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D(2) dopamine receptor (Dopamine D2 receptor)

 DRD2_HUMAN              Reviewed;         443 AA.
P14416; Q9NZR3; Q9UPA9;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 2.
27-SEP-2017, entry version 204.
RecName: Full=D(2) dopamine receptor;
AltName: Full=Dopamine D2 receptor;
Name=DRD2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2533064; DOI=10.1089/dna.1.1989.8.683;
Selbie L.A., Hayes G., Shine J.;
"The major dopamine D2 receptor: molecular analysis of the human D2A
subtype.";
DNA 8:683-689(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
PubMed=2531656;
Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A.,
Shivers B.D., Seeburg P.H.;
"The dopamine D2 receptor: two molecular forms generated by
alternative splicing.";
EMBO J. 8:4025-4034(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Retina;
PubMed=2138729; DOI=10.1093/nar/18.5.1299;
Robakis N.K., Mohamadi M., Fu D.Y., Sambamurti K., Refolo L.M.;
"Human retina D2 receptor cDNAs have multiple polyadenylation sites
and differ from a pituitary clone at the 5' non-coding region.";
Nucleic Acids Res. 18:1299-1299(1990).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2532362; DOI=10.1073/pnas.86.24.9762;
Grandy D.K., Marchionni M.A., Makam H., Stofko R.E., Alfano M.,
Frothingham L., Fischer J.B., Burke-Howie K.J., Bunzow J.R.,
Server A.C., Civelli O.;
"Cloning of the cDNA and gene for a human D2 dopamine receptor.";
Proc. Natl. Acad. Sci. U.S.A. 86:9762-9766(1989).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Retina;
PubMed=2137193;
Stormann T.M., Gdula D.C., Weiner D.M., Brann M.R.;
"Molecular cloning and expression of a dopamine D2 receptor from human
retina.";
Mol. Pharmacol. 37:1-6(1990).
[6]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
PubMed=2144985;
Selbie L.A., Hayes G., Shine J.;
"DNA homology screening: isolation and characterization of the human
D2A dopamine receptor subtype.";
Adv. Second Messenger Phosphoprotein Res. 24:9-14(1990).
[7]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=1363862; DOI=10.1016/0197-0186(92)90071-X;
Araki K., Kuwano R., Morii K., Hayashi S., Minoshima S., Shimizu N.,
Katagiri T., Usui H., Kumanishi T., Takahashi Y.;
"Structure and expression of human and rat D2 dopamine receptor
genes.";
Neurochem. Int. 21:91-98(1992).
[8]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Retina;
PubMed=1835903; DOI=10.1007/BF00734808;
Dearry A., Falardeau P., Shores C., Caron M.G.;
"D2 dopamine receptors in the human retina: cloning of cDNA and
localization of mRNA.";
Cell. Mol. Neurobiol. 11:437-453(1991).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=8471125; DOI=10.1038/npp.1993.15;
Seeman P., Ohara K., Ulpian C., Seeman M.V., Jellinger K., Tol H.H.,
Niznik H.B.;
"Schizophrenia: normal sequence in the dopamine D2 receptor region
that couples to G-proteins. DNA polymorphisms in D2.";
Neuropsychopharmacology 8:137-142(1993).
[10]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
TISSUE=Corpus striatum;
PubMed=10719223; DOI=10.1016/S0169-328X(99)00343-5;
Seeman P., Nam D., Ulpian C., Liu I.S.C., Tallerico T.;
"New dopamine receptor, D2(Longer), with unique TG splice site, in
human brain.";
Brain Res. Mol. Brain Res. 76:132-141(2000).
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
Kidd K.K.;
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[14]
INTERACTION WITH CADPS AND CADPS2.
PubMed=15857609; DOI=10.1016/j.bcp.2005.02.015;
Binda A.V., Kabbani N., Levenson R.;
"Regulation of dense core vesicle release from PC12 cells by
interaction between the D2 dopamine receptor and calcium-dependent
activator protein for secretion (CAPS).";
Biochem. Pharmacol. 69:1451-1461(2005).
[15]
INTERACTION WITH GNAI2.
