO; GO:0015872; P:dopamine transport; IEA:Ensembl.
GO; GO:0046323; P:glucose import; IEA:Ensembl.
GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
GO; GO:0046959; P:habituation; IEA:Ensembl.
GO; GO:0007612; P:learning; IBA:GO_Central.
GO; GO:0060292; P:long term synaptic depression; IEA:Ensembl.
GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
GO; GO:0007617; P:mating behavior; IEA:Ensembl.
GO; GO:0007613; P:memory; IEA:Ensembl.
GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
GO; GO:0035106; P:operant conditioning; IEA:Ensembl.
GO; GO:0030432; P:peristalsis; IEA:Ensembl.
GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IBA:GO_Central.
GO; GO:0010579; P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; IEA:InterPro.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
GO; GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl.
GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0046960; P:sensitization; IEA:Ensembl.
GO; GO:0021756; P:striatum development; IEA:Ensembl.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
GO; GO:0042311; P:vasodilation; IEA:InterPro.
GO; GO:0008542; P:visual learning; IEA:Ensembl.
InterPro; IPR001413; Dopamine_D1_rcpt.
InterPro; IPR000929; Dopamine_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00565; DOPAMINED1AR.
PRINTS; PR00242; DOPAMINER.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
Endoplasmic reticulum; G-protein coupled receptor; Glycoprotein;
Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 446 D(1A) dopamine receptor.
/FTId=PRO_0000069374.
TOPO_DOM 1 23 Extracellular. {ECO:0000255}.
TRANSMEM 24 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 60 Cytoplasmic. {ECO:0000255}.
TRANSMEM 61 87 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 88 96 Extracellular. {ECO:0000255}.
TRANSMEM 97 119 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 120 138 Cytoplasmic. {ECO:0000255}.
TRANSMEM 139 163 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 164 192 Extracellular. {ECO:0000255}.
TRANSMEM 193 218 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 219 272 Cytoplasmic. {ECO:0000255}.
TRANSMEM 273 299 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 300 312 Extracellular. {ECO:0000255}.
TRANSMEM 313 337 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 338 446 Cytoplasmic. {ECO:0000255}.
LIPID 347 347 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 351 351 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 175 175 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 96 186 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 446 AA; 49292 MW; DFB6B9D765D600A5 CRC64;
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN
FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD
RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNATSLA
ETIDNCDSSL SRTYAISSSV ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN
CQTTTGNGKP VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
GETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPATNNAIET
VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED LKKEEAAGIA RPLEKLSPAL
SVILDYDTDV SLEKIQPITQ NGQHPT


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