PubMed=17550964; DOI=10.1242/jcs.005611;
Lopez-Aranda M.F., Acevedo M.J., Gutierrez A., Koulen P., Khan Z.U.;
"Role of a Galphai2 protein splice variant in the formation of an
intracellular dopamine D2 receptor pool.";
J. Cell Sci. 120:2171-2178(2007).
[16]
HOMOOLIGOMERIZATION, AND INTERACTION WITH DRD4.
PubMed=21184734; DOI=10.1016/j.bbrc.2010.12.083;
Borroto-Escuela D.O., Van Craenenbroeck K., Romero-Fernandez W.,
Guidolin D., Woods A.S., Rivera A., Haegeman G., Agnati L.F.,
Tarakanov A.O., Fuxe K.;
"Dopamine D2 and D4 receptor heteromerization and its allosteric
receptor-receptor interactions.";
Biochem. Biophys. Res. Commun. 404:928-934(2011).
[17]
INTERACTION WITH HTR2A, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=21645528; DOI=10.1016/j.neuropharm.2011.05.023;
Albizu L., Holloway T., Gonzalez-Maeso J., Sealfon S.C.;
"Functional crosstalk and heteromerization of serotonin 5-HT2A and
dopamine D2 receptors.";
Neuropharmacology 61:770-777(2011).
[18]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 208-226.
PubMed=17264214; DOI=10.1073/pnas.0608599104;
Johnston C.A., Siderovski D.P.;
"Structural basis for nucleotide exchange on G alpha i subunits and
receptor coupling specificity.";
Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007).
[19]
ERRATUM, AND RETRACTION.
PubMed=22408789; DOI=10.1073/pnas.1200173109;
Johnston C.A., Siderovski D.P.;
Proc. Natl. Acad. Sci. U.S.A. 109:1808-1808(2012).
[20]
VARIANT CYS-311.
PubMed=7902708; DOI=10.1006/bbrc.1993.2404;
Itokawa M., Arinami T., Futamura N., Hamaguchi H., Toru M.;
"A structural polymorphism of human dopamine D2 receptor,
D2(Ser311->Cys).";
Biochem. Biophys. Res. Commun. 196:1369-1375(1993).
[21]
VARIANT ILE-154.
PubMed=10220438; DOI=10.1073/pnas.96.9.5173;
Klein C., Brin M.F., Kramer P., Sena-Esteves M., de Leon D.,
Doheny D., Bressman S., Fahn S., Breakefield X.O., Ozelius L.J.;
"Association of a missense change in the D2 dopamine receptor with
myoclonus dystonia.";
Proc. Natl. Acad. Sci. U.S.A. 96:5173-5176(1999).
[22]
INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
PubMed=15389757; DOI=10.1002/ajmg.b.30085;
Johann M., Putzhammer A., Eichhammer P., Wodarz N.;
"Association of the -141C Del variant of the dopamine D2 receptor
(DRD2) with positive family history and suicidality in German
alcoholics.";
Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005).
[23]
CHARACTERIZATION OF VARIANT ILE-154.
PubMed=10716258;
DOI=10.1002/1531-8249(200003)47:3<369::AID-ANA14>3.3.CO;2-0;
Klein C., Gurvich N., Sena-Esteves M., Bressman S., Brin M.F.,
Ebersole B.J., Fink S., Forsgren L., Friedman J., Grimes D.,
Holmgren G., Kyllerman M., Lang A.E., de Leon D., Leung J.,
Prioleau C., Raymond D., Sanner G., Saunders-Pullman R., Vieregge P.,
Wahlstrom J., Breakefield X.O., Kramer P.L., Ozelius L.J.,
Sealfon S.C.;
"Evaluation of the role of the D2 dopamine receptor in myoclonus
dystonia.";
Ann. Neurol. 47:369-373(2000).
[24]
VARIANT GLU-327.
PubMed=21179162; DOI=10.1038/nature09629;
Bevilacqua L., Doly S., Kaprio J., Yuan Q., Tikkanen R., Paunio T.,
Zhou Z., Wedenoja J., Maroteaux L., Diaz S., Belmer A.,
Hodgkinson C.A., Dell'osso L., Suvisaari J., Coccaro E., Rose R.J.,
Peltonen L., Virkkunen M., Goldman D.;
"A population-specific HTR2B stop codon predisposes to severe
impulsivity.";
Nature 468:1061-1066(2010).
-!- FUNCTION: Dopamine receptor whose activity is mediated by G
proteins which inhibit adenylyl cyclase.
{ECO:0000269|PubMed:21645528}.
-!- SUBUNIT: Forms homo- and heterooligomers with DRD4. The
interaction with DRD4 may modulate agonist-induced downstream
signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By
similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2
(By similarity). Interacts with KCNA2 (By similarity). Interacts
with GNAI2 isoform sGi2, the interaction allows the creation of an
intracellular pool of DRD2 that can be released to cell surface
upon agonist stimulation. Interacts with HTR2A.
{ECO:0000250|UniProtKB:P61168, ECO:0000250|UniProtKB:P61169,
ECO:0000269|PubMed:15857609, ECO:0000269|PubMed:17550964,
ECO:0000269|PubMed:21184734, ECO:0000269|PubMed:21645528}.
-!- INTERACTION:
Self; NbExp=4; IntAct=EBI-2928178, EBI-2928178;
P29274:ADORA2A; NbExp=2; IntAct=EBI-2928178, EBI-2902702;
P21917:DRD4; NbExp=4; IntAct=EBI-11686358, EBI-8592297;
Q01959:SLC6A3; NbExp=4; IntAct=EBI-2928178, EBI-6661445;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21645528};
Multi-pass membrane protein {ECO:0000269|PubMed:21645528}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1; Synonyms=D2(Long);
IsoId=P14416-1; Sequence=Displayed;
Name=2; Synonyms=D2(Short);
IsoId=P14416-2; Sequence=VSP_001870;
Name=3; Synonyms=D2(Longer);
IsoId=P14416-3; Sequence=VSP_026455;
-!- POLYMORPHISM: Genetic variations in DRD2 may determine the genetic
susceptibility to alcoholism [MIM:103780]. Genetic variations in
DRD2 might be a protective factor against the development of
withdrawal symptoms but might also be a risk factor in a highly
burdened subgroup of alcoholics with a paternal and grandpaternal
history of alcoholism and might contribute to suicide risk in
alcoholics. {ECO:0000305|PubMed:15389757}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; M30625; AAA88024.1; -; mRNA.
EMBL; X51645; CAB56463.1; -; mRNA.
EMBL; X51646; CAB37869.1; -; Genomic_DNA.
EMBL; X51362; CAA35746.1; -; mRNA.
EMBL; M29066; AAA52761.1; -; mRNA.
EMBL; S62137; AAB26819.1; -; mRNA.
EMBL; S69899; AAB20571.1; -; mRNA.
EMBL; S58589; AAB26274.1; -; Genomic_DNA.
EMBL; S58577; AAB26274.1; JOINED; Genomic_DNA.
EMBL; S58584; AAB26274.1; JOINED; Genomic_DNA.
EMBL; S58586; AAB26274.1; JOINED; Genomic_DNA.
EMBL; S58588; AAB26274.1; JOINED; Genomic_DNA.
EMBL; AF176812; AAF61479.1; -; mRNA.
EMBL; AB065860; BAC06078.1; -; Genomic_DNA.
EMBL; AF050737; AAC78779.1; -; Genomic_DNA.
EMBL; BC021195; AAH21195.1; -; mRNA.
CCDS; CCDS8361.1; -. [P14416-1]
CCDS; CCDS8362.1; -. [P14416-2]
PIR; S08417; DYHUD2.
RefSeq; NP_000786.1; NM_000795.3. [P14416-1]
RefSeq; NP_057658.2; NM_016574.3. [P14416-2]
RefSeq; XP_016872785.1; XM_017017296.1. [P14416-1]
UniGene; Hs.73893; -.
PDB; 1I15; Model; -; A=34-58, B=72-97, C=108-129, D=153-172, E=190-210, F=371-396, G=403-426.
PDB; 5AER; X-ray; 2.19 A; B/C=430-443.
PDBsum; 1I15; -.
PDBsum; 5AER; -.
ProteinModelPortal; P14416; -.
SMR; P14416; -.
BioGrid; 108147; 18.
DIP; DIP-5977N; -.
IntAct; P14416; 6.
MINT; MINT-201447; -.
STRING; 9606.ENSP00000354859; -.
BindingDB; P14416; -.
ChEMBL; CHEMBL217; -.
DrugBank; DB01614; Acepromazine.
DrugBank; DB01063; Acetophenazine.
DrugBank; DB05766; ACP-104.
DrugBank; DB01425; Alizapride.
DrugBank; DB00915; Amantadine.
DrugBank; DB06288; Amisulpride.
DrugBank; DB00543; Amoxapine.
DrugBank; DB00182; Amphetamine.
DrugBank; DB04599; Aniracetam.
DrugBank; DB00714; Apomorphine.
DrugBank; DB01238; Aripiprazole.
DrugBank; DB09207; AS-8112.
DrugBank; DB06216; Asenapine.
DrugBank; DB04889; Bicifadine.
DrugBank; DB04888; Bifeprunox.
DrugBank; DB05687; BL-1020.
DrugBank; DB04857; Brasofensine.
DrugBank; DB09128; Brexpiprazole.
DrugBank; DB01200; Bromocriptine.
DrugBank; DB09018; Bromopride.
DrugBank; DB00490; Buspirone.
DrugBank; DB00248; Cabergoline.
DrugBank; DB06016; Cariprazine.
DrugBank; DB01038; Carphenazine.
DrugBank; DB00477; Chlorpromazine.
DrugBank; DB01239; Chlorprothixene.
DrugBank; DB00568; Cinnarizine.
DrugBank; DB00363; Clozapine.
DrugBank; DB01151; Desipramine.
DrugBank; DB01184; Domperidone.
DrugBank; DB00988; Dopamine.
DrugBank; DB01142; Doxepin.
DrugBank; DB00450; Droperidol.
DrugBank; DB01049; Ergoloid mesylate.
DrugBank; DB00696; Ergotamine.
DrugBank; DB00875; Flupentixol.
DrugBank; DB00623; Fluphenazine.
DrugBank; DB04842; Fluspirilene.
DrugBank; DB00502; Haloperidol.
DrugBank; DB04946; Iloperidone.
DrugBank; DB00458; Imipramine.
DrugBank; DB05816; intranasal apomorphine.
DrugBank; DB04924; Itopride.
DrugBank; DB01221; Ketamine.
DrugBank; DB01235; Levodopa.
DrugBank; DB00589; Lisuride.
DrugBank; DB00408; Loxapine.
DrugBank; DB06077; Lumateperone.
DrugBank; DB08815; Lurasidone.
DrugBank; DB00934; Maprotiline.
DrugBank; DB01043; Memantine.
DrugBank; DB00933; Mesoridazine.
DrugBank; DB01403; Methotrimeprazine.
DrugBank; DB01233; Metoclopramide.
DrugBank; DB06148; Mianserin.
DrugBank; DB00805; Minaprine.
DrugBank; DB00370; Mirtazapine.
DrugBank; DB01618; Molindone.
DrugBank; DB00540; Nortriptyline.
DrugBank; DB00334; Olanzapine.
DrugBank; DB01267; Paliperidone.
DrugBank; DB01186; Pergolide.
DrugBank; DB00850; Perphenazine.
DrugBank; DB05316; Pimavanserin.
DrugBank; DB01100; Pimozide.
DrugBank; DB01621; Pipotiazine.
DrugBank; DB00413; Pramipexole.
DrugBank; DB00433; Prochlorperazine.
DrugBank; DB00420; Promazine.
DrugBank; DB01069; Promethazine.
DrugBank; DB00777; Propiomazine.
DrugBank; DB01224; Quetiapine.
DrugBank; DB00409; Remoxipride.
DrugBank; DB00734; Risperidone.
DrugBank; DB01549; Rolicyclidine.
DrugBank; DB00268; Ropinirole.
DrugBank; DB05271; Rotigotine.
DrugBank; DB06144; Sertindole.
DrugBank; DB05280; SLV 308.
DrugBank; DB00391; Sulpiride.
DrugBank; DB04844; Tetrabenazine.
DrugBank; DB00372; Thiethylperazine.
DrugBank; DB01622; Thioproperazine.
DrugBank; DB00679; Thioridazine.
DrugBank; DB01623; Thiothixene.
DrugBank; DB13025; Tiapride.
DrugBank; DB00831; Trifluoperazine.
DrugBank; DB00508; Triflupromazine.
DrugBank; DB00726; Trimipramine.
DrugBank; DB01392; Yohimbine.
DrugBank; DB00246; Ziprasidone.
DrugBank; DB01624; Zuclopenthixol.
GuidetoPHARMACOLOGY; 215; -.
TCDB; 9.A.14.3.10; the g-protein-coupled receptor (gpcr) family.
iPTMnet; P14416; -.
PhosphoSitePlus; P14416; -.
SwissPalm; P14416; -.
BioMuta; DRD2; -.
DMDM; 118206; -.
PaxDb; P14416; -.
PeptideAtlas; P14416; -.
PRIDE; P14416; -.
DNASU; 1813; -.
Ensembl; ENST00000346454; ENSP00000278597; ENSG00000149295. [P14416-2]
Ensembl; ENST00000362072; ENSP00000354859; ENSG00000149295. [P14416-1]
Ensembl; ENST00000538967; ENSP00000438215; ENSG00000149295. [P14416-3]
Ensembl; ENST00000542968; ENSP00000442172; ENSG00000149295. [P14416-1]
GeneID; 1813; -.
KEGG; hsa:1813; -.
UCSC; uc001pnz.4; human. [P14416-1]
CTD; 1813; -.
DisGeNET; 1813; -.
EuPathDB; HostDB:ENSG00000149295.13; -.
GeneCards; DRD2; -.
HGNC; HGNC:3023; DRD2.
HPA; HPA015691; -.
MalaCards; DRD2; -.
MIM; 103780; phenotype.
MIM; 126450; gene.
neXtProt; NX_P14416; -.
OpenTargets; ENSG00000149295; -.
Orphanet; 36899; Myoclonus-dystonia syndrome.
PharmGKB; PA27478; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00760000118795; -.
HOVERGEN; HBG106962; -.
InParanoid; P14416; -.
KO; K04145; -.
OMA; RNWSRPF; -.
OrthoDB; EOG091G06VI; -.
PhylomeDB; P14416; -.
TreeFam; TF334382; -.
Reactome; R-HSA-390651; Dopamine receptors.
Reactome; R-HSA-418594; G alpha (i) signalling events.
SignaLink; P14416; -.
SIGNOR; P14416; -.
EvolutionaryTrace; P14416; -.
GeneWiki; Dopamine_receptor_D2; -.
GenomeRNAi; 1813; -.
PRO; PR:P14416; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000149295; -.
CleanEx; HS_DRD2; -.
ExpressionAtlas; P14416; baseline and differential.
Genevisible; P14416; HS.
GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
GO; GO:0030424; C:axon; ISS:BHF-UCL.
GO; GO:0043679; C:axon terminus; IEA:Ensembl.
GO; GO:0060170; C:ciliary membrane; IDA:SYSCILIA_CCNET.
GO; GO:0030425; C:dendrite; ISS:BHF-UCL.
GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
GO; GO:0097730; C:non-motile cilium; IDA:SYSCILIA_CCNET.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IDA:WormBase.
GO; GO:0014069; C:postsynaptic density of dendrite; IEA:Ensembl.
GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
GO; GO:0035240; F:dopamine binding; IBA:GO_Central.
GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:BHF-UCL.
GO; GO:0008144; F:drug binding; IDA:BHF-UCL.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl.
GO; GO:0015459; F:potassium channel regulator activity; NAS:BHF-UCL.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0032147; P:activation of protein kinase activity; IEA:Ensembl.
GO; GO:0021984; P:adenohypophysis development; ISS:BHF-UCL.
GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0007628; P:adult walking behavior; ISS:BHF-UCL.
GO; GO:0050482; P:arachidonic acid secretion; IDA:BHF-UCL.
GO; GO:0008306; P:associative learning; ISS:BHF-UCL.
GO; GO:0031223; P:auditory behavior; IEA:Ensembl.
GO; GO:0007409; P:axonogenesis; ISS:BHF-UCL.
GO; GO:0048148; P:behavioral response to cocaine; ISS:BHF-UCL.
GO; GO:0048149; P:behavioral response to ethanol; ISS:BHF-UCL.
GO; GO:0048755; P:branching morphogenesis of a nerve; ISS:BHF-UCL.
GO; GO:0006874; P:cellular calcium ion homeostasis; IC:BHF-UCL.
GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; ISS:BHF-UCL.
GO; GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO; GO:0032922; P:circadian regulation of gene expression; ISS:BHF-UCL.
GO; GO:0042417; P:dopamine metabolic process; IC:BHF-UCL.
GO; GO:0007631; P:feeding behavior; IEA:Ensembl.
GO; GO:0002031; P:G-protein coupled receptor internalization; IEA:Ensembl.
GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IDA:BHF-UCL.
GO; GO:0007626; P:locomotory behavior; ISS:BHF-UCL.
GO; GO:0007616; P:long-term memory; IEA:Ensembl.
GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:BHF-UCL.
GO; GO:0045776; P:negative regulation of blood pressure; ISS:BHF-UCL.
GO; GO:0030336; P:negative regulation of cell migration; ISS:BHF-UCL.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.
GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; IEA:Ensembl.
GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; ISS:BHF-UCL.
GO; GO:0033602; P:negative regulation of dopamine secretion; IEA:Ensembl.
GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; ISS:BHF-UCL.
GO; GO:0050709; P:negative regulation of protein secretion; IDA:BHF-UCL.
GO; GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.
GO; GO:1901386; P:negative regulation of voltage-gated calcium channel activity; IDA:BHF-UCL.
GO; GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; ISS:BHF-UCL.
GO; GO:0007270; P:neuron-neuron synaptic transmission; ISS:BHF-UCL.
GO; GO:0021769; P:orbitofrontal cortex development; IEA:Ensembl.
GO; GO:0030432; P:peristalsis; ISS:BHF-UCL.
GO; GO:0046488; P:phosphatidylinositol metabolic process; ISS:BHF-UCL.
GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IGI:MGI.
GO; GO:0043473; P:pigmentation; IEA:Ensembl.
GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IDA:BHF-UCL.
GO; GO:0051586; P:positive regulation of dopamine uptake involved in synaptic transmission; ISS:BHF-UCL.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl.
GO; GO:1900168; P:positive regulation of glial cell-derived neurotrophic factor secretion; IDA:CACAO.
GO; GO:0060124; P:positive regulation of growth hormone secretion; ISS:BHF-UCL.
GO; GO:1900273; P:positive regulation of long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; ISS:BHF-UCL.
GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0035810; P:positive regulation of urine volume; IEA:Ensembl.
GO; GO:0060134; P:prepulse inhibition; ISS:BHF-UCL.
GO; GO:0008104; P:protein localization; ISS:BHF-UCL.
GO; GO:0030814; P:regulation of cAMP metabolic process; IDA:BHF-UCL.
GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
GO; GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IC:BHF-UCL.
GO; GO:0002027; P:regulation of heart rate; ISS:BHF-UCL.
GO; GO:0090325; P:regulation of locomotion involved in locomotory behavior; IEA:Ensembl.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; ISS:BHF-UCL.
GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
GO; GO:0043266; P:regulation of potassium ion transport; ISS:BHF-UCL.
GO; GO:0002028; P:regulation of sodium ion transport; ISS:BHF-UCL.
GO; GO:0051823; P:regulation of synapse structural plasticity; IEA:Ensembl.
GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; ISS:BHF-UCL.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:BHF-UCL.
GO; GO:0001975; P:response to amphetamine; ISS:BHF-UCL.
GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
GO; GO:0042220; P:response to cocaine; ISS:BHF-UCL.
GO; GO:0042493; P:response to drug; ISS:BHF-UCL.
GO; GO:0034776; P:response to histamine; IDA:BHF-UCL.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0014854; P:response to inactivity; IEA:Ensembl.
GO; GO:0010039; P:response to iron ion; IEA:Ensembl.
GO; GO:0009416; P:response to light stimulus; ISS:BHF-UCL.
GO; GO:0043278; P:response to morphine; ISS:BHF-UCL.
GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
GO; GO:0009636; P:response to toxic substance; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; ISS:BHF-UCL.
GO; GO:0021756; P:striatum development; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; ISS:BHF-UCL.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IBA:GO_Central.
GO; GO:0001659; P:temperature homeostasis; ISS:BHF-UCL.
GO; GO:0008542; P:visual learning; ISS:BHF-UCL.
GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
InterPro; IPR001922; Dopamine_D2_rcpt.
InterPro; IPR000929; Dopamine_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00567; DOPAMINED2R.
PRINTS; PR00242; DOPAMINER.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane; Complete proteome;
Disease mutation; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 443 D(2) dopamine receptor.
/FTId=PRO_0000069387.
TOPO_DOM 1 37 Extracellular. {ECO:0000250}.
TRANSMEM 38 60 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 61 70 Cytoplasmic. {ECO:0000250}.
TRANSMEM 71 93 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 94 108 Extracellular. {ECO:0000250}.
TRANSMEM 109 130 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 131 151 Cytoplasmic. {ECO:0000250}.
TRANSMEM 152 172 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 173 188 Extracellular. {ECO:0000250}.
TRANSMEM 189 213 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 214 373 Cytoplasmic. {ECO:0000250}.
TRANSMEM 374 395 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 396 409 Extracellular. {ECO:0000250}.
TRANSMEM 410 431 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 432 443 Cytoplasmic. {ECO:0000250}.
REGION 190 197 Agonist binding. {ECO:0000250}.
REGION 211 373 Interaction with PPP1R9B. {ECO:0000250}.
REGION 386 394 Agonist binding. {ECO:0000250}.
BINDING 114 114 Agonist. {ECO:0000250}.
SITE 194 194 Important for receptor activation.
{ECO:0000250}.
SITE 197 197 Important for receptor activation.
{ECO:0000250}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 17 17 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 23 23 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 107 182 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 399 401 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VAR_SEQ 242 270 Missing (in isoform 2).
{ECO:0000303|PubMed:2531656}.
/FTId=VSP_001870.
VAR_SEQ 270 270 V -> VVQ (in isoform 3).
{ECO:0000303|PubMed:10719223}.
/FTId=VSP_026455.
VARIANT 154 154 V -> I (found in patients with alcohol-
responsive myoclonus-dystonia; unknown
pathological significance; the mutation
does not affect functional properties;
dbSNP:rs104894220).
{ECO:0000269|PubMed:10220438,
ECO:0000269|PubMed:10716258}.
/FTId=VAR_017143.
VARIANT 310 310 P -> S (in dbSNP:rs1800496).
/FTId=VAR_014674.
VARIANT 311 311 S -> C (may be associated with a higher
risk for schizophrenia; dbSNP:rs1801028).
{ECO:0000269|PubMed:7902708}.
/FTId=VAR_003462.
VARIANT 327 327 K -> E (in dbSNP:rs71653614).
{ECO:0000269|PubMed:21179162}.
/FTId=VAR_064579.
CONFLICT 40 40 L -> R (in Ref. 7; AAB26819).
{ECO:0000305}.
HELIX 431 442 {ECO:0000244|PDB:5AER}.
SEQUENCE 443 AA; 50619 MW; 9BF8EA36C988A2E2 CRC64;
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS
REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA
SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN
ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL
KGNCTHPEDM KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK TRTSLKTMSR
RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD CNIPPVLYSA FTWLGYVNSA
VNPIIYTTFN IEFRKAFLKI LHC


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